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| 1 | A novel partner of Scalloped regulates Hippo signaling via antagonizing Scalloped-Yorkie activity显示文摘由调整 transcriptional 激活剂 Yorkie (Yki ) 的活动的河马(Hpo ) 小径控制织物生长和机关尺寸,它在原子核与抄写因素 Scalloped (Sd ) 联系下游地支持指向基因表示。这里,我们识别新奇蛋白质 Sd-Binding-Protein (SdBP )/Tgi,它直接通过它的 TDU 域为绑定与 Yki 竞争到 Sd 并且禁止 Sd-Yki transcriptional 活动。我们也发现 SdBP 经由它的 PPXY 主题与 Yki WW 领域通过协会在原子核保留 Yki。一起,我们作为 Hpo 小径的一个新奇部件识别 SdBP,否定地调整 Sd-Yki 的 transcriptional 活动限制织物生长。 | Tong Guo Yi Lu Peixue Li Meng-Xin Yin Dekang Lv Wenjing Zhang Huizhen Wang Zhaocai Zhou Hongbin Ji Yun Zhao Lei Zhang | 2013 | Cell Research2013，23，10： | 13 |
| 2 | ZrC-ZrB_2-SiC ceramic nanocomposites derived from a novel single-source precursor with high ceramic yield显示文摘For the first time, ZrC-ZrB_2-SiC ceramic nanocomposites were successfully prepared by a single-source-precursor route, with allylhydridopolycarbosilane(AHPCS),triethylamine borane(TEAB),and bis(cyclopentadienyl) zirconium dichloride(Cp_2 ZrCl_2) as starting materials. The polymer-to-ceramic transformation and thermal behavior of obtained single-source precursor were characterized by means of Fourier transform infrared spectroscopy(FT-IR) and thermal gravimetric analysis(TGA). The results show that the precursor possesses a high ceramic yield about 85% at 1000 ℃.The phase composition and microstructure of formed ZrC-ZrB_2-SiC ceramics were investigated by means of X-ray diffraction(XRD) and high resolution transmission electron microscopy(HRTEM).Meanwhile, the weight loss and chemical composition of the resultant ZrC-ZrB_2-SiC nanocomposites were investigated after annealing at high temperature up to 1800 ℃. High temperature behavior with respect to decomposition as well as crystallization shows a promising high temperature stability of the formed ZrC-ZrB_2-SiC nanocomposites. | Zhaoju YU Xuan LV Shuyi LAI Le YANG Wenjing LEI Xingang LUAN Ralf RIEDEL | 2019 | Journal of Advanced Ceramics2019，8，1： | 8 |
| 3 | Utilization of Ogura CMS germplasm with the clubroot resistance gene by fertility restoration and cytoplasm replacement in Brassica oleracea L显示文摘Clubroot disease,a major plant root disease caused by Plasmodiophora brassicae,has become one of the most destructive diseases among cultivated cruciferous vegetables.However,clubroot-resistant Brassica oleracea materials are rare.A few clubroot-resistant cabbage varieties are available on the market,but all are Ogura cytoplasmic male sterile(CMS)types.Therefore,in this study,to reutilize the clubroot-resistant Ogura CMS germplasm of cabbage,a new fertility-restored Ogura CMS material,16Q2-11,was used as a bridge to transfer the clubroot resistance(CR)gene from the Ogura CMS cytoplasm to the normal cytoplasm by a two-step method(a fertility restoration and cytoplasm replacement method).In the first cross for fertility restoration of Ogura CMS clubroot-resistant cabbage(FRCRC),16Q2-11 was used as a restorer to cross with Ogura CMS materials containing the CR gene CRb2.Eleven Rfo-positive progenies were generated,of which four contained CRb2:F8-514,F8-620,F8-732 and F8-839.After inoculation with race 4 of P.brassicae,these four CRb2-positive individuals showed resistance.Furthermore,F8-514 and F8-839 were then used as male parents in the second cross of FRCRC to cross with cabbage inbred lines,resulting in the successful introgression of the CRb2 gene into the inbred lines.All offspring produced from this step of cross,which had a normal cytoplasm,showed a high resistance to race 4 of P.brassicae and could be utilized for the breeding of clubrootresistant cabbage varieties in the future.This is the first time that the Ogura CMS restorer has been used to restore the fertility of Ogura CMS clubroot-resistant cabbages,which could improve germplasm diversity in cabbage and provide a reference method for using CMS germplasm in Brassica crops. | Wenjing Ren Zhiyuan Li Fengqing Han Bin Zhang Xing Li Zhiyuan Fang Limei Yang Mu Zhuang Honghao Lv Yumei Liu Yong Wang Hailong Yu Yangyong Zhang | 2020 | Horticulture Research2020，7，1： | 7 |
| 4 | Effect of nitrogen limitation on antioxidant qualities is highly associated with genotypes of lettuce(Lactuca sativa L.)显示文摘Antioxidants are highly beneficial to human health, and their accumulation in lettuce, one of the most popular leafy vegetables, depends on both genetic and environmental factors. Nitrogen(N) availability plays an essential role in regulating antioxidant accumulation, but the influence of genotype × N interactions on the antioxidant qualities of lettuce is poorly understood. Therefore, the present study investigated the variation of growth and antioxidant qualities of 20 lettuce(Lactuca sativa L.) genotypes(10 green lettuce genotypes and 10 red lettuce genotypes) under limited N(low N, LN) conditions and standard N(high N, HN) conditions. For all 20 genotypes, LN conditions reduced shoot(i.e., leaf) growth, but increased plant concentrations of vitamin C,glutathione, and phenolic compounds, with the exception of carotenoids, compared with HN conditions. Because of reduced biomass under LN conditions, not all lettuce genotypes exhibited increased antioxidant yields or total antioxidant capacity yield. The variation in antioxidant quality was primarily genetically determined. Generally, the green lettuce genotypes exhibited more pronounced increases in antioxidant yields and total antioxidant capacity yield than the red lettuce genotypes under LN conditions. These results suggest that even though LN conditions generally tend to improve the antioxidant qualities of lettuce, the extent of this effect is highly dependent on genotype. Therefore, genotype should be given priority in future studies that aim to improve antioxidant qualities in lettuce through N management. | Weiwei ZHOU Ting LV Yan HU Wenjing LIU Qingfang BI Chongwei JIN Lingli LU Xianyong LIN | 2020 | Pedosphere2020，30，3： | 4 |
| 5 | Use of catalytic wet air oxidation (CWAO) for pretreatment of high-salinity high-organic wastewater显示文摘Catalytic wet air oxidation(CWAO)coupled desalination technology provides a possibility for the effective and economic degradation of high salinity and high organic wastewater.Chloride widely occurs in natural and wastewaters,and its high content jeopardizes the efficacy of Advanced oxidation process(AOPs).Thus,a novel chlorine ion resistant catalyst Bsite Ru doped LaFe_(1-x)Ru_(x)O_(3-)δin CWAO treatment of chlorine ion wastewater was examined.Especially,LaFe_(0.85)Ru_(0.15)O_(3-δ)was 45.5% better than that of the 6%RuO_(2)@TiO_(2)(commercial carrier)on total organic carbon(TOC)removal.Also,doped catalysts LaFe_(1-x)Ru_(x)O_(3-)δshowed better activity than supported catalysts RuO_(2)@LaFeO_(3) and RuO_(2)@TiO_(2) with the same Ru content.Moreover,LaFe_(0.85)Ru_(0.15)O_(3-)δhas novel chlorine ion resistance no matter the concentration of Cl^(−) and no Ru dissolves after the reaction.X-ray diffraction(XRD)refinement,X-ray photoelectron spectroscopy(XPS),transmission electron microscope(TEM),and X-ray absorption fine structure(XAFS)measurements verified the structure of LaFe_(0.85)Ru_(0.15)O_(3-)δ.Kinetic data and density functional theory(DFT)proved that Fe is the site of acetic acid oxidation and adsorption of chloride ions.The existence of Fe in LaFe_(0.85)Ru_(0.15)O_(3-)δcould adsorb chlorine ion(catalytic activity inhibitor),which can protect the Ru site and other active oxygen species to exert catalytic activity.This work is essential for the development of chloride-resistant catalyst in CWAO. | Wenjing Sun Hongxia Lv Lei Ma Xiangdong Tan Chengyu Jin Huiling Wu Lili Chen Mengyang Liu Huangzhao Wei Chenglin Sun | 2022 | Journal of Environmental Sciences2022，34，10： | 4 |
| 6 | The jasmonate-induced bHLH gene SlJIG functions in terpene biosynthesis and resistance to insects and fungus显示文摘Jasmonic acid(JA)is a key regulator of plant defense responses.Although the transcription factor MYC2,the master regulator of the JA signaling pathway,orchestrates a hierarchical transcriptional cascade that regulates the JA responses,only a few transcriptional regulators involved in this cascade have been described.Here,we identified the basic helix-loop-helix(bHLH)transcription factor gene in tomato(Solanum lycopersicum),METHYL JASMONATE(MeJA)-INDUCED GENE(SlJIG),the expression of which was strongly induced by MeJA treatment.Genetic and molecular biology experiments revealed that SlJIG is a direct target of MYC2.SlJIG knockout plants generated by gene editing had lower terpene contents than the wild type from the lower expression of TERPENE SYNTHASE(TPS)genes,rendering them more appealing to cotton bollworm(Helicoverpa armigera).Moreover,SlJIG knockouts exhibited weaker JA-mediated induction of TPSs,suggesting that SlJIG may participate in JA-induced terpene biosynthesis.Knocking out SlJIG also resulted in attenuated expression of JA-responsive defense genes,which may contribute to the observed lower resistance to cotton bollworm and to the fungus Botrytis cinerea.We conclude that SlJIG is a direct target of MYC2,forms a MYC2-SlJIG module,and functions in terpene biosynthesis and resistance against cotton bollworm and B.cinerea. | Yunyun Cao Lun Liu Kangsheng Ma Wenjing Wang Hongmei Lv Ming Gao Xinman Wang Xichun Zhang Shuxin Ren Na Zhang Yang-Dong Guo | 2022 | Journal of Integrative Plant Biology2022，64，5： | 4 |
| 7 | Up-regulation of glycolipid transfer protein by bicyclol causes spontaneous restriction of hepatitis C virus replication显示文摘Bicyclol is a synthetic drug for hepatoprotection in clinic since 2004. Preliminary clinical observations suggest that bicyclol might be active against hepatitis C virus(HCV) with unknown mechanism. Here, we showed that bicyclol significantly inhibited HCV replication in vitro and in hepatitis C patients. Using bicyclol as a probe, we identified glycolipid transfer protein(GLTP) to be a novel restrictive factor for HCV replication. The GLTP preferentially bound host vesicle-associated membrane protein-associated protein-A(VAP-A) in competition with the HCV NS5 A, causing an interruption of the complex formation between VAP-A and HCV NS5 A. As the formation of VAP-A/NS5 A complex is essential for viral RNA replication, up-regulation of GLTP by bicyclol reduced the level of VAP-A/NS5 A complex and thus inhibited HCV replication. Bicyclol also exhibited an inhibition on HCV variants resistant to direct-acting antiviral agents(DAAs) with an efficacy identical to that on wild type HCV. In combination with bicyclol, DAAs inhibited HCV replication in a synergistic fashion. GLTP appears to be a newly discovered host restrictive factor for HCV replication, Up-regulation of GLTP causes spontaneous restriction of HCV replication. | Meng-Hao Huang Hu Li Rong Xue Jianrui Li Lihua Wang Junjun Cheng Zhouyi Wu Wenjing Li Jinhua Chen Xiaoqin Lv Qiang Li Pei Lan Limin Zhao Yongfeng Yang Zonggen Peng Jiandong Jiang | 2019 | Acta Pharmaceutica Sinica B2019，9，4： | 3 |
| 8 | Cerebral regional and network characteristics in asthma patients: a resting-state fMRI study显示文摘Asthma is a serious health problem that involves not only the respiratory system but also the central nervous system.Previous studies identified either regional or network alterations in patients with asthma,but inconsistent results were obtained.A key question remains unclear:are the regional and neural network deficits related or are they two independent characteristics in asthma?Answering this question is the aim of this study.By collecting resting-state functional magnetic resonance imaging from 39 patients with asthma and 40 matched health controls,brain functional measures including regional activity(amplitude of low-frequency fluctuations)and neural network function(degree centrality(DC)and functional connectivity)were calculated to systematically characterize the functional alterations.Patients exhibited regional abnormities in the left angular gyrus,right precuneus,and inferior temporal gyrus within the default mode network.Network abnormalities involved both the sensorimotor network and visual network with key regions including the superior frontal gyrus and occipital lobes.Altered DC in the lingual gyrus was correlated with the degree of airway obstruction.This study elucidated different patterns of regional and network changes,thereby suggesting that the two parameters reflect different brain characteristics of asthma.These findings provide evidence for further understanding the potential cerebral alterations in the pathophysiology of asthma. | Siyi Li Peilin Lv Min He Wenjing Zhang Jieke Liu Yao Gong Ting Wang Qiyong Gong Yulin Ji Su Lui | 2020 | Frontiers of Medicine2020，14，6： | 3 |
| 9 | SRSF1 inhibits autophagy through regulating Bcl-x splicing and interacting with PIK3C3 in lung cancer显示文摘Alternative splicing is a critical process to generate protein diversity.However,whether and how alternative splicing regulates autophagy remains largely elusive.Here we systematically identify the splicing factor SRSF1 as an autophagy suppressor.Specifically,SRSF1 inhibits autophagosome formation by reducing the accumulation of LC3-ⅡI and numbers of autophagosomes in different cell lines.Mechanistically,SRSF1 promotes the splicing of the long isoform of Bcl-x that interacts with Beclinl,thereby dissociating the Beclin1-PIK3C3 complex.In addition,SRSF1 also directly interacts with PIK3C3 to disrupt the interaction between Beclinl and PIK3C3.Consequently,the decrease of SRSF1 stabilizes the Beclinl and PIK3C3 complex and activates autophagy.Interestingly,SRSF1 can be degraded by starvation-and oxidative stresses-induced autophagy through interacting with LC3-Ⅱ,whereas reduced SRSF1 further promotes autophagy.This positive feedback is critical to inhibiting Gefitinib-resistant cancer cell progression both in vitro and in vivo.Consistently,the expression level of SRSF1 is inversely correlated to LC3 level in clinical cancer samples.Our study not only provides mechanistic insights of alternative splicing in autophagy regulation but also discovers a new regulatory role of SRSF1 in tumorigenesis,thereby offering a novel avenue for potential cancer therapeutics. | Yuesheng Lv Wenjing Zhang Jinyao Zhao Bing Sun Yangfan Qi Haoyu Ji Chaoqun Chen Jinrui Zhang Junxiu Sheng Taishu Wang Daniel Dominguez Han Liu Quentin Liu Songshu Meng Xiaoling Li Yang Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 10 | Distributed Mobility Load Balancing with RRM in LTE显示文摘 | Weihao Lv Wenjing Li | 2010 | IEEE2010，，： | 1 |
| 11 | Distributed Mobility Load Balancing withRRM in LTE显示文摘 | Weihao Lv Wenjing Li | 2010 | IEEE2010，，： | 1 |
| 12 | Asymptomatic and pre-symptomatic infection in Coronavirus Disease 2019 pandemic显示文摘With the presence of Coronavirus Disease 2019(COVID-19)asymptomatic infections detected,their proportion,transmission potential,and other aspects such as immunity and related emerging challenges have attracted people’s attention.We have found that based on highquality research,asymptomatic infections account for at least one-third of the total cases,whereas based on systematic review and meta-analysis,the proportion is about one-fifth.Evaluating the true transmission potential of asymptomatic cases is difficult but critical,since it may affect national policies in response to COVID-19.We have summarized the current evidence and found,compared with symptomatic cases,the transmission capacity of asymptomatic individuals is weaker,even though they have similar viral load and relatively short virus shedding duration.As the outbreak progresses,asymptomatic infections have also been found to develop long COVID-19.In addition,the role of asymptomatic infection in COVID-19 remains to be further revealed as the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants continue to emerge.Nevertheless,as asymptomatic infections transmit the SARS-CoV-2 virus silently,they still pose a substantial threat to public health.Therefore,it is essential to conduct screening to obtain more knowledge about the asymptomatic infections and to detect them as soon as possible;meanwhile,management of them is also a key point in the fight against COVID-19 community transmission.The different management of asymptomatic infections in various countries are compared and the experience in China is displayed in detail. | Yutong Wang Ke Zheng Wenjing Gao Jun Lv Canqing Yu Lan Wang Zijun Wang Bo Wang Chunxiao Liao Liming Li | 2022 | Medical Review2022，2，1： | 0 |
| 13 | Immunity-and-matrix-regulatory cells enhance cartilage regeneration for meniscus injuries: a phase I dose-escalation trial显示文摘Immunity-and-matrix-regulatory cells(IMRCs)derived from human embryonic stem cells have unique abilities in modulating immunity and regulating the extracellular matrix,which could be mass-produced with stable biological properties.Despite resemblance to mesenchymal stem cells(MSCs)in terms of self-renew and tri-lineage differentiation,the ability of IMRCs to repair the meniscus and the underlying mechanism remains undetermined.Here,we showed that IMRCs demonstrated stronger immunomodulatory and pro-regenerative potential than umbilical cord MSCs when stimulated by synovial fluid from patients with meniscus injury.Following injection into the knees of rabbits with meniscal injury,IMRCs enhanced endogenous fibrocartilage regeneration.In the dose-escalating phase I clinical trial(NCT03839238)with eighteen patients recruited,we found that intra-articular IMRCs injection in patients was safe over 12 months post-grafting.Furthermore,the effective results of magnetic resonance imaging(MRI)of meniscus repair and knee functional scores suggested that 5×107 cells are optimal for meniscus injury treatment.In summary,we present the first report of a phase I clinical trial using IMRCs to treat meniscus injury.Our results demonstrated that intra-articular injection of IMRCs is a safe and effective therapy by providing a permissive niche for cartilage regeneration. | Liangjiang Huang Song Zhang Jun Wu Baojie Guo Tingting Gao Sayed Zulfiqar Ali Shah Bo Huang Yajie Li Bo Zhu Jiaqi Fan Liu Wang Yani Xiao Wenjing Liu Yao Tian Zhengyu Fang Yingying Lv Lingfeng Xie Sheng Yao Gaotan Ke Xiaolin Huang Ying Huang Yujuan Li Yi Jia Zhongwen Li Guihai Feng Yan Huo Wei Li Qi Zhou Jie Hao Baoyang Hu Hong Chen | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 14 | Different conformational responses of theβ_(2)-adrenergic receptor-Gs complex upon binding of the partial agonist salbutamol or the full agonist isoprenaline显示文摘G protein-coupled receptors(GPCRs)are responsible for most cytoplasmic signaling in response to extracellular ligands with different efficacy profiles.Various spectroscopic techniques have identified that agonists exhibiting varying efficacies can selectively stabilize a specific conformation of the receptor.However,the structural basis for activation of the GPCR-G protein complex by ligands with different efficacies is incompletely understood.To better understand the structural basis underlying the mechanisms by which ligands with varying efficacies differentially regulate the conformations of receptors and G proteins,we determined the structures ofβ_(2)AR-Gαsβγbound with partial agonist salbutamol or bound with full agonist isoprenaline using single-particle cryo-electron microscopy at resolutions of 3.26?A and3.80?A,respectively.Structural comparisons between theβ_(2)AR-Gs-salbutamol andβ_(2)AR-Gs-isoprenaline complexes demonstrated that the decreased binding affinity and efficacy of salbutamol compared with those of isoprenaline might be attributed to weakened hydrogen bonding interactions,attenuated hydrophobic interactions in the orthosteric binding pocket and different conformational changes in the rotamer toggle switch in TM6.Moreover,the observed stronger interactions between the intracellular loop 2 or 3(ICL2 or ICL3)ofβ_(2)AR and Gαswith binding of salbutamol versus isoprenaline might decrease phosphorylation in the salbutamol-activatedβ_(2)AR-Gs complex.From the observed structural differences between these complexes ofβ_(2)AR,a mechanism ofβ_(2)AR activation by partial and full agonists is proposed to provide structural insights intoβ_(2)AR desensitization. | Fan Yang Shenglong Ling Yingxin Zhou Yanan Zhang Pei Lv Sanling Liu Wei Fang Wenjing Sun Liaoyuan A.Hu Longhua Zhang Pan Shi Changlin Tian | 2021 | National Science Review2021，8，9： | 0 |
| 15 | Self-supporting and dual-active 3D Co-S nanosheets constructed by ligand replacement reaction from MOF for rechargeable Al battery显示文摘Metal sulfides with high theoretical capacities are expected as promising cathode materials of Al batteries(AIBs). However, powdery active materials are mainly synthesized and loaded on current collector by insulating binder without capacity. Meanwhile, S as inert element in metal sulfides can not usually provide capacity. So, powdery metal sulfides only exhibit limiting practical capacity and poor cycling stability due to weak conductivity and low mass utilization. Herein, the novel self-supporting and dual-active Co-S nanosheets on carbon cloth (i.e. Co-S/CC) with hierarchically porous structure are constructed as cathode of AIBs. Co-S nanosheets are derived from ZIF-67 nanosheets on CC by a facile ligand replacement reaction. As a result, the binder-free Co-S/CC cathode with good conductivity delivers excellent initial discharge capacity of 383.4 m Ah g^(-1)(0.211 m Ah cm^(-2)) at current density of 200 m A g^(-1)and maintain reversible capacity of 156.9 m Ah g^(-1)(0.086 m Ah cm^(-2)) with Coulombic efficiency of 95.8% after 500 cycles,which are much higher than those of the traditional slurry-coating cathodes. Both Co and S as active elements in Co-S/CC contribute to capacity, which leads to a high mass utilization. This work provides a significant strategy for the construction of self-supporting metallic cathode for advanced high-energy density Al battery. | Aijing Lv Songle Lu Mingyong Wang Haotian Shi Wenjing Yan Shuqiang Jiao | 2022 | Journal of Energy Chemistry2022，31，6： | 0 |
| 16 | Changing Gly311 to an acidic amino acid in the MATE family protein DTX6 enhances Arabidopsis resistance to the dihydropyridine herbicides显示文摘In modern agriculture,frequent application of herbicides may induce the evolution of resistance in plants,but the mechanisms underlying herbicide resistance remain largely unexplored.Here,we report the char-acterization of rtp 1(resistant to paraquat 1),an Arabidopsis mutant showing strong resistance to the widely used herbicides paraquat and diquat.The rtp1 mutant is semi-dominant and carries a point mutation in the gene encoding the multidrug and toxic compound extrusion family protein DTX6,leading to the change of glycine to glutamic acid at residue 311(G311E).The wild-type DTX6 with glycine 311 conferred weak para-quat and diquat resistance when overexpressed,while mutation of glycine 311 to a negatively charged amino acid(G311E or G311D)markedly increased the paraquat and diquat resistance of plants,whereas mutation to a positively charged amino acid(G311R or G311K)compromised the resistance,suggesting that the charge property of residue 311 of DTX6 is critical for the paraquat and diquat resistance of Arabi-dopsis plants.DTX6 is localized in the endomembrane trafficking system and may undergo the endosomal sorting to localize to the vacuole and plasma membrane.Treatment with the V-ATPase inhibitor ConA reduced the paraquat resistance of the rtp1 mutant.Paraquat release and uptake assays demonstrated that DTX6 is involved in both exocytosis and vacuolar sequestration of paraquat.DTX6 and DTX5 show functional redundancy as the dtx5 dtx6 double mutant but not the dtx6 single mutant plants were more sen-sitive to paraquat and diquat than the wild-type plants.Collectively,our work reveals a potential mecha-nism for the evolution of herbicide resistance in weeds and provides a promising gene for the manipulation of plant herbicide resistance. | Zeyu Lv Mingming Zhao Wenjing Wang Qi Wang Mengqi Huang Chaoqun Li Qichao Lian Jinqiu Xia Ji Qi Chengbin Xiang Huiru Tang Xiaochun Ge | 2021 | Molecular Plant2021，14，12： | 0 |
| 17 | The host microbiota is associated with the occurrence and development of esophageal squamous cell carcinoma显示文摘DearEditor,Microecology is an emerging research area,particularly that of the digestive system(Marchesi et al.,2016;Wang et al.,2018).The intestinal microbiota contains a rich and complex microbial ecosystem that is in dynamic balance,the disruption of which can result in disease(Yatsunenko et al.,2012;Li et al.,2017;He et al.,2018).For example,studies have found that the esophagus has a variety of colonizing bacteria that may be related to esophageal cancer. | Jing Zuo Yanjun Liu Wenjing Lv Yudong Wang Zhisong Fan Long Wang Li Feng Xue Zhang Jing Hani Zhiyu Ni | 2023 | Protein & Cell2023，14，4： | 0 |
| 18 | Van der Waals heterostructure tunnel FET with potential modulation beyond junction region显示文摘Dear editor,State-of-the-art semiconductor technology is approaching the atomic scale,greatly boosting the switching behavior of transistors towards the physical limit of the thermionic emission mechanism[1,2].A fundamental revolution is needed to break this limit and reduce power dissipation.Owing to the band-to-band tunneling mechanism. | Wenjing QIN Yawei LV Zhen XIA Lei LIAO Changzhong JIANG | 2022 | Science China(Information Sciences)2022，65，10： | 0 |
| 19 | Plasma HGF and OPN as Potential Biomarkers of Pulmonary Arterial Hypertension in Congenital Heart Disease显示文摘Objectives:Pulmonary arterial hypertension in congenital heart disease(PAH-CHD)is the most common type of PAH and increases morbidity and mortality in patients with CHD.Right heart catheterization(RHC)is the standard method to diagnose PAH.However,RHC is an invasive and complicated method with relatively high cost.Noninvasive,feasible,and cost-efficient methods are urgently needed.The objective of this study was to evaluate three potential biomarkers of PAH-CHD:Hepatocyte growth factor(HGF),osteopontin(OPN),and suppression of tumorigenicity 2(ST2).Methods:Plasma samples were collected from patients with CHD(n=46)and healthy individuals(n=22)and divided into four groups according to the severity of PAH.The levels of HGF,OPN,and ST2 were then analyzed using an enzyme-linked immunosorbent assay.Correlations between HGF,OPN,ST2,and clinical parameters of PAH-CHD were analyzed.Results:The plasma HGF levels in the moderate to the severe group were significantly higher than those in the mild group,nonPAH group,and healthy control group(p<0.05).Derived from a receiver operating characteristic(ROC)curve analysis,a cut-off value of 356.75 ng/ml for the HGF concentration was able to predict PAH-CHD with 53%sensitivity and 89%specificity.The HGF level was positively related to pulmonary arterial systolic pressure(PASP)(r=0.36,p<0.05)and pulmonary vascular resistance(PVR)(r=0.36,p<0.05).Plasma OPN levels in the mild group were significantly higher than other groups and positively correlated with the pulmonary-systemic shunt ratio(Qp/Qs)(r=0.33,p<0.05).There was no statistically significant between-group difference in plasma soluble ST2(sST2)levels.Conclusion:The plasma HGF level was elevated in PAH-CHD patients and can be used as a potential biomarker.The plasma OPN level was positively correlated with the Qp/Qs. | Dongdong Zheng Chi Shen Wenshi Liu Wenjing Lv Xiaofei Li | 2021 | Congenital Heart Disease2021，16，4： | 0 |
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