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| 1 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 2 | Smad4 restoration leads to a suppression of Wnt/β-catenin signaling activity and migration capacity in human colon carcinoma cells显示文摘 | Tian Xiaoxiao Du Hao Fu Xiangsheng | 2009 | Biochemical and Biophysical Research Communications2009，380，： | 1 |
| 3 | Generation of Diffuse Bands Stimulated Emission in 488-522 nm Region in Lithium Dimer显示文摘We report diffuse bands stimulated emission of Li_(2) in the 488-522nm region,produced by two-photon resonance excited Li(4s)states transferring energy to Ii2 higb triplet states via collision in Li-Lio system.The diffuse bands could be assigned to triplet bound-free(2^(3)∑_(g)^(+)-a^(3)∑_(u)^(+))transitions.The mechanisms for producing and emission of the diffuse bands are discussed. | LI Yongfang ZHANG Yinke LI Fu'an LI Xiangsheng FU Kede | 1992 | Chinese Physics Letters1992，9，1： | 0 |
| 4 | Clogging of slurry-shield tunnel-boring machine drives in sedimentary soft rock:A case study显示文摘This paper presents a case study of the clogging of a slurry-shield tunnel-boring machine(TBM)experienced during tunnel operations in clay-rich argillaceous siltstones under the Ganjiang River,China.The clogging experienced during tunneling was due to special geological conditions,which had a considerably negative impact on the slurry-shield TBM tunneling performance.In this case study,the effect of clogging on the slurry-shield TBM tunneling performance(e.g.,advance speed,thrust,torque,and penetration per revolution)was fully investigated.The potential for clogging during tunnel operations in argillaceous siltstone was estimated using an existing empirical classification chart.Many improvement measures have been proposed to mitigate the clogging potential of two slurry-shield TBMs during tunneling,such as the use of an optimum cutting wheel,a replacement cutting tool,improvements to the circulation flushing system and slurry properties,mixed support integrating slurry,and compressed air to support the excavation face.The mechanisms and potential causes of clogging are explained in detail,and the contributions of these mitigation measures to tunneling performance are discussed.By investigating the actual operational parameters of the slurry-shield TBMs,these mitigation measures were proven to be effective in mitigating the clogging potential of slurry-shield TBMs.This case study provides valuable information for slurry-shield TBMs involving tunneling in clay-rich sedimentary rocks. | Chengyong CAO Xiangsheng CHEN Chenghua SHI Yanbin FU Chenjie GONG Zuxian WANG | 2023 | Frontiers of Structural and Civil Engineering2023，17，10： | 0 |
| 5 | DLG7/DLGAP5 as a potential therapeutic target in gastric cancer显示文摘To the Editor:Gastric cancer is a highly invasive disease.An estimated 1.09 million cases were diagnosed and 770,000 gastric cancer-related deaths occurred only in 2020.[1]Advanced gastric cancer can no longer be subjected to surgery and can only be treated with sequential lines of chemotherapy.However,the survival period is usually short.[2]Therefore,it is of utmost importance to identify new and more effective treatments and therapeutic targets to combat gastric cancer.Disc large homolog 7(DLG7)is the microtubule-associated protein encoded by the DLG associated protein 5(DLGAP5)gene,which affects chromosome rearrangement and gene stability[3];thus,its overexpression may cause canceration.Some studies revealed that DLGAP5 is highly expressed in gastric cancer tissues,suggesting that it may also have a role in this disease.However,the role and mechanism of DLGAP5 in gastric cancer are still unclear.[4]Therefore,this study aimed at exploring the role of DLGAP5 in the growth and invasion of gastric cancer as well as the potential use as a therapeutic target to combat this disease. | Kang Li Xiangsheng Fu Ping Wu Bianba Zhaxi Hanhuan Luo Qijie Li | 2022 | Chinese Medical Journal2022，，13： | 0 |
| 6 | Reflections on Petroleum-substitute Strategy:Methanol and Ethanol显示文摘Methanol fuel Pure methanol and pure etha-nol(ethyl alcohol)can be usedas vehicle fuels.Such vehicles are usually called methanol vehicles or ethanol vehicles.They can also be used | Fu Xiangsheng,China National Chemical Corporation | 2008 | China Chemical Reporter2008，，1： | 0 |
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