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| 1 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 2 | Efficient generation of mice carrying homozygous double-floxp alleles using the Cas9-Avidin/Biotin-donor DNA system显示文摘 | Ming Ma Fengfeng Zhuang Xiongbing Hu Bolun Wang Xian-Zi Wen Jia-Fu Ji Jianzhong Jeff Xi | 2017 | Cell Research2017，27，4： | 7 |
| 3 | Design and Analysis ofa Re-configurable Parallel Robot 显示文摘 | Xi Fengfeng XU Younan Xiong Guoliang | 2006 | Mechanism and Machine Theory2006，41，： | 1 |
| 4 | Static Balancing of Parallel Robots 显示文摘 | RUSSO Andrea SINATRA Rosario XI Fengfeng | 2005 | Mechanism and Machine Theory2005，40，2： | 1 |
| 5 | Design and analysis of a re - configurable parallel robot 显示文摘 | Fengfeng Xi Younan Xu C uoliang Xiong | 2006 | Mechanism and Machine Theory2006，，41： | 1 |
| 6 | Static balancing of parallel robots显示文摘 | Andrea Russo Rosario Sinatra Fengfeng Xi | 2005 | Mechanism and Machine Theory2005，2，： | 1 |
| 7 | Volatile fingerprints and biomarkers of Chinese fragrant and non-fragrant japonica rice before and after cooking obtained by untargeted GC/MS-based metabolomics显示文摘China has a rich resource of fragrant japonica rice that is gaining increasing consumers’ interests.In the present study,an untargeted gas chromatography-mass spectrometry-based metabolomics was employed to investigate the volatile profile of Chinese fragrant and non-fragrant japonica varieties.Partial least square discriminative analysis (PLS-DA) along with univariate analysis was taken to seek specific markers in raw and cooked Chinese japonica rice distinguishing fragrant and non-fragrant varieties.Volatile profile of raw Chinese japonica rice dominated by alkanes was completely different from that of cooked rice predominated by aldehydes.Thirteen and eleven volatile compounds were selected as the potential discriminative markers in raw and cooked Chinese japonica rice,respectively.Only 2-acetylpyrrole and decanal served as the specific marker in both raw and cooked Chinese japonica rice.Fragrant Chinese japonica rice varieties contained more 2-acetylpyrrole,(E )-2-octenal,nonanal,1-tetradecene,decanal and (E )-2-decenal in raw rice.While fragrant Chinese japonica rice varieties contained more 2-acetyl-1-pyrroline,2-acetylpyrrole,1-hexanol,decanal and indole in cooked rice.The results provided an in-depth understanding of volatile variation in raw and cooked form of aromatic and non-aromatic cultivars and will benefit rice adulteration identification and marker-assisted flavor breeding in the future. | Qiyan Zhao Jinzhong Xi Xueming Xu Yun Yin Dan Xu Yamei Jin Qunyi Tong Li Dong Fengfeng Wu | 2022 | Food Bioscience2022，47，3： | 1 |
| 8 | Analysis of Dig- itizing Errors of a Laser Scanning System 显示文摘 | His-Yung Feng Yixin Liu Fengfeng Xi | 2001 | Journal of the International Societies for Precision Engineering and Nanotechnology2001，25，： | 1 |
| 9 | Analysis of parallel kinematic machine with kinetostaticmodelling method 显示文摘 | Zhang Dan Xi Fengfeng Chris M M | 2004 | Robotics and Computer-lntegrated Manufacturing2004，20，2： | 1 |
| 10 | Analysis of digitizing errors of a laser scanning system显示文摘 | Feng His-Yung Liu Yixin Xi Fengfeng | 2001 | Precision Engineering2001，25，： | 1 |
| 11 | Staticbalancing of parallel robots显示文摘 | Russo Andrea Sinatra Rosario Xi Fengfeng | 2005 | Mechanism and MachineTheory2005，40，2： | 1 |
| 12 | A Shape Adaptive Motion Control System with Application to Robotic Polishing显示文摘 | Zhiwei Yang Fengfeng Xi Bin Wu | 2005 | Robotics and Computer-Integrated Manufacturing2005，，21： | 1 |
| 13 | Optimal module selection for preliminary design of reconfigurable machine tools 显示文摘 | Chen Li Xi Fengfeng Macwan Ashish | 2005 | ASME Journal of Manufacturing Science and Engineering2005，127，1： | 1 |
| 14 | A parallel robotic attachment and its remote manipulation显示文摘 | Wang Lihui Xi Fengfeng Zhang Dan | 2006 | Robotics and Computer- Integrated Manufacturing2006，22，56： | 1 |
| 15 | Static Balancing of Parallel Robots显示文摘 | RUSSO Andrea SINATRA Rosario XI Fengfeng | 2005 | Mechanism and Machine Theory2005，40，2： | 1 |
| 16 | A tolerance method for industrial image-based inspection显示文摘 | Haibin Jia Fengfeng (Jeff) Xi Ahmad Ghasempoor Amer Dawoud | 2009 | The International Journal of Advanced Manufacturing Technology (-)2009，，11： | 1 |
| 17 | Integrating Java 3D model and sensor date for remote monitoring and control显示文摘 | Wang Lihui Sams Ryan Verner Marcel Xi Fengfeng | 2003 | Robotics and Computer Integrated Manufacturing2003，，19： | 1 |
| 18 | A Shape Adaptive MotionControl System with Application to Robotic Polishing 显示文摘 | Yang Zhiwei Xi Fengfeng Wu Bin | 2005 | Roboticsand Computer~Integrated Manufacturing2005，，21： | 1 |
| 19 | Modeling and control of automated polishing/deburring process using a dual-purpose compliant toolhead显示文摘 | LIAO Liang XI Fengfeng LIU Kefu | 2008 | International Journal of Machine Tools & Manufacture2008，48，： | 1 |
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