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| 1 | Time-course pattern of neuronal loss and gliosis in gerbil hippocampi following mild, severe, or lethal transient global cerebral ischemia显示文摘Transient ischemia in the whole brain leads to neuronal loss/death in vulnerable brain regions. The striatum, neocortex and hippocampus selectively loose specific neurons after transient ischemia. Just 5 minutes of transient ischemia can cause pyramidal neuronal death in the hippocampal cornu ammonis (CA) 1 field at 4 days after transient ischemia. In this study, we investigated the effects of 5-minute (mild), 15-minute (severe), and 20-minute (lethal) transient ischemia by bilateral common carotid artery occlusion (BCCAO) on behavioral change and neuronal death and gliosis (astrocytosis and microgliosis) in gerbil hippocampal subregions (CA1-3 region and dentate gyrus). We performed spontaneous motor activity test to evaluate gerbil locomotor activity, cresyl violet staining to detect cellular distribution, neuronal nuclei immunohistochemistry to detect neuronal distribution, and Fluoro-Jade B histofluorescence to evaluate neuronal death. We also conducted immunohistochemical staining for glial fibrillary acidic protein and ionized calcium-binding adapter molecule 1 (Ibal) to evaluate astrocytosis and microgliosis, respectively. Animals subjected to 20-minute BCCAO died in at least 2 days. BCCAO for 15 minutes led to pyramidal cell death in hippocampal CA1-3 region 2 days later and granule cell death in hippocampal de匚tate gyrus 5 days later. Similar results were not found in animals subjected to 5-minute BCCAO. Gliosis was much more rapidly and severely progressed in animals subjected to 15-minute BCCAO than in those subjected to 5- minute BCCAO. Our results indicate that neuronal loss in the hippocampal formation following transient ischemia is significantly different according to regions and severity of transient ischemia. The experimental protocol was approved by Institutional Animal Care and Use Committee (AICUC) of Kangwon National University (approval No. KW-180124-1) on May 22, 2018. | Tae-Kyeong Lee Hyunjung Kim Minah Song Jae-Chul Lee Joon Ha Park Ji Hyeon Ahn Go Eun Yang Hyeyoung Kim Taek Geun Ohk Myoung Cheol Shin Jun Hwi Cho Moo-Ho Won | 2019 | Neural Regeneration Research2019，14，8： | 3 |
| 2 | Prognostic value of 18-fluorodeoxyglucose positron emission tomography-computed tomography in resectable colorectal cancer显示文摘AIM:To assess the prognostic value of preoperative 18 fluorodeoxyglucose positron emission tomography(FDG-PET)/computed tomography(CT) in patients with resectable colorectal cancer.METHODS:One hundred sixty-three patients with resectable colorectal cancer who underwent FDG-PET/CT before surgery were included.Patient data including pathologic stage at presentation,histology,treatment,disease-free survival and the maximum standardized uptake value(SUVmax) of the primary tumor on FDG-PET/CT were retrospectively analyzed.Median follow up duration was 756(range,419-1355).The primary end point was disease-free survival.RESULTS:Twenty-five of 163 patients(15.3%) had recurrences.The median SUVmax values of the recurrence and no-recurrence groups were 8.9(range,5-24) and 8.2(range,0-23,P = 0.998).Receiver operating characteristic(ROC) curve analysis showed no significant association between SUVmax and recurrence(area under the curve = 0.5,P = 0.998,95% CI:0.389-0.611).Because a statistically significant value was not found,SUVmax was dichotomized at its median of 8.6.The disease-free survival curve was analyzed using the median SUVmax(8.6) as the cut off.Univariate and multivariate analysis did not provide evidence that disease-free survival rates for the subgroups defined by the median SUVmax were significantly different(P = 0.52,P = 0.25).CONCLUSION:Our study suggests that the high FDG uptake of primary mass in resectable colorectal cancer doesn't have a significant relationship with tumor recurrence and disease-free survival. | Jang Eun Lee Sang Woo Kim Jin Su Kim Kyu Yong Choi Won Kyung Kang Seong Taek Oh Ie Ryung Yoo Sung Hoon Kim | 2012 | World Journal of Gastroenterology2012，18，36： | 3 |
| 3 | Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis显示文摘 | Chang Sik Yu Hae Ran Yun Eung Jin Shin Kang Yong Lee Nam Kyu Kim Seok-Byung Lim Seong Taek Oh Sung-Bum Kang Won Joon Choi Woo Yong Lee | 2013 | The American Journal of Surgery2013，，： | 2 |
| 4 | Electrospinning of ultrafine cellulose acetate fibers:studies of a new solvent system and deacetylation of ultrafine cellulose acetate fibers显示文摘 | WON Keun Son JI Ho Youk TAEK Seung Lee | 2004 | Journal of Polymer Science:Part B:Polymer Physics2004，，42： | 1 |
| 5 | Chitin and chitosan nanofibers: electrospinning of chitin and deacetylation of chitin nanofibers显示文摘 | Byung-Moo Min Sung Won Lee Jung Nam Lim Young You Taek Seung Lee Pil Hyun Kang Won Ho Park | 2004 | Polymer2004，，21： | 1 |
| 6 | Definitive chemoradiation therapy with capecitabine in locally advanced pancreatic cancer显示文摘 | Hyo Song Kim Seong Yoon Yi Hyun Jung Jun Jeeyun Lee Se Hoon Park Jong Kyun Lee Kyu Taek Lee Kwang Hyuck Lee Dong Wook Choi Seong-Ho Choi Jin Seok Heo Young Suk Park Ho Yeong Lim Won Ki Kang Hee Chul Park Do Hoon Lim Joon Oh Park | 2010 | Anti-Cancer Drugs2010，，1： | 1 |
| 7 | Effectiveness of stent placement for palliative treatment in malignant colorectal obstruction and predictive factors for stent occlusion显示文摘 | Jung Pil Suh Sang Woo Kim Yu Kyung Cho Jae Myung Park In Seok Lee Myung-Gyu Choi In-Sik Chung Hyung Jin Kim Won Kyung Kang Seong Taek Oh | 2010 | Surgical Endoscopy2010，，2： | 1 |
| 8 | Single-port transumbilical laparoscopic appendectomy: 43 consecutive cases显示文摘 | Hyung Jin Kim Jae Im Lee Yoon Suk Lee In Kyu Lee Jung Hyun Park Sang Kuon Lee Won Kyung Kang Hyeon-Min Cho Young Kyuong You Seong Taek Oh | 2010 | Surgical Endoscopy2010，，11： | 1 |
| 9 | Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia显示文摘 | Hye Seung Jung Kun Wook Chung Jeong Won Kim Jin Kim Masaaki Komatsu Keiji Tanaka Yen Hoang Nguyen Tong Mook Kang Kun-Ho Yoon Ji-Won Kim Yeon Taek Jeong Myoung Sook Han Moon-Kyu Lee Kwang-Won Kim Jaekyoon Shin Myung-Shik Lee | 2008 | Cell Metabolism2008，，4： | 1 |
| 10 | A phase II trial of gemcitabine plus capecitabine for patients with advanced pancreatic adenocarcinoma显示文摘 | Byeong-Bae Park Joon Oh Park Hyo Rak Lee Jeeyun Lee Dong Wook Choi Seong-Ho Choi Jin Seok Heo Jong Kyun Lee Kyu Taek Lee Do Hoon Lim Young Suk Park Ho-Yeong Lim Won Ki Kang Keunchil Park | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 11 | A phase II trial of gemcitabine plus capecitabine for patients with advanced pancreatic adenocarcinoma显示文摘 | Byeong-Bae Park Joon Oh Park Hyo Rak Lee Jeeyun Lee Dong Wook Choi Seong-Ho Choi Jin Seok Heo Jong Kyun Lee Kyu Taek Lee Do Hoon Lim Young Suk Park Ho-Yeong Lim Won Ki Kang Keunchil Park | 2007 | Cancer Chemotherapy and Pharmacology2007，，4： | 1 |
| 12 | Repetitive control of Catofin process 显示文摘 | Seo Seung -Taek Won Wangyun Lee K S | 2007 | Korean Journal of Chemical Engineering2007，24，6： | 1 |
| 13 | Highly hydro- phobic nanofibrous surfaces genearated by poly(vinylidene flu- oride)显示文摘 | Lee Myung Sun Lee Taek Seung Park Won Ho | 2013 | Fibers and Polymers2013，14，8： | 1 |
| 14 | Electrospinning of ultrafine cellulose acetate fibers:Studies of a new solvent system and deacetylation of ultrafine cellulose acetate fibers 显示文摘 | Won keun Son Ji Ho Youk Taek Seung Lee | 2004 | Journal of Polymer Science Part B: Polymer Physics2004，，42： | 1 |
| 15 | Synthesis of chitooligosaccharide derivative with quaternary ammonium group and its antimicrobial activity against Streptococcus mutans显示文摘 | Ji Young Kim Jong Keun Lee Taek Seung Lee Won Ho Park | | International Journal of Biological Macromolecules0，32，12： | 1 |
| 16 | Preparation of Antimicrobial Ultrafine Cellulose Acetate Fibers with Silver Nanoparticles 显示文摘 | Won Keun Son Ji Ho Youk Taek Seung Lee | 2004 | Mac romolecular Rapid Communications2004，，25： | 1 |
| 17 | Single-port transumbilical laparoscopic appendectomy: 43 consecutive cases显示文摘 | Hyung Jin Kim Jae Im Lee Yoon Suk Lee In Kyu Lee Jung Hyun Park Sang Kuon Lee Won Kyung Kang Hyeon-Min Cho Young Kyuong You Seong Taek Oh | 2010 | Surgical Endoscopy2010，，11： | 1 |
| 18 | The effects of solution properties and polyelectrolyte on electro- spinning of ultrafine poly(ethylene oxide) fibers显示文摘 | Son Won Keun Youk Ji Ho Lee Taek Seung | 2004 | Polymer2004，45，： | 1 |
| 19 | The Electromagnetic Interference Shielding Effect of Indium-zinc Oxide/Silver Alloy Multilayered Thin Films显示文摘 | Kim Won Mok Ku Dae Young Lee In-kyu Seo Yong Woon Cheong Byung-ki Lee Taek Sung Kim In-ho Lee Kyeong Seok | 2005 | Thin Solid Films2005，473，2： | 1 |
| 20 | Effects of Noscarna? on hypertrophic scarring in the rabbit ear model: Histopathological aspects显示文摘 | Dong Won Lee Sae Kwang Ku Hyuk Jun Cho Jeong Hwan Kim Tran Tuan Hiep Sang Duk Han Bo Gyun Kim Min Kyung Kang Eui Seon Do Joon Ho Jun Sun Woo Jang Mi-Won Son Young Taek Sohn Han-Gon Choi Chul Soon Yong Jong Oh Kim | 2012 | Archives of Pharmacal Research2012，，11： | 1 |
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