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| 1 | Factors associated with 5-year survival of combined hepatocellular and cholangiocarcinoma显示文摘BACKGROUND Combined hepatocellular and cholangiocarcinoma(HCC/CC)is a rare primary hepatic malignancy which carries a poor prognosis due to its aggressive nature.Few centers have enough cases to draw definitive conclusions and there is limited understanding of prognosis.Given the rarity of HCC/CC,an analysis of large national cancer database was needed to obtain larger number of HCC/CC cases.AIM To identify associated factors for 5-year survival of HCC/CC.METHODS We conducted a retrospective study of The Surveillance,Epidemiology,and End Results(SEER)database obtained from SEER*Stat 8.3.6 software.Previously defined histology code 8180 for the International Classification of Disease for Oncology,3rd edition was used to identify HCC/CC cases from 2004 to 2015.We collected demographics,American Joint Committee on Cancer(AJCC)stage,treatment,tumor size,and survival data.These data were converted to categorical variables.The Shapiro-Wilk normality test was used to assess normal distribution.Mann-Whitney U test was used to compare continuous variables without normal distribution,and t-test was used to compare continuous variables with a normal distribution.The Kaplan-Meier survival curve analyzed 5-year survival.Univariate and multivariate logistic regression model was used to analyze factors associated with 5-year survival.Multivariate Cox proportional hazard regression was done on 5-year survival.We defined P<0.05 was statistically significant.RESULTS We identified 497 patients with the following characteristics:Mean age 62.4 years(SD:11.3),149(30.0%)were female,racial distribution was:276(55.5%)white,53(10.7%)black,84(16.9%)Asian and Pacific Islander(API),77(15.5%)Hispanic,and 7(1.4%)others or unknown.Stage I/II disease occurred in 41.5%and tumor size<50 mm was seen in 35.6%of patients.Twenty-four(4.8%)received locoregional therapy(LRT),119(23.9%)underwent resection,and 50(10.1%)underwent liver transplantation.The overall median survival was 6 mo[Interquartile range(IQR):1-22].After multivariate logistic regression,tumor size<50 mm[Odds ratios(OR):2.415,P=0.05],resection(OR:12.849,P<0.01),and transplant(OR:27.129,P<0.01)showed significance for 5-year survival.Age>60,sex,race,AJCC stages,metastasis,and LRT were not significant.However,API vs white showed significant OR of 2.793(CI:1.120-6.967).Cox proportional hazard regression showed AJCC stages,tumor size<50 mm,LRT,resection,and transplant showed significant hazard ratio.CONCLUSION HCC/CC patients with tumor size<50 mm,resection,and transplant were associated with an increase in 5-year survival.API showed advantageous OR and hazard ratios over white,black. | Tomoki Sempokuya Eric A Wien Robert J Pattison Jihyun Ma Linda L Wong | 2020 | World Journal of Hepatology2020，12，11： | 2 |
| 2 | Three-dimensional analysis of single pile response to lateral soil movements显示文摘 | Pan J L Goh A T C Wong K S | 2002 | International Journal for Numerical and Analytical Methods in Geomechanics2002，，26： | 1 |
| 3 | A PLL clock generator with 5 to 110 MHz of lock range for microprocessors显示文摘 | YOUNG I A GREASON J K WONG K L | 1992 | IEEE J Sol Sta Circ1992，27，4： | 1 |
| 4 | A differential requirement for the COOH-terminal region of the epidermal growth factor(EGF) receptor in amphiregulin and EGF mitogenic signaling显示文摘 | Wong L Deb T B Thompson S A | 1999 | J Biol Chem1999，274，13： | 1 |
| 5 | Experimental investigation of drying shrinkage and creep of concrete using fibre-optic sensors 显示文摘 | Wong A C L Childs P A Terry W | 2007 | Advances in Structural Engineering2007，10，3： | 1 |
| 6 | Simultaneous pattern and data clustering for pattern cluster analysis显示文摘 | Wong A K C Li G C L | 2008 | IEEE Transaction on Knowledge and Data Engineering2008，20，： | 1 |
| 7 | Enhanced Multi-Line Code for Minutiae-Based Fingerprint Template Protection 显示文摘 | Wong W J Teoh A B J Wong M L D | 2013 | Pattern Recognition Letters2013，34，11： | 1 |
| 8 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 9 | Three-dimensional finite element analyses of passive pile behaviour显示文摘 | Miao L F Goh A T C Wong K S | 2006 | International Journal for Numerical and Analytical Methods in Geomechanics2006，，30： | 1 |
| 10 | Fentanyl dose-response curves when inserting the LMA Classic^TM laryngeal mask airway 显示文摘 | Wong C M Critchley L A Lee A | 2007 | Anaesthesia2007，62，7： | 1 |
| 11 | Characterization of SU1 isoamylase,a determinant of storage starch structure in maize显示文摘 | Wong K S Jane J L Myers A M James M G | 1998 | Plant physiology1998，117，： | 1 |
| 12 | The role of mast cell tryptase in neoanglogenesis of premallgnant and malignant lesions of the uterine cmwix 显示文摘 | Benftez-Bribiesca L Wong A Utrera D | 2001 | J Histochem Cytochem2001，49，8： | 1 |
| 13 | Pricing of New Equity Issues in Singapore显示文摘 | Wong K A Chiang H L | 1986 | Asia Pacific Journal of Management1986，41，： | 1 |
| 14 | Leukotriene B4 strongly increases monocyte chemoattractant protein-1 in human monocytes显示文摘 | HUANG L ZHAO A WONG F | 2004 | Arterioscler Thromb Vasc Biol2004，24，： | 1 |
| 15 | Analysis of raw meats and fats of pigs using polymerase chain reaction for Halal authentication 显示文摘 | Aida A A Che Man Y B Wong C M V L | 2005 | Meat Science2005，69，： | 1 |
| 16 | Isolation and expression pattern of a cDNA encoding a cathepsin B-like protease from Nicotiana rustica显示文摘 | Lidgett A J Moran M Wong K A L | 1995 | Plant Molecular Biology1995，29，2： | 1 |
| 17 | A unified framework for the deployment, exposure and access of HPC appli- cations as services in clouds 显示文摘 | WONG A K L GOSCINSKI A M | 2013 | Future Generation Computer Systems2013，29，6： | 1 |
| 18 | Metabolic syndrome increases the risk of liver cirrhosis in chronic hepatitis B显示文摘 | Wong G L Wong V W Choi P C Chan A W Chim A M Yiu K K | 2009 | Gut2009，58，： | 1 |
| 19 | Three- dimensional analysis of single pile response to lateral soil movements显示文摘 | PAN J L GOH A T C WONG K S | 2002 | International Journal for Numerical and Analytical Methods in Geomechanics2002，26，8： | 1 |
| 20 | Identification and purification of a new staphylococcal enterotoxin显示文摘 | Su Y C A C L Wong | 1995 | H Appl Environ Microbiol1995，61，： | 1 |
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