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| 1 | Human fetal mesenchymal stem cells differentiate into brown and white adipocytes: a role for ERRα in human UCP1 expression显示文摘我们调查了胎儿的间充质的干细胞(fMSCs ) 的能力区分进棕色、白的 adipocytes 并且比较了很多标记基因和关键规章的因素的表示。我们证明关键 adipocyte 管理者和标记的表示在另外的人、鼠科的 adipocyte 模型在区别期间类似于那,包括 PPAR 纬 2 和 FABP4 的正式就职。尤其是,我们发现 preadipocyte 标记, Pref-1,当这个过程继续,显著地在区别然后衰落早被导致,当他们承诺 adipogenic 系,建议 fMSCs 首先获得 preadipocyte 特征,在他们进成熟 adipocytes 的区别以前。在 adipogenic 正式就职以后,某干细胞孤立区分了进类似于棕色的 adipocytes 和其它进白 adipocytes 的房间。一个的详细调查孤立证明新奇棕色的胖决定的因素 PRDM16 在区别前后两个都被表示。重要地,展出的这些房间提高了基础 UCP-1 表示,它依赖于孤儿的活动原子受体犯错伪,加亮一个新奇角色为犯错在人的棕色的脂肪的伪。因此 fMSCs 代表一在 vitro 有用为人的 adipogenesis 当模特儿,并且提供机会在对 adipocyte 系的承诺以前学习阶段。他们也提供无价的卓见进人的棕色的脂肪的特征。 | Daniel L Morganstein Pensee Wu Meritxell R Mane Nick M Fisk Roger White Malcolm G Parker | 2010 | Cell Research2010，20，4： | 5 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Interprofessional, multiple step simulation course improves pediatric resident and nursing staff management of pediatric patients with diabetic ketoacidosis显示文摘AIM To investigate the use of a multidisciplinary, longitudinal simulation to educate pediatric residents and nurses on management of pediatric diabetic ketoacidosis.METHODS A multidisciplinary, multiple step simulation course was developed by faculty and staff using a modified Delphi method from the Pediatric Simulation Center and pediatric endocrinology department. Effectiveness of the simulation for the residents was measured with a pre- and post-test and a reference group not exposed to simulation. A follow up post-test was completed 3-6 mo after the simulation. Nurses completed a survey regarding the education activity. RESULTS Pediatric and medicine-pediatric residents(n = 20) and pediatric nurses(n = 25) completed the simulation course. Graduating residents(n = 16) were used as reference group. Pretest results were similar in the control and intervention group(74% ± 10% vs 76% ± 15%, P = 0.658). After completing the intervention, participants improved in the immediate post-test in comparison to themselves and the control group(84% ± 12% post study; P < 0.05). The 3-6 mo follow up post-test results demonstrated knowledge decay when compared to their immediate post-test results(78% ± 14%, P = 0.761). Residents and nurses felt the interdisciplinary and longitudinal nature of the simulation helped with learning.CONCLUSION Results suggest a multidisciplinary, longitudinal simulation improves immediate post-intervention knowledge but important knowledge decay occurs, future studies are needed to determine ways to decrease this decay. | Linnea M Larson-Williams Amber Q Youngblood Dawn Taylor Peterson J Lynn Zinkan Marjorie L White Hussein Abdul-Latif Leen Matalka Stephen N Epps Nancy M Tofil | 2016 | World Journal of Critical Care Medicine2016，5，4： | 4 |
| 4 | 在接受治疗的急性冠状动脉综合征患者中,肌钙蛋白峰值与长期缺血事件之间的关系显示文摘非ST段抬高急性冠状动脉综合征(acutecoro-narysyndromes,ACS)患者肌钙蛋白水平与结局的关系虽然已经明确,但接受抗血小板治疗管理的非ST段抬高ACS患者肌钙蛋白水平与长期结局的关系尚未明确。 | 刘莉 叶鹏 Goldstein SA Newby LK Cyr DD Neely M Lüscher TF Brown EB White HD Ohman EM Roe MT Hamm CW | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 5 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 6 | Construction of a genetic linkage map in man using restriction fragment length polymorphisms 显示文摘 | Botstein D White R L Skolnick M | 1980 | Am J Hum Genet1980，32，： | 1 |
| 7 | Construction of a genetic linkage map in man using restriction fragment length polymorphisms显示文摘 | Botstein D White R L Skolnick M | 1980 | Am J Hum Genet1980，32，： | 1 |
| 8 | Construction of a genetic linkage map in manusing restriction fragment length polymorphisms 显示文摘 | Botstein D White R L Skolnick M | 1980 | Am J Hum Genet1980，32，3： | 1 |
| 9 | Construction of a Genetic Linkage Maps in Man Using Restriction Fragment Length Polymorphisms显示文摘 | Bostein D White R L Skolnic M | 1980 | Amer J Hum Genet1980，32，： | 1 |
| 10 | A statistical analysis of conditional launch for gigabit ethernet links using multimode fiber显示文摘 | Webster M Raddatz L White I H et el | 1999 | J Lightwave Technol1999，17，9： | 1 |
| 11 | Construction of a genetic linkage map in man using restriction fragment length polymorphisms显示文摘 | Botstein D White R L Skolnick M | 1980 | Am J Hum Genet1980，32，3： | 1 |
| 12 | Construction of a genetic linkage map in man using restriction fragment length polymorphisms显示文摘 | Botstein D White R L Skolnick M et ol | 1980 | Am J Human Genet1980，32，3： | 1 |
| 13 | Construction of a genet- ic linkage map in man using restriction fragment length polymor- phisms显示文摘 | Botstein D White R L Skolniek M | 1980 | Am J Hum Genet1980，32，3： | 1 |
| 14 | Construction of a genetic linkage map in man using restriction fragment length polymorphisms显示文摘 | BOTSTEIN D WHITE R L SKOLNICK M | 1980 | Am J Hum Genet1980，32，3： | 1 |
| 15 | MRI characteristics of nodular fasciitis of the musculoskeletal system显示文摘 | COYLE J WHITE L M DICKSON B | 2013 | Skeletal Ra- diol2013，42，7： | 1 |
| 16 | Construction of a genetic linkage map in man using restriction fragment length polymorphisms显示文摘 | BOTSTEIN D WHITE R L SKOLNICK M | 1980 | American Journal of Human Genetics1980，32，3： | 1 |
| 17 | An examination of message-relevant affect in road safety messages:Should road safety advertisements aim to make us feel good or bad?显示文摘 | Watson I L White K M | 2008 | Transportation Research Part F2008，11，40： | 1 |
| 18 | Study of the distribution of some geochemical data显示文摘 | Tennant C B White M L | 1959 | Economic Geology1959，54，： | 1 |
| 19 | Acute lateral patel-lar dislocation at M R imaging:injury patterns of medialpatellar soft-tissue restraints and osteochondral injuries ofthe inferomedial patella显示文摘 | Elias D A White L M Fithian D C | 2002 | Radiology2002，225，3： | 1 |
| 20 | Enhanced in vitro growth of murine fibroblast cells and preimplantation embryos cultured in medium supplemented with an amphipathic peptide显示文摘 | Reed W A White K L Enright F M | 1992 | Mol Reproduct1992，31，2： | 1 |
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