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| 1 | Olmutinib(HM61713) reversed multidrug resistance by inhibiting the activity of ATPbinding cassette subfamily G member 2 in vitro and in vivo显示文摘Overexpressing of ATP-binding cassette(ABC) transporters is the essential cause of multidrug resistance(MDR), which is a significant hurdle to the success of chemotherapy in many cancers.Therefore, inhibiting the activity of ABC transporters may be a logical approach to circumvent MDR.Olmutinib is an epidermal growth factor receptor(EGFR) tyrosine kinase inhibitor(TKI), which has been approved in South Korea for advanced EGFR T790 M-positive non-small cell lung cancer(NSCLC). Here,we found that olmutinib significantly increased the sensitivity of chemotherapy drug in ABCG2-overexpressing cells. Furthermore, olmutinib could also increase the retention of doxorubicin(DOX) and rhodamine 123(Rho 123) in ABC transporter subfamily G member 2(ABCG2)-overexpressing cells. In addition, olmutinib was found to stimulate ATPase activity and inhibit photolabeling of ABCG2 with [^(125) I]-iodoarylazidoprazosin(IAAP). However, olmutinib neither altered ABCG2 expression at protein and m RNA levels nor blocked EGFR, Her-2 downstream signaling of AKT and ERK. Importantly,olmutinib enhanced the efficacy of topotecan on the inhibition of S1-MI-80 cell xenograft growth. All the results suggest that olmutinib reverses ABCG2-mediated MDR by binding to ATP bind site of ABCG2 and increasing intracellular chemotherapeutic drug accumulation. Our findings encouraged to further clinical investigation on combination therapy of olmutinib with conventional chemotherapeutic drugs in ABCG2-overexpressing cancer patients. | Zhiqiang Zhang Xiaoran Guo Kenneth K.W.To Zhen Chen Xiaona Fang Min Luo Chunling Ma Jianhua Xu Shirong Yan Liwu Fu | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 9 |
| 2 | Identification of microRNA-like RNAs in Ophiocordyceps sinensis显示文摘Ophiocordyceps sinensis is well known as a traditional Chinese medicine and has widely been used for over 2,000 years to stimulate immune system, decrease blood pressure and to inhibit tumor growth. While miRNAs are increasingly recognized for their roles in post-transcriptional regulation of gene expression in animals and plants, miRNAs in fungi were less studied until the discovery of microRNA-like RNA(milRNA). High-throughput sequencing and bioinformatics approaches were used to identify conserved and novel milRNAs in O. sinensis. 40 conserved milRNAs were identified, while 23 pre-miRNA candidates encoding 31 novel milRNAs were predicted. Furthermore, the potential target genes of milRNAs in human were predicted and gene ontology analysis was applied to these genes. Enrichment analysis of GO-represented biological process showed that target genes of both conserved and novel milRNAs are involved in development, metabolic and immune processes, indicating the potential roles of milRNAs of O. sinensis in pharmacological effects as health food and traditional Chinese medicine. This study is the first report on genome-wide analysis of milRNAs in O. sinensis and it provides a useful resource to further study the potential roles of milRNAs as active components of O. sinensis in health food or traditional Chinese medicine. | Wen Zhang Xiaona Li Lina Ma Uzair Urrehman Xilinqiqige Bao Yujing Zhang Chen-Yu Zhang Dongxia Hou Zhen Zhou | 2019 | Science China(Life Sciences)2019，62，3： | 6 |
| 3 | Exploitation of methane in the hydrate by use of carbon dioxide in the presence of sodium chloride显示文摘The replacement process of CH4 from CH4 hydrate formed in NaCl solution by using pressurized CO2 was investigated with a self-designed device at temperatures of 271.05,273.15 and 275.05 K and a constant pressure of 3.30 MPa.The mass fraction of the NaCl solution was either 0.5 wt% or 1.0 wt%.The effects of temperature and concentration of NaCl solution on the replacement process were investigated.Experimental results showed that high temperature was favorable to the replacement reaction but high NaCl concentration had a negative effect on the replacement process.Based on the experimental data,kinetic models of CH4 hydrate decomposition and CO2 hydrate formation in NaCl solution were established.The calculated activation energies suggested that both CH4 hydrate decomposition and CO2 hydrate formation are dominated by diffusion in the hydrate phase. | Zunzhao Li Xuqiang Guo Lanying Yang Xiaona Ma | 2009 | Petroleum Science2009，6，4： | 5 |
| 4 | Numerical simulation of hot stamping of side impact beam显示文摘Ls-DYNA software is adopted to conduct research of numerical simulation on hot stamping of side impact beam to calculate the temperature field distribution,stress field distribution,forming limit diagram(FLD) figure,etc.in the course of hot stamping so as to predict and analyze the formability of parts.ProCAST software is employed to conduct research of numerical simulation on solid quenching course concerning hot stamping to calculate temperature field distribution of tools and component of multiple stamping cycles.The results obtained from numerical simulation can provide significant reference value to hot stamping part design,formability predication and tools cooling system design. | Guo Yihui Ma Mingtu Fang Gang Song Leifeng Liu Qiang Wang Xiaona Zhou Dianwu | 2012 | Engineering Sciences2012，10，6： | 4 |
| 5 | Comparative analysis by simulating and testing pole impact for hot stamping front crossbeam of automobile显示文摘Hot stamping 22MnB5 steel plate with ultra-high strength has been widely used for body structural members in consideration of automobile safety and lightweight.This paper presents a verification program of simulating and testing pole impact in order to verify if the front crossbeam reinforcement assembly can meet the design requirements,reduce the overall vehicle simulation and test cost and shorten the operation period.In the same condition,the simulation proved conforming to the design requirements;however,the bumper cracked at the impacting point in the course of pole impact test.The analysis of the crack by optical microscope,Vickers and scanning electron microscope indicates that mixture of ferrite,bainite and martensite was produced in the weld heat-affected zone of the 340/590DP tow hook holder and the 22MnB5 front crossbeam;therefore,their hardness and mechanical property were reduced obviously,so that they fractured when impacted.No welding process with continuous weld but spot welding or other bonding method may be employed for the reason that the capacity of the 22MnB5 steel plate in the weld heat-affected zone was reduced obviously. | Ma Fangwu Yao Zaiqi Liu Qiang Wang Xiaona Zhao Fuquan Li Fangfang Lin Jianping | 2012 | Engineering Sciences2012，10，6： | 2 |
| 6 | Spatial Pattern and Influencing Factor of County-level Industrial Development in Liaoning Province of China显示文摘County-level industrial development and structure upgrade is one of the most important issues of revitaliz- ing old industrial base of China. After the cluster analysis on GDP per capita and GDP per area of each county in Liaoning Province, this paper finds the similarity of population size, land use intensity, and economic development of each county. Location quotient reflects the specialization intensity of industries in each county, and it also reflects the spatial differences of county-level industrial development. Economic development level is higher in the southeast than in the northwest of Liaoning, and the industry driving effect on county-level economy is apparent. The main influenc- ing factors include location, industrial foundation and economic system reform, capital input level, knowledge and technology dissemination, conditions of domestic and overseas markets, population and labor force transfer. Industri- alization is an important approach to urbanization for the counties in Liaoning Province. The proportion of agriculture is much higher in the northwest than in the southeast of Liaoning, so it will be take longer time for counties in the northwest of Liaoning to make industrialization, urbanization and modernization. | GAO Xiaona MA Yanji | 2008 | Chinese Geographical Science2008，18，1： | 2 |
| 7 | Sulfated modification can enhance the adjuvanticity of lentinan and improve the immune effect of ND vaccine显示文摘 | Zhenhuan Guo Yuanliang Hu Deyun Wang Xia Ma Xiaona Zhao Bingkai Zhao Junmin Wang Ping Liu | 2008 | Vaccine2008，，5： | 1 |
| 8 | Experimental and Molecular Simulation of Volumetric Properties of Methyl Nonanoate,n-Dodecane,and Their Binary Mixtures显示文摘Densities of methyl nonanoate,n-dodecane,and their binary mixtures were investigated to provide the necessary data for their engineering applications as promising fuels and fuel additives.In the present work,densities were measured under atmospheric pressure at 293.15—463.15 K.The density data for the binary mixtures were fitted into a forai of excess molar volume.The excess molar volumes were mostly positive,and the maximum value was obtained at molar fractions of n-dodecane between 0.5 and 0.6.Molecular simulations of specified systems were carried out by using four kinds of force fields,and the suitable force fields for describing the volume properties of the system were AMBER96 and OPLS-AA.The relative deviations for these two force fields between the simulated and the experimental data were well within±4%,which meets the general engineering requirement. | ZANG Dongyun ZHAO Guanjia LIU Xiaona YIN Jianguo MA Suxia | 2019 | Chemical Research in Chinese Universities2019，35，2： | 1 |
| 9 | Hupo powder promotes autophagy of menstrual blood-derived stem cells from patients with endometriosis显示文摘Objective:To explore the effect of Hupo powder(HP)on autophagy in menstrual blood-derived stem cells(MenSCs)with endometriosis(EMT).Methods:EMT MenSCs(E-MenSCs)and healthy MenSCs(H-MenSCs)were isolated from the menstrual blood of patients with EMT and healthy female participants,respectively.We identified their stem cells’characteristics via adipogenic and osteogenic differentiation.Twelve male SpragueeDawley rats received 0.9% NaCl and HP-dispensing granules by gastric irrigation to prepare blank serum and medicated serum,respectively.We used serum concentrations of 5%,10%,and 20%,each at administered times of 12,24,and 48 h to select the best condition.These cells were divided into three groups:blank serum of the control group,blank serum of the model group,and medicated serum of the HP group.H-MenSCs were used in the control group,while E-MenSCs were used in the model and HP groups.We analyzed cell viability using a cell counting kit-8 assay,observed cell morphology,evaluated the amounts of auto-phagosomes and autolysosomes by transmission electron microscopy,and detected the protein expression of autophagy markers(LC3-II and Beclin1)by Western blot.Results:E-MenSCs and H-MenSCs became long fusiform with a diffuse radial pattern,forming lipid droplets and calcium nodules after adipogenic and osteogenic differentiation.We then used the best conditiond 20% serum and 48 hdfor the subsequent experiments.In contrast to the model group,the HP group exhibited lower cell viability(=0.007),larger amounts of autophagosomes and autolysosomes(P<0.001 and P=0.001,respectively),and higher expression of LC3-II and Beclin1(P=0.021 and P=0.019,respectively).Conclusion:Hupo powder can promote autophagy in E-MenSCs,which might be one of the mechanisms underlying its therapeutic effects. | Yuejian Zhang Changxiang Li Conglu Sui Xiuping Zhang Ya'nan Guo Tiantian He Taoxiu Lin Xiaona Ma | 2023 | Journal of Traditional Chinese Medical Sciences2023，10，2： | 1 |
| 10 | THMs precursor removal by an integrated process of ozonation and biological granular activated carbon for typical Northern China water显示文摘 | Mingquan Yan Dongsheng Wang Xiaona Ma Jinren Ni Hansong Zhang | 2010 | Separation and Purification Technology2010，，3： | 1 |
| 11 | Adsorption characteristics of methylene blue on polar leaf in batch mode:Equilibrium,kinetics and thermodynamics显示文摘 | HAN Xiuli NIU Xiaona MA Xiaojian | 2012 | Korean J Chem Eng2012，29，4： | 1 |
| 12 | Alzheimer's Disease and Methanol Toxicity (Part 2): Lessons from Four Rhesus Macaques (Macaca mulatta) Chronically Fed Methanol显示文摘 | Meifeng Yang Junye Miao Joshua Rizak Rongwei Zhai Zhengbo Wang Tanzeel Huma Ting Li Na Zheng Shihao Wu Yingwei Zheng Xiaona Fan Jianzhen Yang Jianhong Wang Shangchuan Yang Yuanye Ma Longbao Lü Rongqiao He Xintian Hu | 2014 | Journal of Alzheimer's Disease2014，，4： | 1 |
| 13 | Targeted cancer ther-apy based on single -wall carbon nanohorns with doxorubicin in vitro and in vivo 显示文摘 | Xiaona Ma Shang Shu Jing Guo | 2014 | N anopart Res2014，，8： | 1 |
| 14 | Oral administration of the herbal oligonucleotide XKC-sRNA-h3 prevents angiotensinⅡ-induced hypertension in mice显示文摘Hypertension has become a growing public health concern worldwide.In fact,hypertension is commonly associated with increased morbidity and mortality.Currently,oligonucleotide drugs have proven to be promising therapeutic agents for various diseases.In the present study,we aimed to demonstrate that a herbal small RNA(s RNA),XKC-sRNA-h3(B55710460,F221.I000082.B11),exhibits potent antihypertensive effects by targeting angiotensin-converting enzyme(ACE)in mice.When compared with captopril,oral administration of the sphingosine(d18:1)-XKC-s RNA-h3 bencaosome more effectively prevented angiotensin II-induced hypertensive cardiac damage and alleviated kidney injury in mice.Such findings indicated that XKC-sRNA-h3 may be a novel orally available ACE inhibitor type oligonucleotide drug for hypertension. | Kegong Tang Xiaona Wang Yu Zhao Xiaobei Li Zhenyu Jiang Song Mei Mingrui Chen Yiming Ma Xinyi Du Xiangyu Qiao Na Sun Jiaqi Liu Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 15 | Protective Effects of Lycium barbarum Polysaccharides on Testis Spermatogenic Injury Induced by Bisphenol A in Mice显示文摘 | Caili Zhang Anzhong Wang Xiaona Sun Xiaocai Li Xinghua Zhao Shuang Li Aituan Ma Rainer W. Bussmann | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 1 |
| 16 | 显示文摘 | Li Yujie Ma Guoli Zhang Xiaona Jie Wanqi | 2002 | J Electron Mater2002，31，： | 1 |
| 17 | Human Plague Case Diagnosed in Ningxia Tracked to Animal Reservoirs—Inner Mongolia Autonomous Region,China,2021显示文摘Summary What is already known about this topic?There were a total of 4 and 3 human plague cases that occurred in the Inner Mongolia Autonomous Region in 2019 and 2020,respectively,with 1 and 2 deaths in 2019 and 2020 respectively,which indicated that plague still poses a significant threat to human health especially for farmers,shepherds,or residents living in native plague foci.What is added by this report?On August 14,2021,1 patient from the Otog Qi(County)in the Inner Mongolia sought treatment in Yinchuan City(the capital of Ningxia Hui Autonomous Region). | Jianwei Gao Yanhong Hu Cheng Ju Jingyuan Liu Yiting Wang Jiangtao Ma Xiaona Shen Fang Liu Jin Guo Xinxin Yu Wen Zhang Shuyi Wang Kun Li Zhongbing Zhang Biao Kan Wenrui Wang Xianbin Cong Mengguang Fan Wei Li Kuidong Shao Tao Zhang Jianyun Li Yumeng Wang | 2021 | China CDC weekly2021，3，52： | 1 |
| 18 | THMs precursor removal by an integrated process of ozonation and biological granular activated carbon for typical Northern China water显示文摘 | Yah Mingquan Wang Dongsheng Ma Xiaona | 2010 | Separation and Purification Technology2010，72，3： | 1 |
| 19 | Study on Features of Traditional Folk Dwellings in Yimeng Mountainous Areas显示文摘Traditional folk dwellings in Yimeng mountainous areas in south Shandong were studied,the formation factors and characteristics analyzed according to the existing folk dwellings,then advantages and disadvantages of thatched cottages in the local area expounded,which is signifi cant for the inheritance of traditional folk dwellings in south Shandong and the folk dwelling design in the new countryside. | MA Jun ZHU Xiaodong HUANG Xiaona | 2014 | Journal of Landscape Research2014，6，3： | 1 |
| 20 | Adsorption characteristics of methylene blue on poplar leaf in batch mode:Equilibrium,kinetics and thermodynamics显示文摘 | Han Xiuli Niu Xiaona Ma Xiaojian | 2012 | Korean J Chem Eng2012，29，4： | 1 |
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