|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Circadian rhythm of heart and heart rate variability 显示文摘 | Massin MM Maeyns K Withofs N | 2000 | Arch Dis Child2000，83，： | 2 |
| 2 | ^18 F-fluoride PET/CT for as- sassing bone involvement in prostate and breast cancers 显示文摘 | Withofs N Grayet B Tancredi T | 2011 | Nucl Med Commun2011，32，3： | 1 |
| 3 | Carcinoembryonic antigen elevation in agnogenic myeloid metapla显示文摘 | Withofs M Offner F De Paepe P | 2000 | British J Haematology2000，110，3： | 1 |
| 4 | Circadian rhythm of heart rate and heart rate variability 显示文摘 | lassin MM Maeyns K Withofs N | 2000 | Arch Dis Child2000，83，2： | 1 |
| 5 | Circadian rhythm of heart rate and heart rate variability显示文摘 | Massin M M Maeyns K Withofs N | 2000 | Arch Dis Child2000，83，2： | 1 |
| 6 | Circadian rhythm of heart rate and heart rate variability显示文摘 | Massin MM Maeyns K Withofs N | | 0，，02： | 1 |
| 7 | Circadian rhythm of heart rate and heart rate variablity显示文摘 | Massin MM Maeyns K Withofs N | 2000 | Arch Dis Child2000，83，2： | 1 |
| 8 | Circadian rhythm of heart rate and heart rate variability显示文摘 | Massin M M Maeyns K Withofs N | 2000 | Arch Dis Child2000，83，2： | 1 |
| 9 | Circadian rhythm of heart rate and heart rate variability 显示文摘 | Massin MM Maeyns K Withofs N | 2000 | Arch Dis Child2000，83，： | 1 |
| 10 | The role of positron emission tomography-computed tomography and magnetic resonance imaging in diagnosis and follow up ofmultiple myeloma显示文摘 | Caers J Withofs N Hillengass J | 2014 | Haematologica2014，99，4： | 1 |
| 11 | Cirradian rhythm of heart and heart rate variability显示文摘 | Massin MM Maeyns K Withofs N | 2000 | Arch Dis Child2000，83，2： | 1 |
| 12 | pet imaging of tumor neo- vascularization in a transgenic mouse model with a novel ~cu-dota- knottin peptide显示文摘 | Nielsen CH KimuraRH Withofs N | 2010 | Cancer Res2010，70，22： | 1 |
| 13 | Carcinoembryonic antigen elevation in agnogenic myeloid metaplasia 显示文摘 | Withofs M Offner F de Paepe P | 2000 | Br J Haematol2000，110，3： | 1 |
| 14 | Imaging bone metasta- ses in breast cancer 显示文摘 | Withofs N Collignon J Hustinx R | 2011 | Rev Med Liege2011，66，56： | 1 |
| 15 | Circadian rhythm of heart rate and heart rate variability显示文摘 | Massin MM Maeyns K Withofs N | 2000 | Arch Dis Chid2000，83，2： | 1 |
| 16 | Toward diagnostic relevance of theαVβ5,αVβ3,andαVβ6 integrins in OA:expression within human cartilage and spinal osteophytes显示文摘We previously reported 18FPRGD2 uptake by the coxofemoral lining,intervertebral discs and facet joint osteophytes in OA using PET/SCAN imaging.However,the molecular mechanism by which the PRGD2 tracer interacts with joint tissues and osteophytes in OA remains unclear.As PRGD2 ligands are expected to belong to the RGD-specific integrin family,the purpose of this study was(i)to determine which integrin complexes display the highest affinity for PRGD2-based ligands,(ii)to analyze integrin expression in relevant tissues,and(iii)to test integrin regulation in chondrocytes using OA-related stimuli to increase the levels of fibrosis and ossification markers.To this end,the affinity of PRGD2-based ligands for five heterodimeric integrins was measured by competition with 125I-echistatin.In situ analyses were performed in human normal vs.OA cartilage and spinal osteophytes.Osteophytes were characterized by(immuno-)histological staining.Integrin subunit expression was tested in chondrocytes undergoing dedifferentiation,osteogenic differentiation,and inflammatory stimulation.The integrinsαVβ5,αVβ3,andαVβ6 presented the highest affinity for PRGD2-based ligands.In situ,the expression of these integrins was significantly increased in OA compared to normal cartilage.Within osteophytes,the mean integrin expression score was significantly higher in blood vessels,fibrous areas,and cells from the bone lining than in osteocytes and cartilaginous zones.In vitro,the levels of integrin subunits were significantly increased during chondrocyte dedifferentiation(except forβ6),fibrosis,and osteogenic differentiation as well as under inflammatory stimuli.In conclusion,anatomical zones(such as OA cartilage,intervertebral discs,and facet joint osteophytes)previously reported to show PRGD2 ligand uptake in vivo expressed increased levels ofαVβ5,αVβ3,andβ6 integrins,whose subunits are modulated in vitro by OA-associated conditions that increase fibrosis,inflammation,and osteogenic differentiation.These results suggest that the increased levels of integrins in OA compared to normal tissues favor PRGD2 uptake and might explain the molecular mechanism of OA imaging using the PRGD2-based ligand PET/CT. | Edith Charlier Céline Deroyer Sophie Neuville Zelda Plener Olivier Malaise Federica Ciregia Philippe Gillet Gilles Reuter Mallory Salvé Nadia Withofs Roland Hustinx Dominique de Seny Michel G.Malaise | 2020 | Bone Research2020，8，4： | 1 |
| 17 | 18F-fluoride PET/CT for assessing bone involvement in prostate and breast cancers显示文摘 | Withofs N Grayet B Tancredi T | 2011 | Nucl Med Commun2011，32，3： | 1 |
| 18 | Imaging bone metastases in breast cancer显示文摘 | Withofs N Collignon J Hustinx R | 2011 | Rev Med Liege2011，66，56： | 1 |
| 19 | Circadian rhythm of heart and heart rate variability 显示文摘 | MASSIN M M AEYNS K WITHOFS N | 2000 | Arch Dis Chilct2000，83，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员