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| 1 | Vitamin C induces periodontal ligament progenitor cell differentiation via activation of ERK pathway mediated by PELP1显示文摘The differentiation of periodontal ligament(PDL)progenitor cells is important for maintaining the homeostasis of PDL tissue and alveolar bone.Vitamin C(VC),a water-soluble nutrient that cannot be biosynthesized by humans,is vital for mesenchymal stem cells differentiation and plays an important role in bone remodeling.Therefore,the objective of this study was to determine the function and mechanism of VC in PDL progenitor cells osteogenic differentiation at the molecular level.We demonstrated that VC could induce the osteogenic differentiation and maturation of PDL progenitor cell without other osteogenic agents.During the process,VC preferentially activated ERK1/2 but did not affect JNK or p38.Co-treatment with ERK inhibitor effectively decreased the Vitamin C-induced expression of Runx2.ERK inhibitor also abrogated Vitamin C-induced the minimized nodules formation.PELP1,a nuclear receptor co-regulator,was up-regulated under VC treatment.PELP1 knockdown inhibited ERK phosphorylation.The overexpression of PELP1 had a positive relationship with Runx2 expression.Taken together,we could make a conclude that VC induces the osteogenic differentiation of PDL progenitor cells via PELP1-ERK axis.Our fi nding implies that VC may have a potential in the regeneration medicine and application to periodontitis treatment. | Yan Yan Wenfeng Zeng Shujun Song Fayun Zhang Wenxi He Wei Liang Zhongying Niu | 2013 | Protein & Cell2013，4，8： | 6 |
| 2 | Med19 Promotes Osteosarcoma Growth and Metastasis and Associates with Prognosis显示文摘 | Wenxi Yu Zhang Zhichang Min Daliu Yang Qingcheng Du Xuefei Tang Lina Lin Feng Sun Yuanjue Zhao Hui Zheng Shuier He Aina Li Hongtao Yao Yang Zan Shen | 2014 | European Journal of Cancer2014，，： | 1 |
| 3 | MICROSTRUCTURE AND REVERSE SHAPE MEMORY EFFECT IN A Cu-Zn-Al ALLOY显示文摘The bainite structure in a Cu-Zn-A1 alloy related to the reverse shape memory effect hasbeen observed by means of TEM.The reverse memory effect may be improved by up to oneorder of magnitude under applied constraint stress.The widespread propagation of bainite wasconfirmed to be the diffusion controlled shear process by the parabolic configuration of sideinterface of bainite plate and the twisting of intersected bainite plates. | DONG Jianxin CHEN Fumin CHEN Jinming LIU Wenxi Tianjin University,Tianjin,China At pressent he works in Department of materials Science and Technology,University of Science and Technology,Beijing. | 1991 | Acta Metallurgica Sinica(English Letters)1991，4，3： | 1 |
| 4 | Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity显示文摘Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions.Cisplatin(CDDP)elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion.Alterations to renal drug transporter expression have been discovered during nonalcoholic steatohepatitis(NASH),however,associated changes to substrate toxicity is unknown.To test this,a methionine-and choline-deficient diet-induced rat model was used to evaluate NASH-associated changes to CDDP pharmacokinetics,transporter expression,and toxicity.NASH rats administered CDDP(6 mg/kg,i.p.)displayed 20%less nephrotoxicity than healthy rats.Likewise,CDDP renal clearance decreased in NASH rats from 7.39 to 3.83 mL/min,renal secretion decreased from 6.23 to 2.80 mL/min,and renal CDDP accumulation decreased by 15%,relative to healthy rats.Renal copper transporter-1 expression decreased,and organic cation transporter-2 and ATPase copper transporting protein-7 b increased slightly,reducing CDDP secretion.Hepatic CDDP accumulation increased 250%in NASH rats relative to healthy rats.Hepatic organic cation transporter-1 induction and multidrug and toxin extrusion protein-1 and multidrug resistance-associated protein-4 reduction may contribute to hepatic CDDP sequestration in NASH rats,although no drug-related toxicity was observed.These data provide a link between NASH-induced hepatic and renal transporter expression changes and CDDP renal clearance,which may alter nephrotoxicity. | Joseph L.Jilek Kayla L.Frost Kevyn A.Jacobus Wenxi He Erica L.Toth Michael Goedken Nathan J.Cherrington | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 1 |
| 5 | Detection of vertical root fractures in non‐endodontically treated molars using cone‐beam computed tomography: a report of four representative cases显示文摘 | Ping Wang Wenxi He Hantang Sun Qun Lu Longxing Ni | 2011 | Dental Traumatology2011，，： | 1 |
| 6 | Result of proton beam energy calibration of GECAM satellite charged particle detector显示文摘Purpose A charged particle detector(CPD)is one of two main detectors on the GECAM satellite.It was designed to detect charged particles.Electrons and protons are space’s mainly charged particles.So,a research on the proton detection ability of a CPD and deriving the energy response to charged particles of the CPD in the two designed operating modes is important.Method The proton calibration tests of the CPD under diferent working modes were carried out at the Heavy Ion Research Facility in Lanzhou.Result and conclusion Through testing and analysis,it was concluded that when CPD works in semi-component mode,it can detect the maximum energy,and when working in full-component mode,it can provide better energy resolution. | Chaoyue Zhang Xiaohua Liang Yanbing Xu Wenxi Peng Jianjian He Dongya Guo Ke Gong Yaqing Liu Zhenghua An Dali Zhang Sheng Yang Xiaojing Liu Xiangyang Wen Rui Qiao Jinzhou Wang Min Gao Shaolin Xiong Fan Zhang Xinqiao Li Xingzhu Cui Chaoyang Li Jilong Tang Xiaohua Wang Dengkui Wang Zhipeng Wei | 2022 | Radiation Detection Technology and Methods2022，6，1： | 0 |
| 7 | Expert consensus on irrigation and intracanal medication in root canal therapy显示文摘Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. | Xiaoying Zou Xin Zheng Yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen Zhang Liming Chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao Song Shen Xuedong Zhou Lin Yue | 2024 | International Journal of Oral Science2024，16，1： | 0 |
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