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		题名	作者	年代	出处	被引量
	1	Colonic manifestations of PTEN hamartoma tumor syndrome: Case series and systematic review显示文摘AIM:To investigate our clinical experience with the colonic manifestations of phosphatase and tensin homolog on chromosome ten(PTEN)hamartoma tumor syndrome(PHTS)and to perform a systematic literature review regarding the same.METHODS:This study was approved by the appropriate institutional review board prior to initiation.A clinical genetics database was searched for patients with PHTS or a component syndrome that received gastrointestinal endoscopy or pathology interpretation at our center.These patient’s records were retrospectively reviewed for clinical characteristics(including family history and genetic testing),endoscopy results and pathology findings.We also performed a systematic review of the literature for case series of PHTS or component syndromes that reported gastrointestinal manifestations and investigations published after consensus diagnostic criteria were established in 1996.These results were compiled and reported.RESULTS:Eight patients from our institution met initial inclusion criteria.Of these,5 patients underwent4.2 colonoscopies at mean age 45.8±10.8 years.All were found to have colon polyps during their clinical course and polyp histology included adenoma,hyperplastic,ganglioneuroma and juvenile.No malignant lesions were identified.Two had multiple histologic types.One patient underwent colectomy due to innumerable polyps and concern for future malignant potential.Systematic literature review of PHTS patients undergoing endoscopy revealed 107 patients receiving colonoscopy at mean age 37.4 years.Colon polyps were noted in92.5%and multiple colon polyp histologies were reported in 53.6%.Common polyp histologies included hyperplastic(43.6%),adenoma(40.4%),hamartoma(38.3%),ganglioneuroma(33%)and inflammatory(24.5%)polyps.Twelve(11.2%)patients had colorectal cancer at mean age 46.7 years(range 35-62).Clinical outcomes secondary to colon polyposis and malignancy were not commonly reported.CONCLUSION:PHTS has a high prevalence of colon polyposis with multiple histologic types.It should be considered a mixed polyposis syndrome.Systematic review found an increased prevalence of colorectal cancer and we recommend initiating colonoscopy for colorectal cancer surveillance at age 35 years.	Peter P Stanich Robert Pilarski Jonathan Rock Wendy L Frankel Samer El-Dika Marty M Meyer	2014	World Journal of Gastroenterology2014，20，7：	5
	2	Managemnent strategy impacts on ammonia volatilization from swine manure 显示文摘	Daine M P Wendy J P Jeffery C L	2005	J Environ Qual2005，34，：	1
	3	Workplace Change and Em- ployee Mental Health: Results from a Longitudinal Study 显示文摘	WENDY L STEPHEN P FRANK P	2010	Bri J Manag2010，21，2：	1
	4	Supply net- work synthesis on rubber seed oil utilisation as potential biofuel feedstock 显示文摘	WENDY P Q N HON L L SUZANA Y	2013	Energy2013，55，：	1
	5	Reversible hydrogels fromself-assembling artificial proteins显示文摘	Wendy A P James L H Kevin P M	1998	ProQuest Biology Journals Science1998，281，：	1
	6	Conserved CTL epitopes within EBV latent membrane protein 2: a potential target forCTL-based tumor therapy 显示文摘	Steven P L Rosemary J T Wendy A T	1997	J Immunol1997，158，7：	1
	7	Origin and outcome of pregnancies affected by androgentic/biparental chimerism显示文摘	Wendy P Julie L Micheil A	2007	Hum Repod2007，22，4：	1
	8	查看详情显示文摘	Jindra P Kim F D P Wendy Z Eltjo J V Arend J S Michelle L C		0，，15：	1
	9	Inactivation of IL-6 and soluble IL-6 receptor by neutrophil derivedserine proteases in cystic fibrosis显示文摘	Eamon P M Philip L D Wendy P	2010	Biochim Biophys Aeta2010，1802，：	1
	10	An application-specific protocol architecture for wireless microsensor networks显示文摘	Heinze L Wendi B Anantha P	2002	IEEE Transactions on Wireless Communications2002，1，4：	1
	11	Prostate-derived factor-a novel inhibitor of drug-induced cell death in colon cancer cells显示文摘	Irina P Leanne S Wendy L		0，，：	1
	12	Conserved CTL epitopes within EBV latent membrane protein 2:a potential target for CTL-based tumor therapy显示文摘	Steven P L Rosemary J T Wendy A T	1997	J Immunol1997，158，7：	1
	13	Control of DrosophilaOpsm Gene Expression by Carotenoids and Retinoic Acid:Northern and Western Analyses显示文摘	Wendy L P De M C Ronnie D L	1996	Exp Eye Res1996，63，：	1
	14	Soil respiration in northern forests exposed to elevated atmospheric carbon dioxide and ozone 显示文摘	Kurt P Wendy L Mark K	2006	Oecelogia2006，148，3：	1
	15	Using the Gini coefficient with BIOLOG sub- strate utilization data to provide an alternative quantitative measure for comparing bacterial soil communities显示文摘	Bronwyn D H Raymond L C Wendy M Clive A K and Clive E P	1997	Jour- nal of Microbiological Methods1997，30，：	1
	16	Com- mon genetic variation in the DKK1 gene is associated with hip axis length but not with bone mineral density and bone turnover markers in young adult men: Re- sults from the odense androgen study显示文摘	ELKE P WENDY B TORBEN L N	2010	Calcif Tis- sue Int2010，86，：	1
	17	Risk of late effects of treatment in children newly diagnosed with standard-risk acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor Study cohort显示文摘	Stefan Essig Qiaozhi Li Yan Chen Johann Hitzler Wendy Leisenring Mark Greenberg Charles Sklar Melissa M Hudson Gregory T Armstrong Kevin R Krull Joseph P Neglia Kevin C Oeffinger Leslie L Robison Claudia E Kuehni Yutaka Yasui Paul C Nathan	2014	Lancet Oncology2014，，：	1
	18	Reversible hydrogels fromself-assembling artificial proteins显示文摘	Wendy A P James L H Kevin P M	1998	ProQuest Biology Journals Science1998，281，：	1

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