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| 1 | Effects of nonalcoholic fatty liver disease on the development of metabolic disorders显示文摘 | Fan, JG Li, F Cai, XB Peng, YD Ao, QH Gao, Y | 2007 | 中国生物学文摘2007，21，11： | 51 |
| 2 | Bile acids:Chemistry,physiology,and pathophysiology显示文摘The family of bile acids includes a group of molecular species of acidic steroids with very peculiar physical-chemical and biological characteristics.They are synthesized by the liver from cholesterol through several complementary pathways that are controlled by mechanisms involving finetuning by the levels of certain bile acid species.Although their best-known role is their participation in the digestion and absorption of fat,they also play an important role in several other physiological processes.Thus,genetic abnormalities accounting for alterations in their synthesis,biotransformation and/or transport may result in severe alterations,even leading to lethal situations for which the sole therapeutic option may be liver transplantation.Moreover,the increased levels of bile acids reached during cholestatic liver diseases are known to induce oxidative stress and apoptosis,resulting in damage to the liver parenchyma and,eventually,extrahepatic tissues.When this occurs during pregnancy,the outcome of gestation may be challenged.In contrast,the physical-chemical and biological properties of these compounds have been used as the bases for the development of drugs and as pharmaceutical tools for the delivery of active agents. | Maria J Monte Jose JG Marin Alvaro Antelo Jose Vazquez-Tato | 2009 | World Journal of Gastroenterology2009，15，7： | 36 |
| 3 | Dynamic and ultrastructural study of sphincter of Oddi in early-stage cholelithiasis in rabbits with hypercholesterolemia显示文摘AIM To study the relationship between pre-formation of gallstone and the kinetics and ultra-structure of sphincter of Oddi.METHODS Adult female rabbits were used anddivided into 3 groups,and fed with either normalor high cholesterol diet for four or eight weeks.Each group contained eight rabbits.Themanometry of sphincter of Oddi,biliarycineradiography,gallbladder volumemeasurement and ultrastructure observationunder electron microscope were performed.RESULTS In groups Ⅰ and Ⅱ,the basalpressure in low-pressure ampulla or highpressure zone of sphincter of Oddi waselevated,the amplitude of phasic contractionwas decreased and the volume of gallbladderwere increased,with a significant difference(P<0.01)from those of control.Gallstones werefound in group Ⅱ rabbits(7/8).Undercineradiography,low-pressure ampulla showeda spasmodic status without apparent peristalticcontraction.Under electron microscope,insidethe muscular cells of sphincter of Oddi,loosening of microfilament and swelling ofplasmosomes which congregated at the top wereobserved.The amount showed no obviouschange under nitric oxide synthase(NOS)stain.CONCLUSION Twisting of the microfilamentand disarrangement of kink macula densa insidethe muscular ceils suggested that the sphincterof Oddi was under spasmodic status.Theimpaired diastolic function caused andaggravated the stasis of cystic bile.Theswelling plasmosome could be one of theimportant factors in elevating the tonic pressureof sphincter of Oddi. | Wei JG Wang YC Du F Yu HJ | 2000 | World Journal of Gastroenterology2000，6，1： | 19 |
| 4 | Awakening concentration of desflurane is decreased in patients with obstructive jaundice显示文摘 | Song JG Cao YF Yang LQ Yu WF Li Q Song JC Fu XY Fu Q | 2005 | 第二军医大学学报2005，26，8： | 15 |
| 5 | 早期头颅成形术和神经学改善显示文摘在减压的颅骨切除术后,头颅成形术普遍用于美容和对大脑的保护。传统上,外科医生会在头颅成形术前等数月来使最初的创伤恢复。这项系统回顾评估了头颅成形术在神经功能方面的效果,以及进一步确定是否手术的选择时间会影响恢复。进行了一项对1990年1月到2016年4月已发表文献的系统回顾。 | 金丹丹 顾旭东 Malcolm JG Rindler RS Chu JK | 2018 | 中国康复2018，33，3： | 15 |
| 6 | 应用生态模型研究近海贝类养殖的可持续发展显示文摘建立了一个贝藻混养生态模型 ,并应用于桑沟湾栉孔扇贝、太平洋牡蛎和海带混养生态系统的模拟。这一模型在个体生长模型的基础上模拟种群的生长情况 ;通过模拟不同播苗养殖和收获方式下的产量 ,以及不同混养方式对海洋生态系统的影响来确定养殖容量。采用该模型的研究结果表明 :当养殖密度分别增加到目前扇贝和牡蛎放苗量的 2倍和 15倍时总产量最高 (达到养殖容量 ) ,但单位面积产量和产量 /播苗比减少 ,因此效益是下降的 ;扇贝放苗量增加到目前的 15倍 ,牡蛎增加到 30倍时会导致养殖生产崩溃 ,同时生态系统也发生改变 :在目前养殖密度下 ,桑沟湾向黄海输出初级生产产品 ,但是当放苗密度增加到 15~ 2 0倍时 ,桑沟湾需要黄海向其输入初级生产产品。上述结果表明 ,该模型可以迅速模拟养殖生物量和生态系统的变化 。 | 朱明远 张学雷 汤庭耀 FERREIRA JG 方建光 王兴章 | 2002 | 海洋科学进展2002，20，4： | 14 |
| 7 | Evaluation of hepatic cystic lesions显示文摘Hepatic cysts are increasingly found as a mere coincidence on abdominal imaging techniques, such as ultrasonography (USG), computed tomography (CT) and magnetic resonance imaging (MRI). These cysts often present a diagnostic challenge. Therefore, we performed a review of the recent literature and developed an evidence-based diagnostic algorithm to guide clinicians in characterising these lesions. Simple cysts are the most common cystic liver disease, and diagnosis is based on typical USG characteristics. Serodiagnostic tests and microbubble contrast-enhanced ultrasound (CEUS) are invaluable in differentiating complicated cysts, echinococcosis and cystadenoma/cystadenocarcinoma when USG, CT and MRI show ambiguous findings. Therefore, serodiagnostic tests and CEUS reduce the need for invasive procedures. Polycystic liver disease (PLD) is arbitrarily defined as the presence of > 20 liver cysts and can present as two distinct genetic disorders: autosomal dominant polycystic kidney disease (ADPKD) and autosomal dominant polycystic liver disease (PCLD). Although genetic testing for ADPKD and PCLD is possible, it is rarely performed because it does not affect the therapeutic management of PLD. USG screening of the liver and both kidneys combined with extensive family history taking are the cornerstone of diagnostic decision making in PLD. In conclusion, an amalgamation of these recent advances results in a diagnostic algorithm that facilitates evidence-based clinical decision making. | Marten A Lantinga Tom JG Gevers Joost PH Drenth | 2013 | World Journal of Gastroenterology2013，19，23： | 12 |
| 8 | Immune responses against SARS-coronavirus nucleocapsid protein induced by DNA vaccine显示文摘 | Zhao P Cao J Zhao LJ Ke JS Pan W Ren H Yu JG Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 12 |
| 9 | 烟酰胺磷酸核糖基转移酶促进肺血管重塑,是肺动脉高压的治疗靶点显示文摘肺动脉高压(pulmonary arterial hypertension,PAH)是一种严重的进行性疾病,其标志之一是肺血管重塑。烟酰胺磷酸核糖基转移酶(nicotinamide phosphoribosyl transferase,NAMPT)是调节细胞内烟酰胺腺嘌呤二核苷酸水平、细胞氧化还原状态,调节组蛋白脱乙酰酶,促进细胞增殖和抑制凋亡的一种细胞酶。研究人员假设NAMPT可促进肺血管重塑, | Chen J Sysol JR Singla S Zhao S Yamamura A Valdez-Jasso D Abbasi T Shioura KM Sahni S Reddy V Sridhar A Gao H Torres J Camp SM Tang H Ye SQ Comhair S Dweik R Hassoun P Yuan JX Garcia JG Machado RF 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，2： | 10 |
| 10 | Dynamic Contrast-Enhanced Perfusion MR Imaging Measurements of Endothelial Permeability: Differentiation between Atypical and Typical Meningiomas显示文摘BACKGROUND: AND PURPOSE: The measurement of relative cerebral blood volume (rCBV) and the volume transfer constant (K(trans)) by means of dynamic contrast-enhanced (DCE) perfusion MR imaging (pMRI) can be useful in characterizing brain tumors. The purpose of our study was to evaluate the utility of these measurements in differentiating typical meningiomas and atypical meningiomas. METHODS: Fifteen patients with pathologically confirmed typical meningiomas and seven with atypical meningiomas underwent conventional imaging and DCE pMRI before resection.rCBV measurements were calculated by using standard intravascular | Law M Zagzag D Golfinos JG Knopp EA Johnson G | 2003 | 中国神经肿瘤杂志2003，1，3： | 10 |
| 11 | 常规脂蛋白检测和载脂蛋白在心血管病预测中的比较显示文摘总胆固醇和高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)测量值对于心血管病风险评估至关重要,但对于其他脂质用于风险预测的效用一直存在争议。该研究纳入来自英国生物银行(Biobank)的无基线心血管病、未服用他汀类药物、有相关的脂质指标(n=346 686)的受试者。 | Welsh C Celis-Morales CA Brown R Mackay DF Lewsey J Mark PB Gray SR Ferguson LD Anderson JJ Lyall DM Cleland JG Jhund PS Gill J MR Pell JP Sattar N Welsh P 刘青(译) 叶鹏(摘、审校) | 2019 | 中华高血压杂志2019，27，7： | 10 |
| 12 | Current updates on laboratory techniques for the diagnosis of male reproductive failure显示文摘导致不孕的男繁殖失败的发生,是否由于推迟的做家长,环境问题,基因因素,药,等等,在全世界正在增加。男 subfertility 的诊断和预后成为了挑战。当基本精液评价被执行许多年了时,很多研究询问传统的精液特征的价值。这是部分由于不适当的方法和标准化,为优秀保证的技术要求的有限知识,和一个精液评价能提供临床的信息的不完全的理解。当前执行精液和内分泌的评价表演伟人可变性的实验室。世界健康组织() 精液的评估的手册是在许多年在这个领域的进一步的开发帮助了的 andrology 和生育力评估的核心。这些包括精液,对精子计数的评价,活动性,活力,形态学,和精子和精液样品的功能的方面的物理外观。这些测试也由于氧化应力包括男内分泌的侧面,精液的生物化学的评估,在浆液的 antisperm 抗体的察觉,电脑辅助的精子分析(房屋) 的使用,精子 DNA 正直,和它的损坏。帮助繁殖技术(例如, IVF, ICSI ) 显示出大成功,但是是太昂贵的。与更新的技术在这块地里推进开发,广泛的火车 / 说明能改进精确性和还原剂可变性,因此维持如此的评估的质量和标准。有迫切需要标准化了训练中心并且为繁殖成功在 mens 健康的这个区域增加了了解。 | Suresh C Sikka Wayne JG Hellstrom | 2016 | Asian Journal of Andrology2016，18，3： | 9 |
| 13 | 成人缺血性卒中早期治疗指南(节译Ⅲ)显示文摘该指南是美国在2003年卒中指南基础上的更新版本,汇集了近年来缺血性卒中的最新临床研究数据,从循证医学的角度提出了科学的治疗建议。全文包括卒中救治的组织、早期评价、急性期整体治疗、溶栓治疗、抗栓治疗、扩容及升压治疗、血管外科与血管内干预、再灌注治疗、并发症处理等内容,涉及急性缺血性卒中从发病、转送、诊断、治疗、预后等多个方面。尽管该指南主要是基于欧美人种的临床研究结果,但对于中国急性缺血性卒中患者的处理亦具借鉴意义。鉴于篇幅,本刊分3期连载(节译Ⅰ见2007年第4卷第7期第332~334页,节译Ⅱ见2007年第4卷第8期第381~384页)。 | Adams HP del Zoppo JG Alberts MJ 焦力群 马妍 李萌 凌锋 | 2007 | 中国脑血管病杂志2007，4，9： | 7 |
| 14 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 15 | Excretion of biliary compounds during intrauterine life显示文摘In adults,the hepatobiliary system,together with the kidney,constitute the main routes for the elimination of several endogenous and xenobiotic compounds into bile and urine,respectively.However,during intrauterine life the biliary route of excretion for cholephilic compounds,such as bile acids and biliary pigments,is very poor.Although very early in pregnancy the fetal liver produces bile acids,bilirubin and biliverdin,these compounds cannot be efficiently eliminated by the fetal hepatobiliary system,owing to the immaturity of the excretory machinery in the fetal liver.Therefore,the potentially harmful accumulation of cholephilic compounds in the fetus is prevented by their elimination across the placenta.Owing to the presence of detoxifying enzymes and specifi c transport systems at different locations of the placental barrier,such as the endothe-lial cells of chorionic vessels and trophoblast cells,this organ plays an important role in the hepatobiliary-like function during intrauterine life.The relevance of this excretory function in normal fetal physiology is evident in situations where high concentrations of biliary compounds are accumulated in the mother.This may result in oxidative stress and apoptosis,mainly in the placenta and fetal liver,which might affect normal fetal development and challenge the fate of the pregnancy.The present article reviews current knowledge of the mechanisms underlying the hepatobiliary function of the fetal-placental unit and the repercussions of several pathological conditions on this tandem. | Rocio IR Macias Jose JG Marin Maria A Serrano | 2009 | World Journal of Gastroenterology2009，15，7： | 6 |
| 16 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 17 | Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C:a randomised trial显示文摘 | Manns MP McHutchison JG Gordon SC | | The Lancet0，，： | 4 |
| 18 | Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study显示文摘 | Shamir R Mehta Salim Yusuf Ron JG Peters Michel E Bertrand Basil S Lewis Madhu K Natarajan Klas Malmberg Hans-Jürgen Rupprecht Feng Zhao Susan Chrolavicius Ingrid Copland Keith AA Fox | 2001 | The Lancet . 2001 (9281)2001，，9281： | 4 |
| 19 | 肿瘤低温手术中正常器官的热保护问题显示文摘在应用低温外科方法对人体深部的肿瘤进行杀伤时,既要有最大的杀伤效果,又要有保证周围正常组织(特别是一些重要器官)能免受冷冻伤害,近年来出现了热保护系统。本文对热保护问题进行了分析,提出了模型、计算方法,并给出了计算结果和安全区与危险区的范围,这为外科医生设计低温手术方案(如低温探头的尺寸、数量及放置位置等)提供了方法。 | 华泽钊 Baus.,JG | 1995 | 制冷学报1995，17，2： | 4 |
| 20 | The role of reduced intracellular concentrations of active drugs in the lack of response to anticancer chemotherapy显示文摘 | Jose JG MARIN Maria J MONTE Alba G BLAZQUEZ Rocio IR MACIAS Maria A SERRANO Oscar BRIZ | 2014 | Acta Pharmacologica Sinica2014，35，1： | 4 |
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