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19篇 您的检索式:作者名="Woolbright"
    题名 作者 年代 出处 被引量
1Novel insight into mechanisms of cholestatic liver injury显示文摘Cholestasis results in a buildup of bile acids in serum and in hepatocytes.Early studies into the mechanisms of cholestatic liver injury strongly implicated bile acidinduced apoptosis as the major cause of hepatocellular injury.Recent work has focused both on the role of bile acids in cell signaling as well as the role of sterile inflammation in the pathophysiology.Advances in modern analytical methodology have allowed for more accurate measuring of bile acid concentrations in serum,liver,and bile to very low levels of detection.Interestingly,toxic bile acid levels are seemingly far lower than previously hypothesized.The initial hypothesis has been based largely upon the exposure of μmol/L concentrations of toxic bile acids and bile salts to primary hepatocytes in cell culture,the possibility that in vivo bile acid concentrations may be far lower than the observed in vitro toxicity has far reaching implications in the mechanism of injury.This review will focus on both how different bile acids and different bile acid concentrations can affect hepatocytes during cholestasis,and additionally provide insight into how these data support recent hypotheses that cholestatic liver injury may not occur through direct bile acid-induced apoptosis,but may involve largely inflammatory cell-mediated liver cell necrosis.Benjamin L Woolbright Hartmut Jaeschke 2012World Journal of Gastroenterology2012,18,36:21
2Current strategies to minimize hepatic ischemia–reperfusion injury by targeting reactive oxygen species显示文摘Hartmut Jaeschke Benjamin L. Woolbright 2012Transplantation Reviews2012,,2:2
3Current strategies to minimize hepatie ischemia-reperfusion injury by targeting reactive oxygen species 显示文摘Jaeschke H Woolbright BL 2012Transplant Rev (Orlando)2012,26,2:1
4Sexual selection and size dimorphism in anuran amphibia显示文摘Woolbright L 1983American Naturalist1983,121,:1
5Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species 显示文摘Jaeschke H Woolbright B L 2012Transplant Rev (Orlando)2012,26,2:1
6Current strategies to minimize hepatic ischemia–reperfusion injury by targeting reactive oxygen species显示文摘Hartmut Jaeschke Benjamin L. Woolbright 2012Transplantation Reviews2012,,2:1
7Heme oxygenase-1 and plate-lets in hepatic ischemia reperfusion injury 显示文摘WOOLBRIGHT BL JAESCHKE H 2013J GastroenterolHepatol2013,28,5:1
8Glycodeoxyeholie acid levels as prognostic biomarker in acetaminophen-induced acute liver failure patients显示文摘Woolbright BL MeGill MR Staggs VS 2014Toxicol Sci2014,142,2:1
9Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defec- tive hepatic autophagy 显示文摘NI HM WOOLBRIGHT BL WILLIAMS J 2014J Hepatol2014,61,3:1
10Current strategies to minimize hepaticischemia - reperfusion injury by targeting reactive oxygen species 显示文摘Jaeschke H Woolbright BL 2012Transplant Rev (Orlando)2012,26,2:1
11Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defec- tive hepatic autophagy 显示文摘Ni HM Woolbright BL Williams J 2014J Hepatol2014,61,3:1
12Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice显示文摘Min Yang Anup Ramachandran Hui-Min Yan Benjamin L. Woolbright Bryan L. Copple Peter Fickert Michael Trauner Hartmut Jaeschke 2014Toxicology Letters2014,,2:1
13Nrf2 promotes the development of fibrosis and tumorigenesis in mice with defeetive hepatic autophagy 显示文摘Ni HM Woolbright BL Williams J 2014J Hepatol2014,61,:1
14Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species显示文摘Jaeschke H Woolbright BL 0,,02:1
15Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species显示文摘Jaeschke H Woolbright BL 2012Transplant Rev(Orlando)2012,26,2:1
16Current strategies to minimize hepatic ischemia–reperfusion injury by targeting reactive oxygen species显示文摘Hartmut Jaeschke Benjamin L. Woolbright 2012Transplantation Reviews2012,,2:1
17Specific regulation of CYP27B1 and VDR in proximal versus distal renal cells显示文摘Bajwa A Forster MN Maiti A Woolbright BL Beckman MJ 0,,1:1
18Current strategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species显示文摘Jaeschke H Woolbright BL 0,,:1
19Currentstrategies to minimize hepatic ischemia-reperfusion injury by targeting reactive oxygen species显示文摘Jaeschke H Woolbright BL 2012Transplant Rev(Orlando)2012,26,2:1
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