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| 1 | Role of glycosylation in TGF-β signaling and epithelial-to-mesenchymal transition in cancer显示文摘Glycosylation is a common posttranslational modification on membrane-associated and secreted proteins that is of pivotal importance for regulating cell functions.Aberrant glycosylation can lead to uncontrolled cell proliferation,cell-matrix interactions,migration and differentiation,and has been shown to be involved in cancer and other diseases.The epithelial-to-mesenchymal transition is a key step in the metastatic process by which cancer cells gain the ability to invade tissues and extravasate into the bloodstream.This cellular transformation process,which is associated by morphological change,loss of epithelial traits and gain of mesenchymal markers,is triggered by the secreted cytokine transforming growth factor-β(TGF-β).TGF-βbioactivity is carefully regulated,and its effects on cells are mediated by its receptors on the cell surface.In this review,we first provide a brief overview of major types of glycans,namely,N-glycans,O-glycans,glycosphingolipids and glycosaminoglycans that are involved in cancer progression.Thereafter,we summarize studies on how the glycosylation of TGF-βsignaling components regulates TGF-βsecretion,bioavailability and TGF-βreceptor function.Then,we review glycosylation changes associated with TGF-β-induced epithelial-to-mesenchymal transition in cancer.Identifying and understanding the mechanisms by which glycosylation affects TGF-βsignaling and downstream biological responses will facilitate the identification of glycans as biomarkers and enable novel therapeutic approaches. | Jing Zhang Peter ten Dijke Manfred Wuhrer Tao Zhang | 2021 | Protein & Cell2021，12，2： | 4 |
| 2 | Rolling strain effects on the interlaminar properties of roll bonded copper/aluminium metal laminates显示文摘 | X. K. Peng R. Wuhrer G. Heness W. Y. Yeung | 2000 | Journal of Materials Science2000，，17： | 3 |
| 3 | Targeted identification of a unique glycan epitope of Schistosoma mansoni egg antigens using a diagnostic antibody显示文摘 | Robijn MLM Koeleman CAM Wuhrer M | 2007 | Molecular & Biochemical Parasitology2007，151，2： | 1 |
| 4 | Rolling strain effects on the interlaminar properties of roll bonded copper/ aluminium metal laminates 显示文摘 | Peng X K Wuhrer R Heness G | 2000 | Journal of Materials Science2000，35，17： | 1 |
| 5 | Fuc ( 1→3 ) GalNAc- : the major antigenic motif of Schistosoma mansoni glycolipids implicated in infection sera and keyhole-limpet haemocyanin cross-reactivity显示文摘 | Kantelhardt SR Wuhrer M Dennis RD | 2002 | Biochem J2002，366，1： | 1 |
| 6 | IPSE/alpha-1,a major secretory glycoprotein antigen from schistosome eggs,expresses the Lewis X motif on core-difucosylated N-glycans显示文摘 | Wuhrer M Balog CI Catalina MI | 2006 | FEBS Journal2006，273，10： | 1 |
| 7 | On the interface development and fracture behaviour of roll bonded copper/aluminum metal laminates显示文摘 | PENG X K WUHRER R HENESS G | 1999 | Journal of Materials Science1999，34，9： | 1 |
| 8 | IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif on core difucosylated N-gt'ycans 显示文摘 | Wuhrer M Balog CA Catalina MI | 2006 | FEBS J2006，273，10： | 1 |
| 9 | A comparative study of magnetronco-sputtered nanocrystalline titanium aluminium andchromium aluminium nitride coatings显示文摘 | Wuhrer R Yeung W Y | 2004 | ScriptaMaterialia2004，50，12： | 1 |
| 10 | Characterization of keyhole limpet hemocyanin (KLH) glycans sharing a carbohydrate epitope with Schistosoma mansoni glycoconjugates显示文摘 | Geyer H Wuhrer M Kurokawa T | 2004 | Micron2004，35，： | 1 |
| 11 | Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphoma显示文摘 | Kaufmann H Raderer M Wuhrer S | 2004 | Blood2004，104，8： | 1 |
| 12 | IPSE/alpha-1, a major secretory glycoprotein antigen from sehistosome eggs, expresses the Lewis X motif on core-difucosylated N-glycans显示文摘 | Wuhrer M Balog CI Catalina MI | 2006 | FEBS J2006，273，10： | 1 |
| 13 | Regulated glycosylation patterns of IgG during alloimmune responses against human platelet antigens 显示文摘 | Wuhrer M Porcelijn L Kapur R | 2009 | J Proteome Res2009，8，： | 1 |
| 14 | Protein glyeosylation analysis by liquid chromatography-mass spectrometry显示文摘 | Wuhrer M Deelder AM Hokke CH | 2005 | J Chromatogr B Analyt Technol Biomed Life Sei2005，825，2： | 1 |
| 15 | On production of nanocrystalline ternary nitride coatings via magnetron sputtering显示文摘 | Wuhrer R McCredie G Yeung W Y | 2003 | Mater Sci For2003，，2： | 1 |
| 16 | Lack of complex N-glycans on HIV-1 envelope glycoproteins preserves protein conformation and entry function显示文摘 | Eggink D Melchers M Wuhrer M | 2010 | Virology2010，401，12： | 1 |
| 17 | Estimating 3D human shapes from measure ments显示文摘 | Wuhrer S Shu C | 2013 | Machine vision and applications2013，24，6： | 1 |
| 18 | Characterization of keyhole limpet hemocyanin (KLH) glycans sharing a carbohydrate epitope with Schistosoma mansoni glycoconjugates 显示文摘 | Geyer H Wuhrer M Kurokawa T | 2004 | Micron2004，35，12： | 1 |
| 19 | On the interface development and fracture behaviour of roll bonded copperaluminium metal laminates 显示文摘 | PENG X K WUHRER R HENESS G YEUNG W Y | 1999 | Journal of Materials Science1999，34，9： | 1 |
| 20 | Localization andCharacterization of Polysialic Acid-containing N-linked Glycansfrom Bovine NCAM 显示文摘 | Ohe M Wheeler S F Wuhrer M | 2002 | Glycobiology2002，12，1： | 1 |
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