|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | A meta-analysis of soluble suppression of tumorigenicity 2 (sST2) and clinical outcomes in pulmonary hypertension显示文摘 | King Sum Luk Christina Ip Meng-Qi GONG Sunny Hei WONG William KK Wu Mei DONG Guang-Ping LI Ka Pang Chan Yi-Mei DU Tong LIU Martin CS Wong David Shu Cheong Hui Gary Tse | 2017 | Journal of Geriatric Cardiology2017，14，12： | 5 |
| 2 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 3 | Cathelicidins in inflammation and tissue repair: Potential therapeutic applications for gastrointestinal disorders显示文摘Cathelicidins,主人防卫肽的一个家庭,高度在感染,发炎并且创伤愈合期间被表示。这些肽不仅举办用途广泛的抗菌剂活动,而且由在 diseased 纸巾改变 cytokine 反应和煽动性的房间的 chemoattraction 调制发炎。在这个连接,老鼠 cathelicidin 被表明了通过提高粘液生产并且减少支持 inflammatory cytokines 的生产在冒号阻止发炎。另外, cathelicidins 支持创伤在受伤纸巾通过 re-epithelialization 和 angiogenesis 的刺激愈合。在胃的溃疡的一个动物模型,老鼠 cathelicidin 支持溃疡由在 vitro 并且在 vivo 导致胃的上皮的房间的增长愈合。在结论, cathelicidins 在在胃肠的 mucosa 和另外的机关操作发炎和组织修理的复杂集成的天生的免疫系统代表受动器分子的一个重要的组。 | William Ka Kei WU Clover Ching Man WONG Zhi Jie LI Lin ZHANG Shun Xiang REN Chi Hin CHO | 2010 | Acta Pharmacologica Sinica2010，31，9： | 2 |
| 4 | High Incidence of Mortality and Recurrent Bleeding in Patients With Helicobacter pylori –Negative Idiopathic Bleeding Ulcers显示文摘 | Grace Lai–Hung Wong Vincent Wai–Sun Wong Yawen Chan Jessica Yuet–Ling Ching Kim Au Aric Josun Hui Larry Hin Lai Dorothy Kai–Lai Chow Danny Ka–Fai Siu Yan–Ni Lui Justin Che–Yuen Wu Ka–Fai To Lawrence Cheung–Tsui Hung Henry Lik–Yuen Chan Joseph Jao–Yiu Sung | 2009 | Gastroenterology2009，，2： | 2 |
| 5 | Cyclooxygenase-2 in tumorigenesis of gastrointestinal cancers: An update on the molecular mechanisms显示文摘 | William Ka Kei Wu Joseph Jao Yiu Sung Chung Wa Lee Jun Yu Chi Hin Cho | 2010 | Cancer Letters2010，，1： | 2 |
| 6 | Perinatal outcome in singletons following in vitro fertilization:a meta-analysis显示文摘 | Jackson RA Gibson KA Wu YW | 2004 | Obstet Gynecol2004，103，3： | 1 |
| 7 | Glutamine-enriehed total parenteral nutrition maintains intestinal neterleukin-4 and mucosal immunoglobulin A levels 显示文摘 | Kudsk KA Wu Y Fukatsu K | 2000 | JPEN2000，24，10： | 1 |
| 8 | Route and type of nutrition influence IgA-mediating intestinal cytokines 显示文摘 | Wu Y Kudsk KA DeWitt RC | 1999 | Ann Surg1999，229，： | 1 |
| 9 | Functional comparison of transmyocardial revascularization by mechanical and laser means 显示文摘 | Horvath KA Belkind N Wu I | 2001 | Ann Thorac Surg2001，72，6： | 1 |
| 10 | Pituitary microadenoma: MR appearance and correlation with CT 显示文摘 | Wu W Thuomas KA | 1995 | Acta Radiology1995，36，： | 1 |
| 11 | Formal literature review of quality - of - life instruments used in end - stage renal disease显示文摘 | Cagney KA Wu AW Fink NE | 2000 | American Journal of Kidney Diseases2000，36，2： | 1 |
| 12 | In vivo ^31P NMR spectroscopic changes during liver regeneration显示文摘 | Campbell KA Wu YP Chacko VP | 1990 | J Surg Res1990，49，： | 1 |
| 13 | Degenerative changes following anterior cervical discectomy and fusion evaluated by fast spin-echo MR imaging显示文摘 | Wu W Thuomas KA Hedlund R | 1996 | Acta Radiol1996，37，5： | 1 |
| 14 | Glutamine-enriched total parenteral nutrition maintains intestinal interleukin-4 and mucosal immunoglobulin A levels显示文摘 | Kudsk KA Wu Y Fukatsu K | 2000 | J Parenter Enteral Nutr2000，24，5： | 1 |
| 15 | Kinetic Models for Ultrasound - Assisted Extraction of Water - Solu- ble Components and Polysaccharides from Medicinal Fungi 显示文摘 | Cheung YiChing Siu Ka - Chai Wu Jian - Yong | 2013 | Food Bioprocess Technology2013，，6： | 1 |
| 16 | Pediatric traumatic macular hole:Results of autologous plasmin enzyme-assisted vitrectomy 显示文摘 | Wu WC Drenser KA Trese MT | 2007 | Am J Ophthalmol2007，144，5： | 1 |
| 17 | Modulation of transforming growth factor β-1 gene expression by interleukin-12显示文摘 | Wilkinson KA Aung H Wu M | 2000 | Scand J Immunol2000，52，： | 1 |
| 18 | Autoimmune limbicencephalitis in 39patients:immunophenotypes and outcomes显示文摘 | Bataller L Kleopa KA Wu GF | 2007 | J Neurol Neurosurg Psychiatry2007，78，4： | 1 |
| 19 | Glutamine-enriched total parenteral nutrition maintains intestinal interleukin-4 and mucosal immunoglobulin A levels显示文摘 | Kudsk KA Wu Y Fukatsu K | 2000 | JPEN2000，24，3： | 1 |
| 20 | Primary visual cortex vol- ume and total neuron number are reduced in schizophrenia 显示文摘 | Dorph-Petersen KA Pierri JN Wu Q | 2007 | J Comp Neurol2007，501，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员