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| 1 | 神经连接蛋白-3缺乏可阻止高分级神经胶质瘤生长显示文摘在一项新的研究中,来自美国国家卫生研究院、斯坦福大学、达纳法伯癌症研究所和哈佛医学院的研究人员发现某些侵袭性脑瘤的生长能够通过切断它们获取大脑中神经细胞产生的一种信号分子加以阻止.这些研究人员发现当这种被称作神经连接蛋白-3(neuroligin-3,NLGN3)的信号分子缺乏时,或者当利用药物干扰这种信号分子时,人高分级神经胶质瘤不能够在小鼠大脑中扩散. | Venkatesh H S Tam L T Woo P J | 2017 | 临床误诊误治2017，30，11： | 3 |
| 2 | 有机小分子发光材料与聚合物发光材料在大气存放条件下的稳定性对比研究显示文摘分别采用紫外光电子能谱 (UPS)、X光电子能谱 (XPS)、原子力显微镜 (AFM )、以及光致发光光谱(PL)等方法对在大气存放条件下的 8 羟基喹啉铝 (Alq)薄膜和聚 ( 9,9 二辛烷基芴 ) (PFO)薄膜的电子结构、表面形貌以及发光特性进行了对比研究。研究结果表明 ,PFO的电子结构、表面形貌以及发光特性受外界气氛影响极小 ,是一种非常稳定的聚合物发光材料。这为聚合物发光器件的稳定性提供了有利的条件。 | 徐正 廖良生 李振声 李述汤 Inbase karan M Woo E P Wu W W | 2000 | 发光学报2000，21，3： | 3 |
| 3 | Identification and characterization of Trichoderma species aggressive to Pleurotus in Italy显示文摘In the late 1980’s the deve lop ment of a severe epidemic of green mold caused by Trichoderma spp. was not ed in the commercial production of Agaricus bisporus (champignon) in the U nited Kingdom, North America, Spain and Holland, which caused extensive economic losses. The parasitic fungi isolated from the edible mushroom belonged to four biotypes, Th1, Th2, Th3 and Th4 of T. harzianum. However, among these biotypes, only Th2 (since c lassified as T. aggressivum f. europaeum) and Th4 (T. aggressivum f. aggressivum) were identified as the fungi causing problems in Agaricus production. In general, mushroom compost hosts both aggressive and innocuous is olates of Trichoderma, which are not morphologically distinguishable. Abo ut four years ago, a problem with green mold became apparent in the production o f Pleurotus ostreatus in Northern Italy, which eventually developed to a c risis situation in the South two years later and threatened to seriously comprom ise the Pleurotus market. This study was initiated to: isolate and identif y the aggressive fungi, then morphologically, physiologically and genetically characterize the isolates, dete rmine the source and phases of infection, and study methods of control. Samples were obtained from different phases of compost preparation at the locality of a major producer and supplier of compost to the mushroom industry in Southern Ital y, and microbial counts were conducted. Although the presence of Trichoderma was detected in the initial stages of composting, this value was reduced to zero from the phase of pasteurization to seeding with Pleurotus. Trichoderma infestations were noted in the packaged Pleurotus bales at various time s during the incubation phase (7-15 days after seeding) and after shipping to th e mushroom greenhouses, where the pathogen infestations greatly reduced the qual ity and quantity of the mushroom yield, as well as the number of potential harvest cycles. Preliminary r esults from the morphological and genetic characterization of Trichoderma isolates parasitic to Pleurotus indicated that they are different from bot h T. aggressivum forms parasitic to Agaricus, and the majority of the isolates probably belong to the species T. harzianum. In vitr o confrontation plates were performed with 26 isolates of aggressive Trich oderma obtained from compost, three Trichoderma isolates used in biolog ical control and 12 varieties of Pleurotus. No inhibitory effect was obse rved between any of the Trichoderma isolates with Pleurotus, althou gh some growth inhibition was caused by the biocontrol isolates of Trichoderm a on some of the aggressive isolates. The temperature optimum for Pleurotus growth was at 28 ℃, whereas Trichoderma grew well at a wider range (20- 28 ℃), and exceeded the growth rate of Pleurotus by three times at 25 ℃. T he pH optimum for the growth of Pleurotus was alkaline (pH 8-9) whereas Trichoderma preferred acidic-neutral pH (5-7) . Various commercial fungicides used in agriculture (procloraz, thiabendazole, dichloran, benomyl, p r opiconazole, thiofanatomethyl) were tested against the aggressive and biocontro l isolates of Trichoderma, as well as the different varieties of Pleuro tus to determine dose response curves and combinations that would inhibit spo re germination, mycelial growth and subsequent sporulation. Both procloraz and thiabendazole, which are pesticides allowed in e dible mushroom production, were found to control the growth of the aggressive Trichoderma isolates and did not have a negative effect on Pleurotus. | Woo S L Di Benedetto P Senatore M Abadi K Gigante S Soriente I Ferraioli S Scala F Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Genetic improvement of Trichoderma ability to induce systemic resistance显示文摘The beneficial applications of Trichoderma spp. in agriculture include not only the control of plant pathogens, but also the improvement of plant growth, micronutrient availability, and plant tolerance to abiotic stress. In addition, it has been suggested that these fungi are able to increase plant disease resistance by activating induced systemic resistance (ISR) . The mode of action of these beneficial fungi in the Trichoderma -plant-pathogen interaction are many, complex and not completely understood. Numerous lytic enzymes have been characterized, the encoding genes (ech42 gluc78, nag1 from T. atroviride strain P1) cloned, and their role in biocontrol demonstrated. The corresponding biocontrol-related inducible promoters have been used in a reporter system based on the Aspergillus niger glucose oxidase gene (goxA) to monitor biocontrol activity. Glucose oxidase catalyzes the oxygen-dependent oxidation of D-glucose to D-glucono-1,5-lactone and hydrogen peroxide; this latter compound is known to have an antifungal effect and activate the plant defence cascade, thus increasing resistance to pathogen attack. T. atroviride P1 transformants with various promoters gox were tested as seed coating treatments on bean seeds planted in soil infested with a soilborne fungal pathogen. Successively, the emergent leaves were inoculated with a foliar pathogen to determine the effect of the GOX transformants on biocontrol and resistance to pathogen attack. Inoculations with the P1-GOX transformants not only reduced disease symptoms caused by a soil pathogen, but also the lesions of various foliar pathogens applied far from the Trichoderma colonization, thus activating ISR. A similar approach is being use to genetically improve T. harzianum T22, a rhizosphere competent and commercially marketed strain not transformed yet, by using four different gox gene constructs under the control of constitutive and inducible promoters. Plasmids have been introduced in Trichoderma by protoplasts co-transformation. hygromicin resistant progeny selected, and mitotically stable transformants analysed to confirm the presence of the novel enzyme activity. Progenies are being tested for biocontrol ISR inducing activity. | Ciliento R Woo S L Di Benedetto P Ruocco M Scala F Soriente I Ferraioli S Brunner K Zeilinger S Mach R L Lorito M | 2004 | 浙江大学学报(农业与生命科学版)2004，30，4： | 2 |
| 6 | Catheter-related microbacterium bacteremia identified by 16 S rRNA gene sequencing显示文摘 | Lau K P Woo C Y Moo M Y et a1 | 2002 | Clin Microbiol2002，40，7： | 1 |
| 7 | Unique immunogenicity of hepatitis B virus DNA vaccine presented by live-attenuated Salmonella typhimurium显示文摘 | Woo P C Wong L P Zheng B J | 2001 | Vaccine2001，19，： | 1 |
| 8 | Hyperhomocysteinemia is a risk factor for arterial endothelial dysfunction in humans显示文摘 | Woo K S Chook P Lolin Y I | 1997 | Circulation1997，95，12： | 1 |
| 9 | Annual Floods in Southwestern British Columbia,Canada显示文摘 | Waylen P R Woo M | 1983 | Journal of Hydrology1983，62，： | 1 |
| 10 | Unsaturated Fatty Acids,Desaturases,and Human Health显示文摘 | Hyungjae L Woo J P | 2014 | Journal of Medicinal Food2014，17，2： | 1 |
| 11 | Homocysteine, endothelial dysfunction, and coronary artery disease: emerging strategy for secondary prevention显示文摘 | Woo KS Qiao M Chook P | 2002 | J Card Surg2002，17，5： | 1 |
| 12 | Poly(DM AEMA- NVP)- b-PEG- galactose as gene delivery vector for hepatocytes显示文摘 | Dong Woo L Young I1 Y Tae Gwan P | 2000 | Bioconjugate Chem2000，11，： | 1 |
| 13 | Tne yin and yang of neu- rotrophin action显示文摘 | Lu B Pang P T Woo N H | 2005 | Nat Rev Neurosci2005，6，8： | 1 |
| 14 | 1L-6 polymorphisms: a useful genetic tool for inflammation research? 显示文摘 | Woo P Humphries S E | 2013 | j Clin Invest2013，123，4： | 1 |
| 15 | Systemic juvenile idiopathic arthritis:Diagnosis,management,and outcome显示文摘 | Woo P | | 0，，01： | 1 |
| 16 | Impact of Caregiving on Health and Quality of Life : A Comparative Popu- lation-based Study of Caregivers for Elderly Persons and Noncaregivers 显示文摘 | Ho S C Chan A Woo J Chong P and Sham A | 2009 | Journals of Gerontology Series A: Biologi- cal Sciences and Medical Sciences2009，64，： | 1 |
| 17 | Hyperhomocysteinemia is a risk factor for arterial endothelial dysfunction in humans显示文摘 | Chook P Lolin YI | 1997 | Circulation1997，96，： | 1 |
| 18 | Neural network-based adaptive controller design of robotic manipulators with an observer显示文摘 | Sun F C Sun Z Q Woo P Y | 2001 | IEEE Transactions on Neural networks2001，12，1： | 1 |
| 19 | A randomized crossover investigation of pain at dressing change comparing 2 foam dressings显示文摘 | Woo KY Coutts PM Price P | 2009 | Advances Skin Wound Care2009，22，7： | 1 |
| 20 | Fabrication and properties of thermalinsulating glass fiber reinforced composites from low temperature cur-able polyphosphate inorganic polymers显示文摘 | Kim D P Woo H G Ha H | 2003 | Composites Science andTechnology2003，63，34： | 1 |
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