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| 1 | Enhanced rectification, transport property and photocurrent generation of multilayer ReSe2/MoS2 p-n heterojunctions显示文摘 | Xiaoting Wang Le Huang Yuting Peng Nengjie Huo Kedi Wu Congxin Xia Zhongming Wei Sefaattin Tongay Jingbo Li | 2016 | Nano Research2016，9，2： | 16 |
| 2 | Effect of electroacupuncture on chemotherapy-induced peripheral neuropathy in patients with malignant tumor:a single-blinded,randomized controlled trial显示文摘OBJECTIVE:To evaluate the effect of electroacupuncture on chemotherapy-induced peripheral neuropathy(CIPN), quality of life and immune status of patients with malignant tumors.METHODS:From Jan, 2013 to May, 2014, 37 patients with malignant tumors were included in this prospective single-blinded study, and randomized to receive either electroacupuncture or acupuncture treatment on basis of chemotherapy.The chemotherapy was continued for 2 courses as previous before the treatments, with 21 days as a course of treatment.Patients received acupuncture and electroacupuncture once per day starting at the day before chemotherapy for consecutive 7 days followed by 14 days off, with 21 days as a course of treatment, and continued for two courses of treatment.Then CIPN, traditional Chinese clinical symptoms,quality of life and immune status were all evaluated for each patient prior treatment and after two courses of treatment.RESULTS:The gender, age, cancer species as well as incidence(83.3% vs 84.2%) and grades of CIPN before treatments were all similar in patients receiving acupuncture or electroacupuncture(all P >0.05).After treatments, most patients with peripheral neuropathy were cured by two courses of electroacupuncture(84.2% vs 21.1%), whereas the other group of patients had similar incidences of peripheral neuropathy compared with prior-acupuncture(83.3% vs 72.2%).Besides, patients receiving electroacupuncture had lower incidence of peripheral neuropathy than those receiving acupuncture treatment(χ~2= 9.745, P = 0.002).The grades of peripheral neuropathy were significantly different in the two groups post-treatment(χ~2= 13.983, P =0.007).The total effective rates for traditional Chinese clinical symptoms were 16.7% and 84.2% in acupuncture and electroacupuncture groups, respectively(Z =-4.239, P < 0.001).The electroacupuncture treatment provided a more satisfactory life for patients compared with acupuncture(Z =-4.76, P < 0.001).Both electroacupuncture and acupuncture had no effects on immune function.CONCLUSION:Electroacupuncture could alleviate CIPN, and improve traditional Chinese clinical symptoms and quality of life, but did not affect immune function. | Zhang Shiqiang Wu Tingting Zhang Haisheng Yang Yun Jiang Haiyan Cao Shengcheng Xie Fang Xia Xiaoting Lü Junqiang Zhong Yi | 2017 | Journal of Traditional Chinese Medicine2017，37，2： | 7 |
| 3 | Production and characterization of exopolysaccharides in mycelial culture of Cordyceps sinensis fungus Cs-HK1 with different carbon sources显示文摘The effects of different carbon sources(sugars) on the production and molecular properties of exopolysaccharides(EPS) were evaluated in the mycelial liquid culture of a medicinal fungus Cordyceps sinensis Cs-HK1. Galactose or mannose was used(at 5 g·L^(-1)) as a secondary carbon source with glucose(35 g·L^(-1)) at the mass ratio of 1:7. Mannose was consumed notably since the first day of culture, but galactose was not even after glucose was exhausted.The volumetric yield of EPS in culture was increased slightly with the addition of galactose and decreased with mannose. The monosaccharide composition of EPS was also different, e.g., on day 8, the glucose contents of EPS were 76%with the addition of mannose, 59% with galactose, compared with 62% with glucose only. The molecular weight distribution of EPS was also affected by the secondary carbon source, being generally lower compared with that with glucose only. The results suggested that the addition of galactose improved the total yield of EPS in culture while mannose can improve the yield of glucan constituent of EPS. | Xia Chen Jian-yong Wu Xiaoting Gui | 2016 | Chinese Journal of Chemical Engineering2016，24，1： | 4 |
| 4 | Serum semaphorin 4C as a diagnostic biomarker in breast cancer:A multicenter retrospective study显示文摘Background:To date,there is no approved blood-based biomarker for breast cancer detection.Herein,we aimed to assess semaphorin 4C(SEMA4C),a pivotal protein involved in breast cancer progression,as a serum diagnostic biomarker.Methods:We included 6,213 consecutive inpatients from Tongji Hospital,Qilu Hospital,and Hubei Cancer Hospital.Training cohort and two validation cohorts were introduced for diagnostic exploration and validation.A pan-cancer cohort was used to independently explore the diagnostic potential of SEMA4C among solid tumors.Breast cancer patients who underwent mass excision prior to modified radical mastectomy were also analyzed.We hypothesized that increased pretreatment serum SEMA4C levels,measured using optimized in-house enzymelinked immunosorbent assay kits,could detect breast cancer.The endpoints were diagnostic performance,including area under the receiver operating characteristic curve(AUC),sensitivity,and specificity.Post-surgery pathological diagnosis was the reference standard and breast cancer staging followed the TNM classification.There was no restriction on disease stage for eligibilities.Results:We included 2667 inpatients with breast lesions,2378 patients with other solid tumors,and 1168 healthy participants.Specifically,118 patients with breast cancer were diagnosed with stage 0(5.71%),620 with stage I(30.00%),966 with stage II(46.73%),217 with stage III(10.50%),and 8 with stage IV(0.39%).Patients with breast cancer had significantly higher serum SEMA4C levels than benign breast tumor patients and normal controls(P<0.001).Elevated serum SEMA4C levels had AUC of 0.920(95%confidence interval[CI]:0.900–0.941)and 0.932(95%CI:0.911–0.953)for breast cancer detection in the two validation cohorts.The AUCs for detecting early-stage breast cancer(n=366)and ductal carcinoma in situ(n=85)were 0.931(95%CI:0.916–0.946)and 0.879(95%CI:0.832–0.925),respectively.Serum SEMA4C levels significantly decreased after surgery,and the reduction was more striking after modified radical mastectomy,compared with mass excision(P<0.001).The positive rate of enhanced serum SEMA4C levels was 84.77%for breast cancer and below 20.75%for the other 14 solid tumors.Conclusions:Serum SEMA4C demonstrated promising potential as a candidate biomarker for breast cancer diagnosis.However,validation in prospective settings and by other study groups is warranted. | Ya Wang Long Qiao Jie Yang Xiong Li Yaqi Duan Jiahao Liu Shaoqi Chen Huayi Li Dan Liu Tian Fang Jingjing Ma Xiaoting Li Fei Ye Junxiang Wan Juncheng Wei Qin Xu Ensong Guo Ping Jin Mingfu Wu Lin Zhang Yun Xia Yaqun Wu Jun Shao Yaojun Feng Qing Zhang Zongyuan Yang Gang Chen Qinghua Zhang Xingrui Li Shixuan Wang Junbo Hu Xiaoyun Wang Mona P.Tan Kazuaki Takabe Beihua Kong Qifeng Yang Ding Ma Qinglei Gao | 2021 | Cancer Communications2021，41，12： | 3 |
| 5 | Early inoculation with caecal fermentation broth alters small intestine morphology,gene expression of tight junction proteins in the ileum,and the caecal metabolomic profiling of broilers显示文摘Background:The establishment of stable microbiota in early life is beneficial to the individual.Changes in the intestinal environment during early life play a crucial role in modulating the gut microbiota.Therefore,early intervention to change the intestinal environment can be regarded as a new regulation strategy for the growth and health of poultry.However,the effects of intestinal environmental changes on host physiology and metabolism are rarely reported.This study was conducted to investigate the effects of early inoculation with caecal fermentation broth on small intestine morphology,gene expression of tight junction proteins in the ileum,and cecum microbial metabolism of broilers.Results:Our data showed that early inoculation with caecal fermentation broth could improve intestine morphology.The small intestine villus height was significantly increased(P<0.05)in the intervened broilers compared to the control group,especially on day 28.A similar result was observed in the ratio of villus height to crypt depth(P<0.05).Meanwhile,we found early inoculation significantly increased(P<0.05)the expression levels of zonula occludens-1(ZO1)on days 14 and 28,claudin-1(CLDN1)on day 28,whereas the gene expression of claudin-2(CLDN2)was significantly decreased(P<0.05)on days 14 and 28.Gas chromatography time-of-flight/mass spectrometry(GC-TOF/MS)technology was further implemented to systematically evaluate the microbial metabolite profiles.Principal component analysis(PCA)and orthogonal partial least squares discriminant analysis(OPLS-DA)displayed a distinct trend towards separation between the fermentation broth group(F group)and the control group(C group).The differentially expressed metabolites were identified,and they were mainly functionally enriched in beta-alanine metabolism and biosynthesis of unsaturated fatty acids.In addition,1,3-diaminopropane was selected as a key biomarker that responded to early inoculation with caecal fermentation broth.Conclusions:These results provide insight into intestinal metabolomics and confirm that early inoculation with caecal fermentation broth can be used as a potential strategy to improve intestinal health of broilers. | Yujie Gong Wenrui Xia Xueting Wen Wentao Lyu Yingping Xiao Hua Yang Xiaoting Zou | 2020 | Journal of Animal Science and Biotechnology2020，11，2： | 3 |
| 6 | Herbal formula of Bushen Jianpi(补肾健脾方)combined with sorafenib inhibits hepatocellular carcinoma growth by promoting cell apoptosis and blocking the cell cycle显示文摘OBJECTIVE:To investigate the efficacy of an herbal formula of Bushen Jianpi(补肾健脾方,BSJP)combined with sorafenib on hepatocellular carcinoma(HCC)in vitro and in vivo,and to study the underlying mechanisms of action.METHODS:BSJP,a mixture of 12 raw herbs,was extracted in 70%alcohol/30%water and freeze-dried into a powder.The in vitro effects of BSJP alone,sorafenib alone,and their combination on cell survival,apoptosis,and cell cycle distribution were evaluated in HCC cell lines HCCLM3,HepG2,and SMMC-7721.The expression of B-cell lymphoma-2(Bcl-2),caspase-3,and caspase-9 in HCCLM3 cells was measured using Western blots after drug administration.The in vivo effects of BSJP and sorafenib were evaluated in a tumor surgical resection model using 4-week old male athymic BALB/c nude mice injected with HCCLM3 cells.Immunohistochemical analysis of tumor tissues was performed to evaluate the effects of BSJP alone,sorafenib alone,and their combination on the expression of caspase-3,caspase-9,and Bcl-2.RESULTS:BSJP decreased the survival rate of HCC cell lines,and the combination of BSJP and sorafenib further decreased the survival rate.BSJP significantly promoted cell apoptosis and blocked cell-cycle progression in HCCLM3,HepG2,and SMMC-7721 cells in a dose-dependent manner.Furthermore,the administration of BSJP and sorafenib inhibited the growth of HCCLM3 cell xenografts in nude mice,with no reduction in body weight.In vivo and in vitro experiments showed that BSJP combined with sorafenib could significantly decrease the expression of Bcl-2.CONCLUSION:Our findings suggest that the herbal formula of BSJP is a potential HCC antitumor agent. | ZHOU Zhangjie LIU Xinhua WU Tingting QUE Zujue WU Zhonghua WU Weizhong FU Shujuan ZHANG Shiqiang YANG Yun JIANG Haiyan XIA Xiaoting LV Junqiang DU Boqian LI Yun LU Tao ZHANG Zhihui ZHONG Yi | 2021 | Journal of Traditional Chinese Medicine2021，41，2： | 3 |
| 7 | New process development and process evaluation for capturing CO2 in flue gas from power plants using ionic liquid[emim][Tf2N]显示文摘Using the ionic liquid[emim][Tf2N]as a physical solvent,it was found by Aspen Plus simulation that it was possible to attempt to capture CO2 from the flue gas discharged from the coal-fired unit of the power plant.Using the combination of model calculation and experimental determination,the density,isostatic heat capacity,viscosity,vapor pressure,thermal conductivity,surface tension and solubility of[emim][Tf2N]were obtained.Based on the NRTL model,the Henry coefficient and NRTL binary interaction parameters of CO2 dissolved in[emim][Tf2N]were obtained by correlating[emim][Tf2N]with the gas–liquid equilibrium data of CO2.Firstly,the calculated relevant data is imported into Aspen Plus,and the whole process model of the ionic liquid absorption process is established.Then the absorption process is optimized according to the temperature distribution in the absorption tower to obtain a new absorption process.Finally,the density,constant pressure heat capacity,surface tension,thermal conductivity,and viscosity of[emim][Tf2N]were changed to investigate the effect of ionic liquid properties on process energy consumption,solvent circulation and heat exchanger design.The results showed that based on the composition of the inlet gas stream to the absorbers,CO2 with a capture rate of 90%and a mass purity higher than 99.5%was captured.These results indicate that the[emim][Tf2N]could be used as a physical solvent for CO2 capture from coal-fired units.In addition,the results will provide a theoretical basis for the design of new ionic liquids for CO2 capture. | Lan Li Xiaoting Huang Quanda Jiang Luyue Xia Jiawei Wang Ning Ai | 2020 | Chinese Journal of Chemical Engineering2020，28，3： | 2 |
| 8 | Color rendering and luminous efficacy of trichromatic and tetrachromatic LED-based white LED 显示文摘 | Zhang Lei Guo Xia Liang Ting Gu Xiaoting Lin QiaoMing Shen Guangdi | 2007 | Microelectronics Journal2007，，1： | 1 |
| 9 | Flexible Large-Area Graphene Films of 50-600 nm Thickness with High Carrier Mobility显示文摘Bulk graphene nanofilms feature fast electronic and phonon transport in combination with strong light-matter interaction and thus have great potential for versatile applications,spanning from photonic,electronic,and optoelectronic devices to charge-stripping and electromagnetic shielding,etc.However,large-area flexible close-stacked graphene nanofilms with a wide thickness range have yet to be reported.Here,we report a polyacrylonitrile-assisted’substrate replacement’strategy to fabricate large-area free-standing graphene oxide/polyacrylonitrile nanofilms(lateral size~20 cm).Linear polyacrylonitrile chains-derived nanochannels promote the escape of gases and enable macro-assembled graphene nanofilms(nMAGs)of 50-600 nm thickness following heat treatment at 3,000℃.The uniform nMAGs exhibit 802-1,540 cm^(2)V-1s-1carrier mobility,4.3-4.7 ps carrier lifetime,and>1,581 W m^(-1)K^(-1)thermal conductivity(n MAG-assembled 10μm-thick films,mMAGs).nMAGs are highly flexible and show no structure damage even after 1.0×10^(5)cycles of folding-unfolding.Furthermore,n MAGs broaden the detection region of graphene/silicon heterojunction from near-infrared to mid-infrared and demonstrate higher absolute electromagnetic interference(EMI)shielding effectiveness than state-of-the-art EMI materials of the same thickness.These results are expected to lead to the broad applications of such bulk nanofilms,especially as micro/nanoelectronic and optoelectronic platforms. | Shiyu Luo Li Peng Yangsu Xie Xiaoxue Cao Xiao Wang Xiaoting Liu Tingting Chen Zhanpo Han Peidong Fan Haiyan Sun Ying Shen Fan Guo Yuxing Xia Kaiwen Li Xin Ming Chao Gao | 2023 | Nano-Micro Letters2023，15，5： | 1 |
| 10 | Assessment of causal effects of physical activity on neurodegenerative diseases:A Mendelian randomization study显示文摘Background:Physical activity has been hypothesized to play a protective role in neurodegenerative diseases.However,effect estimates previously derived from observational studies were prone to confounding or reverse causation.Methods:We performed a two-sample Mendelian randomization(MR)analysis to explore the causal association of accelerometer-measured physical activity with 3 common neurodegenerative diseases:Alzheimer’s disease(AD),Parkinson’s disease(PD),and amyotrophic lateral sclerosis(ALS).We selected genetic instrumental variants reaching genome-wide significance(p<5×10^(-8))from 2 largest meta-analyses of about 91,100 UK Biobank participants.Summary statistics for AD,PD,and ALS were retrieved from the up-to-date studies in European ancestry led by the international consortia.The random-effect,inverse-variance weighted MR was employed as the primary method,while MR pleiotropy residual sum and outlier(MR-PRESSO),weighted median,and MR-Egger were implemented as sensitivity tests.All statistical analyses were performed using the R programming language(Version 3.6.1;R Foundation for Statistical Computing,Vienna,Austria).Results:Primary MR analysis and replication analysis utilized 5 and 8 instrumental variables,which explained 0.2%and 0.4%variance in physical activity,respectively.In each set,one variant at 17q21 was significantly associated with PD,and MR sensitivity analyses indicated them it as an outlier and source of heterogeneity and pleiotropy.Primary results with the removal of outlier variants suggested odds ratios(ORs)of neurodegenerative diseases per unit increase in objectively measured physical activity were 1.52 for AD(95%confidence interval(95%CI):0.88-2.63,p=0.13)and 3.35 for PD(95%CI:1.32-8.48,p=0.01),while inconsistent results were shown in the replication set for AD(OR=1.06,95%CI:1.01-1.12,p=0.02)and PD(OR=0.99,95%CI:0.88-0.12,p=0.97).Similarly,the beneficial effect of physical activity on ALS(OR=0.51,95%CI:0.29-0.91,p=0.02)was not confirmed in the replication analysis(OR=0.96,95%CI:0.91-1.02,p=0.22).Conclusion:Genetically predicted physical activity was not robustly associated with risk of neurodegenerative disorders.Triangulating evidence across other studies is necessary in order to elucidate whether enhancing physical activity is an effective approach in preventing the onset of AD,PD,or ALS. | Peng-Fei Wu Hui Lu Xiaoting Zhou Xuchen Liang Ruizhuo Li Wan Zhang Danyang Li Kun Xia | 2021 | Journal of Sport and Health Science2021，10，4： | 0 |
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