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| 1 | Redox-responsive polymer prodrug/AgNPs hybrid nanoparticles for drug delivery显示文摘A drug carrier system of the hybrid nanoparticles based on the redox-responsive P[(2-((2-((camptothecin)-oxy)ethyl)disulfanyl)ethylmethacrylate)-co-(2-(D-galactose)methylmethacryl-ate)](P(MACPTS-co-MAGP)) and AgNPs is developed to deliver the anti-cancer drug camptothecin(CPT) and monitor the drug release by the recovery of the fluorescence of CPT. CPT is linked to the polymer sidechains via a redox-responsive disulfide bond, attaching on the surface of AgNPs and leading to the quenching of CPT fluorescence( 'off' state) due to the nanoparticle surface energy transfer(NSET) effect.Upon the exposure to glutathione(GSH), the disulfide bond is cleaved to release CPT, resulting in the recovery of the fluorescence of CPT('on' state). The system offers a platform to track the CPT delivery and releasing in real | Liang Qiu Linfei Zhao Chengfen Xing Yong Zhan | 2018 | Chinese Chemical Letters2018，29，2： | 6 |
| 2 | Controlling the gelation temperature of biomimetic polyisocyanides显示文摘Thermosensitive polymers show an entropy-driven transition from a well-solvated to a poorly solvated polymer chain, resulting in a more compact globular conformation. The transition at the lower critical solution temperature(LCST) is often sharp, which allows for a wide range of smart material applications.At the LCST, oligo(ethylene glycol)-substituted polyisocyanides(PICs) form soft hydrogels, composed of polymer bundles similar to biological gels, such as actin, fibrin and intermediate filaments. Here, we show that the LCST of PICs strongly depends linearly on the length of the ethylene glycol(EG) tails; every EG group increases the LCSTand thus the gelation temperature by nearly 30 ℃. Using a copolymerisation approach, we demonstrate that we can precisely tailor the gelation temperature between 10 ℃ and 60 ℃and, consequently, tune the mechanical properties of the PIC gels. | Paul H.J. Kouwer Paula de Almeida Onno ven den Boomen Zaskia H. Eksteen-Akeroyd Roel Hammink Maarten Jaspers Stijn Kragt Mathijs F.J. Mabesoone RoelandJ.M. Nolte Alan E. Rowan Martin G.T.A. Rutten Vincent A.A. Le Sage Daniel C. Schoenmakers Chengfen Xing Jialiang xu | 2018 | Chinese Chemical Letters2018，29，2： | 2 |
| 3 | Fluorescence Turn-On Detection of Nitric Oxide in Aqueous Solution Using Cationic Conju-gated Polyelectrolytes显示文摘 | Xing Chengfen Yu Minghui Wang Shu | | 0，，03： | 1 |
| 4 | Conjugated Polymers for Combatting Antimicrobial Resistance显示文摘Antimicrobial resistance(AMR)is one of the major challenges in pathogenic infections,which endangers human health and brings devastating public health threats.Therefore,developing new materials to reduce the over-reliance on antibiotics or to replace antibiotics is in great need to solve this problem.Conjugated polymers(CPs)with excellent light-harvesting properties and good biocompatibility are ideal candidate materials for combat-ting AMR through photodynamic antimicrobial therapy(PACT)by sensitizing oxygen and photothermal therapy(PTT)by light to heat conversion.Sig-nificant works of CPs-based antimicrobial approaches have been reported in recent years.Herein,we summarize the types of CPs-based antimicrobial materials,illustrate their antimicrobial mechanisms,and discuss their applications in combating AMR mainly by PACT or antimicrobial PTT.In addi-tion,we proposed some other antimicrobial treatment strategies based on CPs,hoping to provide inspiring insight for overcoming AMR. | Zijuan Wang Hao Geng Chenyao Nie Chengfen Xing | 2022 | Chinese Journal of Chemistry2022，40，6： | 1 |
| 5 | Strategies for Inhibition and Disaggregation of Amyloid-β Fibrillation显示文摘Comprehensive Summary Amyloid-β protein(Aβ)is a fatal cause of Alzheimer's disease,which can trigger a series of cytotoxicity by the abnormal aggregation of Aβ in human brain.The strategies for inhibition and disaggregation of Aβ fibrillation are mostly based on the interaction between monomers,oligomers,fibrils,and materials. | Hao Geng Dong Gao Zijuan Wang Xiaoning Liu Zhanshuo Cao Chengfen Xing | 2022 | Chinese Journal of Chemistry2022，40，4： | 0 |
| 6 | Functional molecular materials显示文摘Molecular materials,together with metals,ceramics,and polymer materials,are among the most important materials.The research efforts on molecular materials are targeting three main aspects,namely the assembly technique,multi-functionality,and their diverse application.In this regard,the main attention from the community is focused on the identification | Jialiang Xu Chengfen Xing Xian-He Bu | 2018 | Chinese Chemical Letters2018，29，2： | 0 |
| 7 | Carbon dioxide-controlled assembly based on conjugated polymer and boron nitride显示文摘C02-controlled assembly of conjugated polymer and boron nitride(BN)was fabricated via electrostatic and hydrophobic interactions between the BN fiber and conjugated polymer of PFBT containing fluorene units and 2,1,3-benzothiadiazole units.C02,an effective and green stimulus for regulating the assembly of PFBT and BN fibers,leads to an obvious fluorescence variation.Moreover,PFBT enables the assembly with the signal amplification and light-harvesting properties.This work provides a new triggering method to construct intelligent conjugated polymer-based platform,and offers fluorescence monitoring strategy for carbon dioxide capture. | Bo Wang Chengfen Xing Dong Gao Hongbo Yuan Liang Qiu Xue Yang Yang Huang Yong Zhan | 2020 | Chinese Chemical Letters2020，31，1： | 0 |
| 8 | CO2/NIR light dual-controlled nanoparticles for dsDNA unzipping显示文摘Both of carbon dioxide(CO2)and near-infrared(NIR)light as triggers for non-invasive remotely control are attracting wide attentions due to their good biocompatibility and easy operation.Here,CO2/NIR light dual controlled nanoparticles are proposed to remotely regulate the unzipping of dsDNA by using imidazole functionalized conjugated polymer nanoparticles(imidazole-CPNs).The dsDNA successfully coats on the shell of imidazole-CPNs to form imidazole-CPNs/dsDNA assembly due to intensively electrostatic interaction triggered by CO2.Furthermore,the unzipping process of dsDNA is remotely controlled by NIR light based on the photothermal effect,and it can be readily monitored by the fluorescence intensity of ethidium bromide(EB)and CD spectra of dsDNA.Thus,dual stimulation responsive imidazole-CPNs effectively control dsDNA unzipping under CO2 stimulus and NIR light,promising a new direction in the biological applications of DNA,such as the treatments of diseases caused by gene duplication abnormality. | Yanjing Wang Hongbo Yuan Dawei Li Chengfen Xing | 2020 | Chinese Chemical Letters2020，31，1： | 0 |
| 9 | Side Chain Functional Conjugated Porous Polymers for NIR Controlled Carbon Dioxide Adsorption and Release显示文摘Conjugated porous polymers exhibit considerable advantage as attractive candidate for carbon dioxide(CO_(2)) capture. However, the regeneration of the CO_(2) still faces the problem of high energy cost. Here we synthesize a near-infrared region(NIR) light responsive conjugated porous polymer(PDPP-Gu) [DPP=3,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione] by constructing porous amorphous networks with a side chain engineering strategy to regulate CO_(2) adsorption and release through photothermal conversion. The PDPP-Gu is featured by a torsional conjugated backbone as well as a functional side chain of guanidino group. The donor-acceptor configuration of PDPP-Gu afforded strong absorption in the NIR and an excellent photothermal conversion capability of up to 48.8%, as well as a high surface energy. Moreover, guanidine modified side chain further enhanced the CO_(2)-polymers interactions, resulting in a high CO_(2) selective adsorption capacity(0.8 mmol/g) at 273 K, 1 bar(1 bar=105 Pa). The adsorbed CO_(2) can be released under NIR light irradiation. This strategy of molecule design combined the dual features of photothermal conversion and gas adsorption, which is beneficial for the development of materials to dynamically control the adsorption and release of CO_(2) through NIR light. | CHEN Liquan LI Dawei REN Jinghan LI Yameng GAO Dong XING Chengfen | 2022 | Chemical Research in Chinese Universities2022，38，6： | 0 |
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