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| 1 | Novel fibrin-fibronectin matrix accelerates mice skin wound healing显示文摘Plasma fibrinogen(F1)and fibronectin(pFN)polymerize to form a fibrin clot that is both a hemostatic and provisional matrix for wound healing.About 90%of plasma F1 has a homodimeric pair ofγchains(γγF1),and 10%has a heterodimeric pair ofγand more acidicγ′chains(γγ′F1).We have synthesized a novel fibrin matrix exclusively from a 1:1(molar ratio)complex ofγγ′F1 and pFN in the presence of highly active thrombin and recombinant Factor XIII(rFXIIIa).In this matrix,the fibrin nanofibers were decorated with pFN nanoclusters(termedγγ′F1:pFN fibrin).In contrast,fibrin made from 1:1 mixture ofγγF1 and pFN formed a sporadic distribution of“pFN droplets”(termedγγF1+pFN fibrin).Theγγ′F1:pFN fibrin enhanced the adhesion of primary human umbilical vein endothelium cells(HUVECs)relative to theγγF1+FN fibrin.Three dimensional(3D)culturing showed that theγγ′F1:pFN complex fibrin matrix enhanced the proliferation of both HUVECs and primary human fibroblasts.HUVECs in the 3Dγγ′F1:pFN fibrin exhibited a starkly enhanced vascular morphogenesis while an apoptotic growth profile was observed in theγγF1+pFN fibrin.Relative toγγF1+pFN fibrin,mouse dermal wounds that were sealed byγγ′F1:pFN fibrin exhibited accelerated and enhanced healing.This study suggests that a 3D pFN presentation on a fibrin matrix promotes wound healing. | Carlos Poblete Jara Ou Wang Thais Paulino do Prado Ayman Ismail Frank Marco Fabian Han Li Licio A.Velloso Mark A.Carlson William Burgess Yuguo Lei William H.Velander Eliana P.Araújo | 2020 | Bioactive Materials2020，5，4： | 5 |
| 2 | 肝切除术治疗结直肠癌肝转移的术前影像学检查显示文摘尽管近来在化疗药上取的了很多进步,但是对于转移性的结直肠癌治疗预后仍然很差,就过去20年而言,肝脏转移灶切除术已作为一种有希望的术式,它能改善结直肠癌肝转移患者的生存率,而且该技术在某些案例中显示出长期的治愈效果。为了扩大转移灶切除术的安全性及功效,合适的术前影像是必须的。CT,MRI,PET方面的进步已经改善了隐蔽病灶的探测而且获得更为清晰解剖形态。而CT,PET,MRI在探查大的肝转移瘤上有相似的敏感性,相对于CT及FDG-PET而言,MRI更擅于探知厘米级以下的肝转移灶,特别是与弥散加权成像(DWI)及肝细胞特异性对比剂结合时效果更显著,CT或许可用来作为一种筛选模式或术前计划制定如剩余肝体积的计算或显露肝动脉灌注分布的动脉解剖情况,而技术进步已经带来了史无前例的高画质与高清晰度的图片,但它仍然无法取代专业的,娴熟的具有丰富经验的影像学专家的角色。 | Timothy L.Franke Richard Kinh Gian Do William R.Jarnagin 陈泓西 宋涛 | 2013 | 中国普通外科杂志2013，22，7： | 3 |
| 3 | Hypoxia-preconditioned adipose tissue-derived mesenchymal stem cell increase the survival and gene expression of engineered neural stem cells in a spinal cord injury model显示文摘 | Jin Soo Oh Yoon Ha Sung Su An Momin Khan William A. Pennant Hyo Jin Kim Do Heum Yoon Minhyung Lee Keung Nyun Kim | 2010 | Neuroscience Letters2010，，3： | 2 |
| 4 | Pecutaneous coronary interven tion in the current era compared with 1985-1986:the National Heart,Lung,and Blood Institute Registries 显示文摘 | William DO Holubkov Yeh W | 2000 | Circulation2000，102，： | 1 |
| 5 | Endovascular beta radiation to reduce rcstenosis after coronary ballon angioplasty: Results of the beta energy restenosis trial (BERT) 显示文摘 | Williams DO Chougule P | 1998 | Circulation1998，97，： | 1 |
| 6 | Outcomes of 6906 patients undergoing parcutuneous coronary intervention in the era of drug-eluting stents:report of the DES cover Registry显示文摘 | Williams DO Abbott JD Kip KE | 2006 | Circulation2006，114，20： | 1 |
| 7 | Long-tree outcome of patients with depressed left ventricular undergoing percutaneous transluminal coronary angioplasty: the NHLBIPTCA registry 显示文摘 | Holms DR Detre KM Williams DO | 1993 | Circulation1993，87，1： | 1 |
| 8 | Percutaneous coronary intervention in the current era compared with 1985-1986: The National Heart, Lung, and Blood Institute Registries显示文摘 | Williams DO Holubkov R Yeh W | 2000 | Circulation2000，102，24： | 1 |
| 9 | Results of percutaneous transluminal coronary angioplasty in unstable angina and non - Q - wave myocardial infarction: observations from the TIMI Ⅲ trial显示文摘 | Williams DO Braunwald E Thompson B | 1996 | Circulation1996，94，： | 1 |
| 10 | Regulation of microvascular permeability by vascular endothelial growth factors显示文摘 | Bates DO Hillman NJ Williams B | 2002 | } Anat2002，200，6： | 1 |
| 11 | Percutaneous Coronary Intervention in the Current Era Compared with 1985-1986:the National Heart,Lung,and Blood Institute Registries显示文摘 | Williams DO Holubkov R Yeh W | 2000 | Circulation2000，102，： | 1 |
| 12 | Develop -ment of a health habits scale显示文摘 | Williams RL Thomas SP Young DO et at | 1991 | Res Nurs Health1991，14，1： | 1 |
| 13 | Predicting Dysplasia and Invasive Carcinoma in Intraductal Papillary Mucinous Neoplasms of the Pancreas: Development of a Preoperative Nomogram显示文摘 | Camilo Correa-Gallego Richard Do Jennifer LaFemina Mithat Gonen Michael I. D’Angelica Ronald P. DeMatteo Yuman Fong T. Peter Kingham Murray F. Brennan William R. Jarnagin Peter J. Allen | 2013 | Annals of Surgical Oncology2013，，13： | 1 |
| 14 | safty and efficacy of drug-eluting stent显示文摘 | williams DO kereiakes DJ | 2005 | Rev cardiovasc Med2005，61，： | 1 |
| 15 | Impact of age on pro- cedural and 1-year outcome in percutaneous transluminal coronary angioplasty: a report from the NHLBI dynamic registry 显示文摘 | Cohen HA Williams DO Holmes DR | 2003 | Am Heart J2003，146，3： | 1 |
| 16 | Two and three-year results of the thrombolysis in myocardial infarction(TIMI) phase Ⅱ clinical trial显示文摘 | Terrin ML Williams DO Kleiman NS | 1993 | JACC 19931993，，： | 1 |
| 17 | Outcomes of 6906 patients undergoing percutaneous coronary intervention in the era of drug-eluting stents:report of the DEScover Registry显示文摘 | Williams DO Abbott JD Kip KE | 2006 | Circulation2006，114，20： | 1 |
| 18 | Outcomes of 6906 patients undergoing percutaneous coronary intervention in the era of drug-eluting stents:report of the DEScorer Registry显示文摘 | Williams DO Abbott JD Kip KE | 2006 | Circulation2006，114，20： | 1 |
| 19 | Changes in the practice if percutaneous coronary intervention:a comparison of enrollment waves in the National Heart, Lung, and Blood Institute (NHLBI) Dynamic Registry显示文摘 | Laskey WK Williams DO Vlachis HA | 2001 | Am J Cardiol2001，87，： | 1 |
| 20 | Motion magnification显示文摘 | Ce Liu Antonio Torralba William T. Freeman Frédo Durand Edward H. Adelson | 2005 | ACM Transactions on Graphics (TOG)2005，，3： | 1 |
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