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| 1 | The Epitope Study on the SARS-CoV Nucleocapsid Protein显示文摘The nucleocapsid protein (N protein) has been found to be an antigenic protein in a number of coronaviruses. Whether the N protein in severe acute respiratory syndrome-associated coronavirus (SARS-CoV) is antigenic remains to be elucidated. Using Western blot and Enzyme-linked Immunosorbent Assay (ELISA),the recombinant N proteins and the synthesized peptides derived from the N protein were screened in sera from SARS patients. All patient sera in this study displayed strong positive immunoreactivities against the recombinant N proteins,whereas normal sera gave negative immunoresponses to these proteins, indicating that the N protein of SARS-CoV is an antigenic protein. Furthermore, the epitope sites in the N protein were determined by competition experiments, in which the recombinant proteins or the synthesized peptides competed against the SARS-CoV proteins to bind to the antibodies raised in SARS sera. One epitope site located at the C-terminus was confirmed as the most antigenic region in this protein. A detailed screening of peptide with ELISA demonstrated that the amino sequence from Codons 371 to 407 was the epitope site at the C-terminus of the N protein. Understanding of the epitope sites could be very significant for developing an effective diagnostic approach to SARS. | Shuting Li, Liang Lin, Hao Wang, Jianning Yin, Yan Ren, Zhe Zhao, Jie Wen, Cuiqi Zhou, Xumin Zhang, Xiaolei Li, Jingqiang Wang, Zhengfeng Zhou, Jinxiu Liu, Jianmin Shao, Tingting Lei, Jianqiu Fang, Ningzhi Xu, and Siqi LiuBeijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China & Beijing Proteomics Institute, Beijing 101300, China | 2003 | Genomics, Proteomics & Bioinformatics2003，1，3： | 9 |
| 2 | Vertical Migration of Fine-Grained Sediments from Interior to Surface of Seabed Driven by Seepage Flows–‘Sub-Bottom Sediment Pump Action'显示文摘A scientific hypothesis is proposed and preliminarily verified in this paper: under the driving of seepage flows, there might be a vertical migration of fine-grained soil particles from interior to surface of seabed, which is defined as ‘sub-bottom sediment pump action' in this paper. Field experiments were performed twice on the intertidal flat of the Yellow River delta to study this process via both trapping the pumped materials and recording the pore pressures in the substrate. Experimental results are quite interesting as we did observe yellow slurry which is mainly composed of fine-grained soil particles appearing on the seabed surface; seepage gradients were also detected in the intertidal flat, under the action of tides and small wind waves. Preliminary conclusions are that ‘sediment pump' occurs when seepage force exceeds a certain threshold: firstly, it is big enough to disconnect the soil particles from the soil skeleton; secondly, the degree of seabed fluidization or bioturbation is big enough to provide preferred paths for the detached materials to migrate upwards. Then they would be firstly pumped from interior to the surface of seabed and then easily re-suspended into overlying water column. Influential factors of ‘sediment pump' are determined as hydrodynamics(wave energy), degree of consolidation, index of bioturbation(permeability) and content of fine-grained materials(sedimentary age). This new perspective of ‘sediment pump' may provide some implications for the mechanism interpretation of several unclear geological phenomena in the Yellow River delta area. | ZHANG Shaotong JIA Yonggang WEN Mingzheng WANG Zhenhao Zhang Yaqi ZHU Chaoqi Li Bowen LIU Xiaolei | 2017 | Journal of Ocean University of China2017，16，1： | 8 |
| 3 | Wave flume experiments on the contribution of seabed fluidization to sediment resuspension显示文摘Sediment resuspension is commonly assumed to be eroded from the seabed surface by an excess bottom shear stress and evolves in layers from the top down. Although considerable investigations have argued the importance of wave-induced seabed fluidization in affecting the sediment resuspension, few studies have been able to reliably evaluate its quantitative contribution till now. Attempt is made to preliminarily quantify the contribution of fluidization to resuspension using a series of large-scale wave flume experiments. The experimental results indicated that fluidization of the sandy silts of the Huanghe Delta account for 52.5% and 66.8% of the total resuspension under model scales of 4/20 and 6/20(i.e., relative water depth: the ratio of wave height to water depth), respectively. Some previously reported results obtained using the same flume and sediments are also summarized for a contrastive analysis, through which not only the positive correlation is confirmed, but also a parametric equation for depicting the relationship between the contribution of fluidization and the model scale is established. Finally, the contribution of fluidization is attributed to two physical mechanisms:(1) an attenuation of the erosion resistance of fluidized sediments in surface layers due to the disappearing of original cohesion and the uplifting effect resulting from upward seepage flows, and(2) seepage pumping of fines from the interior to the surface of fluidized seabed. | ZHANG Shaotong JIA Yonggang WANG Zhenhao WEN Mingzheng LU Fang ZHANG Yaqi LIU Xiaolei SHAN Hongxian | 2018 | Acta Oceanologica Sinica2018，37，3： | 6 |
| 4 | Changes in carbon dioxide emissions and LMDI-based impact factor decomposition: the Xinjiang Uygur autonomous region as a case显示文摘Studies on carbon dioxide(CO2)emissions at provincial level can provide a scientific basis for the optimal use of energy and the formulation of CO2reduction policies.We studied the variation of CO2emissions of primary energy consumption and its influencing factors based on data in Xinjiang Uygur autonomous region from1952 to 2008,which were calculated according to the 2006 IPCC Guidelines for National Greenhouse Gas Inventories.Xinjiang’s CO2emission process from 1952 to 2008 could be divided into five stages according to the growth rates of total amount of CO2emissions and CO2emission intensity.The impact factors were quantitatively analyzed using Logarithmic Mean Divisia Index(LMDI)method in each stage.Various factors,including government policies and technological progress related to the role of CO2emissions,were comprehensively analyzed,and the internal relationships among various factors were clarified.The results show that the contribution rates of various impact factors are different in each stage.Overall,economic growth and energy consumption intensity were the main driving factors for CO2emissions.Since the implementation of the birth control policy,the driving force of population growth on the increase in CO2emissions has slowly weakened.The energy consumption intensity was further affected by the industrial structure and energy consumption intensity of primary,secondary and tertiary industries,with the energy consumption intensity of the secondary industries and the proportion of secondary industries being the most important factors affecting the energy consumption intensity.Governmental policies and technological progress were also important factors that affected CO2emissions. | Li ZHANG Jun LEI Xuan ZHOU XiaoLei ZHANG Wen DONG Yu YANG | 2014 | Journal of Arid Land2014，6，2： | 6 |
| 5 | Spatial integration of oasis city group around the western margins of the Tarim Basin显示文摘In this paper,the oasis cities in Kashgar Prefecture and Kizilsu Kirgiz Autonomous Prefecture are taken as an example,through the factor analysis,spatial attraction interaction model and location quotient methods,urban hierarchy system,the intensity of urban economic ties,economic subordination degree,and structure of city functions were analyzed. The results indicated:(1) The urban hierarchy system takes Kashgar city as the main center,Artux city,Yarkant county and Maralbexi county as the sub-centers; (2) The intensity of economic ties among Kashgar city and each county is much higher than others. The interaction of Kashgar city,Shufu county and Shule county are the strongest,and the economic ties of Yarkant,Kagilik,Poskam counties are relatively close; All cities in the study area are economically subordinate to Kashgar city. (3) Three cities of Kashgar city,Shufu county and Shule county should connect strongly,with Kashgar city as the core. The cities and towns along the Southern Xinjiang Railway and along National Road 315 should be regarded as two strips,and the two city strips along the border,and the city strip along Provincial Road 215 should be treated as three axes. The ring structure strategy of 'core ring,closer ring and radiated ring' was proposed. (4) It was proposed to build Kashgar city group in the north,and Yarkant city group in the south,Maralbexi city group in the southeast,and Taxkorgan border city group with four inner groups' development strategy. | Yang, Yu Zhang, XiaoLei Lei, Jun Dong, Wen Zeng, WeiYao Gao, Chao | 2010 | Journal of Arid Land2010，2，3： | 4 |
| 6 | Deployment dynamics for flexible deployable primary mirror of space telescope with paraboloidal and laminated structure by using absolute node coordinate method显示文摘A nonlinear dynamic modeling method for primary mirror of Flower-like Deployable Space Telescope(F-DST)undergoing large deployment motion is proposed in this paper.To ensure pointing accuracy and attitude stability of the paraboloidal primary mirror,the mirror is discretized into equal thickness shell elements by considering shell curvature.And the material nonlinear constitutive relation of flexible mirror is acquired using Absolute Nodal Coordinate Formulation(ANCF).Furthermore,the primary mirror of F-DST can be regarded as a clustered multi-body system,and its dynamic equations of elastic deformation and deployment motion are established by virtual work principle.Finally,the deployment motion of primary mirror by different driving conditions are simulated,the results show that the vibrations of mirrors that driven by elastic hinge device are more than that driven by servo motor.In addition,single sub-mirror deployment process will perturb the pointing accuracy of primary mirror,and the multiple sub-mirrors simultaneously deploying will seriously affect all the sub-mirrors surface accuracy because of the coupling effect.Thus,there are theoretical value and practical significance for the controlling surface accuracy and attitude accuracy of space telescope. | Bindi YOU Dong LIANG Xiangjie YU Xiaolei WEN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 2 |
| 7 | Effect of cooked rice with added fructo-oligosaccharide on faecal microorganisms investigated by in vitro digestion and fermentation显示文摘In the present study,the effects of cooked rice(CR)with added fructo-oligosaccharide(FOS)on faecal flora were studied by a simulated in vitro digestion and fermentation method.The total carbohydrate content,p H,and s hort-chain fatty acids(SCFAs)were determined during in vitro digestion and fermentation.The change in the bacterial phase distribution after the fermentation was also analysed.The results showed that t he total carbohydrate content of the CR with added FOS(FCR)significantly decreased during the simulated digestion.Meanwhile,the p H of the FCR decreased and the SCFAs concentration increased significantly compared to those of the CR during the simulated fermentation.In addition,the FCR showed the advantage of promoting beneficial bacteria,such as Bifidobacterium and Lactobacillus,and inhibiting harmful bacteria,such as Bacteroides and Klebsiella compared to the CR.Therefore,the FOS as a prebiotic could be recommended to produce the high-quality healthy rice food. | Fei Pei Wen Li Xiaolei Ni Xinyang Sun Yijun Yao Yong Fang Wenjian Yang Qiuhui Hu | 2023 | Food Science and Human Wellness2023，12，2： | 2 |
| 8 | Influence of tourist disturbance on soil properties, plant communities, and surface water quality in the Tianchi scenic area of Xinjiang, China显示文摘The impact of tourist disturbance on the environment has become a focal issue of environmental science, ecology, and travel management studies. To assess the influence of tourist disturbance on soils and plants in the Tianchi scenic area of Xinjiang, China, we compared soil properties and plant community characteristics at 0, 5, 10, and 20 m from the tourist trail within areas at three different altitudes, where the intensities of tourist disturbance are distinct. Surface water quality was also studied at three different levels relative to the Tianchi Lake. The results showed that tourist disturbance significantly increased soil p H within 10 m from the trail and soil bulk density on the edge of the trail, but significantly reduced soil organic matter and total nitrogen contents within 5 m from the trail. The number of tree seedlings on the edge of the trail and the shrub coverage and height of herbaceous plants within 5 m from the trail significantly decreased due to tourist disturbance. Changes in herbaceous plant diversity differed by soil zones. In the high altitude region, tourist disturbance led to a remarkable increase in the herbaceous plant diversity on the edge of the trail, while in the low altitude region, tourist disturbance had a low impact on the diversity of herbaceous plants. In addition, tourist activities polluted the surface water, significantly reducing water quality. Thus, current tourist activities have a significant negative impact on the ecological environment in the Tianchi scenic area. | WEN Bin ZHANG Xiaolei YANG Zhaoping XIONG Heigang QIU Yang | 2016 | Journal of Arid Land2016，8，2： | 2 |
| 9 | Regional Structure and Spatial Morphology Characteristics of Oasis Urban Agglomeration in Arid Area——A Case of Urban Agglomeration in Northern Slope of Tianshan Mountains,Northwest China显示文摘It is great important to the health development of urban agglomeration to correctly understand the formation and development law of regional structure of urban agglomeration.Employing the analysis methods like fractal theory and quantitative statistics,coupling with the use of remote sensing images and other spatial data,this article discusses the urban agglomeration of oasis on the northern slope of the Tianshan Mountains in an arid area,and conducts the researches on its city scale,spatial distribution and individual form from 1990 to 2005.The result shows that it has loose hierarchical scale structure and polarization trend of population distribution while its hierarchical scale structure tends to mature.Under the influence of natural conditions,the spatial layout of urban agglomeration of oasis has macro characteristics that suggest cities distributed along oasis edges(dense or sparse),spatially expand along rivers,and cluster around traffic branches.The connectivity among the cities is high and shows an internal organization form of a banding distribution.The whole spatial shape of the internal structure of cities presents a 'dumbbell' form,with mononuclear phenomenon receding and multi-nuclear appearing gradually.Individual cities spatially expand along rivers,portraying a long strip appearance.It indicates that the urban agglomeration of oasis shows regular and close structure but with a tendency to be complicated form and the loose structure.In the development of urban agglomeration,the authors recommend that the development of the city with good economic development conditions should be strengthened,and more attention be put into regional planning. | ZHANG Yufang YANG Degang ZHANG Xinhuan DONG Wen ZHANG Xiaolei | 2009 | Chinese Geographical Science2009，19，4： | 2 |
| 10 | Effect of Leading-Edge Optimization on the Loss Characteristics in a Low-Pressure Turbine Linear Cascade显示文摘This paper presents a numerical study on the aerodynamics loss reduction characteristics after the leading-edge(LE) optimization in a low-pressure turbine linear cascade. The LE was optimized with a simple and practical method of 'Class Function/Shape Function Transformation Technique'(CST). The simulation conditions, covering the whole working range, were independently determined by incidence, Reynolds number and Mach number. Quantitative loss analyses were carried out with a loss breakdown method based on volumetric integration of entropy production rates. To understand the reason of loss reduction, the local sources at different operating points were identified with entropy production rates. The results showed that LE optimization with the CST method played a positive role in decreasing the total losses, and the working range with lower loss was extended. The profile loss and the endwall loss were significantly reduced by the LE optimization, which were also verified to be the major causes of the total loss reduction by loss breakdown. The decrease of profile loss can be attributed to the boundary layer near the LE region and the boundary layer of downstream at off-design incidence. The reduction mostly came from the pressure side at negative incidence, while came from the suction side at the positive incidence. The endwall loss was decreased markedly about 2.5%–5% by the LE optimization at the incidence of-12°, which was 1% at the incidence of 12°. The mechanism for the endwall loss reduction at different incidences was different from each other. At negative incidence, the LE optimization diminished the corner separation vortex on the pressure side. While at positive incidence, the benefits came from three aspects, i.e., reduced suction LE separation bubbles close to the endwall, reduced passage vortex strength, and weakened shear process between passage vortex and trailing shed vortex. The loss of the downstream zone was relatively lower than that of the profile losses and the endwall losses. The effect of LE optimization on the loss of the downstream zone at different conditions was complex and it depended both on the profile boundary layer behavior at the suction trailing edge and on the passage vortex strength. | CUI Tao WANG Songtao TANG Xiaolei WEN Fengbo WANG Zhongqi | 2019 | Journal of Thermal Science2019，28，5： | 1 |
| 11 | Plasmonic Refractive Index Sensors Based on One-and Two-Dimensional Gold Grating on a Gold Film显示文摘In this paper,we propose two kinds of composite structures based on the one-and two-dimensional(1D&2D)gold grating on a gold film for plasmonic refractive index sensing.The resonance modes and sensing characteristics of the composite structures are numerically simulated by the finite-difference time-domain method.The composite structure of the 1D gold semi-cylinder grating and gold film is analyzed first,and the optimized parameters of the grating period are obtained.The sensitivity and figure of merit(FOM)can reach 660 RIU/nm and 169 RIU-1,respectively.Then,we replace the 1D grating with the 2D gold semi-sphere particles array and find that the 2D grating composite structure can excite strong surface plasmon resonance intensity in a wider period range.The sensitivity and FOM of the improved composite structure can reach 985 RIU/nm and 298 RIU-1,respectively.At last,the comparison results of the sensing performance of the two structures are discussed.The proposed structures can be used for bio-chemical refractive index sensing. | Jiankai ZHU Xiangxian WANG Yuan WU Yingwen SU Tianxu JIA Hua YANG Liping ZHANG Yunping QI Xiaolei WEN | 2020 | Photonic Sensors2020，10，4： | 1 |
| 12 | Effect of Different Trench Lips on Downstream Film Cooling Effectiveness and Flow Fields显示文摘In the present study, the trenched configurations, including traditional trench(TT), fillet trench(FT) and varying-radius trench(VRT), are numerically investigated at different conditions in terms of downstream cooling effectiveness and flow fields. Different trench width and fillet radii are discussed at different blowing ratios and density ratios. Results show that the downstream lips mainly change the downstream pressure distributions and then change the lateral coolant distribution. The downstream fillet can reduce the penetration of coolant and improve laterally averaged effectiveness in the configurations with the narrow trench at modest blowing ratios. The enhancement of cooling effectiveness near the centerline plane is the positive effect of downstream fillet. This enhancement becomes more obvious with the increase of fillet radius, except for high blowing ratio. The fillet lip, compared with TT cases, also leads to a decline of coolant lateral spread for configurations with the wide trench and large radius, and more decline in the lateral direction deteriorates downstream overall cooling performance. Besides, the increase of density ratio contributes to a higher cooling effectiveness for fillet trench configurations. VRT cases guarantee the streamwise extension and lateral spread of coolant, therefore improving downstream cooling effectiveness further at blowing ratio M=1.0 and 1.5. | HOU Rui WEN Fengbo CUI Tao TANG Xiaolei WANG Songtao | 2019 | Journal of Thermal Science2019，28，2： | 1 |
| 13 | Plasmonic Coupling Effect in Ag Nanocap–Nanohole Pairs for Surface-Enhanced Raman Scattering显示文摘 | Xiaolei Wen | 2012 | Plasmonics2012，8，： | 1 |
| 14 | Urumqi显示文摘 | Dong Wen Zhang Xiaolei | 2011 | Cities2011，28，1： | 1 |
| 15 | The controlling factors of high suspended sediment concentration in the intertidal flat off the Huanghe River Estuary显示文摘The Huanghe River(Yellow River)is known by its high suspended sediment concentration(SSC)in its river mouth tidal flat.However,the factors controlling the high SSC over there are not well understood.Therefore,we conducted 7-d hydrodynamic observations(water depth,wave height,and current velocity)and SSC measurements on the tidal flat off the Huanghe River Mouth.The data shows that in most of time,under the calm sea condition,the SSC ranges 0.1–3.5 g/L,and sediment discharge from the river is the main source.However,when hydrodynamics are enhanced in a tidal cycle and large-scale erosion occurs on the seafloor,resuspended sediment becomes the main source,and the SSC in the water column reaches 17.3 g/L.We find the suspended sediment flux is mainly controlled by the tidal current and Stokes drift,while the wave-induced shear stress could also affect the variation of suspended sediment flux.During the observation period,when sea under calm-rippled conditions,the current-induced resuspended sediment concentration(RSC)was greater than the wave-induced RSC.In contrast,in smooth-wavelet sea conditions,the wave-induced RSC was greater than the current-induced RSC,for instance,a single wave event was found to cause 11.8 cm seabed erosion within 6 h.This study reveals different controlling factors for the high SSC near a river-influenced tidal flat,and helps us get a better understanding of a delta's depositional and erosional mechanisms. | Bowen Li Yonggang Jia J.Paul Liu Jianfeng Su Xiaolei Liu Mingzheng Wen | 2020 | Acta Oceanologica Sinica2020，39，10： | 1 |
| 16 | Lyapunov-based fixed-time stabilization control of quantum systems显示文摘In this paper,we consider the fixed-time stabilization control problem of quantum systems modeled by Schrodinger equations.Firstly,the Lyapunov-based fixed-time stability criterion is extended to finitedimensional closed quantum systems in the form of coherence vectors.Then for a two-level quantum system with single control input,a non-smooth fractional-order control law is designed using the relative state distance.By integrating the fixed-time Lyapunov control technique and the bi-limit homogeneity theory,the quantum system is proved to be stabilized to an eigenstate of the inherent Hamiltonian in a fixed time.Comparing with existing methods in quantum system control,the proposed approach can guarantee stabilization in a fixed time without depending on the initial states. | Xiaolei Li Changyun Wen Jiange Wang | 2022 | Journal of Automation and Intelligence2022，1，1： | 0 |
| 17 | Enhancement of silicon sub‑bandgap photodetection by helium‑ion implantation显示文摘Silicon sub-bandgap photodetectors can detect light at the infrared telecommunication wavelengths but with relatively weak photo-response.In this work,we demonstrate the enhancement of sub-bandgap photodetection in silicon by helium-ion implantation,without afecting the transparency that is an important benefcial feature of this type of photodetectors.With an implantation dose of 1×10^(13)ions/cm^(2),the minimal detectable optical power can be improved from−33.2 to−63.1 dBm,or,by 29.9 dB,at the wavelength of 1550 nm,and the photo-response at the same optical power(−10 dBm)can be enhanced by approximately 18.8 dB.Our work provides a method for strategically modifying the intrinsic trade-of between transparency and strong photo-responses of this type of photodetectors. | Zhao Wang Xiaolei Wen Kai Zou Yun Meng Jinwei Zeng Jian Wang Huan Hu Xiaolong Hu | 2023 | Frontiers of Optoelectronics2023，16，4： | 0 |
| 18 | Event-triggered H_(∞) PI state estimation for delayed switched neural networks显示文摘On state estimation problems of switched neural networks,most existing results with an event-triggered scheme(ETS)not only ignore the estimator information,but also just employ a fixed triggering threshold,and the estimation error cannot be guaranteed to converge to zero.In addition,the state estimator of non-switched neural networks with integral and exponentially convergent terms cannot be used to improve the estimation performance of switched neural networks due to the difficulties caused by the nonsmoothness of the considered Lyapunov function at the switching instants.In this paper,we aim at overcoming such difficulties and filling in the gaps,by proposing a novel adaptive ETS(AETS)to design an event-based H_(∞)switched proportional-integral(PI)state estimator.A triggering-dependent exponential convergence term and an integral term are introduced into the switched PI state estimator.The relationship among the average dwell time,the AETS and the PI state estimator are established by the triggering-dependent exponential convergence term such that estimation error asymptotically converges to zero with H_(∞)performance level.It is shown that the convergence rate of the resultant error system can be adaptively adjusted according to triggering signals.Finally,the validity of the proposed theoretical results is verified through two illustrative examples. | Yuzhong Wang Changyun Wen Xiaolei Li | 2024 | Journal of Automation and Intelligence2024，3，1： | 0 |
| 19 | Experimental Researches on the Accuracy of Micro- Electromechanical Accelerometer-Array in Seafloor Failure Deformation Measurement显示文摘At present,there are few technologies applied to in situ observation of seabed deformation,among which the micro-electromechanical accelerometer-array(hereinafter referred to as accelerometers array)is a very advantageous measurement method,with both commercial products and successful application cases.However,the coupling effect between accelerometer-array and sur-rounding soil and the linkage effect of accelerometer-array itself during the deformation may influence the accuracy and reliability of the measurement data.A simulation test chamber was designed and processed,and four groups of simulation tests were carried out to explore the coupling effect and linkage effect of accelerometer-array in the soil with different degree of consolidation.The results show that the accelerometer-array and the soil coupled well,and the coupling effect is positively correlated with the degree of soil consoli-dation.The ratio of accumulative deviation to soil lateral deformation is high at the initial stage of deformation(0-50 mm)and reduced with the continuous increase of deformation(>100 mm).In the process of liquefied soil deformation,the linkage effect of accelerometer array can be ignored,and is negatively correlated with the degree of soil consolidation.A concept to improve the measurement accu-racy of accelerometer-array in different seafloor failure deformation modes is proposed.The research results provide references for the modification of accelerometer-array and the improvement for other flexible rod-shaped deformation sensors. | WANG Zhenhao LIU Xiaolei ZHANG Shaotong WEN Mingzheng SHAN Hongxian JIA Yonggang | 2022 | Journal of Ocean University of China2022，21，5： | 0 |
| 20 | Homeobox Gene Six3 is Required for the Differentiation of D2-Type Medium Spiny Neurons显示文摘Medium spiny neurons(MSNs)in the striatum,which can be divided into D1 and D2 MSNs,originate from the lateral ganglionic eminence(LGE).Previously,we reported that Six3 is a downstream target of Sp8/Sp9 in the transcriptional regulatory cascade of D2 MSN development and that conditionally knocking out Six3 leads to a severe loss of D2 MSNs.Here,we showed that Six3 mainly functions in D2 MSN precursor cells and gradually loses its function as D2 MSNs mature.Conditional deletion of Six3 had little effect on cell proliferation but blocked the differentiation of D2 MSN precursor cells.In addition,conditional overexpression of Six3 promoted the differentiation of precursor cells in the LGE.We measured an increase of apoptosis in the postnatal striatum of conditional Six3-knockout mice.This suggests that,in the absence of Six3,abnormally differentiated D2 MSNs are eliminated by programmed cell death.These results further identify Six3 as an important regulatory element during D2 MSN differentiation. | Xiaolei Song Haotian Chen Zicong Shang Heng Du Zhenmeiyu Li Yan Wen Guoping Liu Dashi Qi Yan You Zhengang Yang Zhuangzhi Zhang Zhejun Xu | 2021 | Neuroscience Bulletin2021，37，7： | 0 |
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