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| 1 | Hepatitis C virus therapy with peg-interferon and ribavirin in Myanmar: A resource-constrained country显示文摘AIM To investigate peg-interferon(peg-IFN) and ribavirin(RBV) therapy in Myanmar and to predict sustained virologic response(SVR).METHODS This single-center, open-label, study was conducted in Myanmar between 2009 and 2014. A total of 288 patients infected with HCV genotypes 1, 2, 3 and 6 were treated with peg-IFN alpha-2a(180 μg/wk) or alpha-2b(50 to 100 μg as a weight-based dose) and RBV as a weight-based dose(15 mg/kg/d). Treatment duration was 48 wk for genotypes 1 and 6, 24 wk for genotype 2, and 24 or 48 wk for genotype 3 based on rapid virologic response(RVR). Those co-infected with hepatitis B received 48 wk of therapy.RESULTS Overall, SVR was achieved for 82% of patients and the therapy was well tolerated. All patients achieved SVR at equivalent rates regardless of HCV genotype(P = 0.314). Low fibrosis scores(P < 0.001), high baseline albumin levels(P = 0.028) and low baseline viral loads(P = 0.029) all independently predicted SVR. On the other hand, IL-28 B TT and CC genotypes were not found to significantly predict SVR(P = 0.634; P = 0.618). Among those who completed treatment, the occurrence of RVR showed a > 96% positive predictive value for achieving SVR. Treatment duration did not significantly impact the likelihood of achieving SVR for patients infected with genotype 3 HCV(P = 0.371). The most common adverse events were fatigue(71%) and poor appetite(60%). Among patients with genotype 3 HCV, more patients in the 48-wk treatment group required erythropoietin than in the 24-wk treatment group(61.1% vs 49.2%).CONCLUSION SVR rates were high with peg-IFN and RBV therapy in Myanmar. Fibrosis scores, baseline albumin, HCV RNA levels and RVR independently predicted SVR. | Naomi Khaing Than Hlaing Debolina Banerjee Robert Mitrani Soe Htet Arker Kyaw San Win Nyan Lin Tun Zaw Thant Khin Maung Win K Rajender Reddy | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 2 | Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria显示文摘 | Derick Han Lily Dara Sanda Win Tin Aung Than Liyun Yuan Sadeea Q. Abbasi Zhang-Xu Liu Neil Kaplowitz | 2013 | Trends in Pharmacological Sciences2013，，4： | 2 |
| 3 | c-Jun n-terminal kinase(JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor(TNF)requires mitochondrial Sab protein expression in mice显示文摘 | Win S Than TA Han D | | 0，，40： | 1 |
| 4 | c-Jun n-terminal kinase (JNK)-dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expres- sion in mice显示文摘 | WIN S THAN TA HAN D | 2011 | J Biol Chem2011，286，35： | 1 |
| 5 | Personal Health Record Systems and Their Security Protection显示文摘 | Khin Than Win Willy Susilo Yi Mu | 2006 | Journal of Medical Systems2006，，4： | 1 |
| 6 | Confirmation of elevated arsenic levels in groundwater of Myanmar显示文摘 | Alexander van Geen Kyi Htut Win Than Zaw Win Naing Jacob L. Mey Brian Mailloux | 2014 | Science of the Total Environment2014，，： | 1 |
| 7 | c-Jun N-terminal kinase (JNK)- dependent acute liver injury from acetaminophen or tumor necrosis factor (TNF) requires mitochondrial Sab protein expression in mice显示文摘 | Win S Than TA Han D | 2011 | The Journal of biological chemist ry2011，286，35： | 1 |
| 8 | JNK interaction with Sab mediates ER stress induced inhibition of mitochondri- al respiration and cell death 显示文摘 | Win S Than T A Fernandez-Checa J C etal | 2014 | Cell Death Disease2014，5，1： | 1 |
| 9 | Fish Species Diversity in Upstream and Downstream of Sittaung River,Bago Region,Myanmar显示文摘This research was conducted to generate a primary database on ichthyofauna,distribution and diversities in the upstream and downstream segments of Sittaung River in Bago Region of Myanmar.This study contributes to the information needed on the distribution of river fish in Myanmar.Fish diversities are assessed by calculating the various diversities indices between December,2018 and November,2019.A total of 65 fish species belonging to 9 orders,23 families and 49 genera were recorded.All 65 fish species were found in upstream segment but only 60 species of them were found in downstream segment of the river.In all study sites,Shannon diversity index had value above 3 indicating that the structure of habitat was stable and balanced.Simpson’s index values were close to 1 in all sites indicating that the species richness in the region was satisfactory.The abundance all of above 5%of total catch of Mystus vittatus,M.pulcher,M.cavasius and Erethistes pusillus in their feeding habitat suggested that their upstream and downstream habitats provided suitable feeding conditions.Anguilla bengalensis,Tenualosa ilisha,Mystus gulio,Rita rita and Silonia silondia were least abundant all below 0.1%of total catch showing they could be impacted by unwise anthropogenic activities.Assessing fish species diversity is thus very important to conserve and manage and promote the health of river ecosystem that is necessary for the migration of fish species. | Toe Toe Soe San San Oo Khin Thuzar Win Nyo Nyo Aung Aye Aye Su Khine Wai Yin Nu Hninn Kyaing Win Win Than | 2020 | Journal of Environmental Science and Engineering(A)2020，9，4： | 0 |
| 10 | Seismic Microzonation of Mandalay City, Myanmar显示文摘 | Pyi Soe Thein Junji Kiyono Tun Tun Win Than Than Nu Day Wa Aung | 2018 | Journal of Geological Resource and Engineering2018，6，1： | 0 |
| 11 | Tradeoffbetween Narrowing Optical Band Gap and Enhancing Electrical Conductivity of the Metal Nanoparticles-Modified Titanium Oxide Films显示文摘 | Aung Chan Thar Thaung Hlaing Win Nyein Wint Lwin Than Zaw Oo | 2015 | Journal of Physical Science and Application2015，5，3： | 0 |
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