4篇
您的检索式：作者名="Wennan Zeng"
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| 1 | Effect of Chemical Cross-linking on Properties of Gelatin/Hyaluronic Acid Composite Hydrogels显示文摘 | Zhihua Zhou Zhongmin Yang Tianlong Huang Lihua Liu Qingquan Liu Yanmin Zhao Wennan Zeng Qingfeng Yi Dafu Cao | 2013 | Polymer-Plastics Technology and Engineering2013，，1： | 1 |
| 2 | Taurocholic acid inhibits the response to interferon-αtherapy in patients with HBeAg-positive chronic hepatitis B by impairing CD8^(+)T and NK cell function显示文摘Pegylated interferon-alpha (PegIFNα) therapy has limited effectiveness in hepatitis B e-antigen (HBeAg)-positive chronic hepatitis B (CHB) patients. However, the mechanism underlying this failure is poorly understood. We aimed to investigate the influence of bile acids (BAs), especially taurocholic acid (TCA), on the response to PegIFNα therapy in CHB patients. Here, we used mass spectrometry to determine serum BA profiles in 110 patients with chronic HBV infection and 20 healthy controls (HCs). We found that serum BAs, especially TCA, were significantly elevated in HBeAg-positive CHB patients compared with those in HCs and patients in other phases of chronic HBV infection. Moreover, serum BAs, particularly TCA, inhibited the response to PegIFNα therapy in HBeAg-positive CHB patients. Mechanistically, the expression levels of IFN-γ, TNF-α, granzyme B, and perforin were measured using flow cytometry to assess the effector functions of immune cells in patients with low or high BA levels. We found that BAs reduced the number and proportion and impaired the effector functions of CD3^(+)CD8^(+) T cells and natural killer (NK) cells in HBeAg-positive CHB patients. TCA in particular reduced the frequency and impaired the effector functions of CD3^(+)CD8^(+) T and NK cells in vitro and in vivo and inhibited the immunoregulatory activity of IFN-α in vitro. Thus, our results show that BAs, especially TCA, inhibit the response to PegIFNα therapy by impairing the effector functions of CD3^(+)CD8^(+) T and NK cells in HBeAg-positive CHB patients. Our findings suggest that targeting TCA could be a promising approach for restoring IFN-α responsiveness during CHB treatment. | Zhen Xun Jinpiao Lin Qingqing Yu Can Liu Jinlan Huang Hongyan Shang Jianhui Guo Yuchen Ye Wennan Wu Yongbin Zeng Songhang Wu Siyi Xu Tianbin Chen Jing Chen Qishui Ou | 2021 | Cellular & Molecular Immunology2021，18，2： | 1 |
| 3 | A trans-ortho asymmetrically di-strapped metalloporphyrin integrating three key structural features of ligand in heme显示文摘Heme responsible for the dioxygen fixation,transport and conversion is a metalloporphyrin complex highly dependent on its diverse geometry of ligand.In this work,a trans-ortho-di-strapped zinc porphyrin with dome-like deformation was synthesized by thermodynamically controlling the formation of transprecursor of porphyrinogen.Its single-crystal structure demonstrated that the asymmetric treatment of porphyrin achieves three goals of creating two secondary coordination sphere(SCS)bulks,maintaining a unique dome deformation,and making atomic out-of-plane deviation.In this way,this metallic complex integrates at least three key features of the pocket structure,the differentiated axial ligations,and the ring distortion,making it an ideal heme analog. | Qiuhua Liu Junhao Gao Yusheng Zhang Xin Liu Xi Zhang Qin Lin Wennan Zeng Zaichun Zhou | 2023 | Chinese Chemical Letters2023，34，10： | 0 |
| 4 | Origin of d-π Interaction in Cobalt(ll) Porphyrins under Synergistic Effects of Core Contraction and Axial Ligation: Implications for a Ligand Effect of Natural Distorted Tetrapyrrole显示文摘 | Qiuhua Liu Xi Zhang Wennan Zeng Jianxiu Wang Zaichun Zhou | 2016 | Chinese Journal of Chemistry2016，34，9： | 0 |
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