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| 1 | A wave of Foxp3^(+) regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance显示文摘Newborn animals require tightly regulated local and systemic immune environments to govern the development and maturation of multiple organs/tissues even though the immune system itself is far from mature during the neonatal period.Regulatory T cells(Tregs)are essential for maintaining immune tolerance/homeostasis and modulating inflammatory responses.The features of Tregs in the neonatal liver under steady-state conditions are not well understood.The present study aimed to investigate the phenotype,functions,and significance of neonatal Tregs in the liver.We found a wave of thymus-derived Treg influx into the liver during 1–2 weeks of age.Depletion of these Tregs between days 7 and 11 after birth rapidly resulted in Th1-type liver inflammation and metabolic disorder.More Tregs in the neonatal liver than in the spleen underwent MHC II-dependent activation and proliferation,and the liver Tregs acquired stronger suppressive functions.The transcriptomic profile of these neonatal liver Tregs showed elevated expression of PPARγand T-bet and features of Tregs that utilize lipid metabolic machinery and are capable of regulating Th1 responses.The accumulation of Tregs with unique features in the neonatal liver is critical to ensure self-tolerance and liver maturation. | Mingyang Li Weijia Zhao Yifan Wang Lixue Jin Gaowen Jin Xiuyuan Sun Wei Wang Ke Wang Xi Xu Jie Hao Rong Jin Wenxian Fu Ying Sun Yingjun Chang Xiaojun Huang Xuyu Zhou Hounan Wu Kunshan Zhang Qing Ge | 2020 | Cellular & Molecular Immunology2020，17，5： | 4 |
| 2 | TRAF3IP3 at the trans-Golgi network regulates NKT2 maturation via the MEK/ERK signaling pathway显示文摘Thymic natural killer T(NKT)2 cells are a subset of invariant NKT cells with PLZF^(hi)GATA3^(hi)IL-4^(+).The differentiation of NKT2 cells is not fully understood.In the present study,we report an important role of TRAF3-interacting protein 3(TRAF3IP3)in the functional maturation and expansion of committed NKT2s in thymic medulla.Mice with T-cell-specific deletion of TRAF3IP3 had decreased thymic NKT2 cells,decreased IL-4-producing peripheral iNKTs,and defects in response toα-galactosylceramide.Positive selection and high PLZF expression in CD24^(+)CD44^(−) and CCR7^(+)CD44^(−) immature iNKTs were not affected.Only CD44^(hi)NK1.1^(−) iNKTs in Traf3ip3^(−/−) mice showed reduced expression of Egr2,PLZF,and IL-17RB,decreased proliferation,and reduced IL-4 production upon stimulation.This Egr2 and IL-4 expression was augmented by MEK1/ERK activation in iNKTs,and TRAF3IP3 at the trans-Golgi network recruited MEK1 and facilitated ERK phosphorylation and nuclear translocation.LT βR-regulated bone marrow-derived nonlymphoid cells in the medullary thymic microenvironment were required for MEK/ERK activation and NKT2 maturation.These data demonstrate an important functional maturation process in NKT2 differentiation that is regulated by MEK/ERK signaling at the trans-Golgi network. | Xinwei Zhang Ke Wang Weijia Zhao Li Cao Shusong Zhang Rong Jin Xiuyuan Sun Jie Hao Xiaojun Huang Mingzhao Zhu Hounan Wu Hongshan Zhao Qing Ge | 2020 | Cellular & Molecular Immunology2020，17，4： | 2 |
| 3 | Array organization and data management exploration in racetrack memory显示文摘 | Sun Zhenyu Bi Xiuyuan Wu Wenqing | 2014 | IEEETransonComputers2014，13，6： | 1 |
| 4 | Oligocarpia kepingensis sp.nov.from the Lower Permian of the northern Tarim Basin,Xinjiang and its in situ spores显示文摘A Palaeozoic gleicheniaceous fern Oligocarpia kepingensis sp. nov. is described from the Lower Permian of the northern Tarim Basin, Xinjiang, China. The material comprises fertile organs including sori, sporangia, spores and associated sterile leaf of the Sphenopteris type. The sori are circular and 0.6—0.8 mm in diameter, and each sorus consists of 4—6 oval sporangia without an indusium. A transverse annulus completely encircles the sporangium. Each sporangium produces probably 256 trilete spores resembling the dispersed genus Leiotriletes. Comparisons are made between O. kepingensis and other species of Oligocarpia in the soral organization and spores. It is reasonable to include Oligocarpia in Gleicheniaceae based on its similarities of fertile character to the extant gleicheniaceous members. | Yongdong Wang Xiuyuan Wu | 1999 | Chinese Science Bulletin1999，44，2： | 1 |
| 5 | Induction of apoptosis in colon cancer cells by cyclooxygenase-2 inhibitor NS-398 through a cytochrome c-dependent pathway 显示文摘 | Li Ming Wu Xiuyuan Xu Xiaochun | 2001 | Clin Cancer Res2001，7，： | 1 |
| 6 | The Age and Character of the Yu'erhong Flora from Yumen, Gansu显示文摘From a fresh field investigation, it has been ascertained that the Late Palaeozoic Yu’erhong (Yuernhung) flora from Yu’erhong, Yumen, Gansu, northwestern China, studied by Bohlin in 1971 includes plants from the Westphalian Yangfukou Formation and the Stephanian to Sakmarian Taiyuan Formation. The Yu’erhong flora from the Yanghukou Formation is dominated by Euramerican elements with a few elements of the Cathaysian flora. No Angarian elements have be found in this section for lack of Late Permian strata. The specimens studied by Bohlin might possibly come from the upper part of the Upper Permian at tne southeastern corner . of the Yu’erhong basin. Those fossils from different horizons and localities might be mixed with each other during collection ;so they fail to reflect the exact horizon of certain plant fossils. | Shen Guanglong, Wu Xiuyuan, Wang Jun and Liu Huaqin Department of Geology, Northwest U niversity, Xi’an, Shaanxi Nanjing Institute of Geology and Palaeontology,Chinese Academy of Sciences, Nanjing, Jiangsu | 1995 | Acta Geologica Sinica(English Edition)1995，69，3： | 0 |
| 7 | Virtual Design and Dynamic Simulation on Divider of Corn Harvester显示文摘 | WU Xiuyuan | 2014 | Journal of Zhouyi Research2014，，2： | 0 |
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