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| 1 | Relationship between phenotypes of cell-function differentiation and pathobiological behavior of gastric carcinomas显示文摘AIM To reveal the correlation between thefunctional differentiation phenotypes of gastriccarcinoma cells and the invasion and metastasisby a new way of cell-function classification.METHODS Surgically resected specimens of361 gastric carcinomas (GC) were investigatedwith enzyme-, mucin-, and tumor-related markerimmunohistochemist ry. According to thedirection of cell-function differentiation,stomach carcinomas were divided into fivefunctionally differentiated types.iation type (AFDT): there were 82 (22.7%)patients including 76 (92.7%) aged 45 years.Sixty-nine (84.1%) cases belonged to theintestinal type. Thirty-eight (46.3%) expressedCD44v6 and 9 (13.6%) of 66 male patientsdeveloped liver metastasis. The 5-year survivalrate of patients in this group (58.5%) was higherMucin secreting function differentiation type(MSFDT): 54 (15%) cases. Fifty-three (98.1%)tumors had penetrated the serosa, 12 (22.2%)expressed ER and 22 (40.7%) expressedCD44v6. The postoperative 5-year survival ratefunction differentiation type (AMPFDT): therewere 180 (49.9%) cases, including 31 (17.2%)aged yanger than 45 years. The tumor was morecommon in women (62, 34.4%,) and expressedmore frequently estrogen receptors (ER) ( 129,81.7%) than other types (P<0.01). Ovarymetastasis was found in 12 (19.4%) out of 62female subjects. The patients with this type GChad the lowest 5-year survival rate (24.7%)differentiation type (SFDT): 13 (3.6%) cases.Nine (69.2%) tumors of this type derived fromAPUD system, the other 4 (30.7%) were ofdifferent histological differentiation. Sixty percent of the patients survived at least five years.(8.9%) cases. Nineteen (59.4%) cases hadlymph node metastases but no one with liver orovary metastasis. The 5-year survival rate was28.1%.CONCLUSION This new cell-functionclassification of GC is helpful in indicating thecharacteristics of invasion and metastasis of GCwith different cell-function differentiationphenotypes. Further study is needed to disclosethe correlation between the cell-functionaldifferentiation phenotypes and the relevantgenotypes and the biological behavior of gastriccarcinoma. | Yan Xin Xiao Ling Li Yan Ping Wang Su Min Zhang Hua Chuan Zheng Dong Ying Wu Yin Chang Zhang The Fourth Laboratory of Cancer Institute, China Medical University, Shenyang 110001, Liaoning Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 38 |
| 2 | Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma显示文摘MicroRNAs 是否定地在 post-transcriptional 水平调制基因表示的短规章的 RNA,并且深深地涉及癌症的几种类型的致病。调查特定的 miRNAs 和他们的目标基因是否参予喉的癌的分子的致病, oligonucleotide microarrays 被用来与正常纸巾相比在喉的癌纸巾估计 microRNAs 和 mRNAs 的微分表示侧面。oncogenic miRNA, microRNA-21 (miR-21 ) ,被发现是在喉的癌纸巾的 upregulated。由特定的 antisense oligonucleotides 的 miR-21 击倒而 miR-21 的 overexpression 提高了细胞的生长活动,由殖民地形成试金检测了,禁止了 HEp-2 细胞的增长潜力。miR-21 抑制引起的房间数字减小由于 G1-S 阶段转变的控制的损失,而不是 apoptosis 的显著增加。随后, miR-21 的新目标基因, BTG2,被发现是在喉的癌纸巾的 downregulated。BTG2 被知道充当一个平底锅房间周期管理者和肿瘤 suppressor。这些调查结果显示 miR-21 的那异常表情可以由维持 BTG2 的底层贡献喉的癌的恶意的显型。oncogenic miR-21 和它的目标基因的鉴定, BTG2,为癌症诊断和治疗在喉的癌是潜在地珍贵的。 | Min Liu Haidong Wu Tao Liu Yixuan Li Fang Wang Haiying Wan Xin Li Hua Tang | 2009 | Cell Research2009，19，7： | 40 |
| 3 | Pachytene piRNAs instruct massive mRNA elimination during late spermiogenesis显示文摘在哺乳动物的精子发生被 piRNA 表示的二个波浪描绘:一个人对应于负责的经典 piRNAs 因为 silencing retrotransponsons 和第二个波浪主要在 pachytene spermatocytes 从 nontransposon intergenic 区域被导出,但是这些 pachytene piRNAs 的功能大部分是未知的。这里,我们在在老鼠伸长指示巨大的 mRNA 消除报导 pachytene piRNAs 的参与 spermatids (ES ) 。我们证明包含鼠科的 PIWI (MIWI ) 和 deadenylase CAF1 的导致 piRNA 的 silencing 建筑群(pi-RISC ) 有选择地在 ES 被装配,它负责经由在体的房间类似于 miRNAs 的行动的机制导致 mRNA deadenylation 和腐烂。如此的一个高度安排的节目看起来充分利用 pachytene piRNAs 的能力从 nontransposon intergenic 区域导出的多样化的指向的庞大的全部剧目。这些调查结果建议 pachytene piRNAs 负责为精子生产作准备,从 ES 使广阔细胞的节目失去活性。 | Lan-Tao Gou Peng Dai Jian-Hua Yang Yuanchao Xue Yun-Ping Hu Yu Zhou Jun-Yan Kang Xin Wang Hairi Li Min-Min Hua Shuang Zhao Si-Da Hu Li-Gang Wu Hui-Juan Shi Yong Li Xiang-Dong Fu Liang-Hu Qu En-Duo Wang Mo-Fang Liu | 2014 | Cell Research2014，24，6： | 39 |
| 4 | Induction of apoptosis by shikonin through a ROS/JNK-mediated process in Bcr/Abl-positive chronic myelogenous leukemia (CML) cells显示文摘这研究检验了 shikonin 导致的发信号的事件在 Bcr/Abl-positive 导致 apoptosis 的正式就职长期的骨髓内产生的白血病(电流型逻辑) 房间(例如, K562, LAMA84 ) 。有 shikonin 的 K562 细胞的处理(例如, 0.5 M )导致了反应的氧种类( ROS )的快速的产生伴随的 apoptosis 的深刻正式就职,打击 c-Jun-N-terminal kinase ( JNK )和 p38 的激活, mitochondrial 蛋白质细胞色素 c 和 Smac/DIABLO 的显著版本, PARP 的 caspase-9 和-3,和劈开的激活。完全 ROS 清除堵住了所有上述事件(即, apoptosis 的 JNK 和 p38 phosphorylation,细胞色素 c 和 Smac/DIABLO 版本, caspase 和 PARP 劈开,以及正式就职) 后面的 shikonin 处理。JNK 的抑制并且 JNK1 击倒显著地稀释的细胞色素 c 版本, caspase 劈开和 apoptosis,但是没影响调停 shikonin 的 ROS 生产。另外, caspase 激活的抑制完全堵住了导致 shikonin 的 apoptosis,但是有点没修改调停 shikonin 的细胞色素 c 版本或 ROS 产生。总的来说,这些调查结果证明导致 shikonin 的氧化损害在 apoptotic 发信号在一个近似的点操作串联,并且随后激活,并且导致 apoptosis 压力相关的 JNK 小径,扳机 mitochondrial 机能障碍,细胞色素 c 版本,和 caspase 激活。我们的数据也建议 shikonin 可以是为电流型逻辑的处理的一个有希望的代理人,, ROS 的一个发电机。 | Xin Mao Chun Rong Yu Wen Hua Li Wen Xin Li | 2008 | Cell Research2008，18，8： | 31 |
| 5 | The Association of Maternal Body Composition and Dietary Intake with the Risk of Gestational Diabetes Mellitus during the Second Trimester in a Cohort of Chinese Pregnant Women显示文摘Objective To investigate the association of maternal body composition and dietary intake with the risk of gestational diabetes mellitus(GDM). Methods A total 154 GDM subjects and 981 controls were enrolled in a prospective cohort study in 11 hospitals from May 20, 2012 to December 31, 2013. Bioelectrical impedance analysis and dietary surveys were used to determine body composition and to evaluate the intake of nutrients in subjects at 21-24 weeks' gestation(WG). Logistic regression analysis was applied to explore the relationships of maternal body composition and dietary intake with the risk of GDM morbidity. Results Age, pre-pregnant body weight(BW), and body mass index(BMI) were associated with increased risk of GDM. Fat mass(FM), fat mass percentage(FMP), extracellular water(ECW), BMI, BW, energy, protein, fat, and carbohydrates at 21-24 WG were associated with an increased risk of GDM. In contrast, fat free mass(FFM), muscular mass(MM), and intracellular water(ICW) were associated with a decreased risk of GDM. Conclusion Maternal body composition and dietary intake during the second trimester of pregnancy were associated with the risk of GDM morbidity. | Xu Qing Gao Zhi Ying Li Li Ming Wang Lu Zhang Qian Teng Yue Zhao Xia Ge Sheng Jing Hong Jiang Yang Yong Tao Liu Xiao Jun Lyu Chun Jian Mao Lun Yu Xiao Ming Liu Ying Hua Kong Ai Jing Yang Xue Yan Liu Zhao Zhang Yong Wang Jin Zhang Xin Sheng Xue Chang Yong Lu Yan Ping | 2016 | Biomedical and Environmental Sciences2016，29，1： | 29 |
| 6 | Rapid separation and identification of multiple constituents in Danhong Injection by ultra-high performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight tandem mass spectrometry显示文摘To characterize and identify multiple constituents in Danhong injection(DHI), a fast ultra-high performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight tandem mass spectrometry(UHPLC-ESI-QTOF/MS) method was established and validated in the present study. A total of 63 compounds, including 33 phenolic acids, 2 C-glycosyl quinochalcones, 6 flavonoid O-glycosides, 4 iridoid glycosides, 6 organic acids, 5 amino acids, and 3 nucleosides, were identified or tentatively characterized. In conclusion, the UHPLC-ESI-QTOF/MS method is useful and efficient for in-depth structural elucidation of chemical compounds in complex matrices of herbal medicines such as DHI. | ZHANG Qun-Qun DONG Xin LIU Xin-Guang GAO Wen LI Ping YANG Hua | 2016 | Chinese Journal of Natural Medicines2016，14，2： | 30 |
| 7 | Regulation of multidrug resistance by microRNAs in anti-cancer therapy显示文摘Multidrug resistance(MDR) remains a major clinical obstacle to successful cancer treatment.Although diverse mechanisms of MDR have been well elucidated, such as dysregulation of drugs transporters, defects of apoptosis and autophagy machinery, alterations of drug metabolism and drug targets, disrupti on of redox homeostasis, the exact mechanisms of MDR in a specific cancer patient and the cross-talk among these different mechanisms and how they are regulated are poorly understood.Micro RNAs(mi RNAs) are a new class of small noncoding RNAs that could control the global activity of the cell by post-transcriptionally regulating a large variety of target genes and proteins expression.Accumulating evidence shows that mi RNAs play a key regulatory role in MDR through modulating various drug resistant mechanisms mentioned above, thereby holding much promise for developing novel and more effective individualized therapies for cancer treatment. This review summarizes the various MDR mechanisms and mainly focuses on the role of mi RNAs in regulating MDR in cancer treatment. | Xin An Cesar Sarmiento Tao Tan Hua Zhu | 2017 | Acta Pharmaceutica Sinica B2017，7，1： | 29 |
| 8 | Inducing apoptosis and upregulation of Bax and Fas ligand expression by allicin in hepatocellular carcinoma in Balb/c nude mice显示文摘 | ZHANG Zhi-mian ZHONG Ning GAO Hai-qing ZHANG Shang-zhong WEI Yuan XIN Hua MEI Xing HOU Huai-shui LIN Xi-yun SHI Qing | 2006 | Chinese Medical Journal2006，，5： | 24 |
| 9 | Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats显示文摘瞄准:在可勃起的功能和氮的氧化物 synthase (NOS ) 的表达式上调查 icariin 的效果在阉割的老鼠的 isoforms。方法:32 只成年男 Wistar 老鼠随机被划分成一假冒操作组(A) ,三阉割了组(B, C 和 D ) 。在外科以后的一个星期,老鼠与生理盐水(组 A 和 B ) 或口头的 icariin 被对待(1 mg/[kg.day ] 为组 C 和 5 mg/[kg.day ] 为组 D ) 为 4 个星期。一星期术后疗法,老鼠的可勃起的功能被在 cavernosal 神经的电镀物品刺激期间测量 intracavernosal 压力(ICP ) 估计。浆液睾丸激素(圣)层次,在小梁的织物的平滑肌( PSM )的百分比,和 mRNA 的表示和神经元的氮的氧化物 synthase ( nNOS )的蛋白质,可诱导的氮的氧化物 synthase ( i NOS ),内皮的氮的氧化物 synthase ( eNOS )和在阴茎海绵体( CC )的磷酸二酯酶 V ( PDE5 )也被评估。结果:ICP, PSM,圣和 nNOS, i NOS, eNOS 和 PDE5 的表示显著地在组 A (P 0.01 ) 与那些相比在组 B 被减少。然而, ICP, PSM 和 nNOS 和 i NOS 的表示在组 B (P 0.05 ) 与那些相比在组 C 和 D 被增加。在圣和 eNOS 和 PDE5 的表示的变化不是重要的(P 0.05 ) 在组 C 和 D 与那些相比在组 B。结论:有为 4 个星期的 icariin (98.6 % 纯净) 的口头的处理潜在地改进可勃起的功能。这效果随阉割的老鼠的 CC 的 PSM 和某些 NOS 的表示的增加被相关。这些结果建议 icariin 可以在可勃起的机能障碍上有治疗学的效果。 | Wu-Jiang Liu Zhong-Cheng Xin Hua Xin Yi-Ming Yuan Long Tian Ying-Lu Guo | 2005 | Asian Journal of Andrology2005，7，4： | 22 |
| 10 | Paleoproterozoic reworking of ancient crust in the Cathaysia Block,South China:Evidence from zircon trace elements,U-Pb and Lu-Hf isotopes显示文摘A combined study of zircon LA-ICP-MS U-Pb dating, trace elements and Hf isotope was carried out for gneissic granite from the Sanzhishu area in Jingning, SW Zhejiang Province. Nearly all the zircons separated from the granite exhibited oscillatory zoning and high Th/U ratios (>0.1). The REE profile showed a pronounced positive Ce anomaly, negative Eu anomaly and an enrichment of HREE, which are typical characteristics of magmatic zircon. Thirteen concordant or nearly concordant analytical data yielded a weighted mean 207Pb/206Pb age of 1860±13 Ma (MSWD=0.084), representing the formation age of the granite. The magmatic zircons had negative εHf(t) values of -15.6 to -10.0 and two-stage Hf model ages of 3.1 to 3.4 Ga, indicating that the granites were formed by reworking of ancient crust. The major- and trace-element data indicate that the gneissic granites are metaluminous high-K calc-alkaline rocks and exhibit the same geochemical characteristics as aluminous A-type granites, implying the emplacement of the granite in a post-orogenic extensional tectonic setting. We conclude that the Pa-leoproterozoic crustal reworking event in the Cathaysia Block of South China marked the transition from assembly to break-up of the Columbia supercontinent. | LIU Rui ZHOU Han Wen ZHANG Li ZHONG ZengQiu ZENG Wen XIANG Hua JIN Song LU Xin Qian LI ChunZhong | 2009 | Chinese Science Bulletin2009，54，9： | 22 |
| 11 | Ten cities cross-sectional questionnaire survey of children asthma and other allergies in China显示文摘Asthma,rhinitis and eczema(allergic or non-allergic)have increased throughout the world during the last decades,especially among children.Changes in the indoor environment are suspected to be important causes.China has experienced a dramatic change in indoor environmental exposures during the past two decades.However,such changes and their associations with children’s asthma and other health aspects have not been thoroughly studied.China,Children,Homes,Health(CCHH),Phase I,was a cross-sectional questionnaire survey of 48219 children 1–8 years old in 10 Chinese cities during 2010–2012.The questionnaire includes the International Study of Asthma and Allergies in Childhood(ISAAC)core health questions and additional questions regarding housing,life habits and outdoor environment.In health analyses,children aged 3–6 years old were included.The prevalences of doctor diagnosed asthma varied from 1.7%to 9.8%(mean 6.8%),a large increase from 0.91%in 1999 and 1.50%in2000.The prevalence of wheeze,rhinitis and atopic eczema(last 12 months)varied from 13.9%to 23.7%,24.0%to 50.8%and4.8%to 15.8%,respectively.Taiyuan had the lowest prevalences of all illnesses and Shanghai the highest,except for wheezewhere the highest value was for Urumqi.We found(1)no obvious association between disease prevalences and ambient PM10concentrations and(2)higher prevalences of disease in humid climates with hot summers and cold winters,but with no centrally heated buildings.Associations between the diseases and economic status as indexed by Gross Domestic Product(GDP)requires further study. | ZHANG YinPing LI BaiZhan HUANG Chen YANG Xu QIAN Hua DENG QiHong ZHAO ZhuoHui LI AnGui ZHAO JiaNing ZHANG Xin QU Fang HU Yu YANG Qin WANG Juan ZHANG Ming WANG Fang ZHENG XiaoHong LU Chan LIU ZhiJian SUN YueXia MO JinHan ZHAO YiLi LIU Wei WANG TingTing NORBCK Dan BORNEHAG Carl-Gustaf SUNDELL Jan | 2013 | Chinese Science Bulletin2013，58，34： | 22 |
| 12 | miR-20a promotes proliferation and invasion by targeting APP in human ovarian cancer cells显示文摘MicroRNAs (miRNAs ) 作为小调整 RNA 的一个班正在出现,并且 miRNAs 的改变在人的癌症的开始和前进被含有。我们的学习在房间线能压制的 OVCAR3 卵巢的癌症显示出 miR-20a 的那抑制,而 miR-20a 的 overexpression 能提高房间长期的增长和侵略。我们也作为 miR-20a 的直接目标基因证实了淀粉的先锋蛋白质(应用软件) 。而且,应用软件表示的抑制能也支持卵巢的癌症房间增长和侵略,它与 miR-20a overexpression 的结果一致。因此,我们断定应用软件的规定是重要机制让 miR-20a 在卵巢的癌症房间支持增长和侵略。 | Xingxing Fan Yankun Liu Jiechun Jiang Zhuoya Ma Haidong Wu Tao Liu Min Liu Xin Li Hua Tang | 2010 | Acta Biochimica et Biophysica Sinica2010，42，5： | 20 |
| 13 | The cloning of 3'-truncated preS/S gene from HBV genomic DNA and its expression in transgenic mice显示文摘INTRODUCTIONHepatitis B virus (HBV) is regarded as one of themain etiologic factors involved in the developmentof human hepatocellular carcinoma (HCC).The open reading frame (orf)of X gene of HBVencoded a transactivating factor is the evidence thatstrongly supported the notion that the X gene ofHBV DNA integrated in HCC genomic DNA couldcontribute to the carcinogenesis of liver cells byactivation of some related cellular genes | Yi Ping Hu~1 Yu Cheng Yao~1 Jian Xiu Li~1 Xin Min Wang~1 Hong Li~2 Zhong Hua Wang~1 Zhang Heng Lei~3 1 Department of Cell Biology,Second Military Medical University,Shanghai 200433,China 2 Department of Biology,Department of Basic Medicine,West-China University of Medical Sciences,Chengdu 610041,China 3 Department of Biology,North Sichuan Medical College,Nanchong 637007,China | 2000 | World Journal of Gastroenterology2000，6，5： | 18 |
| 14 | Gene therapy for human colorectal carcinoma using human CEA promoter controlled bacterial ADP-ribosylating toxin genes:PEA and DTA gene transfer显示文摘INTRODUCTIONAmajorrequirementforinvivogenetherapyforcanceristotargetthetherapeuticgeneexpresiontomalignanttissuesbyselectingp... | CAO Guang Wen 1, QI Zhong Tian 1, PAN Xin 1, ZHANG Xiao Qin 1, MIAO Xiao Hui 1, FENG Yan 1, LU Xin Hua 1, Shigeki Kuriyama 2 and DU Ping 1 | 1998 | World Journal of Gastroenterology1998，4，5： | 18 |
| 15 | miR-20a targets BNIP2 and contributes chemotherapeutic resistance in colorectal adenocarcinoma SW480 and SW620 cell lines显示文摘化疗是为 colorectal 腺癌癌症的重要治疗;然而, colorectal 腺癌房间经常开发抵抗到化学疗法的药,导致恶化和差的耐心的预后。药抵抗的发展经常是一个 multifactor 过程,它包含了几基因和细胞的机制。microRNAs 是否定地在 post-transcriptional 水平调整基因表示的内长的小非编码的 RNA。在现在的学习,我们在调整 colorectal 腺癌房间 SW620 和 SW480 的药敏感调查了 microRNAs 的可能的角色。使用 microRNA 表达式数组和我们发现了房间展出了的那 SW620 的量的反向的 transcriptase (RT )-PCR, 与 SW480 房间相比提高了 miR-20a 表示。另外,这二房间行显示了不同敏感到化学疗法的药氟尿嘧啶, oxaliplatin,和 teniposide。miR-20a 的调整改变了 SW620 和 SW480 房间的敏感到这些药;miR-20a 击倒敏化的 SW620 房间到化学疗法的代理人,而在 SW480 房间的 miR-20a 的 overexpression 导致了 chemoresistance。内长的 BNIP2 mRNA 和 BNIP2 蛋白质层次是相反地由量的 RT-PCR 和西方的污点分析与是的 miR-20a 层次有关检测了。荧光记者试金显示出在 miR-20a 和 BNIP2 3UTR 之间的一个直接相互作用。一起拿,我们的调查结果建议 miR-20a 可以在 colorectal 腺癌癌症房间药抵抗起一个作用并且可以是对在 colorectal 腺癌的化疗药抵抗的一个治疗学的目标。 | Huijuan Chai Min Liu Ruiqing Tian Xin Li Hua Tang | 2011 | Acta Biochimica et Biophysica Sinica2011，43，3： | 18 |
| 16 | Activation of the PI3K/AKT pathway mediates FSH-stimulated VEGF expression in ovarian serous cystadenocarclnoma显示文摘有证据建议那刺激滤泡的荷尔蒙(FSH ) 能由在癌症细胞增加脉管的 endothelial 生长因素(VEGF ) 表示便于卵巢的癌症的 neovascularization,尽管这个过程的内在的分子的机制不是众所周知的。因此,我们在卵巢的癌症房间线 SKOV-3 和 ES-2 在 VEGF 表示上调查了 FSH 的效果。有 FSH 的治疗显著地在一个剂量依赖者和时间依赖者举止增加了 VEGF 表示。另外, FSH 治疗提高了 survivin 和组织缺氧可诱导的 factor-1 (HIF-1 ) 的表示。survivin 或 HIF-1 击倒压制的 VEGF 表示,但是 survivin 仅仅击倒禁止的刺激 FSH 的 VEGF 表示。有 LY294002 的预告的处理,一个 phosphoinositide 3-kinase (PI3K )/AKT 禁止者,抵销 FSH,而是治疗与 U0126 导致的 survivin 的提高的表示,激活 mitogen 的蛋白质 kinase/extracellular 调整信号的 kinase 禁止者,没有如此的效果。我们进一步证明卵巢的浆液的 cystadenocarcinoma 样品有积极 AKT 和比的染色的 phosphorylated AKT (pAKT ) 蛋白质的许多更高的发生良性的卵巢的 cystadenoma 取样了(p < 0.01 ) 。5 年的幸存率仅仅在有卵巢的浆液的 cystadenocarcinoma 的病人是大约 15% 有 AKT 和 pAKT 表示,而它在没有 AKT 或 pAKT 表示的那些是大约 80% 。一起拿,这些结果显示 FSH 由 upregulating 增加 VEGF 的表示 survivin 的表示,它被发信号的 PI3K/AKT 激活小径。在 survivin 和 VEGF 的刺激 FSH 的表示理解 PI3K/AKT 小径的角色将为与卵巢的浆液的 cystadenocarcinoma 为病人评估预后并且为对这疾病追求有效治疗是有益的。 | Yan Huang Keqin Hua Xianrong Zhou Hongyan Jin Xiaojun Chen Xin Lu Yinhua Yu Xiliang Zha Youji Feng | 2008 | Cell Research2008，18，7： | 17 |
| 17 | Autophagic deficiency is related to steroidogenic decline in aged rat Leydig cells显示文摘迟了发作的性腺机能减退(LOH ) 是仔细与在年老的男性,而是 the 的第二等的雄激素缺乏有关;机制遗体不清楚。在这研究,我们发现在年老的老鼠 Leydig 房间的那减少的睾丸激素生产与减少的 autophagic 活动被联系。主要老鼠 Leydig 房间和 TM3 老鼠 Leydig 房间线被用来在 Leydig 房间睾丸激素生产上学习 autophagic 缺乏的效果。在从小、年老的老鼠的 Leydig 房间,有 wortmannin 的处理,一个 autophagy 禁止者,禁止的 luteinising 荷尔蒙(LH ) 刺激了 steroidogenic 尖锐规章(星) 蛋白质表示和减少的睾丸激素生产。相反,有 rapamycin, autophagy 使活跃之物,在从的 Leydig 房间的提高的刺激 LH 的 steroidogenesis,然而并非幼仔的处理,老鼠。细胞内部的反应的氧种(ROS ) 层次在与 wortmannin 对待,但是仅仅在与 rapamycin 对待的年老的 Leydig 细胞减少了的年轻、年老的 Leydig 细胞被增加。而且, ROS 的增加的水平,由 H 2 O 2, 导致了刺激 LH 的 steroidogenic 抑制。最后, Beclin 1 击倒在 TM3 老鼠 Leydig 房间的减少的刺激 LH 的星表示和睾丸激素生产,它与增加的细胞内部的 ROS 被联系铺平。这些结果建议那 autophagic 缺乏与在年老的老鼠 Leydig 房间的 steroidogenic 衰落有关,它可能被细胞内部的 ROS 层次影响。 | Wei-Ren Li Liang Chen Zhi-Jie Chang Hua Xin Tao Liu Yan-Quan Zhang Guang-Yong Li Feng Zhou Yan-Qing Gong Zhe-Zhu Gao Zhong-Cheng Xin | 2011 | Asian Journal of Andrology2011，13，6： | 17 |
| 18 | Molecular Epidemiological Characteristics of Streptococcus pyogenes Strains Involved in an Outbreak of Scarlet Fever in China,2011显示文摘Objective To investigate molecular characterization of streptococcus pyogenes isolates involved in an outbreak of scarlet fever in China in 2011.Methods Seventy-four Streptococcal pyogenes involved in an outbreak of scarlet fever were isolated from pediatric patients in the areas with high incidence in China from May to August of 2011.Emm genotyping,pulsed-field gel electrophoresis (PFGE),superantigen (SAg) genes and antimicrobial susceptibility profiling were analyzed for these isolates.Results A total of 4 different emm types were identified.Emm12 was the most prevalent type which contained four predominating PFGE patterns corresponding to four different virulence and superantigen profiles.Emm12 (79.7%) and emml (14.9%) accounted for approximately 94%of all the isolates.The speA gene was all negative in emm12 isolates and positive in emml isolates.All strains were resistant to erythromycin,and 89.4%of them were resistant to erythromycin,tracycline,and clindamycin simultaneously.Conclusion Several highly diversified clones with a high macrolide resistance rate comprise a predominant proportion of circulating strains,though no new emm type was found in this outbreak.The data provide a baseline for further surveillance of scarlet fever,which may contribute to the explanation of the outbreak and development of a GAS vaccine in China. | YOU Yuan Hai SONG Yan Yan YAN Xiao Mei WANG Hai Bin ZHANG Meng Han TAO Xiao Xia Li Lei Lei ZHANG Yu Xin JIANG Xi Hong ZHANG Bing Hua ZHOU Hao XIAO Di JIN Lian Mei FENG Zi Jian LUO Feng Ji ZHANG Jian Zhong | 2013 | Biomedical and Environmental Sciences2013，26，11： | 15 |
| 19 | The CAMS Climate System Model and a Basic Evaluation of Its Climatology and Climate Variability Simulation显示文摘A new coupled climate system model(CSM) has been developed at the Chinese Academy of Meteorological Sciences(CAMS) by employing several state-of-the-art component models. The coupled CAMS-CSM consists of the modified atmospheric model [ECmwf-HAMburg(ECHAM5)], ocean model [Modular Ocean Model(MOM4)], sea ice model [Sea Ice Simulator(SIS)], and land surface model [Common Land Model(CoLM)]. A detailed model description is presented and both the pre-industrial and 'historical' simulations are preliminarily evaluated in this study.The model can reproduce the climatological mean states and seasonal cycles of the major climate system quantities,including the sea surface temperature, precipitation, sea ice extent, and the equatorial thermocline. The major climate variability modes are also reasonably captured by the CAMS-CSM, such as the Madden–Julian Oscillation(MJO), El Ni?o–Southern Oscillation(ENSO), East Asian Summer Monsoon(EASM), and Pacific Decadal Oscillation(PDO).The model shows a promising ability to simulate the EASM variability and the ENSO–EASM relationship. Some biases still exist, such as the false double-intertropical convergence zone(ITCZ) in the annual mean precipitation field,the overestimated ENSO amplitude, and the weakened Bjerknes feedback associated with ENSO; and thus the CAMS-CSM needs further improvements. | Xinyao RONG Jian LI Haoming CHEN Yufei XIN Jingzhi SU Lijuan HUA Tianjun ZHOU Yanjun QI Zhengqiu ZHANG Guo ZHANG Jianduo LI | 2018 | Journal of Meteorological Research2018，32，6： | 15 |
| 20 | Molecular chaperones and hypoxic-ischemic encephalopathy显示文摘Hypoxic-ischemic encephalopathy(HIE) is a disease that occurs when the brain is subjected to hypoxia,resulting in neuronal death and neurological deficits,with a poor prognosis.The mechanisms underlying hypoxic-ischemic brain injury include excitatory amino acid release,cellular proteolysis,reactive oxygen species generation,nitric oxide synthesis,and inflammation.The molecular and cellular changes in HIE include protein misfolding,aggregation,and destruction of organelles.The apoptotic pathways activated by ischemia and hypoxia include the mitochondrial pathway,the extrinsic Fas receptor pathway,and the endoplasmic reticulum stress-induced pathway.Numerous treatments for hypoxic-ischemic brain injury caused by HIE have been developed over the last half century.Hypothermia,xenon gas treatment,the use of melatonin and erythropoietin,and hypoxic-ischemic preconditioning have proven effective in HIE patients.Molecular chaperones are proteins ubiquitously present in both prokaryotes and eukaryotes.A large number of molecular chaperones are induced after brain ischemia and hypoxia,among which the heat shock proteins are the most important.Heat shock proteins not only maintain protein homeostasis; they also exert anti-apoptotic effects.Heat shock proteins maintain protein homeostasis by helping to transport proteins to their target destinations,assisting in the proper folding of newly synthesized polypeptides,regulating the degradation of misfolded proteins,inhibiting the aggregation of proteins,and by controlling the refolding of misfolded proteins.In addition,heat shock proteins exert anti-apoptotic effects by interacting with various signaling pathways to block the activation of downstream effectors in numerous apoptotic pathways,including the intrinsic pathway,the endoplasmic reticulum-stress mediated pathway and the extrinsic Fas receptor pathway.Molecular chaperones play a key role in neuroprotection in HIE.In this review,we provide an overview of the mechanisms of HIE and discuss the various treatment strategies.Given their critical role in the disease,molecular chaperones are promising therapeutic targets for HIE. | Cong Hua Wei-na Ju Hang Jin Xin Sun Gang Zhao | 2017 | Neural Regeneration Research2017，12，1： | 15 |
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