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| 1 | Protective effects of kidney-tonifying Chinese herbal preparation on substantia nigra neurons in a mouse model of Parkinson's disease显示文摘The Chinese herbs Herba Epimedii, Fructus Ligustri Lucidi and Rhizoma Polygonati were injected into Parkinson's disease mice established via intraperitoneal injection of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine hydrochloride. The selective monoamine oxidase B inhibitor selegiline was used as a positive control drug. After successive administration for 4 weeks, Herba Epimedii could downregulate the expression of caspase-3 and increase the brain-derived neurotrophic factor level, as well as increase tyrosine hydroxylase activity in the substantia nigra of Parkinson's disease mouse models. Rhizoma Polygonati could downregulate the expression of caspase-3 and FasL, and increase neural growth factor and brain-derived neurotrophic factor levels. Fructus Ligustri Lucidi could downregulate caspase-3 expression. Rhizoma Polygonati and Fructus Ligustri Lucidi did not produce obvious effects on tyrosine hydroxylase activity. Herba Epimedii and Fructus Ligustri Lucidi yielded similar effects on apoptosis-promoting factors to those elicited by selegiline. Herba Epimedii and Rhizoma Polygonati significantly increased the levels of neurotrophic factors compared with selegiline. Herba Epimedii significantly increased tyrosine hydroxylase activity compared with selegiline. It is indicated that the kidney-tonifying Chinese herbal preparation can downregulate the expression of apoptosis-promoting factors, increase neurotrophic factors levels in the substantia nigra and striatum, as well as increase tyrosine hydroxylase activity in the substantia nigra of Parkinson's disease mouse models, thereby exerting a stronger or similar neuroprotective effects compared with selegiline. | Jing Cai Yun Tian Ruhui Lin Xuzheng Chen Zhizhen Liu Jindong Xie | 2012 | Neural Regeneration Research2012，7，6： | 5 |
| 2 | Specific distribution of orientated C70-fullerene triggered by solvent-tuned macrocycle adlayer显示文摘在可控制的位置的器官的分子的精确本地化是向经由自底向上的策略构造功能的 nanostructures 的一个重要步骤。此处,超分子地在修改 macrocycle 的表面上组织了 C70-fullerene 集会用随理论计算在联合扫描通道显微镜学(STM ) 被调查。结果表明 C70-fullerene adlayers 的一个起来集会成功地在底部 macrocycle 数组上被形成。密度功能的理论(DFT ) 计算证实与共同吸附的溶剂 1-phenyloctane 一起的 macrocycle 网络为套住 C70-fullerene 分子在用作一个选择模板光谱地点并且充当了对 C70-fullerene 分子的支持。C70-fullerene 分子的期刊分发应该在特定的相互作用之上便于 C70-fullerene 的安排的强壮的依赖的理解(除了空间识别) 源于亚单层的修正。 | Yanfang Geng Ping Li Jindong Xue Dapeng Luo Junyong Zhang Lijin Shu Ke Deng Jingli Xie Qingdao Zeng | 2017 | Nano Research2017，10，3： | 2 |
| 3 | Influence of the structure of implanted steel, with Y,Y+ C and Y+Cr on the behaviors of wear, oxidation and corrosion resistance 显示文摘 | Zhang Tonghe Xie Jindong Ji chengzhou | 1995 | Surface and Coatings Technology1995，72，12： | 1 |
| 4 | Cardiac energy metabolism disorder mediated by energy substrate imbalance and mitochondrial damage upon tebuconazole exposure显示文摘Tebuconazole exposure has been described as an increasing hazard to human health.An increasing number of recent studies have shown a positive association between tebuconazole exposure and cardiovascular disease risk,which is characterized by the reduction of adenosine triphosphate(ATP)synthesis.However,researches on the damage of tebuconazole exposure to energy metabolism and the related molecular mechanisms are limited.In the present study,male C57BL/6 mice were treated with tebuconazole at different low concentrations for 4 weeks.The results indicated that tebuconazole could accumulate in the heart and further induce the decrease of ATP content in the mouse heart.Importantly,tebuconazole induced an obvious shift in substrate utilization of fatty acid and glucose by disrupting their corresponding transporters(GLUT1,GLUT4,CD36,FABP3 and FATP1)expression,and significantly repressed the expression of mitochondrial biogenesis(Gabpa and Tfam)and oxidative phosphorylation(CS,Ndufa4,Sdhb,Cox5a and Atp5b)related genes in a dosedependent manner.Further investigation revealed that these alterations were related to the IRS1/AKT and PPARγ/RXRαpathways.These findings contribute to a better understanding of triazole fungicide-induced cardiovascular disease by revealing the key indicators associated with this phenomenon. | Tingting Ku Jindong Hu Mengmeng Zhou Yuanyuan Xie Yutong Liu Xin Tan Lin Guo Guangke Li Nan Sang | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 5 | Loading experiment and thermal analysis for conduction cooled magnet of SMES system显示文摘China’s first 35 kJ high temperature superconducting magnetic energy storage(SMES)system with an experiment equipment was depicted.The dynamic heat analysis of the magnet of the SMES was conducted through the current load test on the directly cooled conduction magnet.The research results were as follows:when the converter charges and discharges the magnet for energy storage,the hysteresis loss is the main part of power loss,and contributes significantly to temperature rise;reducing the current frequency at the side of direct current is conducive to restraining temperature rise.The optimizing factors of the cool-guide structure were analyzed based on the heat stability theory,and it was found that the heat transfer of its key part(at the top of the magnet)must be strengthened to reduce the axial temperature difference of the magnet. | Gang WU Huiling WANG Jiangbo XIE Yan ZHAO Yuejin TANG Jindong LI Jing SHI | 2009 | Frontiers of Electrical and Electronic Engineering in China2009，4，2： | 0 |
| 6 | The burgeoning importance of PIWI-interacting RNAs in cancer progression显示文摘PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ cells.Recent studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and stemness.Additionally,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of tumors.Nonetheless,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully comprehended.This review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer. | Xinpei Deng Tianle Liao Jindong Xie Da Kang Yiwei He Yuying Sun Zhangling Wang Yongluo Jiang Xuan Miao Yixuan Yan Hailin Tang Lewei Zhu Yutian Zou Peng Liu | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 7 | Modified Circumpolar Deep Water inflow to the Dotson-Getz Trough in the summers of 2020 and 2022显示文摘The melting of the West Antarctic Ice Shelf has increased since the 1990s,driven by the relatively warm Circumpolar Deep Water(CDW)that penetrates into the West Antarctic Ice Shelf cavities through submarine glacial troughs across the continental shelf.In this study,temperature,salinity,and current velocity data obtained by the Chinese National Antarctic Research Expedition in the Dotson-Getz Trough(DGT)shows clear differences in distribution of modified Circumpolar Deep Water(mCDW)in the summers of 2020 and 2022.Combined with contemporaneous wind data and additional temperature and salinity data from instrumented seals,the processes and mechanisms responsible for this variation are discussed.Compared with 2020,there is a significant increase in mCDW thickness in 2022,with a doubling of total heat content as the mCDW inflow path across the DGT shifts towards the eastern bank.We propose that a southward shift in the westerly winds in the summer of 2022 moved the upper oceanic divergence zone southward towards the continental slope,promoting the upwelling of mCDW above 500 m.Concurrently,stronger westerly winds over the continental slope strengthened the eastward undercurrent,increasing the transport of this mCDW and its associated heat content to the DGT through Ekman dynamics.These observations show there is strong interannual variability in the strength,path and extent of mCDW inflows to the DGT and that care must be taken when planning observation programs for long-term monitoring of the oceanic heat input to the ice shelves of this globally significant region. | XIE Chunhu SHI Jiuxin SUN Yongming JIANG Jindong Guy DWILLIAMS SHUAI Hongtao LIN Lijin XIAO Changhao CAO Yong WANG Kun | 2023 | Advances in Polar Science2023，34，2： | 0 |
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