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| 1 | The δ^(18)O variation of a stalagmite from Qixing Cave,Guizhou Province and indi-cated climate change during the Holocene显示文摘A stalagmite from Qixing Cave, Guizhou Province was dated with the TIMS U-series method and its oxygen isotope composition was analyzed. On the basis of the ages and the variations of the δ18O of the stalagmite, the climate change of the last 7.7 ka has been reconstructed in this area: 7.7-5.8 ka, summer monsoon maximum period; 5.8-3.8 ka summer monsoon weakening period; 3.8-0.15 ka, weakened summer monsoon and high amplitude climate fluctuations period. We put forward that the increasing trend of δ18O of the stalagmite reflected not only the weakening of the summer monsoon, which was caused by the decreasing of solar radiation in the Northern Hemisphere, but also the possibly decreasing contribution of the southwest monsoon to the rainfall of this area. These results are consistent with the output of the numerical climate-model modeling. The high amplitude fluctuation of the δ18O may imply the quick shift of the contributions of different moisture sources to the precipitation in this area. | CAI Yanjun, ZHANG Meiliang, PENG Zicheng, LIN Yushi, AN Zhisheng, ZHANG Zhaofeng & CAO YunningState Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710054, China Karst Dynamics Laboratory, Ministry of Land and Resources, Guilin 541003, China Department of Earth and Space Science, University of Science & Technology of China, Hefei 230023, China | 2001 | Chinese Science Bulletin2001，46，22： | 18 |
| 2 | Air route network optimization in fragmented airspace based on cellular automata显示文摘Air route network optimization,one of the essential parts of the airspace planning,is an effective way to optimize airspace resources,increase airspace capacity,and alleviate air traffic congestion.However,little has been done on the optimization of air route network in the fragmented airspace caused by prohibited,restricted,and dangerous areas(PRDs).In this paper,an air route network optimization model is developed with the total operational cost as the objective function while airspace restriction,air route network capacity,and non-straight-line factors(NSLF) are taken as major constraints.A square grid cellular space,Moore neighbors,a fixed boundary,together with a set of rules for solving the route network optimization model are designed based on cellular automata.The empirical traffic of airports with the largest traffic volume in each of the 9 flight information regions in China's Mainland is collected as the origin-destination(OD) airport pair demands.Based on traffic patterns,the model generates 35 air routes which successfully avoids 144 PRDs.Compared with the current air route network structure,the number of nodes decreases by 41.67%,while the total length of flight segments and air routes drop by 32.03% and 5.82% respectively.The NSLF decreases by 5.82% with changes in the total length of the air route network.More importantly,the total operational cost of the whole network decreases by 6.22%.The computational results show the potential benefits of the model and the advantage of the algorithm.Optimization of air route network can significantly reduce operational cost while ensuring operation safety. | Shijin WANG Xi CAO Haiyun LI Qingyun LI Xu HANG Yanjun WANG | 2017 | Chinese Journal of Aeronautics2017，30，3： | 16 |
| 3 | PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress显示文摘One of the physiological functions of cellular prion protein(PrP C )is believed to work as a cellular resistance to oxidative stress,in which the octarepeats region within PrP plays an important role.However,the detailed mechanism is less clear.In this study,the expressing plasmids of wild-type PrP (PrP-PG5)and various PrP mutants containing 0(PrP-PG0),9(PrP-PG9)and 12(PrP-PG12)octarepeats were generated and PrP proteins were expressed both in E.coli and in mammalian cells.Protein aggregation and formation of carbonyl groups were clearly seen in the recombinant PrPs expressed from E.coli after treatment of H2O2.MTT and trypan blue staining assays revealed that the cells expressing the mutated PrPs within octarepeats are less viable than the cells expressing wild-type PrP.Statistically significant high levels of intracellular free radicals and low levels of glutathione peroxidase were observed in the cells transfected with plasmids containing deleted or inserted octarepeats.Remarkably more productions of carbonyl groups were detected in the cells expressing PrPs with deleted and inserted octarepeats after exposing to H2O2.Furthermore,cells expressing wild-type PrP showed stronger resistant activity to the challenge of H2O2 at certain extent than the mutated PrPs and mock. These data provided the evidences that the octarepeats number within PrP is critical for maintaining its activity of antioxidation.Loss of its protective function against oxidative stress may be one of the possible pathways for the mutated PrPs to involve in the pathogenesis of familial Creutzfeldt-Jacob diseases. | AN Run1 ,2,DONG ChenFang 2,LEI YanJun 1,2,HAN Lu 2,LI Ping 2,CHEN JianMing 2,WANG GuiRong 2, SHI Qi 2 ,GAO Chen 2 ,JIANG HuiYing 2 ,ZHOU Wei 2 ,HAN Jun 2 ,CHU YongLie 1 ,DONG XiaoPing 2 1School of Medicine,Xi’an JiaoTong University,Xi’an 710061,China 2State Key Laboratory for Infectious Disease Prevention and Control,National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention,YingXin Rd 100,Beijing 100052,China | 2008 | Science China(Life Sciences)2008，51，7： | 3 |
| 4 | Smartphone-powered iontophoresis-microneedle array patch for controlled transdermal delivery显示文摘The incidence rate of diabetes has been increasing every year in nearly all nations and regions.The traditional control of diabetes using transdermal insulin delivery by metal needles is generally associated with pain and potential infections.While microneedle arrays(MAs)have emerged as painless delivery techniques,the integration of MA systems with electronic devices to precisely control drug delivery has rarely been realized.In this study,we developed an iontophoresis-microneedle array patch(IMAP)powered by a portable smartphone for the active and controllable transdermal delivery of insulin.The IMAP in situ integrates iontophoresis and charged nanovesicles into one patch,achieving a one-step drug administration strategy of“penetration,diffusion and iontophoresis”.The MA of the IMAP is first pressed on the skin to create microholes and then is retracted,followed by the iontophoresis delivery of insulin-loaded nanovesicles through these microholes in an electrically controlled manner.This method has synergistically and remarkably enhanced controlled insulin delivery.The amount of insulin can be effectively regulated by the IMAP by applying different current intensities.This in vivo study has demonstrated that the IMAP effectively delivers insulin and produces robust hypoglycemic effects in a type-1 diabetic rat model,with more advanced controllability and efficiency than delivery by a pristine microneedle or iontophoresis.The IMAP system shows high potential for diabetes therapy and the capacity to provide active as well as long-term glycemic regulation without medical staff care. | Jingbo Yang Yanjun Li Rui Ye Ying Zheng Xiangling Li Yuzhen Chen Xi Xie Lelun Jiang | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 5 | The impact of lipids on the cancer—immunity cycle and strategies for modulating lipid metabolism to improve cancer immunotherapy显示文摘Lipids have been found to modulate tumor biology,including proliferation,survival,and metastasis.With the new understanding of tumor immune escape that has developed in recent years,the influence of lipids on the cancer—immunity cycle has also been gradually discovered.First,regarding antigen presentation,cholesterol prevents tumor antigens from being identified by antigen presenting cells.Fatty acids reduce the expression of major histocompatibility complex class I and costimulatory factors in dendritic cells,impairing antigen presentation to T cells.Prostaglandin E2(PGE2)reduce the accumulation of tumor-infiltrating dendritic cells.Regarding T-cell priming and activation,cholesterol destroys the structure of the T-cell receptor and reduces immunodetection.In contrast,cholesterol also promotes T-cell receptor clustering and relative signal transduction.PGE2 represses T-cell proliferation.Finally,regarding T-cell killing of cancer cells,PGE2 and cholesterol weaken granule-dependent cytotoxicity.Moreover,fatty acids,cholesterol,and PGE2 can improve the activity of immunosuppressive cells,increase the expression of immune checkpoints and promote the secretion of immunosuppressive cytokines.Given the regulatory role of lipids in the cancer—immunity cycle,drugs that modulate fatty acids,cholesterol and PGE2 have been envisioned as effective way in restoring antitumor immunity and synergizing with immunotherapy.These strategies have been studied in both preclinical and clinical studies. | Mingming Zheng Wenxin Zhang Xi Chen Hongjie Guo Honghai Wu Yanjun Xu Qiaojun He Ling Ding Bo Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，4： | 1 |
| 6 | Characterisation of SnO2 - COO- MnO- Nb20 Ceramics显示文摘 | Fan J Jiwei Zhao huijun Xi Yanjun | 2010 | Journal of the European Ceramic Society2010，30，2： | 1 |
| 7 | Hot corrosion and oxidation behavior of TiAlCrAg coating 显示文摘 | Xi Yanjun Wang Fuhui He Lianlong | 2004 | Materials Science Forum2004，，： | 1 |
| 8 | A turn-on fluorescent chemosensor for Cu 2+ in aqueous media and its application to bioimaging显示文摘 | Liang Huang Fengjuan Chen Pinxian Xi Guoqiang Xie Zhengpeng Li Yanjun Shi Min Xu Hongyan Liu Zhaorong Ma DeCheng Bai ZhengZhi Zeng | 2011 | Dyes and Pigments2011，，3： | 1 |
| 9 | The regulatory roles of DDIT4 in TDCIPP-induced autophagy and apoptosis in PC12 cells显示文摘Tris(1,3-dichloro-2-propyl) phosphate(TDCIPP) is a commonly used organophosphatebased flame retardant and can bio-accumulate in human tissues and organs. As its structure is similar to that of neurotoxic organophosphate pesticides, the neurotoxicity of TDCIPP has raised widespread concerns. TDCIPP can increase neuronal apoptosis and induce autophagy.However, its regulatory mechanism remains unclear. In this study, we found that the expression upregulation of the DNA Damage-Inducible Transcript 4(DDIT4) protein, which might play essential roles in TDCIPP-induced neuronal autophagy and apoptosis, was observed in TDCIPP-treated differentiated rat PC12 cells. Furthermore, we determined the protective effect of the DDIT4 suppression on the autophagy and apoptosis induced by TDCIPP using Western blot(WB) and Flow cytometry(FACS) analysis. We observed that TDCIPP treatment increased the DDIT4, the autophagy marker Beclin-1, and the microtubule-associated protein light chain 3-II(LC_(3)II) expressions and decreased the mTOR phosphorylation levels. Conversely, the suppression of DDIT4 expression increased the p-mTOR expression and decreased cell autophagy and apoptosis. Collectively, our results revealed the function of DDIT4 in cell death mechanisms triggered by TDCIPP through the m TOR signaling axis in differentiated PC12 cells. Thus, this study provided vital evidence necessary to explain the mechanism of TDCIPP-induced neurotoxicity in differentiated PC12 cells. | Li Li Lingyi Xi JinWu Zunquan Zhao Youliang Chen Weili Liu Zhihui Pan Mingzhu Liu Danfeng Yang Zhaoli Chen Yanjun Fang | 2023 | Journal of Environmental Sciences2023，，3： | 0 |
| 10 | Study on Changes of Industrial Structure and Its Ecological Environment Benefit in Shaanxi Province显示文摘[Objective] To reduce influences of adjustment of regional industrial structure on ecological environment,promote coordinated development of regional economy and ecological environment,and improve the relationship between human beings and natural environment. [Method]Based on the statistical data of Shaanxi Province during 1978- 2013,the ecological environmental impact index and effect index of industrial structure in Shaanxi Province were calculated,and then the ecological environment benefit of changes in industrial structure in Shaanxi Province from1978 to 2013 was assessed quantitatively. [Result]The impact of changes in industrial structure on ecological environment in Shaanxi Province was moderate,but later changes in industrial structure had greater influences on ecological environment than before. [Conclusion]Industrial structure in Shaanxi Province should be optimized further to ensure the healthy development of ecological environment. | Wen Yanjun Liu Xi Zhai Yaqian | 2016 | Meteorological and Environmental Research2016，7，5： | 0 |
| 11 | Author correction to‘Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA'[Acta Pharmaceutica Sinica B 13(2023)2585-2600]显示文摘The authors regret that one author was missed in the author list when preparing the manuscript,while the foundation to him was mentioned in the section of Acknowledgments.Dr.Qinjie Weng should be added to the author list because of his contribution in animal study and his foundation help us to complete this study.The authors sincerely apologize for any inconvenience caused to the journal and readers. | Wenxin Zhang Xiaohui Pan Yanjun Xu Hongjie Guo Mingming Zheng Xi Chen Honghai Wu Fengming Luan Qiaojun He Ling Ding Bo Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，10： | 0 |
| 12 | Mevalonate improves anti-PD-1/PD-L1 efficacy by stabilizing CD274 mRNA显示文摘Mevalonate metabolism plays an important role in regulating tumor growth and progression;however,its role in immune evasion and immune checkpoint modulation remains unclear.Here,we found that non-small cell lung cancer(NSCLC)patients with higher plasma mevalonate response better to antiPD-(L)1 therapy,as indicated by prolonged progression-free survival and overall survival.Plasma mevalonate levels were positively correlated with programmed death ligand-1(PD-L1)expression in tumor tissues.In NSCLC cell lines and patient-derived cells,supplementation of mevalonate significantly upregulated the expression of PD-L1,whereas deprivation of mevalonate reduced PD-L1 expression.Mevalonate increased CD274 mRNA level but did not affect CD274 transcription.Further,we confirmed that mevalonate improved CD274 mRNA stability.Mevalonate promoted the affinity of the AU-rich elementbinding protein HuR to the 3'-UTR regions of CD274 mRNA and thereby stabilized CD274 mRNA.By in vivo study,we further confirmed that mevalonate addition enhanced the anti-tumor effect of anti-PD-L1,increased the infiltration of CD8^(+)T cells,and improved cytotoxic function of T cells.Collectively,our findings discovered plasma mevalonate levels positively correlated with the therapeutic efficacy of anti-PD-(L)1 antibody,and provided the evidence that mevalonate supplementation could be an immunosensitizer in NSCLC. | Wenxin Zhang Xiaohui Pan Yanjun Xu Hongjie Guo Mingming Zheng Xi Chen Honghai Wu Fengming Luan Qiaojun He Ling Ding Bo Yang | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 0 |
| 13 | Combination of Silica Sol and Potassium Silicate via Isothermal Heat Conduction Microcalorimetry显示文摘等温的热传导 microcalorimetry 作为一个新奇描述方法被利用当硅石大音阶的第五音和钾硅酸盐的联合在 25.0 的温度被搅动时,与热力学、运动的参数调查硅石的聚合过程, 35.0 ,吗并且 45.0 桴?湩整?祤?楤瑳湡散?湯琠敨漠楲慧業戠潬正?桴??獲整?慲楤獵删‰潣汵?楤敲瑣祬戠?敤整浲湩摥映潲?桴?楤瑳湡散搠灥湥敤据?景攠敮杲?牴湡晳牥礠敩摬湩?げ?? | Tian Hebao Zhang Chaocan Liu Peng Li Xi Wu Lili Chen Yanjun | 2011 | Chinese Journal of Chemistry2011，29，2： | 0 |
| 14 | APPLICATION OF NONLINEAR PID CONTROLLER IN AERODYNAMICS LOADING SYSTEM显示文摘The design idea of tracking-differentiator and the nonlinear PID controllerare introduced, the applicable algorithm and its real result for distributed aerodynamicsloading control system are discussed, and the construction of the test & contro1 system arealso presented. The application shows that the nonlinear PID algorithm has the advan-tages of high reliability, short run time and strong stability. | Hu Fei Cai Xiaobin Li Yanjun(Department of Computer Science, Northwesternm PolytechnicalUniversity, Xi’an, 710072, China) | 1997 | Chinese Journal of Aeronautics1997，10，2： | 0 |
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