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| 1 | A botanical medicine dragon’s blood exhibited clinical antithrombosis efficacy similar to low molecular weight heparin显示文摘Deep vein thrombosis(DVT)is a common complication following traumatic fracture with a 0.5%–1%annual incidence.Low molecular weight heparin(LMWH)is the most commonly used anticoagulation drug for DVT prevention,but treatment with LMWH is invasive.Our aim is to compare the antithrombotic effect of dragon’s blood,an oral botanical anticoagulant medicine approved by the Chinese FDA,with LMWH in patients undergoing hip fracture surgery and to explore the molecular mechanisms of anticoagulation treatment.Our study recruited patients and divided them into LMWH and dragon’s blood treatment group.Coagulation index tests,Doppler ultrasound and mRNA sequencing were performed before and after anticoagulation therapy.There was no significant difference in postoperative DVT incidence between the two groups(23.1%versus 15.4%,P=0.694).D-dimer(D-D)and fibrinogen degradation product(FDP)showed significant reductions in both groups after anticoagulation treatments.We identified SLC4A1,PROS1,PRKAR2B and seven other genes as being differentially expressed during anticoagulation therapy in both groups.Genes correlated with coagulation indexes were also identified.Dragon’s blood and LMWH showed similar effects on DVT and produced similar gene expression changes in patients undergoing hip fracture surgery,indicating that dragon’s blood is a more convenient antithrombosis medicine(oral)than LMWH(hypodermic injection). | Jiangbin Liang Song Mei Xiangyu Qiao Wei Pan Yan Zhao Shaohui Shi Yaling Zhai Haizhao Wen Guoping Wu Chengyu Jiang | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 2 | A comprehensive analysis of the Bencao(herbal)small RNA Atlas reveals novel RNA therapeutics for treating human diseases显示文摘Cross-kingdom herbal mi RNA was first reported in 2012.Using a modified herbal extraction protocol,we obtained 73,677,287sequences by RNA-seq from 245 traditional Chinese Medicine(TCM),of which 20,758,257 were unique sequences.We constructed a Bencao(herbal)small RNA(s RNA)Atlas(http://gffzz4a3adbfa122d4a47hxvcwcu9bvfp96cuu.ffgz.tsg.suse.edu.cn),annotated the sequences by sequence-based clustering,and created a nomenclature system for Bencao s RNAs.The profiles of 21,757 mi RNAs in the Atlas were highly consistent with those of plant mi RNAs in mi RBase.Using software tools,our results demonstrated that all human genes might be regulated by s RNAs from the Bencao s RNA Atlas,part of the predicted human target genes were experimentally validated,suggesting that Bencao s RNAs might be one of the main bioactive components of herbal medicines.We established roadmaps for oligonucleotide drugs development and optimization of TCM prescriptions.Moreover,the decoctosome,a lipo-nano particle consisting of 0.5%–2.5%of the decoction,demonstrated potent medical effects.We propose a Bencao(herbal)Index,including small-molecule compounds(SM),protein peptides(P),nucleic acid(N),non-nucleic and non-proteinogenic large-molecule compounds(LM)and elements from Mendeleev's periodic table(E),to quantitatively measure the medical effects of botanic medicine.The Bencao s RNA Atlas is a resource for developing gene-targeting oligonucleotide drugs and optimizing botanical medicine,and may provide potential remedies for the theory and practice of one medicine. | Yinghao Cao Yexuan Lin Na Sun Xinyi Du Yixin Dong Song Mei Xingyu Deng Xiaobei Li Shaoting Guo Kegong Tang Jiaqi Liu Xiangyu Qiao Dandan Zhao Yuhao Qin Cong Zhang Tianyi Xin Xiaohu Shi Congzhao Zhou Tao Dong De-an Guo Benedikt MKessler Dong Xu Jingyuan Song Fengming Huang Xiaoyue Wang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 2 |
| 3 | Size-resolved effective density of submicron particles during summertime in the rural atmosphere of Beijing, China显示文摘Particle density is an important physical property of atmospheric particles.The information on high time-resolution size-resolved particle density is essential for understanding the atmospheric physical and chemical aging processes of aerosols particles.In the present study,a centrifugal particle mass analyzer(CPMA) combined with a differential mobility analyzer(DMA) was deployed to determine the size-resolved effective density of 50 to 350 nm particles at a rural site of Beijing during summer 2016.The measured particle effective densities decreased with increasing particle sizes and ranged from 1.43 to 1.55 g/cm^3,on average.The effective particle density distributions were dominated by a mode peaked at around 1.5 g/cm^3 for 50 to350 nm particles.Extra modes with peaks at 1.0,0.8,and 0.6 g/cm3 for 150,240,and 350 nm particles,which might be freshly emitted soot particles,were observed during intensive primary emissions episodes.The particle effective densities showed a diurnal variation pattern,with higher values during daytime.A case study showed that the effective density of Aitken mode particles during the new particle formation(NPF) event decreased considerably,indicating the significant contribution of organics to new particle growth. | Kai Qiao Zhijun Wu Xiangyu Pei Qianyun Liu Dongjie Shang Jing Zheng Zhuofei Du Wenfei Zhu Yusheng Wu Shengrong Lou Song Guo Chak K.Chan Ravi Kant Pathak Mattias Hallquist Min Hu | 2018 | Journal of Environmental Sciences2018，30，11： | 2 |
| 4 | Analysis of equilibria in the doubly synchronous binary asteroid systems concerned with non-spherical shape显示文摘This paper investigates the equilibria and their stabilities in the doubly synchronous binary asteroid systems,which are modelled as the two tri-axial ellipsoids with various shape and system parameters.Particularly,the influences of shape and system parameters on equilibria are discussed analytically.Firstly,the geometrical models of doubly synchronous binary asteroid systems are established.The dual second degree and order gravity fleld is employed to approximate the gravitational potential of the system.Six shape and system parameters are deflned.Then,based on the linearized perturbation equations,the explicit expressions of the offsets of equilibria in doubly synchronous systems are derived,which clearly ilustrate the relationship between the distribution of equilibria and the variations of shape parameters.Further,the approximate expressions are applied to estimate the ftets of equilibria due to parameter etrors,respectively.Finally,in order to have a better insight into the equilibriaum structure,the sabiltis of equilibrisa under diferent system parameters are investigated.In particular,critical regions of triangular equilibria are calculated and the role of the relative distance on the stability is discussed in detail.This study could provide a preliminary analysis of equilibria for the mission design in doubly synchronous binary asteroid systems. | Xiangyu Li Dong Qiao M.A.Barucci | 2018 | Astrodynamics2018，2，2： | 2 |
| 5 | Mission Design of an Aperture-Synthetic Interferometer System for Space-Based Exoplanet Exploration显示文摘In recent years,exoplanet detection has become the technological frontier in the field of astronomy,because it provides evidence of the origin of life and the future human habitable exoplanet.Deploying several satellites to form an aperture-synthetic interferometer system in space may help discover“another Earth”via interferometry and midinfrared broadband spectroscopy.This paper analyzes a space-based exoplanet exploration mission in terms of the scientific background,mission profile,trajectory design,and orbital maintenance.First,the system architecture and working principle of the interferometer system are briefly introduced.Secondly,the mission orbit and corresponding transfer trajectories are discussed.The halo orbit near the Sun-Earth L2(SEL2)orbit is chosen as the candidate mission orbit.The low-energy transfer via stable invariant manifold with multiple perigees is designed,and the proper launch windows are presented.A speed increment less than 10 m/s is imposed for each transfer to achieve the insertion of the halo orbit.Finally,the tangent targeting method(TTM)is applied for high-precision formation maintenance with the whole velocity increments of less than 5×10^(−4)m/s for each spacecraft when the error bound is 0.1 m.The overall fuel budget during the mission period is evaluated and compared.The design in this paper will provide technical support and reliable reference for future exoplanet exploration missions. | Feida Jia Xiangyu Li Zhuoxi Huo Dong Qiao | 2022 | Space(Science & Technology)2022，，1： | 1 |
| 6 | Effect of orbital shadow at an Earth-Moon Lagrange point on relay communication mission显示文摘The shadow effect is an important constraint to be considered during the implementation of exploration missions. In this paper, for the Earth-Moon Lagrange point L2 relay communication mission, shadow effect issues on a periodic orbit about L2 are investigated. A systematic analysis based on the time domain and phase space is performed including the distribution, duration, and frequency of shadows. First, the LindstedtPoincare and second-order differential correction methods are used in conjunction with the DE421 planetary ephemeris to achieve a mission trajectory family in a high-precision ephemeris model. Next, on the basis of a conical shadow model, the influence of different orbital phases and amplitudes on the shadow is analyzed. The distribution of the shadow is investigated as well. Finally, the configuration of the shadow and its characteristics are studied. This study provides an important reference and basis for mission orbit design and shadow avoidance for relay satellites at an Earth-Moon Lagrange point. | Yuhua TANG Weiren WU Dong QIAO Xiangyu LI | 2017 | Science China(Information Sciences)2017，60，11： | 1 |
| 7 | Oral administration of the herbal oligonucleotide XKC-sRNA-h3 prevents angiotensinⅡ-induced hypertension in mice显示文摘Hypertension has become a growing public health concern worldwide.In fact,hypertension is commonly associated with increased morbidity and mortality.Currently,oligonucleotide drugs have proven to be promising therapeutic agents for various diseases.In the present study,we aimed to demonstrate that a herbal small RNA(s RNA),XKC-sRNA-h3(B55710460,F221.I000082.B11),exhibits potent antihypertensive effects by targeting angiotensin-converting enzyme(ACE)in mice.When compared with captopril,oral administration of the sphingosine(d18:1)-XKC-s RNA-h3 bencaosome more effectively prevented angiotensin II-induced hypertensive cardiac damage and alleviated kidney injury in mice.Such findings indicated that XKC-sRNA-h3 may be a novel orally available ACE inhibitor type oligonucleotide drug for hypertension. | Kegong Tang Xiaona Wang Yu Zhao Xiaobei Li Zhenyu Jiang Song Mei Mingrui Chen Yiming Ma Xinyi Du Xiangyu Qiao Na Sun Jiaqi Liu Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 8 | Analysis of non-coding small RNA similarity/sharing between plant and animal genomes显示文摘Dear Editor,During the construction and analysis of the Bencao(herbal)small RNA(s RNA)Atlas,the fact that many s RNAs from the human genome are present in the Bencao(herbal)database attracted our attention(Cao et al.,2023).The Bencao Atlas contains millions of s RNAs from hundreds of plants used in traditional Chinese Medicines(TCMs). | Fengming Huang Xiangyu Qiao Song Mei Cong Zhang Chengyu Jiang | 2023 | Science China(Life Sciences)2023，66，10： | 1 |
| 9 | Interplanetary transfer optimization using cost function with variable coecients显示文摘In this paper,the optimal interplanetary transfer including planetary escape and capture phases is investigated in the heliocentric frame.Based on primer vector theory,a modi ed cost function with variable coecients is developed to re ect the gravitational e ect more precisely.The necessary conditions as well as the transversality conditions of the new cost function are derived to search the optimal solution in xed-time.By introducing the initial and nal coasts,the optimal interplanetary transfer is extended to the time-free situation.Finally,the proposed method is applied to the Earth-Mars and Earth-Asteroid transfer.Comparisons with existing methods show that the proposed method can provide better transfer performances with high eciency.The proposed method extends the application of primer vector theory and provides a fast and accurate reference for preliminary mission design in spacecraft planetary exploration. | Xiangyu Li Dong Qiao Hongbo Chen | 2019 | Astrodynamics2019，3，2： | 1 |
| 10 | Research on the hierarchical structure of the metropolitan system and economic development of the provincial capital urban circle in Shandong显示文摘Regional development is the trend for future urbanization,and the urban circle is a highly efficient economic spatial pattern of regional development.This study selects statistical data of urban area population,GDP,and the output value of tertiary industry for seven cities in China- Jinan,Zibo,Tai'an,Laiwu,Dezhou,Liaocheng,and Binzhou- in the Shandong provincial capital urban circle from 2005 to 2009.It uses the principles and Zipf model,rank-size rule,and Lotka logarithmic model to analyze and study the hierarchical structure of the metropolitan system and economic development of the Shandong provincial capital urban circle.Based on the above research,this paper provides references for decisionmaking on enhancement of the metropolitan system structure,improvement in core city primacy index,the optimal adjustment of industrial structure and the optimal allocation of essential resources. | Xiaoyong Qiao Yanchun Meng Xiangyu Zhu | 2015 | Chinese Journal of Population,Resources and Environment2015，13，1： | 1 |
| 11 | Dynamics of a multiplex neural network with delayed couplings显示文摘Multiplex networks have drawn much attention since they have been observed in many systems,e.g.,brain,transport,and social relationships.In this paper,the nonlinear dynamics of a multiplex network with three neural groups and delayed interactions is studied.The stability and bifurcation of the network equilibrium are discussed,and interesting neural activities of the network are explored.Based on the neuron circuit,transfer function circuit,and time delay circuit,a circuit platform of the network is constructed.It is shown that delayed couplings play crucial roles in the network dynamics,e.g.,the enhancement and suppression of the stability,the patterns of the synchronization between networks,and the generation of complicated attractors and multi-stability coexistence. | Xiaochen MAO Xingyong LI Weijie DING Song WANG Xiangyu ZHOU Lei QIAO | 2021 | Applied Mathematics and Mechanics(English Edition)2021，42，3： | 1 |
| 12 | Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO显示文摘The Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main detector.Some of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator detectors.In this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)Th in the liquid scintillator can be controlled to 10^(-17)g/g.With ten years of data acquisition,approximately 60,000 signal and 30,000 background events are expected.This large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation framework.IfDelta m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith angle.Moreover,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment. | Angel Abusleme Thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli Tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare Thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La Taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky Tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak Timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He Tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera Daojin Hong YuenKeung Hor Shaojing Hou Yee Hsiung Bei-Zhen Hu Hang Hu Jianrun Hu Jun Hu Shouyang Hu Tao Hu Zhuojun Hu Chunhao Huang Guihong Huang Hanxiong Huang Qinhua Huang Wenhao Huang Xingtao Huang Yongbo Huang Jiaqi Hui Wenju Huo Cédric Huss Safeer Hussain Antonio Insolia Ara Ioannisian Daniel Ioannisyan Roberto Isocrate Kuo-Lun Jen Xiaolu Ji Xingzhao Ji Huihui Jia Junji Jia Siyu Jian Di Jiang Xiaoshan Jiang Ruyi Jin Xiaoping Jing Cécile Jollet Jari Joutsenvaara Sirichok Jungthawan Leonidas Kalousis Philipp Kampmann Li Kang Michael Karagounis Narine Kazarian Amir Khan Waseem Khan Khanchai Khosonthongkee Patrick Kinz Denis Korablev Konstantin Kouzakov Alexey Krasnoperov Svetlana Krokhaleva Zinovy Krumshteyn Andre Kruth Nikolay Kutovskiy Pasi Kuusiniemi Tobias Lachenmaier Cecilia Landini Sébastien Leblanc Frederic Lefevre Liping Lei Ruiting Lei Rupert Leitner Jason Leung Demin Li Fei Li Fule Li Haitao Li Huiling Li Jiaqi Li Jin Li Kaijie Li Mengzhao Li Nan Li Nan Li Qingjiang Li Ruhui Li Shanfeng Li Shuaijie Li Tao Li Weidong Li Weiguo Li Xiaomei Li Xiaonan Li Xinglong Li Yi Li Yufeng Li Zhibing Li Ziyuan Li Hao Liang Hao Liang Jingjing Liang Jiajun Liao Daniel Liebau Ayut Limphirat Sukit Limpijumnong Guey-Lin Lin Shengxin Lin Tao Lin Jiajie Ling Ivano Lippi Fang Liu Haidong Liu Hongbang Liu Hongjuan Liu Hongtao Liu Hu Liu Hui Liu Jianglai Liu Jinchang Liu Min Liu Qian Liu Qin Liu Runxuan Liu Shuangyu Liu Shubin Liu Shulin Liu Xiaowei Liu Yan Liu Alexey Lokhov Paolo Lombardi Claudio Lombardo Kai Loo Chuan Lu Haoqi Lu Jingbin Lu Junguang Lu Shuxiang Lu Xiaoxu Lu Bayarto Lubsandorzhiev Sultim Lubsandorzhiev Livia Ludhova Fengjiao Luo Guang Luo Pengwei Luo Shu Luo Wuming Luo Vladimir Lyashuk Qiumei Ma Si Ma Xiaoyan Ma Xubo Ma Jihane Maalmi Yury Malyshkin Fabio Mantovani Francesco Manzali Xin Mao Yajun Mao Stefano MMari Filippo Marini Sadia Marium Cristina Martellini Gisele Martin-Chassard Agnese Martini Davit Mayilyan Axel Müller Ints Mednieks Yue Meng Anselmo Meregaglia Emanuela Meroni David Meyhöfer Mauro Mezzetto Jonathan Miller Lino Miramonti Salvatore Monforte Paolo Montini Michele Montuschi Nikolay Morozov Pavithra Muralidharan Massimiliano Nastasi Dmitry VNaumov Elena Naumova Igor Nemchenok Alexey Nikolaev Feipeng Ning Zhe Ning Hiroshi Nunokawa Lothar Oberauer Juan Pedro Ochoa-Ricoux Alexander Olshevskiy Domizia Orestano Fausto Ortica Hsiao-Ru Pan Alessandro Paoloni Nina Parkalian Sergio Parmeggiano Teerapat Payupol Yatian Pei Nicomede Pelliccia Anguo Peng Haiping Peng Frédéric Perrot Pierre-Alexandre Petitjean Fabrizio Petrucci Luis Felipe Piñeres Rico Oliver Pilarczyk Artyom Popov Pascal Poussot Wathan Pratumwan Ezio Previtali Fazhi Qi Ming Qi Sen Qian Xiaohui Qian Hao Qiao Zhonghua Qin Shoukang Qiu Muhammad Rajput Gioacchino Ranucci Neill Raper Alessandra Re Henning Rebber Abdel Rebii Bin Ren Jie Ren Taras Rezinko Barbara Ricci Markus Robens Mathieu Roche Narongkiat Rodphai Aldo Romani Bedřich Roskovec Christian Roth Xiangdong Ruan Xichao Ruan Saroj Rujirawat Arseniy Rybnikov Andrey Sadovsky Paolo Saggese Giuseppe Salamanna Simone Sanfilippo Anut Sangka Nuanwan Sanguansak Utane Sawangwit Julia Sawatzki Fatma Sawy Michaela Schever Jacky Schuler Cédric Schwab Konstantin Schweizer Dmitry Selivanov Alexandr Selyunin Andrea Serafini Giulio Settanta Mariangela Settimo Muhammad Shahzad Vladislav Sharov Gang Shi Jingyan Shi Yongjiu Shi Vitaly Shutov Andrey Sidorenkov FedorŠimkovic Chiara Sirignano Jaruchit Siripak Monica Sisti Maciej Slupecki Mikhail Smirnov Oleg Smirnov Thiago Sogo-Bezerra Julanan Songwadhana Boonrucksar Soonthornthum Albert Sotnikov Ondrej Sramek Warintorn Sreethawong Achim Stahl Luca Stanco Konstantin Stankevich DušanŠtefánik Hans Steiger Jochen Steinmann Tobias Sterr Matthias Raphael Stock Virginia Strati Alexander Studenikin Gongxing Sun Shifeng Sun Xilei Sun Yongjie Sun Yongzhao Sun Narumon Suwonjandee Michal Szelezniak Jian Tang Qiang Tang Quan Tang Xiao Tang Alexander Tietzsch Igor Tkachev Tomas Tmej Konstantin Treskov Andrea Triossi Giancarlo Troni Wladyslaw Trzaska Cristina Tuve Stefan van Waasen Johannes van den Boom Guillaume Vanroyen Nikolaos Vassilopoulos Vadim Vedin Giuseppe Verde Maxim Vialkov Benoit Viaud Cristina Volpe Vit Vorobel Lucia Votano Pablo Walker Caishen Wang Chung-Hsiang Wang En Wang Guoli Wang Jian Wang Jun Wang Kunyu Wang Lu Wang Meifen Wang Meng Wang Ruiguang Wang Siguang Wang Wei Wang Wenshuai Wang Xi Wang Xiangyue Wang Yangfu Wang Yaoguang Wang Yi Wang Yifang Wang Yuanqing Wang Yuman Wang Zhe Wang Zheng Wang Zhimin Wang Zongyi Wang Apimook Watcharangkool Lianghong Wei Wei Wei Yadong Wei Liangjian Wen Christopher Wiebusch Steven Chan-Fai Wong Bjoern Wonsak Diru Wu Fangliang Wu Qun Wu Wenjie Wu Zhi Wu Michael Wurm Jacques Wurtz Christian Wysotzki Yufei Xi Dongmei Xia Yuguang Xie Zhangquan Xie Zhizhong Xing Benda Xu Donglian Xu Fanrong Xu Jilei Xu Jing Xu Meihang Xu Yin Xu Yu Xu Baojun Yan Xiongbo Yan Yupeng Yan Anbo Yang Changgen Yang Huan Yang Jie Yang Lei Yang Xiaoyu Yang Yifan Yang Haifeng Yao Zafar Yasin Jiaxuan Ye Mei Ye Ugur Yegin Frédéric Yermia Peihuai Yi Xiangwei Yin Zhengyun You Boxiang Yu Chiye Yu Chunxu Yu Hongzhao Yu Miao Yu Xianghui Yu Zeyuan Yu Chengzhuo Yuan Ying Yuan Zhenxiong Yuan Ziyi Yuan Baobiao Yue Noman Zafar Andre Zambanini Pan Zeng Shan Zeng Tingxuan Zeng Yuda Zeng Liang Zhan Feiyang Zhang Guoqing Zhang Haiqiong Zhang Honghao Zhang Jiawen Zhang Jie Zhang Jingbo Zhang Peng Zhang Qingmin Zhang Shiqi Zhang Tao Zhang Xiaomei Zhang Xuantong Zhang Yan Zhang Yinhong Zhang Yiyu Zhang Yongpeng Zhang Yuanyuan Zhang Yumei Zhang Zhenyu Zhang Zhijian Zhang Fengyi Zhao Jie Zhao Rong Zhao Shujun Zhao Tianchi Zhao Dongqin Zheng Hua Zheng Minshan Zheng Yangheng Zheng Weirong Zhong Jing Zhou Li Zhou Nan Zhou Shun Zhou Xiang Zhou Jiang Zhu Kejun Zhu Honglin Zhuang Liang Zong Jiaheng Zou | 2021 | Chinese Physics C2021，45，2： | 0 |
| 13 | Charge transfer complex enabled photoreduction of ether phosphonium salts for the selective oxyalkylation of enamides显示文摘A charge transfer complex(CTC)-enabled photoreduction of ether phosphonium salts for the generation of oxyalkyl radicals was described.The photoreduction provides a convenient method to achieve selective oxyalkylation of enamides with broad substrate scope.The method features operational simplicity,mild and inherent green conditions. | Sen Qiao Kunquan Chen Qiang Liu Zhixiang Wang Xiangyu Chen | 2024 | Chinese Chemical Letters2024，35，2： | 0 |
| 14 | Efficient optimization method for variable-specific-impulse low-thrust trajectories with shutdown constraint显示文摘This paper develops a sequential convex programming(SCP)-based method to solve the minimum-fuel variable-specific-impulse low-thrust transfer problem considering shutdown constraint,with emphasize on improving the computational efficiency.The variable parameter engine is more applicable for many low-thrust scenarios,therefore,both a continuously variable model and a ladder variable model are adopted.First,the original problem is convexified by processing the constraint feasible domain,which is composed of the nonlinear dynamic equations and second-order equality constraint,into convex sets.Then,the approximation is generated to close the optimal solution of the low-thrust problem by iteratively solving the convexified subproblem.Moreover,the switching self-detection and adaptive node refinement methods are presented,which can improve the accuracy of the solution and accelerate the convergence during the approximation process and is especially necessary and effective in the scenarios with shutdown constraint.In numerical simulations,the comparison with the homotopic approach shows that the proposed method only needs 4%computational time as that of the homotopic approach,and two variable-specificimpulse examples further demonstrate the effectiveness and efficiency of the proposed method. | JIA FeiDa QIAO Dong HAN HongWei LI XiangYu | 2022 | Science China(Technological Sciences)2022，65，3： | 0 |
| 15 | Herbal small RNAs in patients with COVID-19 linked to reduced DEG expression显示文摘In China,more than 80%of patients with coronavirus disease 2019(COVID-19)received traditional Chinese medicine(TCM)as a treatment and their clinical efficacy have been reported.However,the underlying molecular mechanism remains unclear.Previous studies have identified herbal small RNAs(s RNAs)as novel functional components.In this study,a cohort of 22patients with COVID-19 treated with Toujie Quwen(TQ)granules was analyzed.We observed thousands of herbal small RNAs that entered the blood cells of patients after the consumption of TQ granules.In response to this treatment,the reduced differentially expressed genes(DEGs)were highly correlated with the predicted target genes of the most prevalent herbal s RNAs detected in the blood.Moreover,the predicted target genes of the top 30 s RNAs from each of the 245 TCMs in the Bencao s RNA Atlas overlapped with 337 upregulated DEGs in patients with mild COVID-19,and 33 TCMs,with more than 50%overlapping genes were identified as effective TCMs.These predicted target genes of top 30 s RNAs from Juhong,Gualoupi and Foshou were confirmed experimentally.Our results not only elucidated a novel molecular mechanism of TCM potential clinical efficacy for COVID-19 patients,but also provided 33 effective COVID-19 TCMs for prescription optimization. | Xiangyu Qiao Fengming Huang Xiaohu Shi Xingyu Deng Cong Zhang Song Mei Zhiqing Wang Congzhao Zhou Chengyu Jiang Xinghua Tan | 2023 | Science China(Life Sciences)2023，66，6： | 0 |
| 16 | Message from the Guest Editors of the Special Issue on Asteroid Exploration显示文摘Dear authors and readers,Mission to asteroids is always a hot topic in the field of deep space exploration,since asteroids may have clues from the evolution and formation of the solar system to the origin of life.Plenty of asteroid exploration missions have been implemented in recent years,bringing astonishing scientific discoveries that greatly promote our understanding of asteroids.In the meantime,more exploration missions are in progress.Deeply understanding the dynamics environment in the vicinity of asteroids is the first step in mission design.Astrodynamics problem becomes the key to the success of the missions,which goes through the entire mission flow,including target selection,transfer trajectory and mission orbital design,stability analysis for proximity and surface operation,guidance and control for precise landing,and so on. | Dong Qiao Jiangchuan Huang Xiangyu Li | 2023 | Astrodynamics2023，7，1： | 0 |
| 17 | Geophysical and orbital environments of asteroid 4692192016 HO3显示文摘Asteroid 469219 Kamo'oalewa,also named 2016 HO3,is a small-size fast-rotating near-Earth asteroid,which is a potential target for future explorations.Owing to its weak gravity and fast spin rate,the dynamics on the surface or in the vicinity of 2016 HO3 are significantly different from those of planets or other small bodies explored in previous missions.In this study,the geophysical and orbital environments of 2016 HO3 were investigated to facilitate a potential mission design.First,the geormnetric and geopotential topographies of 2016 HO3 were examined using difterent shape models.The liftoff and escape conditions on its fast-rotating surface were investigated.Then,the periodic orbits around 2016 HO3 were studied in the asteroid-fixed frame and the Sun-asteroid frame considering the solar radiation pressure.The stable regions of the terminator orbits were discussed using different parameters.Finally,the influence of the nonspherical shape on the terminator orbits was examined.The precise terminator orbits around a real shape model of 2016 HO3 were obtained and verified in the high-fidelity model.This study shows that the polar region of 2016 HO3 is the primary region for landing or sampling,and the terminator orbits are well suited for global mapping and measurements of 2016 HO3.The analysis and methods can also serve as references for the exploration of other small fast-rotating bodies. | Xiangyu Li Daniel J.Scheeres Dong Qiao Zixuan Liu | 2023 | Astrodynamics2023，7，1： | 0 |
| 18 | Analytical configuration uncertainty propagation of geocentric interferometric detection constellation显示文摘Long-term configuration stability is essential for an interferometric detection constellation(IDC),which is closely related to initial uncertainty.Therefore,it is vital to evaluate the uncertainty and characterize the configuration stability.In this study,an analytical method was developed for the configuration uncertainty propagation of a geocentric triangular IDC.The angular momentum and the argument latitude were found to be significantly affected by the initial uncertainty and were selected as the core variables.By averaging the perturbation in one revolution,an analytical solution was proposed for propagating the core orbital elements in one revolution.Subsequently,the analytical solution of the orbit elements during the mission period is obtained by multiplying the solutions in iterative revolutions.The relationship between the selected orbital elements and the configuration stability parameters was established using an analytical solution.The effects of the initial uncertainty in different directions on the configuration and stable domains were studied.Simulations show that the developed method is highly efficient and accurate in predicting the configuration stability.The relative error with respect to the Monte Carlo simulations was less than 3%with a time consumption of 0.1%.The proposed method can potentially be useful for constellation design and stability analysis. | Dong Qiao Xingyu Zhou Xiangyu Li | 2023 | Astrodynamics2023，7，3： | 0 |
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