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| 1 | 膨胀土地基中隧道施工对群桩影响研究显示文摘在膨胀土地基中进行隧道对群桩影响的三维离心模型试验研究,目标地层损失比为2%,着重研究引起的地基沉降槽、桩的附加沉降、附加弯矩、轴力的变化规律。试验得出:隧道开挖沉降槽空间效应明显;隧道开挖从-0.75D至1.25D时,桩附加沉降呈线性增长,隧道开挖至1.25D以后,桩依然沉降明显。前桩与后桩沉降值不同,桩帽会出现倾斜;前桩上部出现负附加弯矩而下部出现正附加弯矩,而后桩仅在下部出现正附加弯矩;前桩附加弯矩最大值出现在隧道轴线附近,且比后桩附加弯矩大得多;前桩附加轴力随着隧道的开挖而增加,且每步最大值在隧道轴线附近。后桩的轴力也随隧道的开挖而增加,但每步最大值出现在桩顶附近。 | 马少坤 WONG K S 吕虎 吴宏伟 赵乃峰 | 2013 | 岩土力学2013，34，11： | 8 |
| 2 | 双隧道对群桩影响的三维离心模型试验研究显示文摘在膨胀土地基中进行了双隧道对群桩影响的三维离心模型试验,目标地层损失比为2%,着重研究引起的地基沉降槽、附加弯矩、轴力的变化规律。试验得出:膨胀土地基中每个隧道开挖形成的地表沉降槽仍符合Peck高斯曲线,双隧道共同作用形成的沉降槽可以看作是每个隧道单独作用形成的沉降槽的叠加;两个隧道开挖引起的前后桩弯矩规律类似,最大附加弯矩均出现在拱冠附近,但存在明显的前桩遮拦效应;随着第一个隧道开挖的临近及远离,前后桩轴力会发生明显不同变化,而第二个隧道影响明显不同,附加轴力最大值约为工作荷载的10%。 | 马少坤 吕虎 Wong K S 吴宏伟 赵乃峰 | 2013 | 岩土工程学报2013，35，7： | 8 |
| 3 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 4 | 地下水位循环变化时隧道开挖对群桩的长期影响研究显示文摘为解决地下水位随季节升降变化时隧道开挖对邻近桩基的长期影响难题,通过三维离心模型试验,研究了地下水位循环变化时隧道对群桩的长期影响。主要分析水位循环变化时地表长期沉降、桩顶长期附加沉降、桩身长期附加弯矩和附加轴力的变化规律。试验结果表明:在隧道附近,地下水位循环变化尤其是降水对地表长期沉降影响更为明显。地表长期附加沉降随着地下水位循环次数增加而增大,且呈衰减式变形,即使经过3次水位升降循环也不能稳定;桩基长期附加沉降显著,其附加沉降量占总沉降量的50%以上;前、后桩的长期附加轴力基本为正值,桩总轴力增加,对既有受压桩极为不利,附加轴力拐点位置及最大值有所区别;经过3次地下水位循环变化后,前、后桩桩身弯矩反弯点个数减少,但桩身最大附加弯矩均明显变大,当达到极限弯矩,桩身出现塑性铰,这对穿越厚软弱层地基中的既有受压柔性桩极为危险。 | 马少坤 邵羽 吕虎 WONG K S 吴宏伟 陈欣 江杰 | 2016 | 岩土力学2016，37，6： | 2 |
| 5 | Biomedical applications of shape-memory polymers:how practically useful are they?显示文摘Shape-memory effect(SME) is the ability of a material to change its dimension in a predefined way in response to an external stimulus. Polymers that exhibit SME are an important class of materials in medicine, especially for minimally invasive deployment of devices. However, the rate of translation of the concept to approved products is extremely low, with mostly nitinolbased devices being approved. In this review, the general aspects of the different types of stimuli that can be used to activate SME are reviewed and sterilization issues of shape-memory polymer(SMP)-based medical devices are addressed. In addition, the general usefulness as well as the limitations of the shape-memory effect for biomedical applications are described. | WONG YeeShan KONG JenFong WIDJAJA Leonardus K VENKATRAMAN Subbu S | 2014 | Science China Chemistry2014，57，4： | 2 |
| 6 | Haematological manifestations in patients with severe acute respiratory syndrome:retrospective analysis显示文摘 | Wong R S Wu A To K F | 2003 | BMJ2003，326，： | 2 |
| 7 | An overview of energy sources for electric vehicles显示文摘 | Chau K T Wong Y S Chan C C | 1999 | Energy Conversion and Management1999，40，10： | 2 |
| 8 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 9 | A survey of threshold techniques显示文摘 | SAHOO P K SOLTANI S Wong A K C | 1988 | Computer Vision Graphics Image Processing1988，41，： | 1 |
| 10 | Three-dimensional analysis of single pile response to lateral soil movements显示文摘 | Pan J L Goh A T C Wong K S | 2002 | International Journal for Numerical and Analytical Methods in Geomechanics2002，，26： | 1 |
| 11 | Integrating Environmental Criteria into the Supplier Selection Process显示文摘 | HUMPHREYS P K WONG Y K CHAN F T S | 2003 | Journal of Materials Processing Technology2003，138，6： | 1 |
| 12 | Hopf bifurcation on a two-neuron system with distributed delays: a frequency domain approach 显示文摘 | LIAO X LI S WONG K | 2003 | Nonlinear Dynamics2003，31，3： | 1 |
| 13 | Dynamic stress and displacement around cylindrical cavities of arbitrary shapes显示文摘 | Datta S K Wong K C Shah A H | 1984 | ASME Journal of Applied Mechanics1984，51，： | 1 |
| 14 | Sand-geotextile interface shear strength by torsional ring shear tests 显示文摘 | S A Tan S H Chew & W K Wong | 1998 | Geotextiles and Geomembranes1998，，16： | 1 |
| 15 | Cross Talk bet-ween ERK and PKA is Required for Ca2+ Stimulation of CREB-dependent Transcription and ERK Nuclear Tran-slocation显示文摘 | IMPEY S OBRIETAN K WONG S T | 1998 | Neuron1998，21，4： | 1 |
| 16 | Comparison of one -dimensional and two- dimensional models for wet surface fin efficiency of a plate - fin - tube heat exchanger 显示文摘 | Liang S Y Wong T N Nathan G K | 2000 | Applied Thermal Engineering2000，20，10： | 1 |
| 17 | The TGF-alpha precursor expressed on the cell surface binds to the EGF receptor on adjacent cells,leading to signal transduction显示文摘 | Wong S T Winchell L F McCune B K | 1989 | Cell1989，56，3： | 1 |
| 18 | A Survey of Thresholding Technique显示文摘 | Sahoo P K Tanis S Wong A K C | 1988 | Computer Vision Graphics Image Processing1988，41，2： | 1 |
| 19 | A dynamic call admission policy with precision QoS guarantee using stochastic control for mobile wireless networks显示文摘 | S Wu K Y M Wong B Li | 2002 | IEEE/ACM Transactions on Networking2002，10，2： | 1 |
| 20 | An effective iterative pose estimation algorithm显示文摘 | Or S H Luk W S Wong K H | 1998 | Image and Vision Computing1998，16，5： | 1 |
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