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| 1 | RANK-ligand and osteoprotegerin as biomarkers in the differentiation between periprosthetic joint infection and aseptic prosthesis loosening显示文摘AIM To assess serum levels of RANK-ligand(RANKL) and osteoprotegerin(OPG) as biomarkers for periprosthetic joint infection(PJI) and compare their accuracy with standard tests.METHODS One hundred and twenty patients presenting with a painful total knee or hip arthroplasty with indication for surgical revision were included in this prospective clinical trial. Based on standard diagnostics(joint aspirate, microbiological, and histological samples) and Musculoskeletal Infection Society consensus classification,patients were categorized into PJI, aseptic loosening,and control groups. Implant loosening was assessed radiographically and intraoperatively. Preoperative serum samples were collected and analyzed for RANKL, OPG, calcium, phosphate, alkaline phosphatase(AP), and the bone-specific subform of AP(b AP). Statistical analysis was carried out, testing for significant differences between the three groups and between stable and loose implants. RESULTS All three groups were identical in regards to age, gender, and joint distribution. No statistically significant differences in the serum concentration of RANKL(P = 0.16) and OPG(P = 0.45) were found between aseptic loosening and PJI, with a trend towards lower RANKL concentrations and higher OPG concentrations in the PJI group. The RANKL/OPG ratio was significant for the comparison between PJI and non-PJI(P = 0.005). A ratio > 60 ruled out PJI in all cases(specificity: 100%, 95%CI: 89, 11% to 100.0%) but only 30% of non-PJI patients crossed this threshold. The positive predictive value remained poor at any cut-off. In the differentiation between stable and loose implants, none of the parameters measured(calcium, phosphate, AP, and b AP) showed a significant difference, and only AP and b AP measurements showed a tendency towards higher values in the loosened group(with P = 0.09 for AP and P = 0.19 for b AP). CONCLUSION Lower RANKL and higher OPG concentrations could be detected in PJI, without statistical significance. | Max J Friedrich Matthias D Wimmer Jan Schmolders Andreas C Strauss Milena M Ploeger Hendrik Kohlhof Dieter C Wirtz Sascha Gravius Thomas M Randau | 2017 | World Journal of Orthopedics2017，8，4： | 4 |
| 2 | Heat loss prevention for preterm infants in the delivery room显示文摘 | Knobel R Wimmer J Holbert D | 2005 | J Perinatol2005，25，3： | 1 |
| 3 | Identification and quantification of differentially expressed transcripts in in vitro-produced bovine preimplantation stage embryos显示文摘 | Tesfaye D Ponsuksili S Wimmers K | 2003 | Mol Reprod Dev2003，66，2： | 1 |
| 4 | Identification and quantification of differentially expressed transcripts in in vitro-produced bovine preimplantation stage embryos 显示文摘 | Tesfaye D Ponsuksili S Wimmers K | 2003 | Mol Reprod Dev2003，66，2： | 1 |
| 5 | Comparison and evaluation of methods for liver segmentation from CT datasets显示文摘 | Heimann T van Ginneken B Styner MA Arzhaeva Y Aurich V Bauer C Beck A Becket C Beichel R Bekes G Bello F Binnig G Bischof H Bornik A Cashman PM Chi Y Cordova A Dawant BM Fidrich M Furst JD Furukawa D Grenacher L Hornegger J Kainmuller D Kitney RI Kobatake H Lamecker H Lange T Lee J Lennon B Li R Li S Meinzer HP Nemeth G Raicu DS Rau AM van Rikxoort EM Rousson M Rusko L Saddi KA Schmidt G Seghers D Shimizu A Slagmolen P Sorantin E Soza G Susomboon R Waite JM Wimmer A Wolf I | 2009 | IEEE Transactions on Medical Imaging2009，28，8： | 1 |
| 6 | Synthesis of chiral cycloalkanols using yeast whole cell bioreactors显示文摘 | Zarevucka M Wimmer Z Saman D | 2004 | Tetrahedron:Asymmetry2004，15，8： | 1 |
| 7 | Identification and quantification of differentially expressed transcripts in in vitro-produced bovine preimplantation stage embryos显示文摘 | Tesfaye D Ponsuksili S Wimmers K | 2003 | Mol Reprod Dev2003，66，2： | 1 |
| 8 | Unexpected stability of mariner transgenes in Drosophila显示文摘 | Lozovsky ER Nurminsky D Wimmer EA | 2002 | Genetics2002，160，2： | 1 |
| 9 | Monocyte enrichment from leukapharesis products for the generation of DCs by plastic adherence, or by positive or negative selection显示文摘 | Felzmann T Witt V Wimmer D | 2003 | Cytotherapy2003，5，5： | 1 |
| 10 | Direct block of hERG potassium channels by the protein kinase C inhibitor bisindolylmaleimide I (GF109203X)显示文摘 | Thomas D Hammerling BC Wimmer AB | 2004 | Cardiovasc Res2004，64，3： | 1 |
| 11 | Compressive failure of microcracked porous brittle solids显示文摘 | Wimmer S A Karr D G | 1996 | Mechanics of Materials1996，22，： | 1 |
| 12 | Identification and quantification of differentially expressed transcripts in invitro-produced bovine preimplantation stage embryos显示文摘 | Tesfye D Ponsuksili S and Wimmers K | 2003 | Mol Reprod Dev2003，66，2： | 1 |
| 13 | Treating patella in- stability in skeletally immature patients显示文摘 | Vavken P Wimmer M D Camathias C | 2013 | Arthroscopy2013，29，8： | 1 |
| 14 | Total ankle re- placement显示文摘 | Barg A Wimmer M D Wiewiorski M | 2015 | Dtsch Arztebl Int2015，112，11： | 1 |
| 15 | Expression of tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors and sensitivity to TRAIL-induced apoptosis in primary B-cell acute lymphoblastic leukaemia cells显示文摘 | Clodi K Wimmer D Li Y | 2000 | Br J Haematol2000，111，2： | 1 |
| 16 | KoenigS-Knorr synthesis of cycloalkyl glycosides 显示文摘 | Wimmer Z Pechova L Saman D | 2004 | Molecules2004，9，11： | 1 |
| 17 | Isotopic and elemental data for tracing the origin of European olive oils显示文摘 | Camin F Larcher R Nicolini G Bontempo L Bertoldi D Perini M Schlicht C Schellenberg A Thomas F Heinrich K Voerkelius S Horacek M Ueckermann H Froeschl H Wimmer B Heiss G Baxter M Rossmann A HoogewerffJ | 2010 | Journal of Agricultural and Food Chemistry2010，58，1： | 1 |
| 18 | How Researchers Respond to Replication Requests 显示文摘 | Reid L N Rotfield H J Wimmer R D | 1982 | Journal of Consumer Research1982，9，2： | 1 |
| 19 | Relationship between pain and medial knee joint loading in mild radio- graphic knee osteoarthritis 显示文摘 | Thorp L E Sumner D R Wimmer M A | 2007 | Arthritis Rheum2007，57，7： | 1 |
| 20 | Expression of turnout necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors and sensitivity to TRAIL-induced apoptosis in primary B-cell acute lymphoblastic leukaemia cells显示文摘 | Clodi K Wimmer D Li Y | 2000 | Br J Haematol2000，111，4： | 1 |
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