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| 1 | 膜型巨噬细胞集落刺激因子对人脑胶质细胞瘤的免疫治疗作用显示文摘摘要 目的 探讨基因转染膜型巨噬细胞集落刺激因子(mM-CSF)对U251MG人脑胶质瘤细胞的免疫治疗作用。方法 用逆转录病毒载体将mM-CSF基因转入U251MG细胞,采用流式细胞术检测mM-CSF的表达;通过细胞毒性实验、兔疫组化方法以及观察转染细胞在免疫缺陷小鼠体内的生长情况研究mM-CSF对U251MG细胞的作用。结果①获得了表达mM-CSF的MG-2F11细胞;②大鼠巨噬细胞、人外周血淋巴细胞(PBL)和人单核细胞均可杀伤MG-2F11细胞,但不能杀伤U251MG母细胞;③接种瘤细胞到裸小鼠皮下18 h后,侵入MG-2F11肿瘤的巨噬细胞明显多于侵入MG-VV(仅转染病毒载体的U251MG细胞)肿瘤的巨噬细胞;④接种MG-2F11细胞的8只裸小鼠均无肿瘤生长,而接种MG-VV细胞的8只裸小鼠中的7只有肿瘤生长(P<0.01);另一免疫缺陷更严重的NIH-bg-nu-xidBR 小鼠,接种MG-2F11细胞后8只中的1只有肿瘤生长,而接种MG-VV细胞后8只中的7只有肿瘤生长(P<0.01)。结论mM-CSF转染的人脑胶质瘤细胞致瘤性降低,有进一步对其进行临床研究的必要。 | 陈义军 Cheri Lloyd Ramon Sanchez Martin R Jadus H Terry Wepsic | 2002 | 中华神经外科疾病研究杂志2002，1，3： | 2 |
| 2 | Growth of transplanted rat tumor following administration of cell-free tumor antigens 显示文摘 | Wepsic HT Alaimo J | 1978 | Cancer Res1978，38，5： | 1 |
| 3 | Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors显示文摘 | Young MR Newby M Wepsic HT | 1987 | Cancer Res1987，47，1： | 1 |
| 4 | Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors显示文摘 | Young MR Newby M Wepsic HT | 1987 | Cancer Res1987，47，1： | 1 |
| 5 | The role of cytokines in graft-versus-host reactions and disease显示文摘 | Jadus MR Wepsic HT | 1992 | Bone Marrow Transplant1992，10，1： | 1 |
| 6 | Hematopoiesis and suppres- sor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors显示文摘 | Young MR Newby M Wepsic HT | 1987 | Cancer Res1987，47，： | 1 |
| 7 | Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic Lewis lung carcinoma tumors 显示文摘 | Young MR Newby M Wepsic HT | 1987 | Cancer Res1987，47，1： | 1 |
| 8 | Hematopoiesis and suppressor bone marrow ceils in mice bearing large metastatic Lewis lung car- cinoma tumors显示文摘 | Young MR Newby M Wepsic I-IT | 1987 | Cancer Res1987，47，1： | 1 |
| 9 | Controlled thermocoagulation of trigeminal ganglion and rootlets for differential destruction of pain fibers显示文摘 | Sweet WH Wepsic JG | 1974 | J Neurosurg1974，40，2： | 1 |
| 10 | Controlled chemocougulation of trigeminal ganglion and rootlets for differential destruction of pain fibers: part 1, trigeminal neuralgia显示文摘 | SWEET W H WEPSIC J G | 1974 | J Neurosurg1974，39，： | 1 |
| 11 | Controlled thermocoagulation of trigeminal ganglion and rootlets for differential destruction of pain fibers: Ⅰtrigeminal neuralgia显示文摘 | Wepsic J | 1974 | J Neurosurg1974，3，： | 1 |
| 12 | Controlled thermocoagulation of trigeminalganglion and rootlets for differential destruction of pain fibes显示文摘 | Sweet WH Wepsic JG | 1974 | J Neuxosury1974，40，2： | 1 |
| 13 | Controlled thermocoagulation of trigeminal ganglion and rootlets for differential destruction of pain fibes显示文摘 | Sweet WH Wepsic JG | | 0，，02： | 1 |
| 14 | Concurrent primaryparathyroid hyperplasia and parathyroid carcinoma 显示文摘 | Haghighi P Astariata R Wepsic T | 1983 | ArchPathol Lab Med1983，107，7： | 1 |
| 15 | Controlled thermocoagulation of trigeminal ganglion and rootlets for differential destruction of pain fibers:I trigeminal neuralgia显示文摘 | Sweet W Wepsic J | 1974 | J Neurosurg1974，40，2： | 1 |
| 16 | Hematopoiesis and suppressor bone marrow cells in mice bearing large metastatic lewis lung carcinama tumors显示文摘 | Young MR Newby M Wepsic HT | 1987 | Cancer Res1987，47，1： | 1 |
| 17 | Coronary collateral vessels : Spectrum of physiologic capabilities with respect to providing rest and stress myocardial perfusion, maintenance of left ventricular function and protection against infarction 显示文摘 | Kolibash A J Bush CA Wepsic RA | 1982 | Am J Cardiol1982，50，2： | 1 |
| 18 | Delayed diagnosis of chiasmal compression显示文摘 | Pructt RC Wepsic JG | 1973 | Am J Ophthalmol1973，76，2： | 1 |
| 19 | Tic douloureux:Etiology,refined treatment显示文摘 | Wepsic JG | | 0，，： | 1 |
| 20 | Contmlled thermocoagul-ation of trigeminal ganglion and rootlets for differe-ntial destruction of pain fibers 显示文摘 | Sweet WH Wepsic JG | 1974 | Trigeminal neural1974，，40： | 1 |
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