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| 1 | Feasibility and safety of autologous bone marrow mononuclear cell transplantation in patients with advanced chronic liver disease显示文摘AIM: To evaluate the safety and feasibility of bone marrow cell (BMC) transplantation in patients with chronic liver disease on the waiting list for liver transplantation. METHODS: Ten patients (eight males) with chronic liver disease were enrolled to receive infusion of autologous bone marrow-derived cells. Seven patients were classified as Child-Pugh B and three as Child-Pugh C. Baseline assessment included complete clinical and laboratory evaluation and abdominal MRI. Approximately 50 ml of bone marrow aspirate was prepared by centrifugation in a ficoll-hypaque gradient. At least of 100 millions of mononuclear-enriched BMCs were infused into the hepatic artery using the routine technique for arterial chemoembolization for liver tumors. Patients were followed up for adverse events up to 4 mo. RESULTS: The median age of the patients was 52 years (range 24-70 years). All patients were discharged 48 h after BMC infusion. Two patients complained ofmild pain at the bone marrow needle puncture site. No other complications or specific side effects related to the procedure were observed. Bilirubin levels were lower at 1 (2.19 ± 0.9) and 4 mo (2.10 ± 1.0) after cell transplantation that baseline levels (2.78 ± 1.2). Albumin levels 4 mo after BMC infusion (3.73 ± 0.5) were higher than baseline levels (3.47 ± 0.5). International normalized ratio (INR) decreased from 1.48 (SD = 0.23) to 1.43 (SD = 0.23) one month after cell transplantation. CONCLUSION: BMC infusion into hepatic artery of patients with advanced chronic liver disease is safe and feasible. In addition, a decrease in mean serum bilirubin and INR levels and an increase in albumin levels are observed. Our data warrant further studies in order to evaluate the effect of BMC transplantation in patients with advanced chronic liver disease. | Andre Castro lyra Milena Botelho Pereira Soares luiz Flavio Maia da Silva Marcos Fraga Fortes André Goyanna Pinheiro Silva Augusto César de Andrade Mota Sheilla A Oliveira Eduardo lorens Braga Wilson Andrade de Carvalho Bernd Genser Ricardo Ribeiro dos Santos luiz Guilherme Costa lyra | 2007 | World Journal of Gastroenterology2007，13，7： | 21 |
| 2 | Development of Junction Elements from Study of the Bionics显示文摘The applications of bionic methodology developed by the Laboratory of Design and Material Selection as basis in the creation of junction elements were demonstrated. These elements favor the application of Ecodesign in reference to the effec-tiveness of product dismount aiming the reduction of ambient impact in all its phases of use. The creation,the development and the confection of new junction elements were described,and case studies of new products developed specifically with this purpose were presented. | Wilson Kindlein Junior Luis Henrique Alves Cndido André Canal Marques Sandra Souza dos Santos Maurício da Silva Viegas | 2007 | Journal of Bionic Engineering2007，4，1： | 2 |
| 3 | Cytochemical aspects of the peripheral blood cells of Oreochromis(Tilapia) niloticus (Linnaeus,1758) (Cichlidae,Teleostei)-Part Ⅱ显示文摘 | Ivete K Mizue I Wilson da Silva | 2001 | Braz J Vet Res Anim Sci2001，38，6： | 1 |
| 4 | Valuation of dynamic reactive power support services for transmission access显示文摘 | Wilson X Zhang Y da Silva L C P | 2001 | IEEE Trans on Power Systems2001，16，4： | 1 |
| 5 | Detailed alignment of Saccharum and Sorghum chromosomes:comparative organization of closely related diploid and polyploid genomes显示文摘 | Ming R Liu S-C Lin Y-R da Silva J Wilson W Brags D van Deynze A Wenslaff TF Wu KK Moore PH Burnquist W Sorrells M E Irvine J E Paterson A H | 1998 | Genetics1998，150，： | 1 |
| 6 | Characterisation of a laboratory electrochemical ozonation system and its application in advanced oxidation processes显示文摘 | Leonardo M. Da Silva Débora V. Franco Juliane C. Forti Wilson F. Jardim Julien F.C. Boodts | 2006 | Journal of Applied Electrochemistry2006，，5： | 1 |
| 7 | Valuation of dynamic reactive power support services for transmission access显示文摘 | Wilson X Zhang Y da Silva L C P | 2001 | IEEE Trans on Power Systems2001，16，4： | 1 |
| 8 | Characterization of organic matter fromcomposting of different residues by physicochemical and spectroscopicmethods显示文摘 | LUCIMAR LOPES FIALHO WILSON TADEU LOPES DA SILVA DBORA M B P MILORI | 2010 | Bioresource Technology2010，101，： | 1 |
| 9 | The Interrelation of Urban Health Indicators and COVID-19:A Study of Passo Fundo/RS显示文摘The COVID-19(Coronavirus Disease 19)pandemic has demonstrated that cities are at the center of major contemporary events.The epidemiological crisis has highlighted the importance of the urban environment,challenging public managers on managing cities.An initiative that aims to assist in this management process is the concept of Smart Cities,which uses ICT(Information and Communication Technology)as tools for transforming urban dynamics,and through urban indicators,measures information about cities.Thus,the research aimed to analyze the health indicators of Passo Fundo/RS,seeking to analyze the interrelationship of these indicators with the epidemiological data from COVID-19.In the methodology,multi-method procedures were applied,using the indicators of the Connected Smart Cities Ranking as reference,as well as a regional selection of medium-sized cities in the southern region of Brazil.The results show that the health indices of Passo Fundo are,for the most part,lower than those of the analyzed cities,with the indicator related to Population Coverage of the Family Health team as the main weakness.However,it also presents satisfactory indices as is the case of the indicator of Beds/1,000 inhabitants.Regarding the epidemiological picture of COVID-19,Passo Fundo had a high lethality rate when compared to the other analyzed cities. | Letícia Müller Thaísa Leal da Silva Wilson Levy Braga da Silva Neto | 2021 | Journal of Civil Engineering and Architecture2021，15，10： | 0 |
| 10 | Economic Feasibility Evaluation of the Use of Wind Microgenerator in Multifamily Building in Southern Brazil显示文摘There is a growing worldwide interest in the potential of using existing buildings to generate their own energy as a way to alleviate problems related to the exhaustion of energy resources,environmental degradation and the constant increase in energy-related prices.Among the distributed electricity generation solutions on the market today,wind energy can be a solution for many existing city buildings worldwide.Thus,the objective of this article is to investigate the economic viability of generating wind energy in a multifamily building located in Southern Brazil,(city of Passo Fundo),seeking to supply the condominium electric energy for the period of one year of consumption with a renewable source.To this end,the energy demand of the condominium and the energy generation of the wind turbine were taken into account to calculate the economic viability of the system.The results showed a positive NPV(net present value)demonstrating the economic feasibility of carrying out such an investment.The IRR(internal rate of return)was 15.22%and the return on investment(payback)occurs in 7.88 years. | Lauro AndréRibeiro Marcos Vinícius de Lima Wilson Levy Braga da Silva Neto Marília Marton Correia Thaísa Leal da Silva | 2022 | Journal of Civil Engineering and Architecture2022，16，10： | 0 |
| 11 | Calculation of Percentage of Coarse Aggregate Present in Concrete Using Processing of Digital Images Obtained with a Commercial Scanner显示文摘 | Jose Renato de Castro Pessoa Joel Sanchez Dominguez Rodrigo Erthal Wilson Vanussa da Silva Charles Gil de Carvalho Joaquim Teixeira de Assis | 2015 | Journal of Chemistry and Chemical Engineering2015，9，2： | 0 |
| 12 | In vitro antileishmanial effects of Physalis angulata root extract on Leishmania infantum显示文摘Objective: In the present study, we evaluated the effects of the aqueous extract of Physalis angulata root(AEPa) on Leishmania infantum proliferation, morphology, and the driving mechanism in leishmanicidal activity and modulatory action on macrophages.Methods: L. infantum promastigotes were treated with 50 and 100 μg/mL AEPa for 72 h and then antipromastigote assay was performed by counts in a Newbauer chamber, morphological changes were analyzed by transmission electron microscopy and the mechanism of the leishmanicidal activity was detected. In addition, macrophages were infected with L. infantum and were used to evaluate anti-amastigote activity of AEPa and effects of AEPa on cytokine secretion after 72-hour treatment.Results: Treatment with AEPa reduced the numbers of L. infantum promastigotes(50% inhibitory concentration(IC_(50))= 65.9 μg/mL; selectivity index(SI) = 22.1) and amastigotes(IC_(50)=37.9 μg/mL; SI = 38.5)compared with the untreated control. Amphotericin B reduced 100% of the promastigote numbers after72 h of treatment(IC_(50) = 0.2 μg/mL). AEPa induced several morphological changes and increased the production of reactive oxygen species and apoptotic death in promastigotes after treating for 72 h.AEPa(100 μg/mL) promoted tumor necrosis factor-α secretion in macrophages infected with L. infantum after 72 h of treatment, but did not induce an increase in this cytokine in noninfected macrophages. In addition, AEPa showed no cytotoxic effect on J774-A1 cells(50% cytotoxic concentration >1000 μg/mL).Conclusion: AEPa presented antileishmanial activity against the promastigotes and amastigotes of L. infantum without macrophage cytotoxicity; these results show that natural products such as P. angulata have leishmanicidal potential and in the future may be an alternative treatment for leishmaniasis. | Bruno Jose Martins Da Silva Sandro Wilson Gomes Pereira Ana Paula Drummond Rodrigues Jose Luiz Martins Do Nascimento Edilene Oliveira Silva | 2018 | Journal of Integrative Medicine2018，16，6： | 0 |
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