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| 1 | Portal vein embolization by fine needle ethanol injection :experimental and clinicalstudies显示文摘AIM To improve the technique of intraportal embolization (PVE) therapy, a new embolic method, was devised and the safety, effectiveness and feasibility were evaluated. METHODS PVE with intraportal ethanol injection via a fine needle was performed in 28 normal dogs, 22 SD rats, and 24 cirrhotic SD rats. After PVE, portography, histological and functional alteration of the liver were evaluated in dogs and rats, and the changes in portal hemodynamics as well as hepatic anatomy were observed in rats. In the clinical study, PVE by ethanol injection was performed in 61 patients with hepatocellular carcinoma under the guidance of portoechography with intraportal injection of CO 2. The effect of PVE was evaluated by ultrasonography and laparotomy. RESULTS The effectiveness and toxicity were dependent on the dose of ethanol. In the dogs, 0 25*!mg/*!kg of ethanol caused incomplete embolization with least liver damage, while 1 0*!mg/*!kg induced complete embolization with a high mortality of 57 1% (4/*!7) due to respiratory arrest. The dose of 0 5*!mg/*!kg resulted in complete embolization with slight toxicity to the liver. In the rats, the survival rate was 100% in normal group but 40 9% in cirrhotic models after ethanol injection by dose of 0 05*!mg/*!100*!g . PVE for cirrhotic rats with 0 03*!mg/*!100*!g of ethanol induced satisfactory embolization with significant hypertrophy in nonembolized lobes, and only slight damage to the hepatic parenchyma, and transient alteration in liver function, portal pressure and portal flow. In the clinical study, 12 cases with reverse portal flow were excluded judged by portoechography. Satisfactory embolization was gained in 90 2% (55/*!61) of the remaining patients determined by ultrasonography and surgery. All cases ran an uneventful postembolization course with no aberrant embolization. CONCLUSION PVE with intraportal ethanol injection of appropriate dosage via a fine needle is safe and effective and has several advantages comparing with transcatheter method. Portoechography is a mandatory approach for the prevention of aberrant embolization. | Lu MD Chen JW Xie XY Liang LJ Huang JF | 1999 | World Journal of Gastroenterology1999，5，6： | 15 |
| 2 | On abiogenic natural gas显示文摘NATURAL gases usually refer to the inflammable gases dominated by methane from the angle of research on energy gases. Three genetic types of natural gases can be recognized according to the process of methane generation: (ⅰ) biogenic (bacterial) gas, mainly the gas formed by the decomposition of organic matter in sediments under the action of anaerobic bacteria; (ⅱ) thermogenic gas, mainly the gas formed by the degradation of organic matter in sediments under the action of certain temperature and pressure; (ⅲ) abiogenic gas, mainly the | Wang, XB Li, CY Chen, JF Xia, XY Guo, ZQ Xie, HS | 1997 | Chinese Science Bulletin1997，42，16： | 5 |
| 3 | Tumor necrosis factor-alpha G- 308A gene polymorphism and coronary heart disease susceptibility: an updated meta-analysis 显示文摘 | Zhang I-IF Xie SL Wang JF | 2011 | Thromb Res2011，127，5： | 1 |
| 4 | A chemical-regulatedinducible RNAi system in plants显示文摘 | Guo HS Fei JF Xie Q | 2003 | Plant J2003，34，3： | 1 |
| 5 | TRPM2, calcium and neurodegenerative diseases显示文摘 | Xie YF Macdonald JF Jackson MF | 2010 | Int J Physiol Pathophysiol Pharmacol2010，2，2： | 1 |
| 6 | Receptor binding of PDGF- AA and PDGF- BB and the modulation of PDGF receptors by TGF-β in Human periodontal ligament cells显示文摘 | Oates TW Kose KN Xie JF | 1996 | J Cellular Physiology1996，162，： | 1 |
| 7 | Mechanical evaluation of three access devices for laparoendoscopic single-site surgery 显示文摘 | Xie XF Zhu JF Song CL | 2013 | J Surg Res2013，185，2： | 1 |
| 8 | Marrow mesenchymal stem ceils transduced with TPO/FL genes as support for ex vivo ex- pansion of hematopoietic stem/progenitor cells显示文摘 | Xie CG Wang JF Xiang Y | 2005 | Cell Mol Life Sci2005，62，21： | 1 |
| 9 | Genetic influences on cognitive decline in Parkinson's disease显示文摘 | Morley JF Xie SX Hurtig HI | 2012 | Mov Disord2012，27，4： | 1 |
| 10 | Evaluation of glomerular filtration rate using cystatin C in diabetic pat ients analysed by multiple factors including tubular function显示文摘 | Zhang PP Zhang JF Xie HL | 2010 | J Int Med Res2010，38，2： | 1 |
| 11 | Use of tubularized peritoneal free grafts as urethral substitutes in the rabbit显示文摘 | Shaul DB Xie HW Diaz JF | 1996 | J Pediats Surg1996，31，2： | 1 |
| 12 | Bidirectional morphological changes induced by dexamethasone in Morris hepatoma cell lines McA-RH7777 and McA-RH8994:independence of fi-bronectin and its receptor显示文摘 | Fukuda K Xie RL Chiu JF | 1991 | Exp Cell Res1991，195，1： | 1 |
| 13 | Evaluation of glomer-ular filtration rate using cystatin C in diabetic patients ana-lysed by multiple factors including tubular function显示文摘 | Zhang PP Zhan JF Xie HL | 2010 | JLntMedRes2010，38，2： | 1 |
| 14 | MicroRNA directs mRNA cleavage of the transcription factor NAC1 to downregulate auxin signals for Arabidopsis lateral root development 显示文摘 | Guo HS Xie Q Fei JF | 2005 | The Plant Cell2005，17，5： | 1 |
| 15 | PDGF-alpha receptor subnit expression down-regulated by IL-1beta in human periodontal ligament cells显示文摘 | Oates TW Xie JF Clinton S | 1998 | J Dent Res1998，77，10： | 1 |
| 16 | Weekly paelitaxel improved pathologicresponse of primary chemotherapy compared with standard 3 weeks schedule in primary breast cancer 显示文摘 | Qi M Li JF Xie YT | 2010 | Breast Cancer Res Treat2010，123，1： | 1 |
| 17 | A new species of genus Ornithoctonus fromsouthChina显示文摘 | Wang JF Peng X J Xie LP | 1993 | Acta SciNatl Univ Norm Hunan1993，16，： | 1 |
| 18 | Bidirectional morphological changes induced bydexamethasonein Morrishepatomacell linesMcA-RH7777 and McA-RH8994:independence of fibronectin and its receptor显示文摘 | Fukuda K Xie RL Chiu JF | 1991 | Exp Cell Res1991，195，1： | 1 |
| 19 | TRPM2,Calcium and neurodegenerative diseases显示文摘 | Xie YF Macdonald JF Jackson MF | 2010 | Int J Physiol Pathophysiol Pharmacol2010，2，2： | 1 |
| 20 | Use of tubularized peritoneal free grafts as urethral substitutes in the rabbit 显示文摘 | Shaul DB Xie HW Diaz JF | 1996 | J Pediatr Surg1996，31，2： | 1 |
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