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| 1 | Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma显示文摘AIM:To determine whether-1195 A→G and/or-765 G→C polymorphisms in Cyclooxygenase-2(COX-2 ) may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population.METHODS:Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area.DNA was isolated from whole blood and used for genotyping.PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis.Odds ratios(OR) and 95% confldence intervals(CI) were estimated.RESULTS:The distribution of the-1195 A→G polymorphism was signif icantly different in esophageal cancer patients compared to controls.The-1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma(OR = 3.85, 95% CI:1.45-10.3) compared with the-1195 AA genotype as a reference.The-765 G→C genotype distribution was not different between the two groups.The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls(OR = 3.45, 95% CI:1.24-9.58;with AG/AG as a reference).The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical signif icance.CONCLUSION:Presence of the COX-2-1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma. | Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman Adriaan CITL Tan Martijn GH van Oijen Jan BMJ Jansen Wilbert HM Peters | 2009 | World Journal of Gastroenterology2009，15，28： | 11 |
| 2 | Effect of prophylactic clip placement following endoscopic mucosal resection of large colorectal lesions on delayed polypectomy bleeding: A meta-analysis显示文摘BACKGROUND The role of prophylactic clipping for the prevention of delayed polypectomy bleeding(DPB) remains unclear and conclusions from prior meta-analyses are limited due to the inclusion of variety of resection techniques and polyp sizes.AIM To conduct a meta-analysis on the effect of clipping on DPB following endoscopic mucosal resection(EMR) of colorectal lesions ≥ 20 mm.METHODS We performed a search of PubMed and the Cochrane library for studies comparing the effect of clipping vs no clipping on DPB following endoscopic resection. The Cochran Q test and I^2 were used to test for heterogeneity. Pooling was conducted using a random-effects model.RESULTS Thirteen studies with a total of 7794 polyps were identified, of which data was available on 1701 cases of EMR of lesions ≥ 20 mm. Prophylactic clipping was associated with a lower rate of DPB(1.4%) when compared to no clipping(5.2%)(pooled OR: 0.24, 95%CI: 0.12-0.50, P < 0.001) following EMR of lesions ≥ 20 mm.There was no significant heterogeneity among the studies(I^2 = 0%, P = 0.67).CONLUSION Prophylactic clipping may reduce DPB following EMR of large colorectal lesions.Future trials are needed to further identify risk factors and stratify high risk cases in order to implement a cost-effective preventive strategy. | Fares Ayoub Donevan R Westerveld Justin J Forde Christopher E Forsmark Peter V Draganov Dennis Yang | 2019 | World Journal of Gastroenterology2019，25，18： | 9 |
| 3 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 4 | A new method for measuring the retardation of a photoelastic modulator using single photon count- ing techniques 显示文摘 | CLINE R A WESTERVELD W B RISLEY J S | 1993 | Review of Scientific Instru- ments1993，64，5： | 1 |
| 5 | Cognitive outcomes after carotid revascularization:the role of cerebral emboli and hypoperfusion显示文摘 | Ghogawala Z Westerveld M Amin-Hanjani S | 2008 | Neurosurgery2008，62，2： | 1 |
| 6 | The dog as an animal model for dish 显示文摘 | Kranenburg H C Westerveld L A Verlaan J J | 2010 | Eur Spine2010，19，8： | 1 |
| 7 | Immunoglobulin coating of faecal bacteria in inflammatory bowel disease显示文摘 | Laurens A van der Waaij Frans GM Kroese Annie Visser Gerardus F Nelis Bram D Westerveld Peter LM Jansen John O Hunter | 2004 | European Journal of Gastroenterology & Hepatology2004，，7： | 1 |
| 8 | Perception of urban retailing environments:an empirical investigation of consumer information and usage fields显示文摘 | Timmermans H J P Van der Heijden R Westerveld H | 1982 | Geoforum1982，13，： | 1 |
| 9 | Language latera-lization in epilepsy patients:fMRI validated with the Wadaprocedure显示文摘 | Arora J Pugh K Westerveld M | 2009 | Epilepsia2009，50，10： | 1 |
| 10 | Functional MRI of language processing:dependence on input modality and temporal lobe epilepsy显示文摘 | Carpentier A Pugh KR Westerveld M | 2001 | Epilepsia2001，42，10： | 1 |
| 11 | Functional MRI of language processing: dependence on input modality and temporal lobe ep/lepsy显示文摘 | Carpentier A Pugh KR Westerveld M | 2001 | Epilepsia2001，42，： | 1 |
| 12 | The dog as an animal model for dish显示文摘 | Kranenburg HC Westerveld LA Verlaan JJ | 2010 | European Spine2010，19，8： | 1 |
| 13 | Clinical significance of pepsinogen A isozymogens, serum pepsinogen A and C levels, and serum gastrin levels显示文摘 | Westerveld BD Pals G Lamers CB | 1987 | Cancer1987，59，： | 1 |
| 14 | Apolipoprotein concentrations during treatment and recurrent coronary artery disease event显示文摘 | Roeters Van Lennep J E Westerveld H T Van Roeters Lennep H W O | 2000 | Arterioscler Thromb Vasc Biol2000，20，11： | 1 |
| 15 | Spinal fractures in patients with ankylosing spinal disorders: a systematic review of the literature on treatment, neurological status and complications显示文摘 | Westerveld LA Verlaan JJ Oner FC | 2009 | Eur Spine J2009，18，2： | 1 |
| 16 | The dog as an animal model for DISH?显示文摘 | H. C. Kranenburg L. A. Westerveld J. J. Verlaan F. C. Oner W. J. A. Dhert G. Voorhout H. A. W. Hazewinkel B. P. Meij | 2010 | European Spine Journal2010，，： | 1 |
| 17 | Cardio-metabolic abnormalities in the polycystic ovary syndromePhar- macotherapeutic insights 显示文摘 | Westerveld HE Hoogendoorn M de Jong AW | 2008 | Pharmacol Ther2008，119，3： | 1 |
| 18 | Cardiometabolic abnormalities in the polycystic ovary syndrome: Pharmacother-apeutic insights 显示文摘 | Westerveld HE Hoogendoorn M de Jong AW | 2008 | PharmacolTher2008，119，3： | 1 |
| 19 | Mutations in the testis-specific NALP14 gene in men suffering from spermatogenic failure显示文摘 | Westerveld GH Korver CM van Pelt AM | 2006 | Hum Beprod2006，21，12： | 1 |
| 20 | Prognosis of solitary fibrous tumors:a multicenter study显示文摘 | van Houdt WJ Westerveld CM Vrijenhoek JE | 2013 | Ann Surg Oncol2013，20，13： | 1 |
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