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| 1 | Preparation of microencapsulatedα-olefin drag reducing polymer used in oil pipeline transportation显示文摘包含油拖减少聚合物粒子的 Microcapsules 被融化散布准备并且聚乙烯蜡压缩,在原处脲和甲醛的聚合,和苯乙烯的界面的聚合分别地。相关过程被一个分子的动力学模拟方法学习,并且 microcapsule 隔离代理人的分子的设计根据模拟被执行。为准备 microencapsulated 油拖减少聚合物粒子的技术被比较并且发行量拖减少 microencapsulated 聚合物粒子的效率基于描述结果和他们的溶解性质被评估。一个 microcapsule 隔离代理人的分子的设计建议石蜡聚合物粒子能被使用能阻止石蜡聚合物粒子的凝块的长链的烷基钠盐表面活化剂稳定地在水里驱散。吸附的模拟的结果处理烷基钠盐表面活化剂的数量能直接影响的表演 microencapsulated 石蜡聚合物粒子的稳定性。并且一定有它的最小的批评数量。在由与不同的壳材料扫描电子显微镜学( SEM )和静态的压力稳定性,特别反应的条件和 microcapsules 的工艺的控制的比较的形态学的描述以后,有poly-(脲甲醛)的石蜡聚合物粒子的 microencapsulation 作为最佳计划作为壳材料被选择,因为它能在温和条件下面反应,它的工艺的过程能在一个大范围被控制。关系拖减少率和显示出的 microcapsules 的溶解时间 microcapsules 的形成没影响最大值拖减少减少每件样品的率的率,和drag 能与溶解时间一起到达大约35%,即 microencapsulation 没影响减少石蜡的性质的drag 聚合物。 | Li Bing Xing Wenguo Dong Guilin Chen Xiangjun Zhou Ningning Qin Zhanbo Zhang Changqiao | 2011 | Petroleum Science2011，8，1： | 3 |
| 2 | DNA damage stress induces the dissociation of Smurf1/2 from MDM2 in a slow manner显示文摘The tumor suppressor p53 locates at the key point of cell growth or apoptosis balance, and the expression level of p53 is tightly controlled by ubiquitin ligases including MDM2. Upon DNA damage stresses, p53 was accumulated and activated, leading to cell cycle arrest or apoptosis. We previously showed that Smad ubiquitylation regulatory factor 1/2 (Smurf1/2) promotes p53 degradation by interacting with and stabilizing MDM2, and consequently enhancing MDM2-mediated ubiquitylation of p53. However, it is unclear how the Smurf1-MDM2 interaction is regulated in response to DNA damage stress. Here, we show that in response to etoposide treatment Smurf1 dissociates from MDM2, resulting in MDM2 destabilization and p53 accumulation. The negative regulation of Smurf1 on apoptosis is released. Notably, this dissociation is a slow process rather than a rapid response, implicating high expression of Smurf1 might confer the resistance against p53 activation. Consistent with this notion, we observed that Smurf1/2 ligases are highly expressed in colon cancer, esophageal squamous cell carcinoma and pancreatic cancer tissues, suggesting the oncogenic tendency of Smurf1/2. | NIE Jing LIU Lin ZHAO XiaoHang XIE Ping ZHOU PingKun XING GuiChun LIU XiangJun HE FuChu HAN WeiDong ZHANG LingQiang | 2011 | Chinese Science Bulletin2011，56，30： | 2 |
| 3 | Potentially functional genetic variants in microRNA processing genes and risk of HBV‐related hepatocellular carcinoma显示文摘 | Li Liu Jiaze An Jibin Liu Juan Wen Xiangjun Zhai Yao Liu Shandong Pan Jie Jiang Yang Wen Zheng Liu Yixin Zhang Jianguo Chen Jinliang Xing Guozhong Ji Hongbing Shen Zhibin Hu Zhining Fan | 2013 | Mol Carcinog2013，，1： | 1 |
| 4 | Prediction of water table depths under soil water-groundwater interaction and stream water conveyance显示文摘Water table over an arid region can be elevated to a critical level to sustain terrestrial ecosystem along the natural channel by the stream water conveyance. Estimation of water table depth and soil moisture on river channel profile may be reduced to a two-dimensional moving boundary problem with soil water-groundwater interaction. The two-dimensional soil water flow with stream water transferred is divided into an unsaturated vertical soil water flow and a horizontal groundwater flow. Therefore, a prediction model scheme for water table depths under the interaction between soil water and groundwater with stream water transferred is presented, which includes a vertical soil water movement model, a horizontal groundwater movement model, and an interface model. The synthetic experiments are conducted to test the sensitivities of the river elevation, horizontal conductivity, and surface flux, and the results from the experiments show the robustness of the proposed scheme under different conditions. The groundwater horizontal conductivity of the proposed scheme is also calibrated by SCE-UA method and validated by data collected at the Yingsu section in the lower reaches of the Tarim River, which shows that the model can reasonably simulate the water table depths. | DI ZhenHua XIE ZhengHui YUAN Xing TIAN XiangJun LUO ZhenDong CHEN YaNing | 2011 | Science China Earth Sciences2011，54，3： | 1 |
| 5 | Nanoporous Vesicular Membranes of Amphiphilic Polymers Containing Trans/Cis Isomers显示文摘Nanoporous membranes and vesicles are interesting systems with potential in applications offering channels for material exchange.Herein,nanoporous membranes and polymersomes are developed by self-assembly of trans-and cis-stereoisomers of amphiphilic polymers.Two polymers,PEG550-TPEChol and PEG550-SS-TPE-SS-Chol,containing a central tetraphenylethene(TPE),a cholesterol(Chol),and a poly(ethylene glycol)(PEG550)are studied. | Hui Chen Xia Yu Yujiao Fan Xiangjun Xing Sylvain Trépout Min-Hui Li | 2022 | CCS Chemistry2022，4，8： | 1 |
| 6 | Single-cell analysis reveals an Angpt4-initiated EPDC-EC-CM cellular coordination cascade during heart regeneration显示文摘Mammals exhibit limited heart regeneration ability,which can lead to heart failure after myocardial infarction.In contrast,zebrafish exhibit remarkable cardiac regeneration capacity.Several cell types and signaling pathways have been reported to participate in this process.However,a comprehensive analysis of how different cells and signals interact and coordinate to regulate cardiac regeneration is unavailable.We collected major cardiac cell types from zebrafish and performed high-precision single-cell transcriptome analyses during both development and post-injury regeneration.We revealed the cellular heterogeneity as well as the molecular progress of cardiomyocytes during these processes,and identified a subtype of atrial cardiomyocyte exhibiting a stem-like state which may transdifferentiate into ventricular cardiomyocytes during regeneration.Furthermore,we identified a regeneration-induced cell(RIC)population in the epicardium-derived cells(EPDC),and demonstrated Angiopoietin 4(Angpt4)as a specific regulator of heart regeneration.angpt4 expression is specifically and transiently activated in RIC,which initiates a signaling cascade from EPDC to endocardium through the Tie2-MAPK pathway,and further induces activation of cathepsin K in cardiomyocytes through RA signaling.Loss of angpt4 leads to defects in scar tissue resolution and cardiomyocyte proliferation,while overexpression of angpt4 accelerates regeneration.Furthermore,we found that ANGPT4 could enhance proliferation of neonatal rat cardiomyocytes,and promote cardiac repair in mice after myocardial infarction,indicating that the function of Angpt4 is conserved in mammals.Our study provides a mechanistic understanding of heart regeneration at single-cell precision,identifies Angpt4 as a key regulator of cardiomyocyte proliferation and regeneration,and offers a novel therapeutic target for improved recovery after human heart injuries. | Zekai Wu Yuan Shi Yueli Cui Xin Xing Liya Zhang Da Liu Yutian Zhang Ji Dong Li Jin Meijun Pang Rui-Ping Xiao Zuoyan Zhu Jing-Wei Xiong Xiangjun Tong Yan Zhang Shiqiang Wang Fuchou Tang Bo Zhang | 2023 | Protein & Cell2023，14，5： | 0 |
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