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| 1 | Complement C3 activation regulates the production of tRNA-derived fragments Gly-tRFs and promotes alcohol-induced liver injury and steatosis显示文摘Complement is known to play a role in alcoholic fatty liver disease (AFLD), but the underlying mechanisms are poorly understood, thereby constraining the development of a rational approach for therapeutic intervention in the complement system. C3 deficiency has been shown to impart protective effects against ethanol-induced hepatic steatosis and inflammation. Here we demonstrate a protection effect in wild-type mice by treatment with CR2-Crry, a specific inhibitor of C3 activation. The expression of glycine transfer (t) RNA-derived fragments (Gly-tRFs) is upregulated in ethanol-fed mice and inhibition of Gly-tRFs in vivo decreases chronic ethanol feeding-induced hepatosteatosis without affecting inflammation. The expression of Gly-tRF was downregulated in C3-deficient or CR2-Crry-treated mice, but not in C5-deficient mice;Gly-tRF expression was restored by the C3 activation products C3a or Asp (C3a-des-Arg) via the regulation of CYP2E1. Transcriptome profiling of hepatic tissues showed that Gly-tRF inhibitors upregulate the expression of sirtuin1 (Sirt1) and subsequently affect downstream lipogenesis and β-oxidation pathways. Mechanistically, Gly-tRF interacts with AGO3 to downregulate Sirt1 expression via sequence complementarity in the 3′ UTR. Notably, the expression levels of C3d, CYP2E1 and Gly-tRF are upregulated, whereas Sirt1 is decreased in AFLD patients compared to healthy controls. Collectively, our findings suggest that C3 activation products contribute to hepatosteatosis by regulating the expression of Gly-tRF. Complement inhibition at the C3 activation step and treatment with Gly-tRF inhibitors may be potential and precise therapeutic approaches for AFLD. | Fudi Zhong Zhigao Hu Keqing Jiang Biao Lei Zhan Wu Guandou Yuan Hongliang Luo Chunqiang Dong Bo Tang Chaowen Zheng Shuai Yang Yonglian Zeng Zhenya Guo Shuiping Yu Huizhao Su Guo Zhang Xiaoqiang Qiu Stephen Tomlinson Songqing He | 2019 | Cell Research2019，29，7： | 14 |
| 2 | Mechanically reprogrammable Pancharatnam-Berry metasurface for microwaves显示文摘Metasurfaces have enabled the realization of several optical functionalities over an ultrathin platform,fostering the exciting field of flat optics.Traditional metasurfaces are achieved by arranging a layout of static meta-atoms to imprint a desired operation on the impinging wavefront,but their functionality cannot be altered.Reconfigurability and programmability of metasurfaces are the next important step to broaden their impact,adding customized on-demand functionality in which each meta-atom can be individually reprogrammed.We demonstrate a mechanical metasurface platform with controllable rotation at the meta-atom level,which can implement continuous Pancharatnam–Berry phase control of circularly polarized microwaves.As the proof-of-concept experiments,we demonstrate metalensing,focused vortex beam generation,and holographic imaging in the same metasurface template,exhibiting versatility and superior performance.Such dynamic control of electromagnetic waves using a single,low-cost metasurface paves an avenue towards practical applications,driving the field of reprogrammable intelligent metasurfaces for a variety of applications. | Quan Xu Xiaoqiang Su Xueqian Zhang Lijuan Dong Lifeng Liu Yunlong Shi Qiu Wang Ming Kang Andrea Alù Shuang Zhang Jiaguang Han Weili Zhang | 2022 | Advanced Photonics2022，4，1： | 5 |
| 3 | Theoretical Study About Effects of H20 and Na+ on Adsorption of CO2 on Kaolinite Surfaces显示文摘 | WU Dinglu JIANG Wen LIU Xiaoqiang QIU Nianxiang XUE Ying | 2016 | Chemical Research in Chinese Universities2016，32，1： | 3 |
| 4 | Synergistic Action of Clonorchiasis,HBV Infection and Alcohol Consumption on Primary Hepatocellular Carcinoma显示文摘OBJECTIVE It has been recognized that HBV infection andalcohol consumption are two important risk factors for primaryhepatocellular carcinoma (HCC). Recently, the role of clonorchiasisas a risk factor for HCC is controversial. We aimed to investigatewhether these factors increase the risk of HCC in Guangxi, China.METHODS A hospital-based, case-control study of HCCwas conducted from July 2005 to July 2007. We enrolled 500consecutive patients with HCC as an experimental group and 500patients without tumor in liver as a control group. The risk factorsthat the patients were exposed to were assessed.RESULTS Comparing the risks of developing the HCC, wefound out the following results. The risk of developing HCC forthe patients with clonorchiasis was 5 folds of that for the patientswithout clonorchiasis (OR = 5.0; 95% CI: 3.1-8.1), and the risk forthe patients with alcohol consumption was 3 folds of that for thepatients without drinking alcohol (OR = 3.4; 95% CI: 2.3-4.9), andsimilarly, the risk for the patients with HBV infection was 21 timesof that for the patients without HBV infection (OR = 20.6; 95% CI:14.3-29.7). According to crossover analysis, there was significantinteraction among clonorchiasis, HBV infection and alcoholconsumption, with synergistic indices greater than 1. The etiologicfractions attributed to these interactions [EF (A x B)] are 0.7465,0.5789 and 0.5506, respectively.CONCLUSION Clonorchiasis, HBV infection and heavy alcoholconsumption are independent risk factors for developing HCC inour population in Guangxi, and as they can interact synergistically,the risk of developing HCC is increased. Data from this study mayindicate new prevention strategies of developing HCC in high-riskindividuals. | Shengkui Tan Xiaoqiang Qiu Hongping Yu Xiaoyun Zeng Zengming Xiao Lequn Li Qiuan Zhong | 2009 | Chinese Journal of Clinical Oncology2009，6，2： | 2 |
| 5 | Short- term wind speed syntheses correcting forecasting model and its application显示文摘 | Nan Xiaoqiang Li Qunzhan Qiu Daqiang | 2013 | Electrical Power and Energy Systems2013，49，： | 1 |
| 6 | The research on intelligent neural extended Petri nets workflow model for inter- organizational collaboration显示文摘 | WU Xiaoqiang QIU Wanhua | 2004 | System Engineer2004，，： | 1 |
| 7 | Mechanical admittance measurement and analysis of dwarf Chinese hickory trees under impact excitations显示文摘 | Du Xiaoqiang Chen Shaozhong Qiu Gaohe | 2014 | Transactions of the ASABE2014，57，2： | 1 |
| 8 | A new construction for optimal optical orthogonal codes显示文摘 | An Xiaoqiang Qiu Kun | 2003 | Journal of Optical Communications2003，24，1： | 1 |
| 9 | Construction for optimal optical orthogonal codes显示文摘 | An Xiaoqiang Kun Qiu | 2002 | IEEE 2002 International Conference on2002，29，1： | 1 |
| 10 | Effect of Dzyaloshinskii-Moriya anisotropic antisymmetric interaction and intrinsic decoherence on entanglement teleportation显示文摘 | Qiu Liang Wang Anmin Su Xiaoqiang | 2008 | Physica A2008，387，26： | 1 |
| 11 | The expression and clinical significance of long non-coding RNA LOC728040 in hepatocellular carcinoma显示文摘Objective:This study aimed to investigate the expression of long non-coding RNA LOC728040in hepatocellular carcinoma(HCC)tissues and normal tissues.Methods:Quantitative reverse-transcription PCR(qPCR)was performed to detect the expression of LOC728040in HCC tissues and paracancer tissues to explore the differences of the clinical indicators of HCC between two groups of low and high expression.And the target genes prediction of LOC728040as a supplement.Results:The lower expression of LOC728040was found in HCC tissues compared with the paracancer tissues(P<0.05).According to the expression,Patients were divided into two groups,and their occupation,tumor capsular and serum alkaline phosphatase(ALP)were significantly different(P<0.05).We found LOC728040upstream existed an alpha albumin gene(AFM)through the Cis analysis by Blast software.Conclusion:Long non-coding RNA LOC728040was markedly downregulated in HCC tissues and was correlated with occupation tumor capsular and serum ALP.The LOC728040might be a biomarker for detection of HCC or other cancers,but its underlying mechanisms still need further study. | Xiaoyun Yang Qian Liao Xiaoqiang Qiu | 2017 | 广西医科大学学报2017，34，5： | 0 |
| 12 | ELIMINATING SPEED PENALTIES IN ECC PROTECTED MEMORY DESIGNS USING “BIT BYPASSING” TECHNIQUES显示文摘In deep sub-micron ICs, growing amounts of on-die memory and scaling effects make embedded memories more vulnerable to reliability problems, such as soft errors induced by radiation. Error Correction Code(ECC) along with scrubbing is an efficient method for protecting memories against these errors. However, the latency of coding circuits brings speed penalties in high performance applications. This paper proposed a 'bit bypassing' ECC protected memory by buffering the encoded data and adding an identifying address for the input data. The proposed memory design has been fabricated on a 130 nm CMOS process. According to the measurement, the proposed scheme only gives the minimum delay overhead of 22.6%, compared with other corresponding memories. Furthermore, heavy ion testing demonstrated the single event effects performance of the proposed memory achieves error rate reductions by 42.9 to 63.3 times. | Zhi Tian Yang Haigang Cai Gang Qiu Xiaoqiang Shu Yi Li Yue Cheng Xiaoyan | 2014 | Journal of Electronics(China)2014，31，4： | 0 |
| 13 | Anisodine hydrobromide alleviates oxidative stress caused by hypoxia/reoxygenation in human cerebral microvascular endothelial cells predominantly via inhibition of muscarinic acetylcholine receptor 4显示文摘Background:Anisodine hydrobromide(AT3),an anti-cholinergic agent,could be delivered to the brain across the blood-brain barrier and has been used clinically for the treatment of cerebral ischemia/reperfusion injury.Endothelial dysfunction can be caused by hypoxia/reoxygenation(H/R)via oxidative stress and metabolic alterations.The present study investigated whether AT3 regulates the production of nitric oxide(NO)and reactive oxygen species(ROS),and the HIF-1αpathway via regulation of muscarinic acetylcholine receptors(mAChRs)in brain microvascular endothelial cells after H/R exposure.Methods:Under H/R conditions,hCMEC/D3 cerebral microvascular endothelial cells were treated with AT3.Specific inhibitors of M2-and M4-mAChRs were used to explore the mechanism by which AT3 influences oxidative stress in endothelial cells.Then,mAChRs expression was detected by western blotting and NO production was detected by Greiss reaction.The intracellular ROS level was measured using DCFH-DA probes.The expression of hypoxia-inducible transcription factor 1α(HIF-1α)was also detected.Results:While H/R induced the expression of M2-and M4-mAChRs,AT3 suppressed the H/R-upregulated M2-and M4-mAChRs.H/R also induced the production of NO,ROS,and apoptosis.AT3 and M4-mAChR inhibitors inhibited the H/R-induced production of NO and ROS and apoptosis.HIF-1αwas induced by H/R,but was suppressed by AT3.Conclusion:Thus,the in vitro evidence shows that AT3 protects against H/R injury in cerebral microvascular endothelial cells via inhibition of HIF-1α,NO and ROS,predominantly through the downregulation of M4-mAChR.The findings offer novel understandings regarding AT3-mediated attenuation of endothelial cell apoptosis and cerebral ischemia/reperfusion injury. | WENLI JIANG JUNYI SHEN XIAOQIANG DU YAN QIU JIAN ZHONG ZHI OUYANG BINGMEI M.FU YE ZENG | 2023 | BIOCELL2023，47，10： | 0 |
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