|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Transcriptomic landscape regulated by the 14 types of bone morphogenetic proteins(BMPs)in lineage commitment and differentiation of mesenchymal stem cells(MSCs)显示文摘Mesenchymal stem cells(MSCs)are ubiquitously-existing multipotent progenitors that can self-renew and differentiate into multiple lineages including osteocytes,chondrocytes,adipocytes,tenocytes and myocytes.MSCs represent one of the most commonly-used adult progenitors and serve as excellent progenitor cell models for investigating lineagespecific differentiation regulated by various cellular signaling pathways,such as bone morphogenetic proteins(BMPs).As members of TGFb superfamily,BMPs play diverse and important roles in development and adult tissues.At least 14 BMPs have been identified in mammals.Different BMPs exert distinct but overlapping biological functions.Through a comprehensive analysis of 14 BMPs in MSCs,we demonstrated that BMP9 is one of the most potent BMPs in inducing osteogenic differentiation of MSCs.Nonetheless,a global mechanistic view of BMP signaling in regulating the proliferation and differentiation of MSCs remains to be fully elucidated.Here,we conducted a comprehensive transcriptomic profiling in the MSCs stimulated by 14 types of BMPs.Hierarchical clustering analysis classifies 14 BMPs into three subclusters:an osteo/chondrogenic/adipogenic cluster,a tenogenic cluster,and BMP3 cluster.We also demonstrate that six BMPs(e.g.,BMP2,BMP3,BMP4,BMP7,BMP8,and BMP9)can induce ISmads effectively,while BMP2,BMP3,BMP4,BMP7,and BMP11 up-regulate Smad-independent MAP kinase pathway.Furthermore,we show that many BMPs can upregulate the expression of the signal mediators of Wnt,Notch and PI3K/AKT/mTOR pathways.While the reported transcriptomic changes need to be further validated,our expression profiling represents the first-of-its-kind to interrogate a comprehensive transcriptomic landscape regulated by the 14 types of BMPs in MSCs. | Linghuan Zhang Qing Luo Yi Shu Zongyue Zeng Bo Huang Yixiao Feng Bo Zhang Xi Wang Yan Lei Zhenyu Ye Ling Zhao Daigui Cao Lijuan Yang Xian Chen Bin Liu William Wagstaff Russell R*Reid Hue H*Luu Rex C*Haydon Michael J*Lee Jennifer Moriatis Wolf Zhou Fu Tong-Chuan He Quan Kang | 2019 | Genes & Diseases2019，6，3： | 11 |
| 2 | Evidence that wakefulness and REM sleep are controlled by a GABAergic pontine mechanism 显示文摘 | XI M C MORALES F R CHASE M H | 1999 | J Neurophysiol1999，82，4： | 1 |
| 3 | The effects of neutron irradiation on the oxygen precipitation in Czochralski-silicon, 显示文摘 | LI Y XI GUO H Y LIU B D LIU T J HAO Q Y LIU C C YANG D R QUE D L | 2003 | J Cryst Growth2003，253，： | 1 |
| 4 | Expression of survivin and livin predicts early recurrence in non-muscle invasive bladder cancer显示文摘 | Xi R C Sheng Y R Chen W H | 2013 | J Surg Oncol2013，107，5： | 1 |
| 5 | Investigation of nanographite/polyurethane electroconductive adhesives:Preparation and characterization显示文摘 | XI X R YU C S LIN W | 2009 | Journal of Adhesion Science and Technology2009，23，15： | 1 |
| 6 | Research of silver plating nano- graphite filled conductive adhesive显示文摘 | Lin W Xi X R Yu C S | 2009 | Synthetic Metals2009，159，78： | 1 |
| 7 | 显示文摘 | Lin W Xi X R Yu C S | 2009 | Synthetic Metals2009，159，： | 1 |
| 8 | Research of silver plating nanographite filled conductive adhesive 显示文摘 | LIN W XI X R YU C S | 2009 | Synthetic Metals2009，159，： | 1 |
| 9 | Transient waves in plates of functionally graded materials显示文摘 | Han X Liu G R Xi Z C Lam K Y | 2001 | International Journal for Numerical Methods in Engineering2001，52，： | 1 |
| 10 | Research of silver plating nano-graphite filled conductive adhesive显示文摘 | Lin W Xi X R Yu C S | 2009 | Synthetic Metals2009，159，78： | 1 |
| 11 | A combination of molecular markers accurately detects lymph node metastasis in non-small cell lung cancer patients显示文摘 | XI Liqiang COELLO M C LITLE V R | 2006 | Clinical Cancer Re- search: an Official Journal of the American Association for Cancer Research2006，12，8： | 1 |
| 12 | Transient waves in a functionally graded cylinder显示文摘 | Han X Liu G R Xi Z C | 2001 | International Journal of Solids and Structures2001，38，17： | 1 |
| 13 | Synthesis and characteristics of nanocrystalline YSZ powder by polyethylene glycol assisted coprecipitati- on combined with a zeotropic-distillation process and its electrical conductivity 显示文摘 | Yao H C Wang Xi W Dong H Pei R R Wang J S Li Z J | 2011 | Ceramics International2011，37，2： | 1 |
| 14 | From sheets to fibers:a novel approach to γ-AIOOH and γ-Al2O3 1D nano structures显示文摘 | Zhang M Zhang R Xi G C | 2006 | J Nanosci Nanotechnol2006，6，5： | 1 |
| 15 | The histone deacetylase inhibitor suberoylanilide hydroxamic acid induces apoptosis via induction of 15-lipoxygenase-1 in colorectal cancer cells 显示文摘 | His L C Xi X P Lotan R | 2004 | Cancer Res2004，64，23： | 1 |
| 16 | Emission ability of La-Sc-Mo cathode 显示文摘 | YANG J C N IE Z R XI X L | 2004 | Applied Surface Science2004，229，1： | 1 |
| 17 | Transient waves in a functionally graded cylinder显示文摘 | Han X Liu G R Xi Z C Lam K Y | 2001 | International Journal of Solids and Structures2001，38，17： | 1 |
| 18 | A comparison between Chinese and Caucasian head shapes 显示文摘 | Ball R Shu C Xi P C | 2010 | Applied Ergonomics2010，41，6： | 1 |
| 19 | A comparison between Chinese and Caucasian head shapes 显示文摘 | Ball R Shu C Xi P | 2010 | Applied Ergonomics2010，41，6： | 1 |
| 20 | Characteristics of Waves in a Functionally Graded Cylinder显示文摘 | Han X Liu G R Xi Z C | 2002 | International Journal for Numerical Methods in Engineering2002，53，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员