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| 1 | The role of high mobility group box 1(HMGB1)in the pathogenesis of kidney diseases显示文摘High mobility group box 1(HMGB1) is a nuclear protein that can bind to DNA and act as a co-factor for gene transcription. When released into extracellular fluid, it plays a proinflammatory role by acting as a damage-associated molecular pattern molecule(DAMP)(also known as an alarmin) to initiate innate immune responses by activating multiple cell surface receptors such as the receptor for advanced glycation end-products(RAGE) and toll-like receptors(TLRs), TLR2, TLR4 or TLR9. This proinflammatory role is now considered to be important in the pathogenesis of a wide range of kidney diseases whether they result from hemodynamic changes, renal tubular epithelial cell apoptosis, kidney tissue fibrosis or inflammation. This review summarizes our current understanding of the role of HMGB1 in kidney diseases and how the HMGB1-mediated signaling pathway may constitute a new strategy for the treatment of kidney diseases. | Qingjie Chen Xiaofeng Guan Xiaocong Zuo Jianglin Wang Wenjun Yin | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 26 |
| 2 | Molecular mechanisms of FK506-induced hypertension in solid organ transplantation patients显示文摘 | Wang Jianglin Guo Ren Liu Shikun Chen Qingjie Zuo Shanru gang Meng Zuo Xiaocong | 2014 | Chinese Medical Journal2014，，20： | 3 |
| 3 | Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B,endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society显示文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use. | XIAOFEN LIU CHENRONG HUANG PHILLIP JBERGEN JIAN LI JINGJING ZHANG YIJIAN CHEN YONGCHUAN CHEN BEINING GUO FUPIN HU JINFANG HU LINLIN HU XIN LI HONGQIANG QIU HUA SHAO TONGWEN SUN YU WANG PING XU JING YANG YONG YANG ZHENWEI YU BIKUI ZHANG HUAIJUN ZHU XIAOCONG ZUO YI ZHANG LIYAN MIAO JING ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 1 |
| 4 | Lower temperature hydrothermal pretreatment improves the anaerobic digestion performance of spent cow bedding显示文摘The anaerobic digestion(AD)performance of spent cow bedding was investigated with different hydrothermal pretreatment(HP)conditions.Spent cow bedding was pretreated with low temperatures(50,70,and 90℃)and different pretreatment times(2-72 h)with ammonia and without ammonia.The results showed that spent cow bedding was a good raw material for AD.After pretreatment,the concentration of volatile fatty acids(VFAs)in the group of hydrothermal pretreatments with ammonia(HPA)was higher than that in the HP group at the same pretreatment temperature and time.The optimal pretreatment condition was achieved with an HPA of 50℃ holding for 72 h.At the optimal condition,the highest concentration of VFAs was 1.58-10.85 times higher than that of the other pretreated groups.The highest hemicellulose and lignin removal rates were 58.07%and 10.32%,respectively.The highest methane yield was 163.0 ml(g· VS)^(-1),which was 48.9%higher than that of the untreated group.The VFAs,pH,and reducing sugars showed positive relationships with the methane yield.Therefore,HP at low temperature can enhance the AD performance of spent cow bedding. | Xitong Wang Hairong Yuan Xiaocong Song Xiujin Li Xiaoyu Zuo | 2021 | Chinese Journal of Chemical Engineering2021，34，11： | 1 |
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