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| 1 | Adjunctive sepsis therapy with aminophylline(STAP):a randomized controlled trial显示文摘Background:Sepsis is a serious disease caused by infection.Aminophylline has anti-asthma and anti-inflammatory effects.We aimed to explore the safety and effect of aminophylline in sepsis.Methods:We conducted a clinical randomized controlled trial involving 100 patients diagnosed with sepsis within 48 h after intensive care unit(ICU)admission in two sites.All patients were randomized in a 1:1 ratio to receive standard therapy with or without aminophylline.The primary clinical outcome was all-cause mortality at 28 days.Results:From September 27,2018 to February 12,2020,we screened 277 septic patients and eventually enrolled 100 patients,with 50 assigned to the aminophylline group and 50 to the usual-care group.At 28 days,7 of 50 patients(14.0%)in the aminophylline group had died,compared with 16 of 50(32.0%)in the usual-care group(P=0.032).Cox regression showed that the aminophylline group had a lower hazard of death(hazard ratio=0.312,95%confidence interval:0.129–0.753).Compared with the usual-care group,patients in the aminophylline group had a longer survival time(P=0.039 by the log-rank test).The effects of aminophylline on vasopressor dose,oxygenation index,and sequential organ failure assessment score were timedependent with treatment.There were no significant differences in total hospitalization days,ICU hospitalization days,and rates of serious adverse events(all P>0.05).No adverse events were observed in the trial.Conclusions:Aminophylline as an adjunct therapy could significantly reduce the risk of death and prolong the survival time of patients with sepsis.Trial registration:ChiCTR.org.cn,ChiCTR1800019173. | Ruifang Zhang Huan Liu Dongmei Dai Xianfei Ding Dong Wang Yan Wang Xuexiu Shi Shuguang Zhang Xiaoguang Duan Haixu Wang Yonggang Luo Shaohua Liu Bing Han Xiaojuan Zhang Yu Fang Jing Yang Wangbin Xu Tongwen Sun | 2022 | Chinese Medical Journal2022，135，23： | 2 |
| 2 | Experimental research on reservoir sensitivity to stress and impacts on productivity in Kela 2 Gas Field显示文摘Kela 2 Gas Field, with high formation pressure (74.35MPa), high pressure coeffi-cient (2.022) and difficulty of potential test and evaluation, is the largest integrated proved dry gas reservoir in China so far and the principal source for West-East Gas Development Project. In order to correctly evaluate the elastic-plastic deformation of rocks caused by the pressure decline during production, some researches, as the experiment on reservoir sensitivity to stress of gas filed with abnormal high pressure, are made. By testing the rock mechanic properties, porosities and permeabilities at different temperature and pressure of 342 core samples from 5 wells in this area, the variations of petro-physical properties at changing pressure are analyzed, and the ap-plicable inspection relationship is concluded. The average productivity curve with the reservoir sensitivity to stress is plotted on the basis of the research, integrated with the field-wide produc-tivity equation. The knowledge lays a foundation for the gas well productivity evaluation in the field and the gas field development plan, and provides effective techniques and measures for basic research on the development of similar gas fields. | SUN Longde SONG Wenjie JIANG Tongwen | 2004 | Science China Earth Sciences2004，47，z2： | 1 |
| 3 | Chinese consensus guidelines for therapeutic drug monitoring of polymyxin B,endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society显示文摘Polymyxin B,which is a last-line antibiotic for extensively drug-resistant Gram-negative bacterial infections,became available in China in Dec.2017.As dose adjustments are based solely on clinical experience of risk toxicity,treatment failure,and emergence of resistance,there is an urgent clinical need to perform therapeutic drug monitoring(TDM)to optimize the use of polymyxin B.It is thus necessary to standardize operating procedures to ensure the accuracy of TDM and provide evidence for their rational use.We report a consensus on TDM guidelines for polymyxin B,as endorsed by the Infection and Chemotherapy Committee of the Shanghai Medical Association and the Therapeutic Drug Monitoring Committee of the Chinese Pharmacological Society.The consensus panel was composed of clinicians,pharmacists,and microbiologists from different provinces in China and Australia who made recommendations regarding target concentrations,sample collection,reporting,and explanation of TDM results.The guidelines provide the first-ever consensus on conducting TDM of polymyxin B,and are intended to guide optimal clinical use. | XIAOFEN LIU CHENRONG HUANG PHILLIP JBERGEN JIAN LI JINGJING ZHANG YIJIAN CHEN YONGCHUAN CHEN BEINING GUO FUPIN HU JINFANG HU LINLIN HU XIN LI HONGQIANG QIU HUA SHAO TONGWEN SUN YU WANG PING XU JING YANG YONG YANG ZHENWEI YU BIKUI ZHANG HUAIJUN ZHU XIAOCONG ZUO YI ZHANG LIYAN MIAO JING ZHANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，2： | 1 |
| 4 | Expert Consensus on Polymyxin Antimicrobial Susceptibility Testing and Clinical Interpretation显示文摘The polymyxins are important antimicrobial agents against antibiotic-resistant gram-negative bacilli.In 2020,the Clinical and Laboratory Standards Institute modified the clinical breakpoints for polymyxin susceptibility test by eliminating the'susceptible'interpretive category,only reporting intermediate(≤2 mg/L)and resistant(≥4 mg/L).However,the European Committee on Antimicrobial Susceptibility Testing recommended the use of clinical breakpoints of W2 mg/L as susceptible and>2 mg/L as resistant.The first-line laboratorians and clinicians in China have been perplexed by the inconsistence of international polymyxin clinical breakpoints and discouraged by the difficulty of conducting polymyxin susceptibility testing.Therefore,it is urgently needed to make it clear for the laboratorians in China to know how to accurately carry out polymyxin susceptibility testing and standardize the interpretation of susceptibility testing results.To this end,the experts from relevant fields were convened to formulate this consensus statement on the testing and clinical interpretation of polymyxin susceptibility.Relevant recommendations are proposed accordingly for laboratorians and clinicians to streamline their daily work. | Qiwen Yang Xiaoling Ma Fupin Hu Jing Zhang Tongwen Sun Baiyi Chen Yingchun Xu Youning Liu Chinese Committee on Antimicrobial Susceptibility Testing(ChiCAST) Expert Committee on Infectious Diseases,China Medical Education Association | 2021 | Chinese Medical Sciences Journal2021，36，1： | 1 |
| 5 | A novel of positively charged asymmetry membrane prepared from poly(2,6-dimethyl-1,4- phenylene oxide) by in situ amination Part Ⅲ:Effect of benzyl and aryl bromination degrees of polymer on membrane performance and morphologies显示文摘 | Tang Beibei Xu Tongwen Sun Peijian | 2006 | Journal of Membrane Science2006，279，： | 1 |
| 6 | Reservoir controlling differences between consequent faults and antithetic faults in slope area outside of source: A case study of the south-central Wenan slope of Jizhong Depression, Bohai Bay Basin, East China显示文摘The control effects of different occurrence faults on oil and gas accumulation and distribution in the outer slope area of oil and gas reservoirs were studied taking the south-central Wen’an slope of the Jizhong depression in the Bohai Bay Basin as an example.Based on 3D seismic data and the distribution of oil and water,the controlling differences between consequent fault and antithetic fault were analyzed and compared from the formation and evolution rule of faults and the formation mechanism of fault traps,including development positions of the consequent fault traps and antithetic fault traps,oil and gas distribution horizon adjusted by fault and formation period of fault traps.The differences between consequent faults and antithetic faults in controlling reservoirs have three main aspects:(1)Consequent fault traps and antithetic fault traps are in different positions,the consequent fault traps are at the segmented growing point in the hanging wall of'hard-linkage'faults,while the antithetic fault traps are developed in the position with the largest throw in the footwall because of tilting action;(2)The two kinds of faults result in different oil and gas distribution vertically,oil and gas adjusted by consequent faults is distributed in a single layer or multi-layers,while oil and gas adjusted by antithetic faults occur in single layers;(3)The two kinds of fault traps are formed in different periods,the consequent fault traps are formed at the time when the related faults enter the stage of'hard-linkage',while the antithetic fault traps are formed at the beginning of the fault active period. | LIU Junqiao WANG Haixue LYU Yanfang SUN Tongwen ZHANG Mengdi HE Wei SUN Yonghe ZHANG Tong WANG Chao CAO Lanzhu | 2018 | Petroleum Exploration and Development2018，45，1： | 1 |
| 7 | An improved PCA method with application to boiler leak detection显示文摘 | Xi Sun Marquez Horacio J Tongwen Chen | 2005 | ISA Transactions2005，44，： | 1 |
| 8 | Prognostic Value of B-type Natriuretic Peptide in Patients with Acute Coronary Syndromes显示文摘 | Tongwen Sun Lexin Wang Yanzhou Zhang | 2006 | Archives of Medical Research2006，，4： | 1 |
| 9 | Effects of Imidapril on Venous Blood Gas Values in Broiler Chickens Exposed to Low Ambient Temperature显示文摘ObjectiveThis study was designed to evaluate the effects of imidapril on blood gas parameters in broiler chickens. MethodTwenty-four chickens were randomly divided into three groups (n=8), control group, low temperature group and imidapril group. Chickens in low temperature group and imidapril group were exposed to low ambient temperature (12-18 ℃) from age at 14 d to 45 d, whereas the control group was exposed to 24-30 ℃; chickens in imidapril group were gavaged with imidapril (3 mg/kg) once daily for 30 d. At age of 45 d, blood was taken from wing vein and blood gas parameters were evaluated by blood gas analyzer in Luoyang Central Hospital Affiliated to Zhengzhou University. ResultImidapril significantly increased hematocrit (HCT) and total hemoglobin content (T HBC ) and blood Na concentration in broiler chickens exposed to low ambient temperature. No significant differences were observed in pH, P CO 2 , P O 2 , K + , Ca 2+ , HCO 3-, HCO 3std , T CO 2 , BE and SO 2c . ConclusionImidapril increases hematocrit, total hemoglobin content and blood Na + concentration in chickens exposed to low ambient temperature. | Xueqin HAO Meng LI Shouyan ZHANG Yongshu WANG Tongwen SUN | 2013 | Agricultural Science & Technology2013，14，7： | 0 |
| 10 | HAT therapy for sepsis:A review of the therapeutic rationale and current clinical evaluation status显示文摘Vitamin C-based cluster therapy,which involves the combined application of hydrocortisone,vitamin C,and thiamine(HAT),is a recently proposed new treatment option for sepsis on top of conventional treatment.This therapy has a strong theoretical basis,but its clinical efficacy remains inconclusive.This review summarizes the rationale for HAT therapy for sepsis and describes the evaluation of its efficacy in clinical observational studies and randomized controlled trials,with the aim of providing a reference for the future clinical practice application of HAT therapy in sepsis. | Yali Sun Yongfang Yang Zhuoyi Ye Tongwen Sun | 2023 | Journal of Intensive Medicine2023，3，4： | 0 |
| 11 | Eu-based anolytes for high-voltage and long-lifetime aqueous flow batteries显示文摘Aqueous flow batteries(AFBs) are among the most promising electrochemical energy storage solutions for the massive-scale adoption of renewable electricity because of decoupled energy and power, design flexibility, improved safety and low cost. The development of high-voltage AFB is, however, limited by the lack of stable anolytes that have low redox potential. Here we report Eu-based anolytes for high-voltage p H-neutral AFB applications. Eu^(3+) has a reduction potential of -0.39 V vs. SHE, which can be dramatically lowered when forming stable complex with inexpensive organic chelates. A typical complex, Eu DTPA,features a low redox potential of -1.09 V vs. SHE, fast redox kinetics, and a high water solubility of 1.5 M. When paired with ferrocyanide, the battery had an open-circuit voltage of 1.56 V and demonstrated stable cell cycling performance, including a capacity retention rate of 99.997% per cycle over500 cycles at 40 m A cm^(-2), a current efficiency of >99.9%, and an energy efficiency of >83.3%. A high concentration anolyte at 1.5 M exhibited a volumetric capacity of 40.2 Ah L^(-1), which is one of the highest known for p H-neutral AFBs, promising a potent solution for the grid-scale storage of renewable electricity. | Pan Sun Yahua Liu Peipei Zuo Yuanyuan Li Qianru Chen Zhengjin Yang Tongwen Xu | 2021 | Journal of Energy Chemistry2021，30，9： | 0 |
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