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| 1 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 2 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 3 | Structural basis of AMPK regulation by adenine nucleotides and glycogen显示文摘激活安培的蛋白质 kinase (AMPK ) 为糖尿病,肥胖,和癌症的治疗是一个中央细胞的精力传感器和精力动态平衡,和一个有希望的药目标的管理者。这里我们人的 α 的现在的低分辨率的水晶结构; 1 β 2 γ 1 holo-AMPK 建筑群跳了到它的 allosteric 调节的人安培和肝糖模仿 cyclodextrin,两个在 phosphorylated (4.05 Å) 并且 non-phosphorylated (4.60 Å) 状态。另外,我们解决了 2.95 Å人的 kinase 领域(KD ) 的结构跳了到邻近的 autoinhibitory 领域(帮助) 并且表现了广泛生物化学并且 mutational 研究。一起,这些研究由安培和肝糖说明 allosteric AMPK 调整的内在的机制,其绑定改变在交替的帮助(安培) 和糖类绑定模块(肝糖) 之间的 equilibria 相互作用。 | Xiaodan Li Lili Wang X Edward Zhou Jiyuan Ke Parker W de Waal Xin Gu M H Eileen Tan Dongye Wang Donghai Wu H Eric Xu Karsten Melcher | 2015 | Cell Research2015，25，1： | 8 |
| 4 | Prevalence of the Metabolic Syndrome Among Employees in Northeast China显示文摘 | Xin Wang Fang Yang Michiel L Bots Wei.Ying Guo Bing Zhao Arno W Hoes Ilonca Vaartjes | 2015 | Chinese Medical Journal2015，，15： | 6 |
| 5 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 6 | Nomenclature,categorization and usage of formulae to adjust QT interval for heart rate显示文摘Assessment of the QT interval on a standard 12 lead electrocardiogram is of value in the recognition of a number of conditions. A critical part of its use is the adjustment for the effect of heart rate on QT interval. A systematic search was conducted to identify studiesthat proposed formulae to standardize the QT interval by heart rate. A nomenclature was developed for current and subsequent equations based on whether they are corrective(QTc) or predictive(QTp). QTc formulae attempt to separate the dependence of the length of the QT interval from the length of the RR interval. QTp formulae utilize heart rate and the output QTp is compared to the uncorrected QT interval. The nomenclature consists of the first letter of the first author's name followed by the next two consonance(whenever possible) in capital letters; with subscripts in lower case alphabetical letter if the first author develops more than one equation. The single exception was the Framingham equation,because this cohort has developed its own 'name' amongst cardiovascular studies. Equations were further categorized according to whether they were linear,rational,exponential,logarithmic,or power based. Data show that a person's QT interval adjusted for heart rate can vary dramatically with the different QTc and QTp formulae depending on the person's heart rate and QT interval. The differences in the QT interval adjustment equations encompasses values that are considered normal or significant prolonged. To further compare the equations,we considered that the slope of QTc versus heart rate should be zero if there was no correlation between QT and heart rate. Reviewing a sample of 107 patient ECGs from a hospital setting,the rank order of the slope- from best(closest to zero) to worst was QTc DMT,QTc RTHa,QTc HDG,QTc GOT,QTcF RM,QTcF RD,QTcB ZT and QTcM YD. For two recent formulae based on large data sets specifically QTcD MT and QTcR THa,there was no significant deviation of the slope from zero. In summary a nomenclature permits easy reference to QT formulae that adjust for heart rate. Twenty different formulae can produce discordant calculations of an adjusted QT interval. While the formulae developed by Bazett and Fridericia(QTc BZT and QTc FRD respectively) may continue to be used clinically,recent formulae from large population studies specifically QTcD MT and QTcR THa appear to be betterto adjust QT for heart rate in clinical practice. | Simon W Rabkin Xin Bo Cheng | 2015 | World Journal of Cardiology2015，7，6： | 2 |
| 7 | Label-retaining liver cancer cells are relatively resistant to sorafenib显示文摘 | Hong-Wu Xin Chenwi M Ambe Danielle M Hari Gordon W Wiegand Tyler C Miller Jin-Qiu Chen Andrew J Anderson Satyajit Ray John E Mullinax Tomotake Koizumi Russell C Langan Douglas Burka Michelle A Herrmann Paul K Goldsmith Alexander Stojadinovic Udo Rudloff S | 2013 | Gut2013，，12： | 2 |
| 8 | Superhydrophobic silica nanocomposite coating by a low-temperature process显示文摘 | DAOUD W A XIN J H TAO X M | 2004 | Journal of American Ceramic Society2004，87，9： | 1 |
| 9 | Superhydrophobie silica nanocom-poaite coating by a low-temperature proeess显示文摘 | DAOUD W A XIN J H TAO X M | 2004 | Journal of the Ameri-Call Ceramic Socienty2004，87，9： | 1 |
| 10 | Photometric measurements of spring aerosol optical properties in dust and non-dust periods in China 显示文摘 | DU W P XIN J Y WANG M X | 2008 | Atmos Environ2008，42，34： | 1 |
| 11 | Optical and electrical properties of Zn1-xCdxO films grown on Si substrates by reactive radio-frequency magnetron sputtering显示文摘 | Sun C W Xin P Ma C Y | 2006 | Appl Phys Lett2006，89，18： | 1 |
| 12 | Effects of arhuscular mycorrhizal fungi and phosphorus on camptothecin content in Camptotheca acuminata seedlings 显示文摘 | Xin Z Yang W Xiu-feng Y | 2007 | Allelopathy Journal2007，20，1： | 1 |
| 13 | Mechanisms of apoptosis in rat cerebellar granule cells induced by hydroxyl radicals and the effects of EGb761 and its constituents显示文摘 | Xin W Wei T Chen C | 2000 | Toxicology2000，148，23： | 1 |
| 14 | Possible use of ail and foxA polymorphisms fordetecting pathogenic Yersinia enterocolitica 显示文摘 | Ying H Xin W Cui Z | 2010 | BMC Microbiol2010，10，： | 1 |
| 15 | Inhibitory effect of Lycium barbarum polysaccharides on cell apoptosis and senescence is potentially mediated by the p53 signaling pathway 显示文摘 | XIA G XIN N LID W | 2014 | Mol Med Rep2014，9，4： | 1 |
| 16 | Quantitative analysis and health risk assessment of polycyclic aromatic hydrocarbons in edible vegetable oils marketed in Shandong of China显示文摘 | Jiang D Xin C Li W | 2015 | Food Chem Toxicol2015，83，： | 1 |
| 17 | Mechanisms of apoptosls in rat cerebellar granule cells induced by hydroxyl radicals and the effects of EGb761 and its constituents 显示文摘 | Xin W Wei T Chen C | 2000 | Toxicology2000，148，23： | 1 |
| 18 | Combined local ischemic postconditioning and remote perconditioning recapitulate cardioprotective effects of local ischemic preconditioning显示文摘 | Xin P Zhu W Li J | 2010 | Am J Physiol Heart Circ Physiol2010，298，6： | 1 |
| 19 | Proteomic analysis of strawberry leaves infected with Colletotrichum fragariae显示文摘 | Fang X P Chen W Y Xin Y Hengmu Z Chengqi Y Hong Y Hui L Wenfei X Shuzhen W Guizhen Z Hongbo L Liang J Huasheng M Songlin R | 2012 | Journal of proteomics2012，75，： | 1 |
| 20 | Serum BAFF is elevated in patients with IgA nephropathy and associated with clinical and histopathological features显示文摘 | Xin G Shi W Xu LX | | 0，，04： | 1 |
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