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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway 显示文摘 | XIA G XIN N LID W | 2014 | Mol Med Rep2014，9，4： | 1 |
| 3 | Serum BAFF is elevated in patients with IgA nephropathy and associated with clinical and histopathological features显示文摘 | Xin G Shi W Xu LX | | 0，，04： | 1 |
| 4 | 显示文摘 | Chen W Xin Q Sun G | 2008 | Journal of Power Sources2008，180，1： | 1 |
| 5 | Ctomegalovirus infection in pregnancy显示文摘 | WEN L Z XIN G W LIU L Q | 2002 | Int J Gyne Obst2002，79，2： | 1 |
| 6 | Malignant peripheral nerve sheath tumors: differentiation patterns and features--a mini-review and our new findings 显示文摘 | Aitao G Aijun L Li X W Xin S | 2012 | J Cancer2012，3，： | 1 |
| 7 | X-ray image segmentation based on genetic algorithm and maximum fuzzy entropy显示文摘 | Xin W Wong B S Chen G T | 2004 | Proceedings of IEEE Conference on Robotics Automation and Mechatronics2004，2，： | 1 |
| 8 | Serum BAFF is elevated in patients with IgA nephropathy and associated with clinical and histopathological features显示文摘 | Xin G Shi W Xu LX | | 0，，： | 1 |
| 9 | NetCamo:camouflaging network traffic for Qos-guaranteed mission critical applications显示文摘 | Yong G Xin W F Wei Z | 2001 | IEEE Transactions on Systems2001，31，4： | 1 |
| 10 | Hyperbranched oxadiazolecontaining polyfluorenes:Toward stable blue light PLEDs显示文摘 | Xin Y Wen G A Zeng W J | 2005 | Macromolecules2005，38，16： | 1 |
| 11 | Investigation of the sulfidation of Mo/TiO2-Al2O3 catalysts by TPS and LRS 显示文摘 | Zhaobin W Xin Q Xiong G | 1992 | Catal Lett1992，15，： | 1 |
| 12 | Significance of T lymphrocyte subset,erythrocyte immunefunction and Ag-NORs in nucleolarorganizer region in patients with carcinoma of endometriun显示文摘 | Xu L Y Zhang Y Xin G W | 2001 | J Fourth Mil Med Univ2001，22，22： | 1 |
| 13 | PEAKS DB:De Novo sequencing assisted database search for sensitive and accurate peptide identification显示文摘 | Zhang J Xin L Shan B Chen W Xie M Yuen D Zhang W Zhang Z Lajoie G A Ma B | | 0，，： | 1 |
| 14 | Visualization of electrode-electrolyte interfaces in LiPFdECIDEC electrolyte for lithium ion batteries via in situ TEM 显示文摘 | ZENG Z LIANG W I LIAO H G XIN H L CHU Y H ZHENG H | 2014 | Nano Letters2014，14，： | 1 |
| 15 | 显示文摘 | Luo Y J Xin W Li G P | 2007 | J Membr Sci2007，303，： | 1 |
| 16 | 显示文摘 | XIONG Xin OUYANG Jin BAEYENS W R G DELANGHE J R SHEN Xiumin YANG Yiping | 2006 | Electrophoresis2006，27，16： | 1 |
| 17 | Characterization and identifi- cation of steroidal alkaloids in Fritillaria species using liquid chromatography coupled with eleetrospray ionization quadrupole time-of-flight tandem mass spectrometry 显示文摘 | Zhou J L Xin G Z Qi L W | 2010 | J Chromatogr A2010，1217，45： | 1 |
| 18 | Studyon the extraction of dyes into a room-temperature ionic liquid and their mechanisms显示文摘 | Li C P Xin B P Xu W G | | 0，，02： | 1 |
| 19 | Combining vegetation index and remotely sensed temperature for estimation of soil moisture in china显示文摘 | Xin J Tian G Liu W | 2006 | International Journal of Remote Sensing2006，27，： | 1 |
| 20 | An energy model approach to people counting for abnormal crowd behavior detection显示文摘 | GUO G X JUN C XIN Y W | 2012 | Neurocomputing2012，83，： | 1 |
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