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1Review on utilization of biochar for metal-contaminated soil and sediment remediation显示文摘Biochar is a carbon-neutral or even carbon-negative material produced through thermal decomposition of plant-and animal-based biomass under oxygen-limited conditions.Recently, there has been an increasing interest in the application of biochar as an adsorbent, soil ameliorant and climate mitigation approach in many types of applications.Metal-contaminated soil remediation using biochar has been intensively investigated in small-scale and pilot-scale trials with obtained beneficial results and multifaceted effects.But so far, the study and application of biochar in contaminated sediment management has been very limited, and this is also a worldwide problem. Nonetheless, there is reason to believe that the same multiple benefits can also be realized with these sediments due to similar mechanisms for stabilizing contaminants. This paper provides a review on current biochar properties and its use as a sorbent/amendment for metal-contaminated soil/sediment remediation and its effect on plant growth, fauna habits as well as microorganism communities. In addition, the use of biochar as a potential strategy for contaminated sediment management is also discussed, especially as regards in-situ planning. Finally, we highlight the possibility of biochar application as an effective amendment and propose further research directions to ensure the safe and sustainable use of biochar as an amendment for remediation of contaminated soil and sediment.Mingming Wang Yi Zhu Lirong Cheng Bruce Andserson Xiaohui Zhao Dayang Wang Aizhong Ding 2018Journal of Environmental Sciences2018,30,1:43
2Wind tunnel experiments on natural snow drift显示文摘Previous wind tunnel experiments on snow drift usually used artificial snow as a substitute of natural snow, which can not fully reflect the motion characteristics of snow drift in natural environments. In this paper we conducted a series of experiments in wind tunnel to investigate the motion of natural snow (fresh snow and old snow), which was collected out-door without destroying the surface structure. The results indicated that the threshold velocity of fresh snow is less than that of old snow, and that the mass flux rates of the two kinds of snow exponentially decrease with height whereas the snow transport rate increases exponentially with wind velocity. Based on the PIV measuring of the velocities of snow particles over two kinds of terrains (flat ground and roadbed), we found that the particle velocity obeys a Gaussian distribution for flat ground, top surface and leeward slope of the roadbed. However, for the windward slope of roadbed the particle velocity distribution displays poor correlation with a Gaussian function due to the acceleration of snow particles when saltating across the slop. Statistical analysis showed that impacting and liftoff velocities of snow particles also obey Gaussian distributions.LU XiaoHui HUANG Ning TONG Ding 2012Science China(Technological Sciences)2012,55,4:14
3A comparative study of calcium sulfate artificial bone graft versus allograft in the reconstruction of bone defect after tumor curettage显示文摘Yang Yongkun Niu Xiaohui Zhang Qing Hao Lin Ding Yi Xu Hairong 2014Chinese Medical Journal2014,,17:11
4Allele-aware chromosome-level genome assembly of Artemisia annua reveals the correlation between ADS expansion and artemisinin yield显示文摘Artemisia annua is the major natural source of artemisinin,an anti-malarial medicine commonly used worldwide.Here,we present chromosome-level haploid maps for two A.annua strains with different artemisinin contents to explore the relationships between genomic organization and artemisinin production.High-fidelity sequencing,optical mapping,and chromatin conformation capture sequencing were used to assemble the heterogeneous and repetitive genome and resolve the haplotypes of A.annua.Approximately 5o,ooo genes were annotated for each haplotype genome,and a triplication event that occurred approximately 58.12million years ago was examined for the first time in this species.A total of 3,903,467-5,193,414 variants(SNPs,indels,and structural variants)were identified in the 1.5-Gb genome during pairwise comparison between haplotypes,consistent with the high heterozygosity of this species.Genomic analyses revealed a correlation between artemisinin concents and the copy number of amorpha-4,11-dienes ynthasegenes.This correlation was further confirmed by resequencing of 36A.annua samples with varied artemisinin contents.Circular consensus sequencing of transcripts facilitated the detection of paralog expression.Collectively,our study provides chromosome-level allele-aware genome assemblies for two A.annua strains and new insights into the biosynthesis of artemisinin and its regulation,which will contribute to conquering malaria worldwide.Baosheng Liao Xiaofeng Shen Li Xiang Shuai Guo Shiyu Chen Ying Meng Yu Liang Dandan Ding Junqi Bai Dong Zhang Tomasz Czechowski Yi Li Hui Yao Tingyu Mai Caroline Howard Chao Sun Haitao Liu Jiushi Liu Jin Pei Jihai Gao Jigang Wang Xiaohui Qiu Zhihai Huang Hongyi Li Ling Yuan Jianhe Wei lan Graham Jiang Xu Boli Zhang Shilin Chen 2022Molecular Plant2022,15,8:9
5Assessment of different biomarkers provides valuable diagnostic standards in the evaluation of the risk of acute rejection显示文摘尖锐拒绝(AR ) 是为长期的拒绝在的一个强壮的风险因素肾移植接受者。AR 事件的精确、及时的诊断为疾病控制和预后是很重要的。因此,客观地评估了病人的有免疫力的地位在移植以后的治疗的地里是必要的。这纵的研究在外部血 mononuclear 房间( PBMC )和活体检视在 sera ,CD4+ T 房间的细胞内部的腺苷 triphosphate ( iATP )版本水平,和 granzyme B/perforin 表示调查了五 biomarkers ,人的白血球抗原( HLA ) -G5 和 sCD30 水平的实用性,总共肾的移植的 84 个案例的检测 AR 和 biomarkers 的决定。数据证明接受者与临床或证明的活体检视拒绝显著地增加了 CD4+ T 房间的 iATP 版本水平,并且提高了 sCD30,但是与稳定的接枝功能与个人相比在 sera 降低了 HLA-G5 水平。granzyme B 和 perforin 的表示层次也在 PBMC 和 AR 病人的接枝活体检视被提高。一起拿,我们鉴别 HLA-G5 的 sCD30, iATP, granzyme B, perforin,和 downregulation 的 upregulation 能提供珍贵诊断标准在 AR 的风险识别那些接受者。并且 iATP 可以比为预言接枝拒绝事件的其它是更好的 biomarker。Jin Zheng Xiaoming Ding Xiaohui Tian Zhankui Jin Xiaoming Pan Hang Yan Xinshun Feng Jun Hou Heli Xiang Li Ren Puxun Tian Wujun Xue 2012Acta Biochimica et Biophysica Sinica2012,44,9:8
6Aerosol influence domain of Beijing and peripheral city agglomeration and its climatic effect显示文摘The aerosol distribution in Beijing and peripheral cities agglomeration (BPCA) and its re- gional climatic effect are investigated on the basis of the statistical analyses of satellite Total Ozone Map- ping Spectrometer (TOMS) retrieval aerosol optical depth (AOD) and the meteorological data of sunshine duration, fog days, and low cloud cover, observed at Beijing and its peripheral meteorological stations. The analysis on multi-samples variational correction of the satellite remote sensing Moderate Resolution Imaging Spectroradiometer (MODIS) AOD under the clear sky and stable weather condition in conjunction with surface observations reveal that there was a “triangle-like” distribution pattern of the high values of aerosols in the southern “valley” of the “U-shape” megarelief of Beijing and its peripheral areas. The distribution pattern suggests that the large-scale transfer and diffusion of city agglomeration pollutants might form a relatively persistent characteristic spatial distribution of city agglomeration pollutants much larger than city-scale. Under the background of the particular megarelief effect of Beijing and periph- eral areas, the high value area of TOMS AOD, as well as regional correlation distribution between clear sky sunshine duration and TOMS AOD are also similar to the composite image of MODIS AOD variational fields, that is to say, the effect of atmospheric aerosols was very distinctive in Beijing and peripheral areas. The high value area of the negative correlation between clear sky sunshine duration and TOMS AOD ap-proximately accorded with the significant negative value area of the sunshine duration deviations of the 1980s to the 1990s, and the daily variations of the AOD also showed an anti-phase relation with those of clear sky sunshine duration. The above high cor- relation area of the urban aerosol impact of Beijing- Tianjin region leant towards south peripheral area, with its “center of gravity” in the south of Beijing- Tianjin agglomeration, and the main body of the high correlation area prolongating southwards, forming an aerosol influence domain of “eccentric ellipse” shape, that is to say, there was an aerosol influence domain of some “radius” in Beijing City and its peripheral areas, within and outside which sunshine duration, low cloud cover, and fog days showed a remarkable difference in interannual variation trend. At the downstream of the city agglomeration there was a significant interdecadal increment area of fog or low cloud cover, which might be associated with the local climatic feature of the regional flow convergent field in the diffusion process of city agglomeration pollut- ants in the aerosol influence domain, and such a local dynamical convergence feature might lead to the regional exacerbation of aerosol impact downstream of the city agglomeration. The research result reveals that the significant area of interdecadal change rate of low cloud cover within the aerosol influence do- main is correlated with the regional strengthening effect of aerosol impact of the local wind structure in the “downstream plume area” of the city.XU Xiangde SHI Xiaohui ZHANG Shengjun DING Guoan MIAO Qiuju ZHOU Li 2006Chinese Science Bulletin2006,51,16:8
7Differential surface uplift: Cenozoic paleoelevation history of the Tibetan Plateau显示文摘The surface uplift history of the Tibetan Plateau has provided a key boundary criterion for various geological, climatic,and environmental events since the Cenozoic. The paleoelevation history of the plateau is organically associated with interactions amongst deep geodynamics, earth surface processes, and climate change. Understanding of plateau uplift history has been advanced by the development of a number of paleoaltimetries and their application to studies of the Tibetan Plateau: the paleogeomorphic scenario for the Early Eocene Tibetan Plateau is thought to include two high mountains, the ca. 4500 m Gangdese Mountains to the south, and the ca. 5000 m Qiangtang Center Watershed Mountains to the north. Between these ranges, a low-elevation basin(ca. 2500 m) is thought to have been present. The Himalayas in the southern Tibetan Plateau was close to sea level at this time,while the Hoh Xil Basin in the north reached an elevation of no more than 1500 m. Thus, the so-called 'Roof of the World' Tibetan Plateau formed subsequent to the Miocene. Nevertheless,, the uplift histories of the different terranes that comprise this plateau currently remain unclear, which constrains the uplift history reconstruction of the entire Tibetan Plateau. Additional paleoelevation data from different areas, obtained using multi-paleoaltimeters, is required to resolve the forms and processes of Tibetan Plateau uplift and extension.LIU XiaoHui XU Qiang DING Lin 2016Science China Earth Sciences2016,59,11:6
8Source apportionment of ambient PM_(10) in urban areas of Wuxi,China显示文摘A total of 168 PM_(10)samples were collected during the year of 2005 at eight sites in the city of Wuxi in China.Fifteen chemical elements,three water-soluble ions,total carbon and organic carbon were analyzed.Six source categories were identified and their contributions to ambient PM_(10)in Wuxi were estimated using a nested chemical mass balance method that reduces the effects of colinearity on the chemical mass balance model.In addition,the concentrations of secondary aerosols,such as secondary organic carbon,sulfate and nitrate,were quantified.The spatially averaged PM_(10)was high in the spring and winter(123μg·m^(-3)and low in the summer-fall(90μg·m^(-3)).According to the result of source apportionment,resuspended dust was the largest contributor to ambient PM_(10),accounting for more than 50%of the PM_(10)mass.Coal combustion(14.6%)and vehicle exhaust(9.4%)were also significant source categories of ambient PM_(10).Construction and cement dust,sulfates,secondary organic carbon,and nitrates made contributions ranging between 4.1%and 4.9%.Other source categories such as steel manufacturing dust and soil dust made low contributions to ambient PM_(10).Bo HAN Xiaohui BI Yonghua XUE Jianhui WU Tan ZHU Baogui ZHANG Jianqing DING Yuanxin DU 2011Frontiers of Environmental Science & Engineering2011,5,4:5
9Analysis to significant climate change in aerosol influence domain of Beijing and its peripheral areas by EOF mode显示文摘Using the total ozone mapping spectrometer (TOMS) aerosol optical depth (AOD)data and the sunshine duration, fog days, Iow cloud cover (LCC), etc. meteorological data in 1979-2000 in North China, as well as empirical orthogonal function (EOF) mode statistical analyses method, the winter aerosol distributive character of Beijing and peripheral city agglomeration and its influence effect on regional climate are investigated in this paper, especially the relation between aerosol influence effect and distinct change regions of eigenvectors of EOF mode. It is found from analyzing the regional distribution of the long-term averaged winter TOMS AOD that there is a large-scale relatively stable high value zone of aerosol concentration in the valley of the Beijing and peripheral U-shape megarelief. A high correlation area of AOD between Beijing and its southern peripheral exists in winter, and in this significant region of aerosol interaction, there is 'in-phase' character of the interannual variations of winter AOD, fog days, and LCCs. It indicates that the variations of aerosol in Beijing and its peripheral areas have impacts on interannual changes of fog days and LCCs in this area. The EOF analyses of the meteorological data further reveal the climate change regions and long-term trends of winter sunshine duration-reducing, and LCC- and fog days-increasing in North China. The areas of significant changes of the first EOF eigenvectors (FEE) of sunshine duration, fog days, LCCs almost superpose on corresponding marked regions of interdecadal differences between the 1990s and 1980s, and all accord with the S-N zonal high value pattern and high correlation region of winter AOD in Beijing and its peripheral areas. Interannual variations of their associated time coefficients (ATC) are in phase with that of regional mean AOD, and both of them have a secular rising trend. Results by EOF mode analyses depict the regional climatic change principal character of winter sunshine duration-reducing, and LCC- and fog days-increasing in peripheral areas to the south of Beijing, and reveal the regional influence effect of aerosol, i.e. the high value zone of long-term averaged winter AOD, significant change regions of FEE of sunshine duration, fog days, and LCC all lie in peripheral city agglomeration to the south of Beijing. These distributive features above suggest that there exists a regional strengthening trend of aerosol climatic effect within influence domain in peripheral city agglomeration to the south of Beijing.SHI Xiaohui, XU Xiangde, ZHANG Shengjun & DING Guoan State Key Laboratory of Severe Weather, Chinese Academy of Meteorological Sciences, Beijing 100081, China Nanjing University of Information Science and Technology, Nanjing 210044, China 2005Science China Earth Sciences2005,48,z2:5
10Comparison of viral RNA-host protein interactomes across pathogenic RNA viruses informs rapid antiviral drug discovery for SARS-CoV-2显示文摘In contrast to the extensive research about viral protein–host protein interactions that has revealed major insights about how RNA viruses engage with host cells during infection,few studies have examined interactions between host factors and viral RNAs(vRNAs).Here,we profiled vRNA–host protein interactomes for three RNA virus pathogens(SARS-CoV-2,Zika,and Ebola viruses)using ChIRP-MS.Comparative interactome analyses discovered both common and virus-specific host responses and vRNA-associated proteins that variously promote or restrict viral infection.In particular,SARS-CoV-2 binds and hijacks the host factor IGF2BP1 to stabilize vRNA and augment viral translation.Our interactome-informed drug repurposing efforts identified several FDA-approved drugs(e.g.,Cepharanthine)as broad-spectrum antivirals in cells and hACE2 transgenic mice.A co-treatment comprising Cepharanthine and Trifluoperazine was highly potent against the newly emerged SARS-CoV-2 B.1.351 variant.Thus,our study illustrates the scientific and medical discovery utility of adopting a comparative vRNA-host protein interactome perspective.Shaojun Zhang Wenze Huang Lili Ren Xiaohui Ju Mingli Gong Jian Rao Lei Sun Pan Li Qiang Ding Jianwei Wang Qiangfeng Cliff Zhang 2022Cell Research2022,32,1:5
11Deterministic Approach to Achieve Full-Polarization Cloak显示文摘Achieving full-polarization(σ)invisibility on an arbitrary three-dimensional(3D)platform is a long-held knotty issue yet extremely promising in real-world stealth applications.However,state-of-the-art invisibility cloaks typically work under a specific polarization because the anisotropy and orientation-selective resonant nature of artificial materials made theσ-immune operation elusive and terribly challenging.Here,we report a deterministic approach to engineer a metasurface skin cloak working under an arbitrary polarization state by theoretically synergizing two cloaking phase patterns required,respectively,at spin-up(σ+)and spin-down(σ−)states.Therein,the wavefront of any light impinging on the cloak can be well preserved since it is a superposition ofσ+andσ−wave.To demonstrate the effectiveness and applicability,several proof-of-concept metasurface cloaks are designed to wrap over a 3D triangle platform at microwave frequency.Results show that our cloaks are essentially capable of restoring the amplitude and phase of reflected beams as if light was incident on a flat mirror or an arbitrarily predesigned shape under full polarization states with a desirable bandwidth of~17.9%,conceiving or deceiving an arbitrary object placed inside.Our approach,deterministic and robust in terms of accurate theoretical design,reconciles the milestone dilemma in stealth discipline and opens up an avenue for the extreme capability of ultrathin 3D cloaking of an arbitrary shape,paving up the road for real-world applications.He-Xiu Xu Yanzhao Wang Chaohui Wang Mingzhao Wang Shaojie Wang Fei Ding Yongjun Huang Xiaokuan Zhang Haiwen Liu Xiaohui Ling Wei Huang 2021Research2021,,1:5
12The effects of diltiazem in renal transplantation patients treated with cyclosporine A显示文摘Objective:To investigate the effects of diltiazem and cyclosporine A(CsA)combination therapy on protecting the kidney,promoting graft functioning and improving post-transplanted kidney recovery.Methods:The blood concentrations of CsA,the condition of the post-transplant kidney,the rate of acute rejection(AR),as well as hepatic and renal toxicity in 636 cases of renal transplant recipients were determined after being treated by CsA,with or without diltiazem.Results:Compared with the control group which received CsA,mycophenolate mofetil(MMF) and prednisolone(Pred)but lacked diltiazem,the group receiving these agents together with diltiazem required reduced dosage of CsA(P<0.01),while blood concentrations of CsA were significantly increased(P<0.01);the recovery time of graft function was reduced from(6.2±1.5)d to(3.9±1.4)d(P<0.01),and the rate of AR was decreased from 13.2%to 7.9%(P<0.01).Conclusion:In renal transplantation patients treated with CsA and diltiazem,blood concentrations of CsA were increased while the dosage was decreased.This efficient combination therapy reduced patients'economic burden,at the same time retained kidney function,promoted graft function recovery and decreased hepatic and renal toxicity and the rate of AR.Wujun Xue Yong Song Puxun Tian Xiaoming Ding Xiaoming Pan Hang Yan Jun Hou Xinshun Feng Heli Xiang Xiaohui Tian 2010The Journal of Biomedical Research2010,24,4:4
13A Scale Sequence Object-based Convolutional Neural Network(SS-OCNN)for crop classification from fine spatial resolution remotely sensed imagery显示文摘The highly dynamic nature of agro-ecosystems in space and time usually leads to high intra-class variance and low inter-class separability in the fine spatial resolution(FSR)remotely sensed imagery.This makes traditional classifiers essentially relying on spectral information for crop mapping from FSR imagery an extremely challenging task.To mine effectively the rich spectral and spatial information in FSR imagery,this paper proposed a Scale Sequence Object-based Convolutional Neural Network(SS-OCNN)that classifies images at the object level by taking segmented objects(crop parcels)as basic units of analysis,thus,ensuring that the boundaries between crop parcels are delineated precisely.These segmented objects were subsequently classified using a CNN model integrated with an automatically generated scale sequence of input patch sizes.This scale sequence can fuse effectively the features learned at different scales by transforming progressively the information extracted at small scales to larger scales.The effectiveness of the SS-OCNN was investigated using two heterogeneous agricultural areas with FSR SAR and optical imagery,respectively.Experimental results revealed that the SS-OCNN consistently achieved the most accurate classification results.The SS-OCNN,thus,provides a new paradigm for crop classification over heterogeneous areas using FSR imagery,and has a wide application prospect.Huapeng Li Ce Zhang Yong Zhang Shuqing Zhang Xiaohui Ding Peter M.Atkinson 2021International Journal of Digital Earth2021,14,11:3
14Effect of Curing Temperature on Intermediate Temperature Properties of Calcium Aluminate Cement Bonded Corundum Castables显示文摘In order to study the effect of the curing temperature on the intermediate temperature properties of calcium aluminate cement bonded corundum castables,the prepared castables were cured at 5,10,25,40 and 50℃,respectively,dried at 110℃ for 24 h and heat treated at 800 and 1100 ℃,respectively.Then the apparent porosity,the cold modulus of rupture and the cold crushing strength were measured.The phase composition of castable matrix specimens treated under the same conditions and the influence of the curing temperature on the intermediate temperature strength of the castables were also analyzed.The results show that with the increase of the curing temperature,the hydration degree of calcium aluminate cement increases,which promotes the uniform distribution of hydration products with AI203 after decomposition,thus enhancing the intermediate temperature strength of castables.LI Ye LIU Kun DING Dafei WANG Qingfeng FU Xiaohui YE Guotian 2021China's Refractories2021,30,3:3
15A power plant for integrated waste energy recovery from liquid air energy storage and liquefied natural gas显示文摘Liquefied natural gas(LNG)is regarded as one of the cleanest fossil fuel and has experienced significant developments in recent years.The liquefaction process of natural gas is energy-intensive,while the regasification of LNG gives out a huge amount of waste energy since plenty of high grade cold energy(-160℃)from LNG is released to sea water directly in most cases,and also sometimes LNG is burned for regasification.On the other hand,liquid air energy storage(LAES)is an emerging energy storage technology for applications such as peak load shifting of power grids,which generates 30%-40%of compression heat(-200℃).Such heat could lead to energy waste if not recovered and used.The recovery of the compression heat is technically feasible but requires additional capital investment,which may not always be economically attractive.Therefore,we propose a power plant for recovering the waste cryogenic energy from LNG regasification and compression heat from the LAES.The challenge for such a power plant is the wide working temperature range between the low-temperature exergy source(-160℃)and heat source(-200℃).Nitrogen and argon are proposed as the working fluids to address the challenge.Thermodynamic analyses are carried out and the results show that the power plant could achieve a thermal efficiency of 27%and 19%and an exergy efficiency of 40%and 28%for nitrogen and argon,respectively.Here,with the nitrogen as working fluid undergoes a complete Brayton Cycle,while the argon based power plant goes through a combined Brayton and Rankine Cycle.Besides,the economic analysis shows that the payback period of this proposed system is only 2.2 years,utilizing the excess heat from a 5 MW/40 MWh LAES system.The findings suggest that the waste energy based power plant could be co-located with the LNG terminal and LAES plant,providing additional power output and reducing energy waste.Tongtong Zhang Xiaohui She Yulong Ding 2021Chinese Journal of Chemical Engineering2021,34,6:3
16Assessing Adaptability of Planted Trees Using Leaf Traits: A Case Study with Robinia pseudoacacia L. in the Loess Plateau, China显示文摘Leaf trait patterns and their variations with climate are interpreted as an adaptive adjustment to environment.This study assessed the adaptability of planted black locust (Robinia pseudoacacia L.) based on the analysis of leaf traits and the comparison of its leaf traits with inter-specific ones existing in the same area.We measured some water and N use related leaf traits: leaf dry mass per unit area (LMA) and N,P and K concentrations based on both leaf area (Narea,Parea and Karea) and leaf mass (Nmass,Pmass and Kmass) of R.pseudoacacia at 31 sites along a water stress gradient in North Shaanxi Province,China.The results show that leaves of R.pseudoacacia have high Nmass and low LMA in the study area.High Nmass and low LMA are usually representative of luxurious resource use,and will advance plant resource competitiveness in high-resource conditions.As a whole,LMA-nutrient relationships of R.pseudoacacia display patterns that are fairly similar to the inter-specific relationships in both direction and intensity.The tendency for LMA and Narea to increase with decreasing water availability and the positive correlation between LMA and Narea reflect the trend for R.pseudoacacia to enhance water use efficiency (WUE) at the expense of down-regulated photosynthetic N use efficiency (PNUE) and high construction cost in dry conditions.However,the positive relationship between LMA and Narea in high mean annual precipitation (MAP) area is either unremarkable or reversed with decreasing water availability.This implies a lower photosynthetic capacity and a higher construction cost for high-LMA leaves.The inter-specific relationship between LMA and Narea is positive and does not change with water availability.This difference between inter-species and intra-species may be due to more diversified anatomies and more specialised structures for inter-species than intra-species.The failure of R.pseudoacacia adaption to dry conditions reflected by LMA-Narea relationship may be partially responsible for the emergence of rampike and dwarf forms found frequently in dry conditions.Incorporating intrinsic characteristics of planted trees into vegetation restoration project will be instructive and meaningful for species selection.JIN Tiantian LIU Guohua FU Bojie DING Xiaohui YANG Lei 2011Chinese Geographical Science2011,21,3:3
17Massive allograft replacement in management of bone tumors显示文摘Objective:To evaluate the functional outcome and complications of allograft replacement in management of bone tumors. Methods:Between March 1992 and September 2002,164 patients underwent bone tumor resection and massive allograft reconstruction of bone defects. The length of the resected part ranged from 5-35 cm. The resections were classified as marginal or wide resections of the tumor on the basis of the Musculoskeletal Tumor Society staging system. Fresh-frozen allografts were employed as osteoarticular grafts(n = 95),hemi-condylar(n = 15),massive(n = 23),allograft-prosthesis composite(n = 12),intercalary grafts(n = 15) or hemi-pelvic grafts(n = 4). Most of the lesions were osteosarcoma and giant cell tumor of bone and located in proximal and distal femur,proximal tibia and humerus. Results:At a median follow-up of 47 months(range,12 to 168 months) after the operation,154 of the patients in the study were free of disease and 10 died of disease. Twenty-one(12.8%) patients had local recurrence and 38(23.2%) nonunion. Late complications included 11(6.7%) fractures of the allograft and 18(11.0%) infections of the graft. Instability of the joint in the form of subluxation was noted in 13(7.9%) patients. Ten extremities were amputated due to local recurrence or severe infection. Conclusion:Allografts can be used for reconstruction of bony defects after tumor resection. Allograft has nearly similar shape,strength,osteo-inductivity and osteo-conductivity with host bone. Allograft implantation is a high complication reconstruction method,and the risk of recurrence increases when less surgical margin achieves.Xiaohui Niu Lin Hao Qing Zhang Yi Ding 2008The Chinese-German Journal of Clinical Oncology2008,7,3:2
18Sea surface temperature and subtropical front movement in the South Tasman Sea during the last 800 ka显示文摘Southern Hemisphere mid-latitude westerlies contribute to the ventilation of the deep Southern Ocean(SO),and drive changes in atmospheric carbon dioxide(CO2) and the global climate.As the westerlies control directly oceanic fronts,the movement of the subtropical front(STF) reflects the westerlies migration.Thus it is important to understand the relationships between STF movement and the weaterlies,ventilation of the deep SO,ice volume and atmospheric CO2.To this end,we use two new high-resolution records from early Marine Isotope Stage(MIS) 20(~800 ka) of sea surface temperature(SST) based on U k' 37 paleo-thermometer and benthic oxygen isotope(δ 18OB) at Ocean Drilling Program(ODP) Site 1170B in the southern Tasman Sea(STS),to construct linkages between the marine records and atmospheric proxies from Antarctic ice-cores.During the last 800 ka,the average SST(10.2℃) at Site 1170B is 1.8℃ lower than today(annual average 12℃).The highest average SST of 11.6℃ occurred during MIS 1,and the lowest average SST of 7.8℃ occurred during MIS 2.The warmest and coldest records of 14.7℃ and 6.2℃ occurred in the MIS 5 and MIS 2,respectively.In the glacial-interglacial cycles of the last 800 ka,variability of reconstructed SST shows that the STF moved northward or southward more than 3° of latitude compared with its present location.In the warmest stage MIS 5,the STF shifted to its southernmost location of ~49°S.In contrast,in the coldest stage MIS 2,the STF moved to its northernmost location of ~43°S.In response to orbital cycles,the westerlies movement led ice volume and atmospheric CO2 changes,but it was in phase with change in Antarctic atmospheric temperature.Ice volume only preceded atmospheric CO2 only a little at the 23-ka precession band,lagged the atmospheric CO2 at the 100-ka eccentricity band,and was in phase with atmospheric CO2 at the 40-ka obliquity band.LI WenBao WANG RuJian XIANG Fei DING XiaoHui ZHAO MeiXun 2010Chinese Science Bulletin2010,55,29:2
19Phosphorylation of a wheat aquaporin at two sites enhances both plant growth and defense显示文摘Eukaryotic aquaporins share the characteristic of functional multiplicity in transporting distinct substrates and regulating various processes,but the underlying molecular basis for this is largely unknown.Here,we report that the wheat(Triticum aestivum)aquaporin TaPIP2;10 undergoes phosphorylation to promote photosynthesis and productivity and to confer innate immunity against pathogens and a generalist aphid pest.In response to elevated atmospheric CO_(2)concentrations,TaPIP2;10 is phosphorylated at the serine residue S280 and thereafter transports CO_(2)into wheat cells,resulting in enhanced photosynthesis and increased grain yield.In response to apoplastic H_(2)O_(2) induced by pathogen or insect attacks,TaPIP2;10 is phosphorylated at S121 and this phosphorylated form transports H_(2)O_(2) into the cytoplasm,where H_(2)O_(2)intensifies host defenses,restricting further attacks.Wheat resistance and grain yield could be simultaneously increased by TaPIP2;10 overexpression or by expressing a TaPIP2;10 phosphomimic with aspartic acid substitutions at S121 and S280,thereby improving both crop productivity and immunity.Kai Lu Xiaochen Chen Xiaohui Yao Yuyan An Xuan Wang Lina Qin Xiaoxu Li Zuodong Wang Shuo Liu Zhimao Sun Liyuan Zhang Lei Chen Baoyan Li Baoyou Liu Weiyang Wang Xinhua Ding Yonghua Yang Meixiang Zhang Shenshen Zou Hansong Dong 2022Molecular Plant2022,15,11:2
20Hypoxic preconditioning advances CXCR4 and CXCR7 expression by activating HIF-1α in MSCs显示文摘Hongbao Liu Wujun Xue Guanqun Ge Xiaohui Luo Yang Li Heli Xiang Xiaoming Ding Puxun Tian Xiaohui Tian 2010Biochemical and Biophysical Research Communications2010,,4:2
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