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| 1 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 2 | Reversal of B-cell hyperactivation and functional impairment is associated with HBsAg seroconversion in chronic hepatitis B patients显示文摘B 房间对再感染在肝炎 B 病毒(HBV ) 和保护的清理起一个重要作用。然而,与长期的 HBV 感染的结果被联系的这些房间的功能的特征仍然保持未知。我们包括地在不同阶段从 CHB 病人调查了外部 B 房间子集的频率,显型,和功能:有免疫力的忍耐(信息技术) ,有免疫力的激活(IA ) ,有免疫力的清理(IC ) ,有 HBsAg seroconversion 的应答者(解决的病人, RP ) ,并且健康控制(HC ) 。IA 病人与另外的组相比显示了外部血记忆 B 房间的更低的百分比。B 房间的全面 polyclonal 激活,由激活标记和 IgG 和 IgM 的分泌物的高水平显示了,在 IA 病人被观察。这 B 房间 hyperactivation 能被增加的 IFN-α 导致;并且在 IA 病人的可溶的 CD40 ligands。尤其是,合作激发器分子 CD80 和浆液 HBsAb 的表示和 HBsAg 特定的 B 房间的频率显著地与 HC 题目相比在信息技术, IA,和 IC 病人被减少。更重要地, B 房间 hyperactivation, co-stimulatory 分子 downregulation 和 HBsAg 特定的 B 房间缺陷在 RP 病人被颠倒。B 房间 hyperactivation 和功能的缺陷的颠倒在长期的肝炎 B 病人与 HBsAg seroconversion 被联系。 | Xiangsheng Xu Qinghua Shang Xinyue Chen Weimin Nie Zhengsheng Zou Ang Huang Ming Meng Lei Jin Ruonan Xu Ji-Yuan Zhang Junliang Fu Lifeng Wang Zirong Tang Yunbo Xie Xiaoming Yang Zheng Zhang Fu-Sheng Wang | 2015 | Cellular & Molecular Immunology2015，12，3： | 15 |
| 3 | Adsorption of VOCs on reduced graphene oxide显示文摘A modified Hummer's method was adopted for the synthesis of graphene oxide(GO) and reduced graphene oxide(rGO). It was revealed that the modified method is effective for the production of GO and rGO from graphite. Transmission electron microscopy(TEM) images of GO and rGO showed a sheet-like morphology. Because of the presence of oxygenated functional groups on the carbon surface, the interlayer spacing of the prepared GO was higher than that of rGO. The presence of \OH and C_O groups in the Fourier transform infrared spectra(FTIR) spectrum and G-mode and 2D-mode in Raman spectra confirmed the synthesis of GO and rGO. rGO(292.6 m^2/g) showed higher surface area than that of GO(236.4 m^2/g). The prepared rGO was used as an adsorbent for benzene and toluene(model pollutants of volatile organic compounds(VOCs)) under dynamic adsorption/desorption conditions. rGO showed higher adsorption capacity and breakthrough times than GO. The adsorption capacity of rGO for benzene and toluene was 276.4 and 304.4 mg/g, respectively.Desorption experiments showed that the spent rGO can be successfully regenerated by heating at 150.0°C. Its excellent adsorption/desorption performance for benzene and toluene makes rGO a potential adsorbent for VOC adsorption. | Lian Yu Long Wang Weicheng Xu Limin Chen Mingli Fu Junliang Wu Daiqi Ye | 2018 | Journal of Environmental Sciences2018，30，5： | 10 |
| 4 | Highly efficient Cu/anatase TiO2 {001}-nanosheets catalysts for methanol synthesis from CO2显示文摘Anatase TiO_2 nanosheets(-ns-) with dominant exposed {001} facets were used as support to load copper,and the synthesized Cu/TiO_2-ns catalysts were evaluated for CO_2 hydrogenation to methanol. Under the reaction conditions, P = 3.0 MPa, T = 260 ℃, V(N_2):V(H_2):V(CO_2) = 8:69:23 and gas hourly space velocity(GHSV) = 3600 mL g^(-1)h^(-1), the methanol yield reached an appealing high value, 5.6%. Copper-loading amount, calcination temperature and reduction atmosphere have been investigated in this work, which significantly influence the particle sizes of copper and/or the defect concentration in TiO_2, then leading to different catalytic performance. Characterizations of XRD, EPR, CO_2-TPD and FTIR demonstrate that higher specific surface area of Cu is good for the hydrogenation of CO_2 and adequate amount of Ti^(3+) plays important roles in CO_2 activation. Both of them facilitate high turnover frequency(TOF) of methanol formation. | Yunfeng Bao Chunlei Huang Limin Chen Yu dong Zhang Long Liang Jinjun Wen Mingli Fu Junliang Wu Daiqi Ye | 2018 | Journal of Energy Chemistry2018，27，2： | 7 |
| 5 | Dependence of corrosion resistance on grain boundary characteristics in a high nitrogen CrMn austenitic stainless steel显示文摘Processing schedules for grain boundary engineering involving different types of cold deformation(tension, compression, and rolling) and annealing were designed and carried out for 18Mn18Cr0.6N high nitrogen austenitic stainless steel. The grain boundary characteristic distribution was obtained and characterized by electron backscatter diffraction(EBSD) analysis. The corrosion resistance of the specimens with different grain boundary characteristic distribution was examined by using potentiodynamic polarization test. The corrosion behavior of different types of boundaries after sensitization was also studied.The fraction of low-∑ boundaries decreased with increasing strain, and it was insensitive to the type of cold deformation when the engineering strain was lower than 20%. At the strain of 30%, the largest and smallest fractions of low-∑ boundaries were achieved in cold-tensioned and rolled specimens, respectively. The fraction of low-∑ boundaries increased exponentially with the increase of grain size. The proportion of low-∑ angle grain boundaries increased with decreasing grain size. Increasing the fraction of low-∑ boundaries could improve the pitting corrosion resistance for the steels with the same grain size.After sensitization, the relative corrosion resistances of low-∑ angle grain boundaries, ∑3 boundaries, and ∑9 boundaries were 100%, 95%, and 25%, respectively, while ∑27 boundaries, other low-∑ boundaries and random high-angle grain boundaries had no resistance to corrosion. | Jianjun Qi Boyuan Huang Zhenhua Wang Hui Ding Junliang Xi Wantang Fu | 2017 | Journal of Materials Science & Technology2017，33，12： | 4 |
| 6 | Macroporous Ni foam-supported Co_3O_4 nanobrush and nanomace hybrid arrays for high-efficiency CO oxidation显示文摘Herein, we reported the synthesis of well-defined Co_3O_4 nanoarrays(NAs) supported on a monolithic three-dimensional macroporous nickel(Ni) foam substrate for use in highefficiency CO oxidation. The monolithic Co_3O_4 NAs catalysts were obtained through a generic hydrothermal synthesis route with subsequent calcination. By controlling the reaction time,solvent polarity and deposition agent, these Co_3O_4 NAs catalysts exhibited various novel morphologies(single or hybrid arrays), whose physicochemical properties were further characterized by using several analytical techniques. Based on the catalytic and characterization analyses, it was found that the Co_3O_4 NAs-6 catalyst with nanobrush and nanomace arrays displayed enhanced catalytic activity for CO oxidation, achieving an efficient 100% CO oxidation conversion at a gas hourly space velocity(GHSV) 10,000 hr^(-1) and 150°C with longterm stability. Compared with the other Co_3O_4 NAs catalysts, it had the highest abundance of surface-adsorbed oxygen species, excellent low-temperature reducibility and was rich in surface-active sites(Co^(3+)/Co^(2+)= 1.26). | Shengpeng Mo Hui He Quanming Ren Shuangde Li Weixia Zhang Mingli Fu Limin Chen Junliang Wu Yunfa Chen Daiqi Ye | 2019 | Journal of Environmental Sciences2019，31，1： | 4 |
| 7 | Large specific surface area S-doped Fe-N-C electrocatalysts derived from Metal-Organic frameworks for oxygen reduction reaction显示文摘It is highly desired but challenging to develop platinum group metal-free electrocatalysts for oxygen reduction reaction(ORR),which can promote the commercialization of fuel cell technology.To achieve this target,we report a one-step doping method to prepare S-doped Fe-N-C catalysts using zeolite imidazole framework(ZIF-8)and iron(Ⅲ)thiocyanate(Fe(SCN)_(3))as precursor.Different from conventional doping approach,i.e.physical mixing,Fe(SCN)_(3) is in-situ added during ZIF-8 formation which would encapsulate Fe(SCN)_(3) molecules inside ZIF-8 to avoid structure destruction and create potential replacement of Zn ions by Fe ions to form uniform Fe-N_(4) complexes.As a result,the prepared S-doped Fe-N-C catalysts own large specific surface areas with a maximum value of 1326 m^(2) g^(-1) and a dual-scale porous structure that benefits mass transport.Significantly,the composition-optimized catalyst exhibits superior ORR activity in both 0.1 M HClO_(4) electrolyte and 0.1 M KOH electrolyte,in which the half-wave potential reaches 0.81 V and 0.92 V(vs.RHE),respectively.Remarkable stability is also attained,which loses 2 m V only after 10000 potential cycles in O_(2)-saturated 0.1 M HClO_(4) and remains almost constant in O_(2)-saturated 0.1 M KOH,surpassing commercial Pt/C catalyst in both acidic and alkaline medium. | Xiaohui Yan Xiaolin Li Cehuang Fu Chen Lin Huanming Hu Shuiyun Shen Guanghua Wei Junliang Zhang | 2020 | Progress in Natural Science:Materials International2020，30，6： | 3 |
| 8 | Unraveling specific role of carbon matrix over Pd/quasi-Ce-MOF facilitating toluene enhanced degradation显示文摘Metal organic frameworks(MOFs)derivatives represented by quasi-MOFs have excellent physical and chemical properties and can be applied for the catalytic combustion of volatile organic compounds(VOCs).In this work,Pd/quasi-Ce-BTC synthesized by simple one-step Npyrolysis was applied to the oxidation of toluene,showing excellent toluene catalytic activity(T_(90)=175℃,30000 mL/(g·h)).Microscopic analyses indicate the formation and interaction of a carbon matrix composite quasi-MOF structure interface.The results show that the amorphous carbon matrix formed during the partial pyrolysis of Ce-BTC significantly improves the adsorption and activation capacity of toluene in the reaction,and constructs a reductive system to maintain high concentrations of Ce^(3+)and Pd^(0),which can facilitate the activation and utilization of oxygen in reaction.Quasi in-situ XPS proves that carbon matrix is indirectly involved in the activation and storage of oxygen,and Pd^(0)is the crucial active site for the activation of oxygen.Stability and water resistance tests display good stability of Pd/quasi-Ce-BTC.This work provides a potential method for designing quasi-MOF catalysts towards VOCs effective abatement. | Chunjing Su Zhi Li Mengqi Mao Wenhua Ye Jinping Zhong Quanming Ren Hairong Cheng Haomin Huang Mingli Fu Junliang Wu Yun Hu Daiqi Ye Haihong Xu | 2022 | Journal of Rare Earths2022，40，11： | 2 |
| 9 | Hydrogen-assisted scalable preparation of ultrathin Pt shells onto surfactant-free and uniform Pd nanoparticles for highly efficient oxygen reduction reaction in practical fuel cells显示文摘Concentrating active Pt atoms in the outer layers of electrocatalysts is a very effective approach to greatly reduce the Pt loading without compromising the electrocatalytic performance and the total electrochemically active surface area(ECSA)for the oxygen reduction reaction(ORR)in hydrogen-based proton-exchange membrane fuel cells.Accordingly,a facile,low-cost,and hydrogen-assisted two-step method is developed in this work,to massively prepare carbon-supported uniform,small-sized,and surfactant-free Pd nanoparticles(NPs)with ultrathin~3-atomic-layer Pt shells(Pd@Pt_(3L) NPs/C).Comprehensive physicochemical characterizations,electrochemical analyses,fuel cell tests,and density functional theory calculations reveal that,benefiting from the ultrathin Pt-shell nanostructure as well as the resulting ligand and geometric effects,Pd@Pt_(3L) NPs/C exhibits not only significantly enhanced ECSA,electrocatalytic activity,and noble-metal(NM)utilization compared to commercial Pt/C,showing 81.24 m^(2)/gPt,0.710 mA/cm^(2),and 352/577 mA/mgNM/Pt in ECSA,area-,and NM-/Pt-mass-specific activity,respectively;but also a much better electrochemical stability during the 10,000-cycle accelerated degradation test.More importantly,the corresponding 25-cm^(2) H2-air/O_(2) fuel cell with the low cathodic Pt loading of~0.152 mgPt/cm^(2)geo achieves the high power density of 0.962/1.261 W/cm^(2)geo at the current density of only 1,600 mA/cm^(2)geo,which is much higher than that for the commercial Pt/C.This work not only develops a high-performance and practical Pt-based ORR electrocatalyst,but also provides a scalable preparation method for fabricating the ultrathin Pt-shell nanostructure,which can be further expanded to other metal shells for other energy-conversion applications. | Liuxuan Luo Cehuang Fu Aiming Wu Zechao Zhuang Fengjuan Zhu Fangling Jiang Shuiyun Shen Xiyang Cai Qi Kang Zhifeng Zheng Chenyi Hu Jiewei Yin Guofeng Xia Junliang Zhang | 2022 | Nano Research2022，15，3： | 2 |
| 10 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 11 | The designable elastic modulus of 3D fabric reinforced bio-compo- sites显示文摘 | FU Tao ZHAO Junliang XU Kewei | 2007 | Materials Letters2007，61，： | 1 |
| 12 | Design and Verification of High Attenuation Vibration Isolation Damper in Remote Sensing Satellite Transport显示文摘To solve the safe horizontal transportation by rail&road of remote sensing satellite problem in the process of unpredictable dynamic load,a high attenuation vibration isolation damper(hereinafter referred to as vibration isolation damper)was developed.By simulation analysis and transportation test using satellite structural model and engineering prototype,validity and reliability of the vibration isolation damper was verified,which can meet the requirements of vibration and shock from various transportation conditions. | Hao Fu Wei Zhang Junliang Liu Shangjie Pan | 2021 | Journal of Harbin Institute of Technology(New Series)2021，28，6： | 1 |
| 13 | Large area van der Waals epitaxy of II-VI CdSe thin films for flexible optoelectronics and full-color imaging显示文摘The demand for future semiconductor devices with enhanced performance and lower cost has driven the development of epitaxial growth of high quality,free-standing semiconductor thin film materials without the requirement of lattice matching to the substrate,as well as their transfer to other substrates and associated device processing technology.This work presents a study on the van der Waals epitaxy based molecular beam epitaxy of CdSe thin films on two-dimensional layered mica substrates,as well as related etch-free layer transfer technology of large area,free-standing layers and their application in flexible photodetectors for full-color imaging.The photoconductor detectors based on these flexible CdSe thin films demonstrate excellent device performance at room temperature in terms of responsivity(0.2 A·W^(-1))and detectivity(1.5×10^(12)Jones),leading to excellent full-color imaging quality in the visible spectral range.An etch-free and damage-free layer transfer method has been developed for transferring these CdSe thin films from mica to other substrate for further device processing and integration.These results demonstrate the feasibility of van der Waals epitaxy method for growing high quality,large area,and free-standing epitaxial layers without the requirement for lattice matching to substrate for applications in low-cost flexible and/or monolithic integrated optoelectronic devices. | Wenwu Pan Junliang Liu Zekai Zhang Renjie Gu Alexandra Suvorova Sarah Gain Han Wang Ziyuan Li Lan Fu Lorenzo Faraone Wen Lei | 2022 | Nano Research2022，15，1： | 1 |
| 14 | Functional impairment in circulating and intrahepatic NK cells and relative mechanism in hepatocellular carcinoma patients显示文摘 | Lun Cai Zheng Zhang Lin Zhou Haiyan Wang Junliang Fu Shuye Zhang Min Shi Hui Zhang Yongping Yang Hao Wu Po Tien Fu-Sheng Wang | 2008 | Clinical Immunology2008，，： | 1 |
| 15 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 16 | Volcanic relationship between wettability of the interface and water migration rate in solar steam generation systems显示文摘Capturing solar energy as heat for water treatment has become a substantial approach to obtain freshwater.To obtain higher performance,the understanding of the mechanism of how water molecules interact with the interface is particularly fundamental,because the migration process of water molecules on the evaporation interface will directly affect the performance of the device.Herein we regulate the number of hydroxyl groups on the surface of reduced graphene oxide quantitatively,to study the effect of different wettability of interfaces on the performance of solar water generators.The water evaporation performance displays a volcanic shape as increasing wettability.Calculated by the computational chemistry method,deviation from proper wetting humidity is not conducive to the migration of water molecules from the surface.The double-edged sword effect of wettability on performances is clarified,and the surface energy density is the key to break through the limit by the finite element method. | Qiang Fu Xiaojuan Li Ning Ma Dier Shi Pohua Chen Junliang Sun | 2022 | Nano Research2022，15，2： | 1 |
| 17 | Bioactive glass promotes the barrier functional behaviors of keratinocytes and improves the Re-epithelialization in wound healing in diabetic rats显示文摘Upon skin injury,re-epithelialization must be triggered promptly to restore the integrity and barrier function of the epidermis.However,this process is often delayed or interrupted in chronic wounds like diabetic foot ulcers.Considering that BG particles can activate multiple genes in various cells,herein,we hypothesized that bioactive glass(BG)might be able to modulate the barrier functional behaviors of keratinocytes.By measuring the transepithelial electrical resistance(TEER)and the paracellular tracer flux,we found the 58S-BG extracts substantially enhanced the barrier function of keratinocyte monolayers.The BG extracts might exert such effects by promoting the keratinocyte differentiation and the formation of tight junctions,as evidenced by the increased expression of critical differentiation markers(K10 and involucrin)and TJ protein claudin-1,as well as the altered subcellular location of four major TJ proteins(claudin-1,occludin,JAM-A,and ZO-1).Besides,the cell scratch assay showed that BG extracts induced the collective migration of keratinocytes,though they did not accelerate the migration rate compared to the control.The in vivo study using a diabetic rat wound model demonstrated that the BG extracts accelerated the process of re-epithelialization,stimulated keratinocyte differentiation,and promoted the formation of tight junctions in the newly regenerated epidermis.Our findings revealed the crucial effects of BGs on keratinocytes and highlighted its potential application for chronic wound healing by restoring the barrier function of the wounded skin effectively. | Fengling Tang Junliang Li Weihan Xie Yunfei Mo Lu Ouyang Fujian Zhao Xiaoling Fu Xiaofeng Chen | 2021 | Bioactive Materials2021，6，10： | 1 |
| 18 | <ce:link locator='fx1'/> Increased Regulatory T Cells Correlate With CD8 T-Cell Impairment and Poor Survival in Hepatocellular Carcinoma Patients显示文摘 | Junliang Fu Dongping Xu Zhenwen Liu Ming Shi Ping Zhao Baoyun Fu Zheng Zhang Huiyin Yang Hui Zhang Chunbao Zhou Jinxia Yao Lei Jin Huifen Wang Yongping Yang Yang-Xing Fu Fu-Sheng Wang | 2007 | Gastroenterology2007，，7： | 1 |
| 19 | Attribution for decreasing streamflow of the Haihe River basin, northern China: Climate variability or human activities?显示文摘 | Zhenxin Bao Jianyun Zhang Guoqing Wang Guobin Fu Ruimin He Xiaolin Yan Junliang Jin Yanli Liu Aijing Zhang | 2012 | Journal of Hydrology2012，，： | 1 |
| 20 | Imbalanced Intrahepatic Cytokine Expression of Interferon-γ, Tumor Necrosis Factor-α, and Interleukin-10 in Patients With Acute-on-Chronic Liver Failure Associated With Hepatitis B Virus Infection显示文摘 | Zhengsheng Zou Baosen Li Dongping Xu Zheng Zhang Jing-Min Zhao Guangde Zhou Yanling Sun Lei Huang Junliang Fu Yongping Yang Lei Jin Wei Zhang Jun Zhao Ying Sun Shaojie Xin Fu-Sheng Wang | 2009 | Journal of Clinical Gastroenterology2009，，2： | 1 |
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