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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 3 | Curcumenol triggered ferroptosis in lung cancer cells via lncRNA H19/miR-19b-3p/FTH1 axis显示文摘Curcumenol,an effective ingredient of Wenyujin,has been reported that exerted its antitumor potential in a few cancer types.However,the effect and molecular mechanism of curcumenol in lung cancer are largely unknown.Here,we found that curcumenol induced cell death and suppressed cell proliferation in lung cancer cells.Next,we demonstrated that ferroptosis was the predominant method that contributed to curcumenol-induced cell death of lung cancer in vitro and vivo for the first time.Subsequently,using RNA sequencing,we found that the long non-coding RNA H19(lncRNA H19)was significantly downregulated in lung cancer cells treated with curcumenol,when compared to untreated controls.Overexpression of lncRNA H19 eliminated the anticancer effect of curcumenol,while lncRNA H19 knockdown promoted ferroptosis induced by curcumenol treatment.Mechanistically,we showed that lncRNA H19 functioned as a competing endogenous RNA to bind to miR-19b-3p,thereby enhanced the transcription activity of its endogenous target,ferritin heavy chain 1(FTH1),a marker of ferroptosis.In conclusion,our data show that the natural product curcumenol exerted its antitumor effects on lung cancer by triggering ferroptosis,and the lncRNA H19/miR-19b-3p/FTH1 axis plays an essential role in curcumenol-induced ferroptotic cell death.Therefore,our findings will hopefully provide a valuable drug for treating lung cancer patients. | Ruonan Zhang Ting Pan Yu Xiang Mingming Zhang Han Xie Zimao Liang Bi Chen Cong Xu Jing Wang Xingxing Huang Qianru Zhu Ziming Zhao Quan Gao Chengyong Wen Wencheng Liu Weirui Ma Jiao Feng Xueni Sun Ting Duan Elaine Lai-Han Leung Tian Xie Qibiao Wu Xinbing Sui | 2022 | Bioactive Materials2022，7，7： | 8 |
| 4 | Rational Fabrication of Superhydrophobic Nanocone Surface for Dynamic Water Repellency and Anti-icing Potential显示文摘In this work,a simple and economic route was presented to fabricate an anti-icing superhydrophobic surface with nanocone structures,which were constructed only by one-step facile method of hydrothermal treatment with zinc acetate on the aluminum substrate.After modifying with fluoroalkylsilane (FAS-17),the nanocone structures with the appropriate size could induce the high superhydrophobicity with the water contact angle reaching 160.2° ± 0.4° and the sliding angle only being 1 ° ± 0.5°.Under the dynamic environments,the impact droplets could rapidly bounced off the surface with the shorter contact time of^1 0.6 ms,and it was mainly attributing to lower capillary adhesive force (water adhesion force of 4.1 μN) induced by the open system of nanocone structures.Furthermore,the superhydrophobic nanocone surfaces were verified to be a promising anti-icing/icephobic materials,on which the water droplets needed to spend the time of ~517 s to complete the entire freezing process at-10 ℃,displaying the increased ~50 times of icing-delay performance comparing with untreated substrate.Even if ice finally was formed on the superhydrophobic nanocone surfaces,it could be easily removed away with lower ice adhesion of^45 kPa.The repeatable measurement of ice adhesion strength on the same place of the superhydrophobic surface is still far less than the surface ice adhesion of smooth substrate,exhibiting better stability. | Yuehan Xie Haifeng Chen Yizhou Shen Jie Tao Mingming Jin Yu Wu Wenqing Hou | 2019 | Journal of Bionic Engineering2019，16，1： | 7 |
| 5 | Stability influence factors analysis and construction of a deep beam anchorage structure in roadway roof显示文摘Deep beam anchorage structures based on spatial distribution analysis of the cable prestressed field have been proposed for roadway roof support. Stability and other factors that influence deep beam structures are studied in this paper using mechanical calculations, numerical analysis and field measurements. A mechanical model of deep beam structure subjected to multiple loading is established, including analysis of roof support in the return airway of S1203 working face in the Yuwu coal mine, China. The expression of maximum shear stress in the deep beam structure is deduced according to the stress superposition criterion. It is found that the primary factors affecting deep beam structure stability are deep beam thickness, cable pre-tension and cable spacing. The variation of maximum shear stress distribution and prestressed field diffusion effects according to various factors are analyzed using Matlabòand FLAC3D^(TM) software, and practical support parameters of the S1203 return airway roof are determined.According to the observations of rock pressure, there is no evidence of roof separation, and the maximum values of roof subsidence and convergence of wall rock are 72 and 48 mm, respectively. The results show that the proposed roof support design with a deep beam structure is feasible and achieves effective control of the roadway roof. | Xie Shengrong Gao Mingming Chen Dongdong Sun Yanding Pan Hao Su Hai Lan Shizhong | 2018 | International Journal of Mining Science and Technology2018，28，3： | 7 |
| 6 | Generation of fertile offspring from Kitw/Kitwv mice through differentiation of gene corrected nuclear transfer embryonic stem cells显示文摘 | Yan Yuan Quan Zhou Haifeng Wan Bin Shen Xuepeng Wang Mei Wang Chunjing Feng Mingming Xie Tiantian Gu Tao Zhou Rui Fu Xingxu Huang Qi Zhou Jiahao Sha Xiao-Yang Zhao | 2015 | Cell Research2015，25，7： | 7 |
| 7 | Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes显示文摘Objective:This study aimed to develop a new polyethylene glycol(PEG)ylatedβ-elemene liposome(PEG-Lipo-β-E)and evaluate its characterization,pharmacokinetics,antitumor effects and safety in vitro and in vivo.Methods:The liposomes were prepared by ethanol injection and high-pressure micro-jet homogenization.Characterization of the liposomes was conducted,and drug content,entrapment efficiency(EE),in vitro release and stability were studied by ultra-fast liquid chromatography(UFLC)and a liquid surface method.Blood was drawn from rats to establish the pharmacokinetic parameters.The anticancer effect was evaluated in a KU-19-19 bladder cancer xenograft model.Histological analyses were performed to evaluate safety.Results:The PEG-Lipo-β-E showed good stability and was characterized as 83.31±0.181 nm in size,0.279±0.004 in polydispersity index(PDI),-21.4±1.06 mV in zeta potential,6.65±0.02 in pH,5.024±0.107 mg/mL inβ-elemene(β-E)content,and 95.53±1.712%in average EE.The Fourier transform infrared spectroscopy(FTIR)and differential scanning calorimetry(DSC)indicated the formation of PEG-Lipo-β-E.Compared to elemene injection,PEG-Lipo-β-E demonstrated a 1.75-fold decrease in clearance,a 1.62-fold increase in half-life,and a 1.76-fold increase in area under the concentration-time curves(AUCs)from 0 hour to 1.5 hours(P<0.05).PEG-Lipo-β-E also showed an enhanced anticancer effect in vivo.Histological analyses showed that there was no evidence of toxicity to the heart,kidney,liver,lung or spleen.Conclusions:The present study demonstrates PEG-Lipo-β-E as a new formulation with ease of preparation,high EE,good stability,improved bioavailability and antitumor effects. | Bingtao Zhai Qibiao Wu Wengang Wang Mingming Zhang Xuemeng Han Qiujie Li Peng Chen Xiaying Chen Xingxing Huang Guohua Li Qin Zhang Ruonan Zhang Yu Xiang Shuiping Liu Ting Duan Jianshu Lou Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 8 | A case study of a Kuroshio main path cut-off event and impacts on the South China Sea in fall-winter 2013–2014显示文摘This study examines a Kuroshio main path(KMP) cut-off event east of Taiwan Island occurred in fall-winter2013–2014 and its impacts on the South China Sea(SCS) by analyzing satellite altimetry and mooring observations. Satellite altimeter sea level anomaly(SLA) images reveal a complete process that a huge cyclonic eddy(CE) from the Pacific collided with the Kuroshio and the western boundary from 15 October 2013 to 15 January 2014. Mooring observations evidenced that the Kuroshio upper ocean volume transport was cut off more than 82% from 17×106 m^3/s in September to 3×106 m^3/s in November 2013. The KMP cut-off event caused the Kuroshio branching and intruding into the SCS and strengthened the eddy kinetic energy in the northern SCS west of the Luzon Strait. Using the total momentum as a dynamic criterion to determine the role of eddy collision with the Kuroshio reasonably explains the KMP cut-off event. | Quanan Zheng Chung-Ru Ho Lingling Xie Mingming Li | 2019 | Acta Oceanologica Sinica2019，38，4： | 6 |
| 9 | Characteristics of Late-Quaternary Activity and Seismic Risk of the Northeastern Section of the Longmenshan Fault Zone显示文摘Following the 2008 Wenchuan M8 earthquake,the seismic risk of the northeastern section of the Longmenshan fault zone and the adjacent Hanzhong basin has become an issue that receives much concern.It is facing,however,the problem of a lack of sufficient data because of little previous work in these regions.The northeastern section of the Longmenshan fault zone includes three major faults:the Qingchuan fault,Chaba-Lin’ansi fault,and Liangshan south margin fault,with the Hanzhong basin at the northern end.This paper presents investigations of the geometry,motion nature,and activity ages of these three faults,and reveals that they are strike slip with normal faulting,with latest activity in the Late Pleistocene.It implies that this section of the Longmenshan fault zone has been in an extensional setting,probably associated with the influence of the Hanzhong basin.Through analysis of the tectonic relationship between the Longmenshan fault zone and the Hanzhong basin,this work verifies that the Qingchuan fault played an important role in the evolution of the Hanzhong basin,and further studies the evolution model of this basin.Finally,with consideration of the tectonic setting of the Longmenshan fault zone and the Hanzhong basin as well as seismicity of surrounding areas,this work suggests that this region has no tectonic conditions for great earthquakes and only potential strong events in the future. | WANG Mingming ZHOU Bengang YANG Xiaoping XIE Chao GAO Xianglin | 2013 | Acta Geologica Sinica(English Edition)2013，87，6： | 6 |
| 10 | Certificateless Sequential Aggregate Signature Scheme on NTRU Lattice显示文摘Having the advantages of certificateless signature and the aggregate signature at the same time,certificateless aggregate signature has been widely applied in e-business, e-government and software security since it was proposed in 2007. Although a number of certificateless aggregate signature schemes have been proposed, all of them are based on the classic number theory problem,which are no longer secure in the quantum era. In this paper, a certificateless sequential aggregate signature over number theory research unit lattice is proposed, which is proven to be secure in random oracle model. Moreover,we extend the new scheme into an efficient certificatebased sequential aggregate signature which is also secure in quantum era. | XIE Jia HU Yupu GAO Juntao JIANG Mingming | 2019 | Chinese Journal of Electronics2019，28，2： | 6 |
| 11 | An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment显示文摘Objective:In this study,we aimed to develop an amino-terminal fragment(ATF)peptide-targeted liposome carryingβ-elemene(ATF24-PEG-Lipo-β-E)for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells combined with cisplatin(DDP)for bladder cancer treatment.Methods:The liposomes were prepared by ethanol injection and high-pressure microjet homogenization.The liposomes were characterized,and the drug content,entrapment efficiency,andin vitro release were studied.The targeting efficiency was investigated using confocal microscopy,ultra-fast liquid chromatography,and an orthotopic bladder cancer model.The effects of ATF24-PEG-Lipo-β-E combined with DDP on cell viability and proliferation were evaluated by a Cell Counting Kit-8(CCK-8)assay,a colony formation assay,and cell apoptosis and cell cycle analyses.The anticancer effects were evaluated in a KU-19-19 bladder cancer xenograft model.Results:ATF24-PEG-Lipo-β-E had small and uniform sizes(~79 nm),high drug loading capacity(~5.24 mg/mL),high entrapment efficiency(98.37±0.95%),and exhibited sustained drug release behavior.ATF24-PEG-Lipo-β-E had better targeting efficiency and higher cytotoxicity than polyethylene glycol(PEG)ylatedβ-elemene liposomes(PEG-Lipo-β-E).DDP,combined with ATF24-PEG-Lipo-β-E,exerted a synergistic effect on cellular apoptosis and cell arrest at the G2/M phase,and these effects were dependent on the caspase-dependent pathway and Cdc25C/Cdc2/cyclin B1 pathways.Furthermore,thein vivo antitumor activity showed that the targeted liposomes effectively inhibited the growth of tumors,using the combined strategy.Conclusions:The present study provided an effective strategy for the targeted delivery ofβ-elemene(β-E)to bladder cancer,and a combined strategy for bladder cancer treatment. | Bingtao Zhai Peng Chen Wengang Wang Shuiping Liu Jiao Feng Ting Duan Yu Xiang Ruonan Zhang Mingming Zhang Xuemeng Han Xiaying Chen Qiujie Li Guohua Li Ying Liu Xingxing Huang Wenzheng Zhang Ting Pan Lili Yan Ting Jin Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，3： | 5 |
| 12 | Feasibility of Tea Saponin-Enhanced Soil Washing in a Soybean Oil-Water Solvent System to Extract PAHs/Cd/Ni Efficiently from a Coking Plant Site显示文摘Mixed contaminated brownfield sites have brought serious risks to human health and environmental safety. With the purpose of removing polycyclic aromatic hydrocarbons(PAHs) and heavy metals from a coking plant site, an innovative technology for ex-situ washing was developed in the present work. The combination of 15.0 mL L^(-1) soybean oil and 7.5 g L^(-1) tea saponin proved an effective method to extract co-pollutants from soil. After two consecutive washing cycles, the efficiency rates of removal for 3-, 4-,5(+6)-ring, and total PAHs, Cd, and Ni were approximately 98.2%, 96.4%, 92.3%, 96.3%, 94.1%, and 89.4%, respectively. Meanwhile,as evaluated by Tenax extraction method and metal stability indices, the residual PAHs and heavy metals after consecutive washing mainly existed in the form with extremely low bioaccessibility in the soil. Thus, in the soil after two washing cycles, there appeared limited environmental transfer risk of co-pollutants. Moreover, a subsequent precipitation method with alkaline solution and PAHdegrading strain Sphingobium sp. PHE9 inoculation effectively removed 84.6%–100% of Cd, 82.5%–91.7% of Ni, and 92.6%–98.4% of PAHs from the first and second washing solvents. The recovered solvents also exhibited a high recycling effectiveness. Therefore, the combined cleanup strategy proposed in this study proved environmentally friendly, which also played a major role in risk assessment and management in mixed polluted sites. | YE Mao SUN Mingming XIE Shanni LIU Kuan FENG Yanfang ZHAO Yu WAN Jinzhong HU Feng LI Huixin ZONG Lianggang JIANG Xin | 2017 | Pedosphere2017，27，3： | 5 |
| 13 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 14 | Ectopic expression of VRT-A2 underlies the origin of Triticum polonicum and Triticum petropavlovskyi with long outer glumes and grains显示文摘Polish wheat (Triticum polonicum) is a unique tetraploid wheat species characterized by an elongated outer glume. The genetic control of the long-glume trait by a single semi-dominant locus, P1 (from Polish wheat), was established more than 100 years ago, but the underlying causal gene and molecular nature remain elusive. Here, we report the isolation of VRT-A2, encoding an SVP-clade MADS-box transcription factor, as the P1 candidate gene. Genetic evidence suggests that in T. polonicum, a naturally occurring sequence rearrangement in the intron-1 region of VRT-A2 leads to ectopic expression of VRT-A2 in floral organs where the long-glume phenotype appears. Interestingly, we found that the intron-1 region is a key ON/OFF molecular switch for VRT-A2 expression, not only because it recruits transcriptional repressors, but also because it confers intron-mediated transcriptional enhancement. Genotypic analyses using wheat accessions indicated that the P1 locus is likely derived from a single natural mutation in tetraploid wheat, which was subsequently inherited by hexaploid T. petropavlovskyi. Taken together, our findings highlight the promoter-proximal intron variation as a molecular basis for phenotypic differentiation, and thus species formation in Triticum plants. | Jing Liu Zhaoyan Chen Zhihui Wang Zhaoheng Zhang Xiaoming Xie Zihao Wang Lingling Chai Long Song Xuejiao Cheng Man Feng Xiaobo Wang Yanhong Liu Zhaorong Hu Jiewen Xing Zhenqi Su Huiru Peng Mingming Xin Yingyin Yao Weilong Guo Qixin Sun Jie Liu Zhongfu Ni | 2021 | Molecular Plant2021，14，9： | 4 |
| 15 | Statistical analysis of mesoscale eddy propagation velocity in the South China Sea deep basin显示文摘Using mesoscale eddy trajectory product derived from satellite altimetry data from 1993 to 2017,this study analyzes the statistical characteristics of spatiotemporal distribution of mesoscale eddy propagation velocities(C)in the South China Sea(SCS)deep basin with depths>1000 m.Climatologically,the zonal propagation velocities(cx)are westwards in the whole basin,and the meridional velocities(cy)are southwards in the northwestern basin,and northwards in the southeastern basin.The variation of cy with longitude is consistent with that of the background meridional currents with correlation coefficient R2 of 0.96,while the variation of cx is related both to the background zonal currents andβeffect.The propagation velocities characterize significant seasonality with the minimum magnitude occurring in summer and the maximum in winter for cx and C.Interannually,larger values of cx and cy mostly occurred in La Ni?a years in the negative phase of the Pacific Decadal Oscillation(PDO).Mesoscale eddies move fast at the beginning and end of their life span,i.e.,at their growth and dissipation periods,and slowly during their stable'midlife'period.This trend is negatively correlated with the rotating tangential velocity with R2 of–0.93.Eddies with extreme propagation velocities are defined,which are slower(faster)than 1.5 cm/s(15.4 cm/s)and take 1.5%(1.9%)of the total eddies.The extremely slow-moving(fastmoving)eddies tend to appear in the middle(on the edge)of the basin,and mostly occur in summer(winter).The mechanism analysis reveals that the spatiotemporal distributions of the propagation velocities of mesoscale eddies in the SCS are modulated by the basin-scale background circulation. | Runqi Huang Lingling Xie Quanan Zheng Mingming Li Peng Bai Keyi Tan | 2020 | Acta Oceanologica Sinica2020，39，11： | 4 |
| 16 | Transcriptome Comparison of Susceptible and Resistant Wheat in Response to Powdery Mildew Infection显示文摘Powdery mildew(Pm) caused by the infection of Blumeria graminis f.sp.tritici(Bgt) is a worldwide crop disease resulting in significant loss of wheat yield.To profile the genes and pathways responding to the Bgt infection,here,using Affymetrix wheat microarrays,we compared the leaf transcriptomes before and after Bgt inoculation in two wheat genotypes,a Pm-susceptible cultivar Jingdong 8(S) and its near-isogenic line(R) carrying a single Pm resistant gene Pm30.Our analysis showed that the original gene expression status in the S and R genotypes of wheat was almost identical before Bgt inoculation,since only 60 genes exhibited differential expression by P = 0.01 cutoff.However,12 h after Bgt inoculation,3014 and 2800 genes in the S and R genotype,respectively,responded to infection.A wide range of pathways were involved,including cell wall fortification,flavonoid biosynthesis and metabolic processes.Furthermore,for the first time,we show that sense-antisense pair genes might be participants in wheat-powdery mildew interaction.In addition,the results of qRT-PCR analysis on several candidate genes were consistent with the microarray data in their expression patterns.In summary,this study reveals leaf transcriptome changes before and after powdery mildew infection in wheat near-isogenic lines,suggesting that powdery mildew resistance is a highly complex systematic response involving a large amount of gene regulation. | Mingming Xin Xiangfeng Wang Huiru Peng Yingyin Yao Chaojie Xie Yao Han ZhongfuNi Qixin Sun | 2012 | Genomics, Proteomics & Bioinformatics2012，10，2： | 3 |
| 17 | Seasonal and interannual variability of water mass sources of Indonesian throughflow in the Maluku Sea and the Halmahera Sea显示文摘So far, large uncertainties of the Indonesian throughflow(ITF) reside in the eastern Indonesian seas, such as the Maluku Sea and the Halmahera Sea. In this study, the water sources of the Maluku Sea and the Halmahera Sea are diagnosed at seasonal and interannual timescales and at different vertical layers, using the state-of-the-art simulations of the Ocean General Circulation Model(OGCM) for Earth Simulator(OFES). Asian monsoon leaves clear seasonal footprints on the eastern Indonesian seas. Consequently, the subsurface waters(around 24.5σ_θ and at ~150 m) in both the Maluku Sea and the Halmahera Sea stem from the South Pacific(SP) during winter monsoon, but during summer monsoon the Maluku Sea is from the North Pacific(NP), and the Halmahera Sea is a mixture of waters originating from the NP and the SP. The monsoon impact decreases with depth, so that in the Maluku Sea, the intermediate water(around 26.8σ_θ and at ~480 m) is always from the northern Banda Sea and the Halmahera Sea water is mainly from the SP in winter and the Banda Sea in summer. The deep waters(around27.2σ_θ and at ~1 040 m) in both seas are from the SP, with weak seasonal variability. At the interannual timescale,the subsurface water in the Maluku Sea originates from the NP/SP during El Ni?o/La Ni?a, while the subsurface water in the Halmahera Sea always originates from the SP. Similar to the seasonal variability, the intermediate water in Maluku Sea mainly comes from the Banda Sea and the Halmahera Sea always originates from the SP. The deep waters in both seas are from the SP. Our findings are helpful for drawing a comprehensive picture of the water properties in the Indonesian seas and will contribute to a better understanding of the ocean-atmosphere interaction over the maritime continent. | Lu Wang Lei Zhou Lingling Xie Quanan Zheng Qiang Li Mingming Li | 2019 | Acta Oceanologica Sinica2019，38，4： | 3 |
| 18 | Revisiting lithium-storage mechanisms of molybdenum disulfide显示文摘Molybdenum disulfide(MoS_(2)),a typical two-dimensional transition metallic layered material,attracts tremendous attentions in the electrochemical energy storage due to its excellent physicochemical properties.However,with the deepening of the research and exploration of the lithium storage mechanism of these advanced MoS_(2)-based anode materials,the complex reaction process influenced by internal and external factors hinders the exhaustive understanding of the lithium storage process.To design stable anode material with high performance,it is urgent to review the mechanisms of reported anode materials and summarize the related factors that influence the reaction processes.This review aims to dissect all possible side reactions during charging and discharging process,uncover internal and external factors inducing various anode reactions and finally put forward strategies of controlling high cycling capacity and super-stable lithium storage capability of MoS_(2).This review will be helpful to the design of MoS_(2)-based lithium-ion batteries(LIBs) with excellent cycle performance to enlarge the application fields of these advanced electrochemical energy storage devices. | Chun Sun Mingming Liu Longlu Wang Lingbin Xie Weiwei Zhao Jianmin Li Shujuan Liu Dafeng Yan Qiang Zhao | 2022 | Chinese Chemical Letters2022，33，4： | 3 |
| 19 | Tidal currents in the coastal waters east of Hainan Island in winter显示文摘Using the 25-h continuing hydrographic observations at three successive stations in February 2012 and the mooring time series of current observations from January to March 2015,the tidal currents and tidal energy fluxes in the coastal waters east of Hainan Island in the northwestern South China Sea were analyzed.The diurnal and semidiurnal(using K_(1) and M_(2) as proxies,respectively)tidal currents and associated isopycnal undulations were derived with harmonic analysis.Results show that the velocities of the diurnal and semidiurnal tides derived from the 25-h observations are comparable to those from the mooring series.The semi-major axes of the tidal ellipses were O(4-7 cm/s)for barotropic tides and O(2-4 cm/s)for baroclinic tides.The directions were in NE-SW at deeper stations to N-S at the shallowest station for the diurnal tide and from NW-SE to NE-SW for the semidiurnal tide.Both the diurnal and semidiurnal isopycnal fl uctuations reached O(5 m),O(8 m),and O(10 m)at the cross-shelf stations(H03,H04,and H05)from 35 m,45 m,to 55 m,respectively,showing insignifi cant vertical variation,and the barotropic signals were predominate.The baroclinic diurnal tide showed fi rst-mode structures at H03-05,as does the semidiurnal tide at H03.The semidiurnal tide at H04 and H05 exhibited higher-mode structures.The time series of both the alongshore and cross-shore components reveal the vertically propagation features of the baroclinic tidal phase and energy.The calculated horizontal energy fl uxes of the diurnal and semidiurnal internal tides decreased from O(0.1 W/m)at H05 to O(0.01 W/m)at H03,implying a propagation and dissipation of energy from off shore to inshore. | Min LI Lingling XIE Xiaolong ZONG Junyi LI Mingming LI Tong YAN Ronglei HAN | 2022 | Journal of Oceanology and Limnology2022，40，2： | 2 |
| 20 | The cruise observation of turbulent mixing in the upwelling region east of Hainan Island in the summer of 2012显示文摘The turbulent mixing in the upwelling region east of Hainan Island in the South China Sea is analyzed based on in situ microstructure observations made in July 2012. During the observation, strong upwelling appears in the coastal waters, which are 3℃ cooler than the offshore waters and have a salinity 1.0 greater than that of the offshore waters. The magnitude of the dissipation rate of turbulent kinetic energy ε in the upwelling region is O(10–9 W/kg), which is comparable to the general oceanic dissipation. The inferred eddy diffusivity K_ρ is O(10–6 m^2/s), which is one order of magnitude lower than that in the open ocean. The values are elevated to K_ρ≈O(10–4 m^2/s) near the boundaries. Weak mixing in the upwelling region is consistent with weak instability as a result of moderate shears versus strong stratifications by the joint influence of surface heating and upwelling of cold water.The validity of two fine-scale structure mixing parameterization models are tested by comparison with the observed dissipation rates. The results indicate that the model developed by Mac Kinnon and Gregg in 2003 provides relatively better estimates with magnitudes close to the observations. Mixing parameterization models need to be further improved in the coastal upwelling region. | LI Mingming XIE Lingling ZONG Xiaolong ZHANG Shuwen ZHOU Lei LI Junyi | 2018 | Acta Oceanologica Sinica2018，37，9： | 2 |
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