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| 1 | Simultaneously optimizing pore morphology and enhancing mechanical properties of Al-Si alloy composite foams by graphene nanosheets显示文摘The integrity and regularity of pore morphology play an important role in determining the mechanical properties of the metallic foam materials.The conventional methods on refining pore morphology are mainly focused on the optimization of fabrication techniques,however,they are usually inconvenient and complicated.Recently,incorporating nano reinforcement is considered to be a suitable way to fabricate metallic composite foams accompanied by optimized pore morphology and enhanced mechanical properties.In this work,through a facile and rapid powder metallurgy foaming method,the aluminum-silicon(Al-Si)alloy composite foams reinforced by graphene nanosheets(GNSs)are successfully fabricated.The microstructure analyses reveal that,for the Al-Si alloy foams incorporating the GNSs(GNSs/Al-Si composite foams),the pore size is transformed to be smaller,the pore size distributions become more homogeneous and the pore shape is also refined to a regular and roundish state.Meanwhile,the shape of Si precipitates is found transforming from an irregular long strip(length of~20μm,width of~5μm)to a fine particle state(diameter of~5μm).Moreover,the compressive testing results show that,the 0.4wt%GNSs/Al-Si composite foams own the optimal compression stress of 11.7±0.5 MPa,plateau stress of 10.0±1.0 MPa and energy absorption capacity of 6.8±0.7 MJ/m^(3),which have improvement of 58.1%,53.8%and 51.1%in comparison with the Al-Si alloy foams counterpart,respectively.The present findings may pave a new way for developing new generation of metallic composite foams that with stable microstructure and excellent mechanical performance. | Weiting Li Xudong Yang Kunming Yang Chunnian He Junwei Sha Chunsheng Shi Yunhui Mei Jiajun Li Naiqin Zhao | 2022 | Journal of Materials Science & Technology2022，，6： | 3 |
| 2 | Iron accumulation and its impact on osteoporotic fractures in postmenopausal women显示文摘Postmenopausal osteoporosis is a kind of degenerative disease,also described as“invisible killer.”Estrogen is generally considered as the key hormone for women to maintain bone mineral content during their lives.Iron accumulation refers to a state of human serum ferritin that is higher than the normal value but less than 1000μg/L.It has been found that iron accumulation and osteoporosis could occur simultaneously with the decrease in estrogen level after menopause.In recent years,many studies indicated that iron accumulation plays a vital role in postmenopausal osteoporosis,and a significant correlation has been found between iron accumulation and fragility fractures.In this review,we summarize and analyze the relevant literature including randomized controlled trials,systematic reviews,and meta-analyses between January 1996 and July 2022.We investigate the mechanism of the effect of iron accumulation on bone metabolism and discuss the relationship of iron accumulation,osteoporosis,and postmenopausal fragility fractures,as well as the main clinical treatment strategies.We conclude that it is necessary to pay attention to the phenomenon of iron accumulation in postmenopausal women with osteoporosis and explore the in-depth mechanism of abnormal bone metabolism caused by iron accumulation,in order to facilitate the discovery of effective therapeutic targets for postmenopausal osteoporosis. | Hui CAI Huimei ZHANG Weiting HE Heng ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，4： | 1 |
| 3 | Mapping reservoir boundary by borehole-surface显示文摘 | ZHANXIANG HE XUEJUN LIU WEITING QIU | 2005 | TFEM:The Leading Edge2005，24，： | 1 |
| 4 | Complexity analysis of the biomedical signal using fuzzy entropy measurement 显示文摘 | Xie Hongbo Chen Weiting He Weixing | 2011 | Applied Soft Computing2011，11，2： | 1 |
| 5 | Cc mplex-ity analysis of the biomedical signal using fuzzy entropy easure- ment 显示文摘 | XIE HONGDO CHEN WEITING HE WELTING | 2011 | Applied Soft Computing2011，11，2： | 1 |
| 6 | Personal glucose meters coupled with signal amplification technologies for quantitative detection of non-glucose targets:Recent progress and challenges in food safety hazards analysis显示文摘Ensuring food safety is paramount worldwide.Developing effective detection methods to ensure food safety can be challenging owing to trace hazards,long detection time,and resource-poor sites,in addition to the matrix effects of food.Personal glucose meter(PGM),a classic point-of-care testing device,possesses unique application advantages,demonstrating promise in food safety.Currently,many studies have used PGM-based biosensors and signal amplification technologies to achieve sensitive and specific detection of food hazards.Signal amplification technologies have the potential to greatly improve the analytical performance and integration of PGMs with biosensors,which is crucial for solving the challenges associated with the use of PGMs for food safety analysis.This review introduces the basic detection principle of a PGM-based sensing strategy,which consists of three key factors:target recognition,signal transduction,and signal output.Representative studies of existing PGM-based sensing strategies combined with various signal amplification technologies(nanomaterial-loaded multienzyme labeling,nucleic acid reaction,DNAzyme catalysis,responsive nanomaterial encapsulation,and others)in the field of food safety detection are reviewed.Future perspectives and potential opportunities and challenges associated with PGMs in the field of food safety are discussed.Despite the need for complex sample preparation and the lack of standardization in the field,using PGMs in combination with signal amplification technology shows promise as a rapid and cost-effective method for food safety hazard analysis. | Feng He Haijie Wang Pengfei Du Tengfei Li Weiting Wang Tianyu Tan Yaobo Liu Yanli Ma Yuanshang Wang A.M.Abd El-Aty | 2023 | Journal of Pharmaceutical Analysis2023，13，3： | 0 |
| 7 | Fluid-Dynamics Analysis and Structural Optimization of a 300 kW MicroGas Turbine Recuperator显示文摘Computational Fluid Dynamics(CFD)is used here to reduce pressure loss and improve heat exchange efficiency in the recuperator associated with a gas turbine.First,numerical simulations of the high-temperature and lowtemperature channels are performed and,the calculated results are compared with experimental data(to verify the reliability of the numerical method).Second,the flow field structure of the low-temperature side channel is critically analyzed,leading to the conclusion that the flow velocity distribution in the low-temperature side channel is uneven,and its resistance is significantly higher than that in the high-temperature side.Therefore,five alternate structural schemes are proposed for the optimization of the low-temperature side.In particular,to reduce the flow velocity in the upper channel,the rib length of each channel at the inlet of the low-temperature side region is adjusted.The performances of the 5 schemes are compared,leading to the identification of the configuration able to guarantee a uniform flow rate and minimize the pressure drop.Finally,the heat transfer performance of the optimized recuperator structure is evaluated,and it is shown that the effectiveness of the recuperator is increased by 1.5%. | Weiting Jiang Tingni He Chongyang Wang Weiguo Pan Jiang Liu | 2023 | Fluid Dynamics & Materials Processing2023，19，6： | 0 |
| 8 | Simulation and Optimization of the Fluid Solidification Process in Brazed Plate Heat Exchangers显示文摘When a brazed plate heat exchanger is used as an evaporator,the working mass in the channel may undergo soli-dification,thereby hindering the refrigeration cycle.In this study the liquid solidification process and its optimi-zation in a brazed plate heat exchanger are investigated numerically for different inlet velocities;moreover,different levels of corrugation are considered.The results indicate that solidificationfirst occurs around the con-tacts,followed by the area behind the contacts.It is also shown that deadflow zones exist in the sharp areas and such areas are prone to liquid solidification.After optimization,the solidification area attains its smallest value when a corrugation spacingλ=4.2 mm is considered. | Weiting Jiang Lei Zhao Chongyang Wang Tingni He Weiguo Pan | 2023 | Fluid Dynamics & Materials Processing2023，19，10： | 0 |
| 9 | A PD-L1-targeting chimeric switch receptor enhances efficacy of CAR-T cell for pleural and peritoneal metastasis显示文摘Pleural and peritoneal metastasis accompanied by malignant pleural effusion(MPE)or malignant ascites(MA)is frequent in patients with advanced solid tumors that originate from the lung,breast,gastrointestinal tract and ovary.Regional delivery of CAR-T cells represents a new strategy to control tumor dissemination in serous cavities.However,malignant effusions constitute an immune-suppressive environment that potentially induces CAR-T cell dysfunction.Here,we demonstrated that the anti-tumor cytotoxicity of conventional 2nd-generation CAR-T cells was significantly inhibited by both the cellular and non-cellular components of MPE/MA,which was primarily attributed to impaired CAR-T cell proliferation and cytokine production in MPE/MA environment.Interestingly,we found that PD-L1 was widely expressed on freshly-isolated MPE/MA cells.Based on this feature,a novel PD-L1-targeting chimeric switch receptor(PD-L1.BB CSR)was designed,which can bind to PD-L1,switching the inhibitory signal into an additional 4-1BB signal.When co-expressed with a 2nd-generation CAR,PD-L1.BB CSR-modified CAR-T cells displayed superior fitness and enhanced functions in both culture medium and MPE/MA environment,causing rapid and durable eradication of pleural and peritoneal metastatic tumors in xenograft models.Further investigations revealed elevated expressions of T-cell activation,proliferation,and cytotoxicity-related genes,and we confirmed that PD-L1 scFv and 4-1BB intracellular domain,the two important components of PD-L1.BB CSR,were both necessary for the functional improvements of CAR-T cells.Overall,our study shed light on the clinical application of PD-L1.BB CSR-modified dual-targeting CAR-T cells.Based on this study,a phase I clinical trial was initiated in patients with pleural or peritoneal metastasis(NCT04684459). | Qizhi Ma Xia He Benxia Zhang Fuchun Guo Xuejin Ou Qiyu Yang Pei Shu Yue Chen Kai Li Ge Gao Yajuan Zhu Diyuan Qin Jie Tang Xiaoyu Li Meng Jing Jian Zhao Zeming Mo Ning Liu Yao Zeng Kexun Zhou Mingyang Feng Weiting Liao Wanting Lei Qiu Li Dan Li Yongsheng Wang | 2022 | Signal Transduction and Targeted Therapy2022，7，12： | 0 |
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