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| 1 | Intelligent and connected vehicles: Current status and future perspectives显示文摘Intelligent connected vehicles(ICVs) are believed to change people's life in the near future by making the transportation safer,cleaner and more comfortable. Although many prototypes of ICVs have been developed to prove the concept of autonomous driving and the feasibility of improving traffic efficiency, there still exists a significant gap before achieving mass production of high-level ICVs. The objective of this study is to present an overview of both the state of the art and future perspectives of key technologies that are needed for future ICVs. It is a challenging task to review all related works and predict their future perspectives, especially for such a complex and interdisciplinary area of research. This article is organized to overview the ICV key technologies by answering three questions: what are the milestones in the history of ICVs; what are the electronic components needed for building an ICV platform; and what are the essential algorithms to enable intelligent driving? To answer the first question, the article has reviewed the history and the development milestones of ICVs. For the second question, the recent technology advances in electrical/electronic architecture, sensors, and actuators are presented. For the third question, the article focuses on the algorithms in decision making, as the perception and control algorithm are covered in the development of sensors and actuators. To achieve correct decision-making, there exist two different approaches: the principle-based approach and data-driven approach. The advantages and limitations of both approaches are explained and analyzed. Currently automotive engineers are concerned more with the vehicle platform technology, whereas the academic researchers prefer to focus on theoretical algorithms. However, only by incorporating elements from both worlds can we accelerate the production of high-level ICVs. | YANG DianGe JIANG Kun ZHAO Ding YU ChunLei CAO Zhong XIE ShiChao XIAO ZhongYang JIAO XinYu WANG SiJia ZHANG Kai | 2018 | Science China(Technological Sciences)2018，61，10： | 31 |
| 2 | Exosome-loaded extracellular matrix-mimic hydrogel with anti-inflammatory property Facilitates/promotes growth plate injury repair显示文摘Growth plate cartilage has limited self-repair ability,leading to poor bone bridge formation post-injury and ultimately limb growth defects in children.The current corrective surgeries are highly invasive,and outcomes can be unpredictable.Following growth plate injury,the direct loss of extracellular matrix(ECM)coupled with further ECM depletion due to the inhibitory effects of inflammation on the cartilage matrix protein greatly hinder chondrocyte regeneration.We designed an exosome(Exo)derived from bone marrow mesenchymal stem cells(BMSCs)loaded ECM-mimic hydrogel to promote cartilage repair by directly supplementing ECM and anti-inflammatory properties.Aldehyde-functionalized chondroitin sulfate(OCS)was introduced into gelatin methacryloyl(GM)to form GMOCS hydrogel.Our results uncovered that GMOCS hydrogel could significantly promote the synthesis of ECM due to the doping of OCS.In addition,the GMOCS-Exos hydrogel could further promote the anabolism of chondrocytes by inhibiting inflammation and ultimately promote growth plate injury repair through ECM remodeling. | Pengfei Guan Can Liu Denghui Xie Shichao Mao Yuelun Ji Yongchang Lin Zheng Chen Qiyou Wang Lei Fan Yongjian Sun | 2022 | Bioactive Materials2022，7，4： | 3 |
| 3 | Facile Synthesis of NiFe_2O_4/Reduced Graphene Oxide Hybrid with Enhanced Electrochemical Lithium Storage Performance显示文摘In this work, a facile, one-pot route has been applied to synthesize nanohybrids based on mixed oxide Ni Fe2O4 and reduced graphene oxide(r GO). The hybrid is constructed by nanosized Ni Fe2O4 crystals confined by fewlayered r GO sheets. The formation mechanism and microstructure of the hybrids have been clarified by X-ray diffraction, Raman spectroscopy, scanning electron microscopy, and transmission electron microscopy.Electrochemical tests show that the performance of Ni Fe2O4 can be considerably improved by r GO incorporation. The performance improvement can be attributed to the two-dimensional conductive channels and the unique hybrid structure r GO constructed. The easy synthesis and good electrochemical performance of Ni Fe2O4/r GO hybrid make it a promising anode material for Li-ion batteries. | Peiyi Zhu Shuangyu Liu Jian Xie Shichao Zhang Gaoshao Cao Xinbing Zhao | 2014 | Journal of Materials Science & Technology2014，30，11： | 2 |
| 4 | Mutagenesis reveals that the rice OsMPT3 gene is an important osmotic regulatory factor显示文摘Plant mitochondrial phosphate transporters regulate phosphate transport and ATP synthesis. Determining whether they function in abiotic stress response process would shed light on their response to salt stress. We used the CRISPR/Cas9 gene-editing system to mutagenize two mitochondrial phosphate transporters, OsMPT3;1 and OsMPT3;2, to investigate their regulatory roles under salt stress. Two cas9(CRISPR-associated protein9)-free homozygous mutants, mpt33 and mpt30, were confirmed to be stable. Both OsMPT3;1 and OsMPT3;2 were markedly induced by salt stress, and their mutagenesis strongly inhibited growth and development, especially under salt stress. Mutagenesis sharply reduced the accumulation of ATP, phosphate, calcium, soluble sugar, and proline and increased osmotic potential, malondialdehyde, and Na^+ /K^+ ratio under salt stress. Both mutants demonstrate normal growth and development in the presence of ATP, revealing high sensitivity to exogenous ATP under salt stress. The mutants showed lowered rates of Na^+ efflux but also of K^+ and Ca^(2+) influx under salt stress. Mutagenesis of OsMPT3;2 altered the enrichment profiles of differentially expressed genes involved mainly in synthesis of secondary metabolites, metabolism of glycolysis, pyruvate, tricarboxylic acid cycle, in response to salt stress. The mutant displayed significant accumulation differences in 14 metabolites involved in 17 metabolic pathways, and strongly up-regulated the accumulation of glutamine, a precursor in proline synthesis, under salt stress. These findings suggest that the OsMPT3 gene modulates phosphate transport and energy supply for ATP synthesis and triggers changes in accumulation of ions and metabolites participating in osmotic regulation in rice under salt stress, thus increasing rice salt tolerance. This study demonstrates the effective application of CRISPR/Cas9 gene-editing to the investigation of plant functional genes. | Shengcai Huang Shichao Xin Guoqiang Xie Jiao Han Zhonglai Liu Bing Wang Shuqing Zhang Qingyu Wu Xianguo Cheng | 2020 | The Crop Journal2020，8，3： | 2 |
| 5 | Co-vacancy-rich CO1-xS nanosheets anchored on rGO for high-efficiency oxygen evolution显示文摘为氧进化开发成本效率的 electrocatalysts 为经由电解的水产生的 H 2 精力的生存能力是重要的。在 electrocatalysts 上设计有利缺点提供可存取的活跃地点能增加懒惰反应热力学或动力学。此处,公司 1x S nanosheets 被控制连续二拍子的圆舞在减少的 graphene 氧化物(rGO ) 上设计并且成长热水的反应。一位像带的基于钴的先锋首先与氨和 rGO 的帮助被形成,它当时是进公司 1x 由在更高热水的温度的 L 半胱氨酸的 S。因为 non-stoichiometric 缺点和 ultrathin 像表的结构,另外的钴空缺(V 公司 ) 在催化剂表面上被形成 / 暴露,它帮助了充电散开并且在与电解质的接触增加了 electroactive 表面。产生公司 1x S/rGO 混血儿展出了在 10 妈象 310 mV 一样低的过电位? | Jiaqing Zhu Zhiyu Ren Shichao Du Ying Xie Jun Wu Huiyuan Meng Yuzhu Xue Honggang Fu | 2017 | Nano Research2017，10，5： | 2 |
| 6 | High dietary lipid level promotes low salinity adaptation in the marine euryhaline crab(Scylla paramamosain)显示文摘The physiological processes involved in adaptation to osmotic pressure in euryhaline crustaceans are highly energy demanding,but the effects of dietary lipids(fat)on low salinity adaptations have not been well evaluated.In the present study,a total of 120 mud crabs(Scylla paramamosain,BW=17.87±1.49 g)were fed control and high-fat(HF)diets,at both medium salinity(23‰)and low salinity(4‰)for 6 wk,and each treatment had 3 replicates with each replicate containing 10 crabs.The results indicated that a HF diet significantly mitigated the reduction in survival rate,percent weight gain and feed efficiency induced by low salinity(P<0.05).Low salinity lowered lipogenesis and activated lipolysis resulting in lipid depletion in the hepatopancreas of mud crabs(P<0.05).Thus,HF diets enhanced the process of lipolysis to supply more energy.In the gills,low salinity and the HF diet increased the levels of mitochondrial biogenesis markers,the activity of mitochondrial complexes,and the expression levels of genes related to energy metabolism(P<0.05).Consequently,the positive effects of the HF diet on energy metabolism in mud crabs at low salinity promoted osmotic pressure regulation.Specifically,significantly higher haemolymph osmotic pressure and inorganic ion content,as well as higher osmotic pressure regulatory enzyme activity in gills,and gene and protein expression levels of NaK-ATPase were observed in crabs fed the HF diet at low salinity(P<0.05).In summary,high dietary lipid levels improved energy provision to facilitate mitochondrial biogenesis,which increased ATP provision for osmotic pressure regulation of mud crabs.This study also illustrates the importance of dietary lipid nutrition supplementation for low salinity adaptations in mud crabs. | Jiaxiang Luo Chen Ren Tingting Zhu Chen Guo Shichao Xie Yingying Zhang Zheng Yang Wenli Zhao Xiangsheng Zhang Jingjing Lu Lefei Jiao Qicun Zhou Douglas R.Tocher Min Jin | 2023 | Animal Nutrition2023，，1： | 0 |
| 7 | Wrinkled Graphene-Reinforced Nickel Sulfide Thin Film as High-Performance Binder-Free Anode for Sodium-Ion Battery显示文摘Sodium-ion batteries(SIBs) recently have received a worldwide attention due to the resource abundance of sodium and similar battery chemistry with lithium-ion batteries(LIBs). However, search for suitable anodes for SIBs still remains a challenge since graphitized carbon, the anode for commercial LIBs, usually exhibits low electrochemical Na-storage activity. In this work, a unique graphene-reinforced Ni_3S_2 thin film(Ni_3S_2/G) has been constructed and investigated as a promising anode for SIBs. The Ni_3S_2 thin film has a thickness of 200–300 nm and is composed of small sized crystals of around 100 nm. The graphene has a wrinkled surface profile which offers three-dimensional networks for electron conductivity and structural reinforcement. The Ni_3S_2/G thin film exhibits high capacity, excellent cycling stability and good rate capability due to the introduction of wrinkled graphene. Ni_3S_2/G can deliver a high initial capacity of 791 m Ah g^(-1)at 50 m A g^(-1). The capacity can be maintained at 563 m Ah g^(-1)after 110 cycles.This work provides a unique design for high-performance SIBs anodes. | Xueke Xia Jian Xie Shichao Zhang Bin Pan Gaoshao Cao Xinbing Zhao | 2017 | Journal of Materials Science & Technology2017，33，8： | 0 |
| 8 | Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells显示文摘Here,we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation.By excising the natural poly-adenylation(poly-A)signal of target genes and replacing it with a synthetic control region harboring RNA-binding protein(RBP)-specific aptamers,cap-dependent translation is rendered exclusively dependent on synthetic translation initiation factors(STIFs)containing different RBPs engineered to conditionally associate with different eIF4F-binding proteins(eIFBPs).This modular design framework facilitates the engineering of various gene switches and intracellular sensors responding to many user-defined trigger signals of interest,demonstrating tightly controlled,rapid and reversible regulation of transgene expression in mammalian cells as well as compatibility with various clinically applicable delivery routes of in vivo gene therapy.Therapeutic efficacy was demonstrated in two animal models.To exemplify disease treatments that require on-demand drug secretion,we show that a custom-designed gene switch triggered by the FDA-approved drug grazoprevir can effectively control insulin expression and restore glucose homeostasis in diabetic mice.For diseases that require instantaneous sense-and-response treatment programs,we create highly specific sensors for various subcellularly(mis)localized protein markers(such as cancer-related fusion proteins)and show that translation-based protein sensors can be used either alone or in combination with other cell-state classification strategies to create therapeutic biocomputers driving self-sufficient elimination of tumor cells in mice.This design strategy demonstrates unprecedented flexibility for translational regulation and could form the basis for a novel class of programmable gene therapies in vivo. | Jiawei Shao Shichao Li Xinyuan Qiu Jian Jiang Lihang Zhang Pengli Wang Yaqing Si Yuhang Wu Minghui He Qiqi Xiong Liuqi Zhao Yilin Li Yuxuan Fan Mirta Viviani Yu Fu Chaohua Wu Ting Gao Lingyun Zhu Martin Fussenegger Hui Wang Mingqi Xie | 2024 | Cell Research2024，34，1： | 0 |
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