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| 1 | Apelin-13 induces ERK1/2 but not p38 MAPK activation through coupling of the human apelin receptor to the Gi2 pathway显示文摘 | Bo Bai Jiyou Tang Haiqing Liu Jing Chen Yalin Li Wengang Song | 2008 | Acta Biochimica et Biophysica Sinica2008，40，4： | 14 |
| 2 | Programmed Death Ligand-1 on Microglia Regulates Th1 Differentiation via Nitric Oxide in Experimental Autoimmune Encephalomyelitis显示文摘Microglia are considered to be potential antigen-presenting cells and have the ability to present antigen under pathological conditions. Nevertheless, whether and how microglia are involved in immune regulation are largely unknown. Here, we investigated the suppressive activity of microglia during experimental autoimmune encephalomyelitis(EAE) induced by myelin oligodendrocyte glycoprotein, with the goal of understanding their role in regulating the T cell reaction. Using flow cytometric analysis, we found that microglia were characterized by increased cell number and up-regulated programmed death ligand-1(PD-L1) at the peak phase of EAE. Meanwhile,both the CD^(4+)T cells and microglia that infiltrated the central nervous system expressed higher levels of PD1, the receptor for PD-L1, accompanied by a decline of Th1 cells.In an ex vivo co-culture system, microglia from EAE mice inhibited the proliferation of antigen-specific CD^(4+)T cells and the differentiation of Th1 cells, and this was significantly inhibited by PD-L1 blockade. Further,microglia suppressed Th1 cells via nitric oxide(NO), the production of which was dependent on PD-L1. Thus, these data suggest a scenario in which microglia are involved in the regulation of EAE by suppressing Th1-cell differentiation via the PD-L1-NO pathway. | Jingxia Hu Hao He Zhengang Yang Guangming Zhu Li Kang Xiuli Jing Hai Lu Wengang Song Bo Bai Hua Tang | 2016 | Neuroscience Bulletin2016，32，1： | 9 |
| 3 | Bifidobacteria DNA Induces Murine Macrophages Activation in vitro显示文摘Previous studies have shown that oligodeoxynucleotides containing unmethylated CpG motifs were used as adjuvants for immunoregulation and immune response. This study was to explore the activation effects of Bifidobacteria DNA containing unmethylated CpG motifs (CpG DNA) on murine macrophage J774A.1 cells. The genomic DNA of Bifidobacteria was extracted and purified, and the methylation degree of CpG motifs was tested.The phagocytic ability of the macrophages was detected by flow cytometry. The cytokines (IL-1β, IL-6, IL-12p40 and TNF-α) levels in the culture supernatants of Bifidobacteria DNA treated J774A.1 cells were assayed by ELISA. The content of nitric oxide (NO) was detected by Griess reagent. After treated with Bifidobacteria DNA for 24h,Nile Red stain increased in J774A.1 macrophage, which suggested that the lipid metabolism increased in the macrophages. The phagocytic ability and levels of NO and cytokines of IL-1β, IL-6, IL-12p40 and TNF-α were significantly higher than PBS group and CT DNA group. The results indicated that Bifidobacteria DNA could activate murine macrophages J774A.1, which could provide scientific basis for the research and application of microorganism DNA preparation. | Yalin Li Xun Qu Hua Yang Li Kang Yingping Xu Bo Bai Wengang Song | 2005 | Cellular & Molecular Immunology2005，2，6： | 6 |
| 4 | Neutralization of interleukin-17A alleviates burn-induced intestinal barrier disruption via reducing pro-inflammatory cytokines in a mouse model显示文摘Background:The intestinal barrier integrity can be disrupted due to burn injury,which is responsible for local and systemic inflammatory responses.Anti-inflammation strategy is one of the proposed therapeutic approaches to control inflammatory cascade at an early stage.Interleukin-17A(IL-17A)plays a critical role in inflammatory diseases.However,the role of IL-17A in the progression of burn-induced intestinal inflammation is poorly understood.In this study,we aimed to investigate the effect of IL-17A and associated pro-inflammatory cytokines that were deeply involved in the pathogenesis of burn-induced intestinal inflammatory injury,and furthermore,we sought to determine the early source of IL-17A in the intestine.Methods:Mouse burn model was successfully established with infliction of 30%total body surface area scald burn.The histopathological manifestation,intestinal permeability,zonula occludens-1 expression,pro-inflammatory cytokines were determined with or without IL-17A-neutralization.Flow cytometry was used to detect the major source of IL-17A^(+)cells in the intestine.Results:Burn caused intestinal barrier damage,increase of intestinal permeability,alteration of zonula occludens-1 expressions,elevation of IL-17A,IL-6,IL-1βand tumor necrosis factor-α(TNF-α),whereas IL-17A neutralization dramatically alleviated burn-induced intestinal barrier disruption,maintained zonula occludens-1 expression,and noticeably,inhibited pro-inflammatory cytokines elevation.In addition,we observed that the proportion of intestinal IL-17A^(+)Vγ4^(+)T subtype cells(but not IL-17A^(+)Vγ1^(+)T subtype cells)were increased in burn group,and neutralization of IL-17A suppressed this increase.Conclusions:The main original findings of this study are intestinal mucosa barrier is disrupted after burn through affecting the expression of pro-inflammatory cytokines,and a protective role of IL-17A neutralization for intestinal mucosa barrier is determined.Furthermore,Vγ4^(+)T cells are identified as the major early producers of IL-17A that orchestrate an inflammatory response in the burn model.These data suggest that IL-17A blockage may provide a unique target for therapeutic intervention to treat intestinal insult after burn. | Yajun Song Yang Li Ya Xiao Wengang Hu Xu Wang Pei Wang Xiaorong Zhang Jiacai Yang Yong Huang Weifeng He Chibing Huang | 2019 | Burns & Trauma2019，7，1： | 5 |
| 5 | MEF2C promotes M1 macrophage polarization and Th1 responses显示文摘The polarization of macrophages to the M1 or M2 phenotype has a pivotal role in inflammation and host defense;however,the underlying molecular mechanism remains unclear.Here,we show that myocyte enhancer factor 2 C(MEF2C)is essential for regulating M1 macrophage polarization in response to infection and inflammation.Global gene expression analysis demonstrated that MEF2C deficiency in macrophages downregulated the expression of M1 phenotypic markers and upregulated the expression of M2 phenotypic markers.MEF2C significantly promoted the expression of interleukin-12 p35 subunit(Il12a)and interleukin-12 p40 subunit(Il12b).Myeloid-specific Mef2c-knockout mice showed reduced IL-12 production and impaired Th1 responses,which led to susceptibility to Listeria monocytogenes infection and protected against DSS-induced IBD in vivo.Mechanistically,we showed that MEF2C directly activated the transcription of Il12a and Il12b.These findings reveal a new function of MEF2C in macrophage polarization and Th1 responses and identify MEF2C as a potential target for therapeutic intervention in inflammatory and autoimmune diseases. | Xibao Zhao Qianqian Di Han Liu Jiazheng Quan Jing Ling Zizhao Zhao Yue Xiao Han Wu Zherui Wu Wengang Song Huazhang An Weilin Chen | 2022 | Cellular & Molecular Immunology2022，19，4： | 4 |
| 6 | Active contours with selective local or global segmentation: A new formulation and level set method显示文摘 | Kaihua Zhang Lei Zhang Huihui Song Wengang Zhou | 2009 | Image and Vision Computing2009，，4： | 2 |
| 7 | Microgia and micreglia-like cell differentiated from DC inhibiet CD4 T cell proliferation 显示文摘 | Bo bai wengang song Yewei ji | 2009 | PLOS One2009，4，11： | 1 |
| 8 | Active contours with selective local or global segmentation: A new formulation and level set method显示文摘 | Kaihua Zhang Lei Zhang Huihui Song Wengang Zhou | 2009 | Image and Vision Computing2009，，4： | 1 |
| 9 | Machine learning for adjoint vector in aerodynamic shape optimization显示文摘Adjoint method is widely used in aerodynamic design because only once solution of flow field is required for it to obtain the gradients of all design variables. However, the computational cost of adjoint vector is approximately equal to that of flow computation. In order to accelerate the solution of adjoint vector and improve the efficiency of adjoint-based optimization, machine learning for adjoint vector modeling is presented. Deep neural network (DNN) is employed to construct the mapping between the adjoint vector and the local flow variables. DNN can efficiently predict adjoint vector and its generalization is examined by a transonic drag reduction of NACA0012 airfoil. The results indicate that with negligible computational cost of the adjoint vector, the proposed DNN-based adjoint method can achieve the same optimization results as the traditional adjoint method. | Mengfei Xu Shufang Song Xuxiang Sun Wengang Chen Weiwei Zhang | 2021 | Acta Mechanica Sinica2021，37，9： | 1 |
| 10 | 粗毛牛膝菊在中国的入侵与生态位漂移有关显示文摘在外来物种入侵和扩散过程中,生态位的漂移可能起到了重要作用。粗毛牛膝菊(Galinsoga quadriradiata)在中国已造成了较为严重的入侵,占据了许多与其原产地不同的气候区。为此,本研究力图揭示粗毛牛膝菊入侵过程中的气候生态位漂移,分析其在该物种入侵中国过程中可能发挥的作用。本研究结合粗毛牛膝菊原产地和入侵地的分布点与气候数据,采用Maxent模型预测了其在中国潜在的分布,并采用主成分分析的方法评估了在入侵中国过程中粗毛牛膝菊气候生态位的漂移。模型结果显示,该物种原产地种群和入侵地种群之间只有32.7%的生态位重叠,两个种群的生态位相似性较低(Schoener's D=0.093,P<0.005),这暗示了在其入侵过程中发生了生态位漂移。相比于其原产地种群,其在中国的入侵种群气候生态位的整体范围和中心都明显地漂移向了温度更低、降水更少的区域;中国南方大部分区域属于粗毛牛膝菊的稳定适生区,而位于入侵前沿的北方地区则存在局域适应和潜在拓殖区域。这些研究结果说明,粗毛牛膝菊在中国的入侵种群仍处于准平衡阶段,未来有可能继续向新的适生区扩散入侵,其生态位的变化有力地解释了为什么该物种在中国的入侵性强、危害范围大。 | Wengang Zhang Xiaoyan Chen Ruiling Liu Xingjiang Song Gang Liu Jiabin Zou Zengqiang Qian Zhihong Zhu Langjun Cui | 2022 | Journal of Plant Ecology2022，15，3： | 1 |
| 11 | Strontium ranelate incorporated 3D porous sulfonated PEEK simulating MC3T3-E1 cell differentiation显示文摘Polyetheretherketone(PEEK)has been used as an implant material because it has similar mechani-cal properties to natural bone.However,inferior osseointegration and bioinertness hamper the clinical application of PEEK.In this study,the surfaces of sulfonated three-dimensional(3D)PEEK porous structures were loaded with different concentrations of strontium ranelate,a compound commonly used in the treatment or prevention of osteoporosis by promoting bone formation and inhibiting bone resorption.Field-emission scanning electron microscopy was used to characterize the topography of the structures,elemental carbon,oxygen and strontium contents were mea-sured by X-ray photoelectron spectroscopy,and surface zeta potentials and water-contact angle were also measured.The results indicated that strontium ranelate was successfully loaded onto the 3D porous structures.In vitro cellular results showed that strontium ranelate-treated sulfonated PEEK(SP-SR)strengthened the adhesion of MC3T3-E1 cells.The activity of alkaline phosphatase,collagen secretion and extracellular matrix mineralization deposition of MC3T3-E1 cells were also improved on the surface of SP-SR.These results indicate that SP-SR could serve a new implant candidate for surgical treatment. | Yingxiao Sunt Xingdan Liu Ji Tan Dan Lv Wengang Song Rui Su Ling Li Xuanyong Liu Liping Ouyang Yun Liao | 2021 | Regenerative Biomaterials2021，8，1： | 0 |
| 12 | Host Genetic Background Impacts Microbiome Composition in Newborn Alligator显示文摘Genetic factors play a key role in determination of the structure of the cloacal flora for newborn Chinese Alligators.We collected the cloacal microbiomes for 24 newborn Chinese Alligators from three different genetic backgrounds for 16S gene amplicon sequencing.The number of cloacal flora for the Chinese Alligators from different groups was comparable but differed structurally.There were variations in proportions of floral compositions at the phylum and family levels;however,the main difference was at the genus level.There were two significant differences in richness and evenness among the three groups.Non-metric multidimensional scaling NMDS analysis revealed that the 24 samples could be clearly divided into three categories based on their genetic backgrounds(stress=0.0244).Thus,we postulated that newborn Chinese Alligators with different genetic backgrounds have different immune strengths,which affects individual responses to environmental microorganisms.In summary,newborn Chinese Alligators from different genetic backgrounds exhibit variations in cloacal microbiome. | Huabin ZHANG Wengang LI Genjun TU Ke SUN Liuyang YANG Ziyi WANG Zirui WU Yongkang ZHOU Song ZHANG Hao SUN Changshun SHENG Xiaoping WANG Rongjun ZHANG Xiaobing WU Tao PAN | 2023 | Asian Herpetological Research2023，14，3： | 0 |
| 13 | Efficient ternary organic solar cells based on a twin spiro-type non-fullerene acceptor显示文摘A novel small-molecule(SM) acceptor DTF-IC is designed and synthesized in this work. The power conversion efficiency(PCE) of ternary OSCs increased up to 12.14% from 10.90% by incorporating 10 wt% of DTF-IC as second acceptors into the binary OSCs consisting of PBDB-T as donor and IT-M as acceptor. This was mainly due to the large increase in short-circuit current(Jsc) from 16.18 to 17.95 mA/cm^2, without any drop in the open-circuit voltage(Voc) and fill factor(FF). The addition of DTF-IC enabled the donor and acceptor to form a distinct complementary absorption profile in the visible-light region, which boosted the photon harvesting in the range of 730–800 nm and consequently increased the Jscof the ternary system by 11%. Moreover, there was an energy transfer between the two SM acceptors, favorable for enhancing charge separation and transfer as well as reducing charge recombination at PBDB-T:IT-M and PBDB-T:DTF-IC interface. Simultaneously, HOMO and LUMO energy levels of DTF-IC were lower than those of PBDB-T, but still higher than those of IT-M. Thus, DTF-IC is able to provide a cascading energy level with the host donor and acceptor which are beneficial for efficient charge transfer between the acceptors and facilitating exciton dissociation and carrier transport. Meanwhile, the highly crystalline DTF-IC as a third component can improve the crystallization process of the active layer while maintaining proper phase separation. This work proposes a novel idea for non-fullerene acceptors achieved via twin spiro-type structure modifying by indanone and provides a new direction for the selection of ternary solar cell materials. | Lirong Wu Lingchao Xie Hanmin Tian Ruixiang Peng Jiaming Huang Billy Fanady Wei Song Songting Tan Wengang Bi Ziyi Ge | 2019 | Science Bulletin2019，64，15： | 0 |
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