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| 1 | LMM5.1 and LMM5.4,two eukaryotic translation elongation factor 1Alike gene family members,negatively affect cell death and disease resistance in rice显示文摘Lesion mimic mutant(LMM) genes, stimulating lesion formation in the absence of pathogens, play significant roles in immune response. In this study, we characterized a rice lesion mimic mutant, lmm5,which displayed light-dependent spontaneous lesions. Additionally, lmm5 plants exhibited enhanced resistance to all of the tested races of Magnaporthe oryzae and Xanthomonas oryzae pv. oryzae(Xoo) by increasing the expression of defense-related genes and the accumulation of hydrogen peroxide. Genetic analysis showed that the lesion mimic phenotype of lmm5 was controlled by two genes, lmm5.1 and lmm5.4, which were isolated with a map-based cloning strategy. Remarkably, LMM5.1 and LMM5.4 share a 97.4% amino acid sequence identity, and they each encode a eukaryotic translation elongation factor 1A(e EF1A)-like protein. Besides, LMM5.1 and LMM5.4 were expressed in a tissue-specific and an indicaspecific manner, respectively. In addition, high-throughput m RNA sequencing analysis confirmed that the basal immunity was constitutively activated in the lmm5 mutant. Taken together, these results suggest that the homologous e EF1A-like genes, LMM5.1 and LMM5.4, negatively affect cell death and disease resistance in rice. | Jiying Zhao Pengcheng Liu Chunrong Li Yanyan Wang Lequn Guo Guanghuai Jiang Wenxue Zhai | 2017 | Journal of Genetics and Genomics2017，44，2： | 10 |
| 2 | Synergistic Action of Clonorchiasis,HBV Infection and Alcohol Consumption on Primary Hepatocellular Carcinoma显示文摘OBJECTIVE It has been recognized that HBV infection andalcohol consumption are two important risk factors for primaryhepatocellular carcinoma (HCC). Recently, the role of clonorchiasisas a risk factor for HCC is controversial. We aimed to investigatewhether these factors increase the risk of HCC in Guangxi, China.METHODS A hospital-based, case-control study of HCCwas conducted from July 2005 to July 2007. We enrolled 500consecutive patients with HCC as an experimental group and 500patients without tumor in liver as a control group. The risk factorsthat the patients were exposed to were assessed.RESULTS Comparing the risks of developing the HCC, wefound out the following results. The risk of developing HCC forthe patients with clonorchiasis was 5 folds of that for the patientswithout clonorchiasis (OR = 5.0; 95% CI: 3.1-8.1), and the risk forthe patients with alcohol consumption was 3 folds of that for thepatients without drinking alcohol (OR = 3.4; 95% CI: 2.3-4.9), andsimilarly, the risk for the patients with HBV infection was 21 timesof that for the patients without HBV infection (OR = 20.6; 95% CI:14.3-29.7). According to crossover analysis, there was significantinteraction among clonorchiasis, HBV infection and alcoholconsumption, with synergistic indices greater than 1. The etiologicfractions attributed to these interactions [EF (A x B)] are 0.7465,0.5789 and 0.5506, respectively.CONCLUSION Clonorchiasis, HBV infection and heavy alcoholconsumption are independent risk factors for developing HCC inour population in Guangxi, and as they can interact synergistically,the risk of developing HCC is increased. Data from this study mayindicate new prevention strategies of developing HCC in high-riskindividuals. | Shengkui Tan Xiaoqiang Qiu Hongping Yu Xiaoyun Zeng Zengming Xiao Lequn Li Qiuan Zhong | 2009 | Chinese Journal of Clinical Oncology2009，6，2： | 2 |
| 3 | Molecular and functional heterogeneity ofT regulatory cells 显示文摘 | Lequn Li Boussiotis V A | 2011 | Clinical Immunology2011，141，3： | 1 |
| 4 | A pathway regulated by cell cycle inhibitor p27Kipl and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance 显示文摘 | Lequn Li Yoshiko Iwamoto Berezovskaya A | 2006 | Nature Immunology ( 1529- 2916 )2006，7，11： | 1 |
| 5 | Experimental research on cartilage viscoelastic properties about natural body joints 显示文摘 | MA Lequn LI Zhenyu MA Hongshun | 1997 | China Journal of Modern Medicine1997，7，12： | 1 |
| 6 | Liver Stem/Progenitor Cells in the Canals of Hering: Cellular Origin of Hepatocellular Carcinoma with Bile Duct Tumor Thrombi?显示文摘 | Ningfu Peng Lequn Li Xiang Cai Shaozao Tan Ting Wu | 2010 | Stem Cell Reviews and Reports2010，，4： | 1 |
| 7 | Hepatitis B virus infection eontributes to oxidative stress in a population exposed to aflatoxin B1 and high risk for hepatocellular carcinoma显示文摘 | Liu Zhiming Li Lequn Peng Minhao | 2008 | Cancer Lett2008，263，2： | 1 |
| 8 | The development and management of private enterprises in conditions of in formalization显示文摘 | Lequn Li Tianji Li | 2013 | International Journal of Technology Management2013，，3： | 0 |
| 9 | Management mechanism and the development Strategies of private enterprises显示文摘 | Lequn Li | 2014 | International Journal of Technology Management2014，，3： | 0 |
| 10 | Management research on private enterprise under the background of diversification strategy显示文摘 | Lequn Li | 2014 | International Journal of Technology Management2014，，2： | 0 |
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