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| 1 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 2 | Abiogenic hydrocarbons in commercial gases from the Songliao Basin,China显示文摘This paper discusses the kinetic fractionation, composition and distribution characteristics of carbon and hydrogen isotopes for various alkane gases formed in different environments, by different mecha- nisms and from different sources in nature. It is demonstrated that the biodegradation or thermode- gradation of complex high-molecule sedimentary organic material can form microbial gas or thermogenic gas. The δ 13C1 value ranges from -110‰ to -50‰ for microbial gases but from -50‰ to -35‰ (even heavier) for thermogenic gases. Controlled by the kinetic isotope fractionation, both microbial and thermogenic gases have δ 13C and δ D values characterized by normal distribution, i.e. δ 13C1< δ 13C2< δ 13C3< δ 13C4 and δ DCH4< δ DC2H6< δ DC3H8<δ DC4H10, and by a positive correlation between the δ 13C and δ D values. Simple carbonbearing molecules (CH4, CO and CO2) can form abiogenic alkane gases via polymerization in the abiological chemical process in nature, with δ 13C1 heavier than -30‰. Moreover, controlled by the kinetic isotope fractionation, abiogenic alkane gases are characterized by a reverse distribution of δ 13C values and a normal trend of δ D values, namely δ 13C1> δ 13C2> δ 13C3> δ 13C4 and δ DCH4<δ DC2H6< δ DC3H8< δ DC4H10. The δ 13C values and δ D values are negatively correlated. Natural gases from 26 commercial gas wells distributed in the Xujiaweizi and Yingshan-Miaotaizi faulted depressions in the Songliao Basin, China, show δ13C1 values ranging from -30.5‰ to -16.7‰ with a very narrow δ D range between -203‰―-196‰. These gases are characterized by a reverse distribution of δ 13C values but a normal distribution of δ D values, and a negative correlation between their δ 13C and δ D values, indicating an abiological origin. The present study has revealed that abiogenic hydrocarbons not only exist in nature but also can make significant contribution to commercial gas reserviors. It is estimated that the reserve volume of alkane gases with abiogenic characteristics in these 26 gas wells in the Songliao Basin is over 500×108 m3. The prospecting practice in the Songliao Basin has demonstrated that abiogenic alkane gases are of a promising resource, and it provides an example for the investigation of and search for abiogenic commercial natural gases worldwide. | WANG XianBin GUO ZhanQian TUO JinCai GUO HongYan LI ZhenXi ZHUO ShengGuang JIANG HongLiang ZENG LongWei ZHANG MingJie WANG LianSheng LIU ChunXue YAN Hong LI LiWu ZHOU XiaoFeng WANG YongLi YANG Hui WANG Guang | 2009 | Science China Earth Sciences2009，52，2： | 6 |
| 3 | A New Curve Fitting Method for Forming Limit Experimental Data显示文摘The forming limit curve (FLC) can be obtained by. means of curve fitting the limit strain points of different strain paths. The theory of percent regression analysis is applied to the curve fitting of forming limit experimental data.Forecast intervals of FLC percentiles can be calculated. Thus reliability and confidence level can be considered. The theoretical method to get the limits of limit strain points distributing region is presented, and the FLC position can be adjusted according to practical requirement. Method for establishing FLC with high reliability using small samples is presented at the same time. This method can make full use of the current experimental data and the previous data.Compared with the traditional method that can only use current experimental data, fewer specimens are required in the present method to obtain the same precision and the result is more accurate with the same number of specimens. | Jieshi CHEN Xianbin ZHOU | 2005 | Journal of Materials Science & Technology2005，21，4： | 3 |
| 4 | Bioresponsive nanotherapy for preventing dental caries by inhibiting multispecies cariogenic biofilms显示文摘Early childhood caries(ECC)is a public healthcare concern that greatly reduces the quality of life of young children.As a leading factor of ECC,cariogenic biofilms are composed of acidogenic/aciduric pathogens and extracellular polysaccharides(EPSs),creating an acidic and protected microenvironment.Antimicrobial photodynamic therapy(aPDT)is a noninvasive,painless,and efficient therapeutic approach that is suitable for treating ECC.However,due to the hyperfine structure of cariogenic biofilms,most photosensitizers(PSs)could not access and penetrate deeply in biofilms,which dramatically hamper their efficiency in the clinic.Herein,bioresponsive nanoparticle loaded with chlorin e6(MPP-Ce6)is developed,which largely increases the penetration depth(by over 75%)and retention(by over 100%)of PS in the biofilm compared with free Ce6.Furthermore,MPP-Ce6-mediated aPDT not only kills the bacteria in preformed biofilms but also inhibits multispecies biofilm formation.A rampant caries model is established to mimic ECC in vivo,where the population of cariogenic bacteria is decreased to 10%after MPP-Ce6-mediated aPDT.Importantly,the number and severity of carious lesions are efficiently reduced via Keyes’scoring and micro-CT analysis.This simple but effective strategy can serve as a promising approach for daily oral hygiene in preventing ECC. | Danfeng Liu Xianbin Ma Yaoting Ji Rourong Chen Shuhui Zhou Hantao Yao Zichen Zhang Mengjie Ye Zhigang Xu Minquan Du | 2022 | Bioactive Materials2022，7，8： | 2 |
| 5 | The solution to boundary- value problems arising in high accuracy panel reflector fabrication 显示文摘 | Hao Changling Zhou Xianbin | 2009 | Chinese Journal of Aeronautics2009，22，3： | 1 |
| 6 | Efficient Removal of Lead from Washing Effluent of Lead-contaminated Soil with Garlic Peel显示文摘 | CHEN Xing YIN Lipu ZHOU Hongyu LIU Junyou LI Xiaohui AI Xianbin HUANG Kai | 2018 | Chemical Research in Chinese Universities2018，34，6： | 1 |
| 7 | Numerical Analysis of Hydroforming Deep Drawing of Conical Cup显示文摘Aided by the FE-code. analysis is carried to find the proper hydroforming deep-drawing condition for the perfect forming of a conical cup that can not be drawn successfully by conventional deep drawing method. Hydraulic counter pressure must be reasonably controlled, otherwise defects such as fracture and wrinkling can not be avoided. Therefore, the forming procedure is divided into three stages, and the counter pressure is adjusted intentionally to make the blank clamped onto the punch at a suitable time, then deformation at dangerous area is resisted by the effect of the counter pressure and the conical cup can be formed without defects. | Yongming KONG Xianbin ZHOU and Min LI Research Center of Sheet Metal Forming, School of Mechanical Engineering & Automation, Beijing University of Aeronautics & Astronautics, Beijing 100083, China | 2001 | Journal of Materials Science & Technology2001，17，1： | 1 |
| 8 | Immunotoxicity of Hydrocortisone on Th1/Th2-Related Cytokine Production Is Associated with Yang-Deficient State in Traditional Chinese Medicine显示文摘Steroid hormone serving as an immunosuppressor often induces immunotoxicity when administered in highest dosage or accumulated in long-term usage. The stage of high concentration of steroid hormone leading to a wide range of symptoms is associated to the yang-deficient state,which is the part of yin-yang imbalance involved in processes of many diseases in traditional Chinese medicine. Here we intend to investigate the profile of Th1/Th2-related cytokine transcriptions under yang-deficient conditions in a yang-deficient animal model by intramuscular injection of hydrocortisone (a kind of steroid hormone). The yang-deficient symptoms were estimated by detecting activity,appetite,body weight and so on. T cell proliferation and cytokine transcriptions were analyzed. The results showed that yang-deficient mice were established successfully since typical yang-deficient symptoms were observed in this model with decreased activities,appetite,body weight and temperature. More interestingly,the transcriptions of IFN-γ,IL-2,IL-4 and IL-10 in this model were markedly suppressed and the proliferation of lymphocytes significantly decreased as well. The results suggested that yang-deficient symptoms were related to the steroid-induced reduction of cytokine transcription and impairment of lymphocyte proliferation. Therefore,novel strategies through regulating cytokine production might be considered as potent approach to patients with yang-deficiency symptoms. | Chengfang Yao Li Wang Jian Zhang Xianbin Zhou Cai Zhang | 2007 | Cellular & Molecular Immunology2007，4，5： | 1 |
| 9 | Inner wall running state monitoring for the main pipe of nuclear power显示文摘The heat conduction equation is solved in this paper under specific boundary conditions.The coefficients of the obtained distribution equation are simplified with the piecewise integral method.Then the associated model for the cylindrical thermal equipment is established.The relationship of the surface temperatures,the material properties and the inner wall state of the cylindrical thermal equipment is described in the associated model.This model is applied to the inner wall running state monitoring of the main pipe.A multi-channel distributed optical fiber temperature measurement system is designed to acquire the external surface temperatures of the main pipe.Then the associated model can be used to analyze the surface temperature data of the main pipe.The location and the physical dimension of the inner wall defect can be got.Therefore,the inner wall defect monitoring of the main pipe can be realized.The feasibility of this method is verified by experiment.This method also provides a theoretical basis for the real-time monitoring of the main pipe’s internal state. | ZHANG YuCun ZHOU Shan FU XianBin | 2013 | Science China(Technological Sciences)2013，56，10： | 1 |
| 10 | 甲羟戊酸通路是疫苗佐剂研发的可药化靶点显示文摘文章简介佐剂是疫苗的一部分,能帮助疫苗更快速、持久地产生免疫应答。在现代疫苗的研发中,佐剂有着不可或缺的作用。但是到目前为止,FDA批准上市的佐剂只有铝佐剂,MF-59,AS03以及AS04等几种。 | 夏贇 谢永华 于正森 Hongying Xiao Guimei Jiang Xiaoying Zhou Yunyun Yang Xin Li Meng Zhao Liping Li Mingke Zheng Shuai Han Zhaoyun Zong Xianbin Meng Haiteng Deng Huahu Ye Yunzhi Fa Haitao Wu Eric Oldfield Xiaoyu Hu 刘万里 石彦 张永辉 | 2019 | 科学新闻2019，0，2： | 0 |
| 11 | A Preliminary Study of Embedded Supervision Thoughts:Based on a Distributed Financial System显示文摘Regulation of technology has been a hot issue in the financial field in recent years.Traditional financial regulation is constructed by a centralized account system,which relies on ex-ante regulation.Embedded supervision,which relies on regulation during and after the matter,operates in a decentralized and trusted environment and has the characteristics of high efficiency,transparency,and safety.It provides a breakthrough to solve the lag of traditional financial supervision.This paper clarifies the concepts and theoretical basis of embedded supervision,constructs the embedded supervision model with a lag,and analyzes the feasibility of embedded supervision with a lag.This research can promote scientific exploration and method innovations in the domestic finance field,enrich China’s financial discipline system,and provide decision-making references for practical financial supervision innovation. | Wu Xiangyi Du Kunlun Tang Zhou Li Xianbin | 2022 | Contemporary Social Sciences2022，7，2： | 0 |
| 12 | Service Function Chain Migration in LEO Satellite Networks显示文摘With the advancements of software defined network(SDN)and network function virtualization(NFV),service function chain(SFC)placement becomes a crucial enabler for flexible resource scheduling in low earth orbit(LEO)satellite networks.While due to the scarcity of bandwidth resources and dynamic topology of LEO satellites,the static SFC placement schemes may cause performance degradation,resource waste and even service failure.In this paper,we consider migration and establish an online migration model,especially considering the dynamic topology.Given the scarcity of bandwidth resources,the model aims to maximize the total number of accepted SFCs while incurring as little bandwidth cost of SFC transmission and migration as possible.Due to its NP-hardness,we propose a heuristic minimized dynamic SFC migration(MDSM)algorithm that only triggers the migration procedure when new SFCs are rejected.Simulation results demonstrate that MDSM achieves a performance close to the upper bound with lower complexity. | Geng Yuhui Wang Niwei Chen Xi Xu Xiaofan Zhou Changsheng Yang Junyi Xiao Zhenyu Cao Xianbin | 2024 | China Communications2024，21，3： | 0 |
| 13 | Inspired heat shock protein alleviating prodrug enforces immunogenic photodynamic therapy by eliciting pyroptosis显示文摘Despite immunotherapy involving immune checkpoint inhibitors(ICIs)have revolutionized cancer therapy,the clinical efficacy is limited due to ICI resistance.Pyroptosis is a gasdermin-mediated programmed cell death that enhances responses to ICIs.However,nontargeted elicitation of pyroptosis may induce systemic side effects and toxicity.Therefore,we reasonably design and construct a tumor-specific prodrug that combines the heat shock protein 90 inhibitor tanespimycin(17-AAG)with the photosensitizer chlorin e6(Ce6)to induce pyroptosis,by utilizing the high glutathione level in the tumor microenvironment.The released Ce6 and 17-AAG produce reactive oxygen species by laser triggering,which induces gasdermin E-mediated pyroptosis.Furthermore,17-AAG reduces myeloid-derived suppressor cells and sensitizes tumors to anti-programmed death^(-1)(PD-1)therapy.Thus,our prodrug strategy achieves tumor-targeted pyroptosis to suppress tumor growth,thereby improving the response to anti-PD-1 therapy and extending the survival of 4T1 breast tumor-bearing mice.Consequently,this pyroptosis-based prodrug represents a novel strategy for enforcing immunogenic photodynamic therapy. | Junjie Zhou Xianbin Ma Hao Li Derun Chen Liang Mao Leilei Yang Tian Zhang Wei Qiu Zhigang Xu Zhi-Jun Sun | 2022 | Nano Research2022，15，4： | 0 |
| 14 | SpectrumChain:a disruptive dynamic spectrum-sharing framework for 6G显示文摘The sixth-generation(6G)wireless network will support ubiquitous connectivity and diversified scenarios to satisfy the requirements of various emerging applications.Full spectrum is a key enabler for 6G to achieve the ambitious goal of a Tbps-scale data rate.In this paper,we first review the scenario and potential spectrum plan for 6G and then focus on SpectrumChain,a blockchain-based dynamic spectrumsharing(DSS)framework for 6G.The unique characteristics of blockchain for DSS are presented along with key technologies.Finally,the conclusion and future development trends are discussed. | Qihui WU Wei WANG Zuguang LI Bo ZHOU Yang HUANG Xianbin WANG | 2023 | Science China(Information Sciences)2023，66，3： | 0 |
| 15 | Hydrophobic Small-Molecule Polymers as High-Temperature-Resistant Inhibitors in Water-Based Drilling Fluids显示文摘Water-based drilling fluids can cause hydration of the wellbore rocks,thereby leading to instability.This study aimed to synthesize a hydrophobic small-molecule polymer(HLMP)as an inhibitor to suppress mud shale hydration.An infrared spectral method and a thermogravimetric technique were used to characterize the chemical composition of the HLMP and evaluate its heat stability.Experiments were conducted to measure the linear swelling,rolling recovery rate,and bentonite inhibition rate and evaluate accordingly the inhibition performance of the HLMP.Moreover,the HLMP was characterized through measurements of the zeta potential,particle size distribution,contact angles,and interlayer space testing.As confirmed by the results,the HLMP could successfully be synthesized with a favorable heat stability.Furthermore,favorable results were found for the inhibitory processes of the HLMP on swelling and dispersed hydration during mud shale hydration.The positively charged HLMP could be electrically neutralized with clay particles,thereby inhibiting diffusion in the double electron clay layers.The hydrophobic group in the HLMP molecular structure resulted in the formation of a hydrophobic membrane on the rock surface,enhancing the hydrophobicity of the rock.In addition,the small molecules of the HLMP could plug the spaces between the layers of bentonite crystals,thereby reducing the entry of water molecules and inhibiting shale hydration. | Xuyang Yao Kecheng Liu Zenan Zhou Jun Zhou Xianbin Huang Tiemei Lu Yongsheng Yu He Li | 2023 | Fluid Dynamics & Materials Processing2023，19，7： | 0 |
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