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| 1 | Preparation, stability and pharmacokinetics evaluation of lipid microspheres loading a promising antitumor candidate, Timataxel显示文摘Timataxel(13-(N-Boc-3-i-butylisoserinoyl-4,10-β-diacetoxy-2-α-benzoyloxy-5-β-20-epoxy-1,13-α-dihydroxy-9-oxo-19-norcyclopropa[g]tax-11-ene)), used to be called TM-2, is a novel semi-synthetic promising candidate for cancer treatment. However the preformulation study showed that TM-2 was insoluble and chemically instable in water, which would limit its application. This study aimed at the preparation of Timataxel lipid microspheres(TM-2 LMs)and investigated the difference between TM-2 LMs and TM-2 solution in pharmacokinetics. In this work, the final formulation was as follows: 0.10%(w/v) TM-2;10.00%(w/v) oil phase(long chain triglyceride:media chain triglyceride = 2.50%:7.50%);1.40%(w/v) phospholipid;0.02%(w/v) NaH2 PO4;2.25%(w/v) glycerin and water to a total volume of 100 ml.The particle size distribution, content and entrapment efficacy were 205.0 ± 43.3 nm, 101.00% and 99.12%, respectively. TM-2 LMs were stable during storage at 25 °C for 3 months, even under the condition of 60 °C and 4500 lx for 10 d. Phosphatidylethanolamine(PE) in phospholipid may contribute to the stability of TM-2 LMs. The pharmacokinetic parameters for TM-2 LMs were as follows: AUC(0-∞) 3663.71 μg/l h and the clearance 2.26 l/h/kg. As for solution, these parameters were 1712.52 μg/l h and 4.77 l/h/kg, respectively. The t1/2 of TM-2 LMs was similar to TM-2 solution. The pharmacokinetic results indicated that the AUC of TM-2 LMs was larger, the clearance was smaller than that of TM-2 solution. In a word, lipid microspheres were a promising drug delivery system for TM-2. | Yan Li Haibing He Qiao Wang Xing Tang | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，6： | 4 |
| 2 | Supersaturation induced by Itraconazole/Soluplus micelles provided high GI absorption in vivo显示文摘To investigate the effect of supersaturation induced by micelle formation during dissolution on the bioavailability of itraconazole(ITZ)/Soluplus~? solid dispersion. Solid dispersions prepared by hot melt extrusion (HME) were compressed into tablets directly with other excipients. Dissolution behavior of ITZ tablets was studied by dissolution testing and the morphology of micelles in dissolution media was studied using transmission electron microscopy (TEM). Drug transferring from stomach into intestine was simulated to obtain a supersaturated drug solution. Bioavailability studies were performed on the ITZ tablets and Sporanox~? in beagle dogs. The morphology of micelles in the dissolution media was observed to be spherical in shape, with an average size smaller than 100 nm. The supersaturated solutions formed by Soluplus~? micelles were stable and no precipitation took place over a period of 180 min. Compared with Sporanox~?, ITZ tablets exhibited a 2.50-fold increase in the AUC (0–96) of ITZ and a 1.95-fold increase in its active metabolite hydroxyitraconazole (OHITZ) in the plasma of beagle dogs. The results obtained provided clear evidence that not only the increase in the dissolution rate in the stomach, but also the supersaturation produced by micelles in the small intestine may be of great assistance in the successful development of poorly water-soluble drugs. The micelles formed by Soluplus~? enwrapped the molecular ITZ inside the core which promoted the amount of free drug in the intestinal cavity and carried ITZ through the aqueous boundary layer(ABL), resulting in high absorption by passive transportation across biological membranes. The uptake of intact micelles through pinocytosis together with the inhibition of P-glycoprotein-mediated drug efflux in intestinal epithelia contributed to the absorption of ITZ in the gastrointestinal tract. These results indicate that HME with Soluplus~?, which can induce supersaturation by micelleformation, may be of great assistance to the successful development of poorly watersoluble drugs. | Yue Zhong Guanghui Jing Bin Tian Hao Huang Yuanyuan Zhang Jingxin Gou Xing Tang Haibing He Yanjiao Wang | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，2： | 3 |
| 3 | Internationalization of the “DPRK Defectors” Issue显示文摘Over the past 20 years,the 'DPRK Defectors' issue has become a security issue affecting China's relations with its neighbors.Not only does this issue exacerbate the conflict between North and South Korea and contribute to unrest on the peninsula,but it also causes diplomatic disputes that affect relations among the big powers in Northeast Asia and China's regional security. | Piao Jianyi Li Zhifei Xing Haibing | 2012 | Contemporary International Relations2012，22，5： | 1 |
| 4 | Tablets of paliperidone using compression-coated technology for controlled ascending release显示文摘The aim of this work was to prepare ascending release compression-coated(CC) tablets with paliperidone(PAL) using a simple manufacturing technique and short manufacturing process.The release behavior and mechanisms in vitro of the final tablets was investigated and evaluated. The PAL CC tablets were comprised of a core layer of high viscosity hydroxypropyl cellulose(HPC-H) and a coating layer of high viscosity hydroxypropyl methylcellulose(HPMCK100 M). Several factors such as materials and core tablet compositions were studied for their influence in the formulation procedure. The drug release mechanism was studied using gravimetric analysis. The data could be fitted to the Peppas model. The ascending drug release results were expressed in terms of the slope of the release curve at different time points.Results showed that the formulation could achieve a good ascending drug release when the weight ratio of PAL was 5:1(core:layer). The fraction of HPC and HPMC was 33 %, and the combination of Eudragit RL-PO was 10%. The ascending release mechanism was due to solvent penetration into the PAL CC tablets, and subsequent drug dissolution from the gelatinous HPC and HPMC matrix erosion. The release mechanism was therefore a combination of diffusion and erosion. This work demonstrated that the compression-coated tablets could achieve controlled ascending release over 24 h for the oral administration systems. | Yingying Tang Huan Teng Yanan Shi Haibing He Yu Zhang Tian Yin Cuifang Cai Xing Tang | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，2： | 1 |
| 5 | Maternal genetic history of ancient Tibetans over the past 4000 years显示文摘The settlement of the Tibetan Plateau epitomizes human adaptation to a high-altitude environment that poses great challenges to human activity.Here,we reconstruct a 4000-year maternal genetic history of Tibetans using 128 ancient mitochondrial genome data from 37 sites in Tibet.The phylogeny of haplotypes M9a1a,M9a1b,D4g2,G2a’c,and D4i show that ancient Tibetans share the most recent common ancestor with ancient Middle and Upper Yellow River populations around the Early and Middle Holocene.In addition,the connections between Tibetans and Northeastern Asians vary over the past 4000 years,with a stronger matrilineal connection between the two during 4000 BPe3000 BP,and a weakened connection after 3000 BP,that are coincident with climate change,followed by a reinforced connection after the Tubo period(1400 BPe1100 BP).Besides,an over 4000-year matrilineal continuity is observed in some of the maternal lineages.We also find the maternal genetic structure of ancient Tibetans is correlated to the geography and interactions between ancient Tibetans and ancient Nepal and Pakistan populations.Overall,the maternal genetic history of Tibetans can be characterized as a long-term matrilineal continuity with frequent internal and external population interactions that are dynamically shaped by geography,climate changes,as well as historical events. | Ganyu Zhang Can Cui Shargan Wangdue Hongliang Lu Honghai Chen Lin Xi Wei He Haibing Yuan Tinley Tsring Zujun Chen Feng Yang Tashi Tsering Shuai Li Norbu Tashi Tsho Yang Yan Tong Xiaohong Wu Linhui Li Yuanhong He Peng Cao Qingyan Dai Feng Liu Xiaotian Feng Tianyi Wang Ruowei Yang Wanjing Ping Ming Zhang Xing Gao Yichen Liu Wenjun Wang Qiaomei Fu | 2023 | Journal of Genetics and Genomics2023，50，10： | 1 |
| 6 | Characteristics of the Current Political Situation in the Middle East显示文摘In 2013 four characteristics defined the situation in the Middle East—political 'chaos' in the Arab world, 'flux and reflux' between moderate and radical Islamists, geopolitical shocks caused by the withdrawal of the U.S., and uncertainty over the Iranian nuclear issue. The influence of volatility and newly regrouped geopolitical factors mean the situation in the Middle East will remain turbulent for a relatively long time unless deep-seated resolution of major issues involves mature governance. | Li Shaoxian Xing Haibing | 2014 | Contemporary International Relations2014，24，1： | 1 |
| 7 | Divergence and Co-operation between China and the U.S.on the Cyberspace Issue显示文摘In the consideration of the establishment of a new type of big power relationship and the principles of the international network,both China and the U.S.should strengthen their governmental and civilian dialogues,promote bilateral co-operation on the fight against cyber crime and the governance of Internet,and have more mutual understanding and agreement on the issue of cyber arms controls and cyber sovereignty. | Yi Wenli Xing Haibing | 2012 | Contemporary International Relations2012，22，4： | 1 |
| 8 | Area-efficient transient power-rail electrostatic discharge clamp circuit with mis-triggering immunity in a 65-nm CMOS process显示文摘A novel, area-efficient transient power-rail electrostatic discharge(ESD) clamp circuit is proposed in this work. Current-mirror capacitors are used to reduce the layout area. Logic threshold voltages of inverters are modified to ensure a fully active on-state for the clamp device in ESD conditions. The proposed circuit reduces the layout area by about 56% compared with a circuit without current-mirror capacitors. Transmission line pulse(TLP) test results based on a 65-nm CMOS process demonstrate that the proposed circuit is an efficient on-chip ESD protection scheme for this process. In addition, the proposed circuit achieves a good immunity to mis-triggering with respect to fast power-up transitions. | Yuan WANG Guangyi LU Haibing GUO Jian CAO Song JIA Xing ZHANG | 2016 | Science China(Information Sciences)2016，59，4： | 1 |
| 9 | An intravenous clarithromycin lipid emulsion with a high drug loading, H-bonding and a hydrogen-bonded ion pair complex exhibiting excellent antibacterial activity显示文摘The aim of this study was to develop an intravenous clarithromycin lipid emulsion(CLE)with good stability and excellent antibacterial activity. The CLE was prepared by the thinfilm dispersed homogenization method. The interaction between clarithromycin(CLA) and cholesteryl hemisuccinate(CHEMS) was confirmed by DSC, FT-IR and^1H NMR analysis. The interfacial drug loading, thermal sterilization, freeze–thaw stability, and in vitro and in vivo antibacterial activity were investigated systematically. DSC, FT-IR and^1H NMR spectra showed that CHEMS(CLA: CHEMS, M ratio 1:2) could interact with CLA through H-bonding and a hydrogen-bonded ion pair. The CHEMS was found necessary to maintain the stability of CLE.Ultracentrifugation showed that almost 88% CLA could be loaded into the interfacial layer.The optimized CLE formulation could withstand autoclaving at 121 °C for 10 min and remain stable after three freeze–thaw cycles. The in vitro susceptibility test revealed that the CLA–CHEMS ion-pair and CLE have similar activity to the parent drug against many different bacterial strains. The in vivo antibacterial activity showed that the ED50 of intravenous CLE was markedly lower than that of CLA solution administrated orally. CLE exhibited pronounced antibacterial activity and might be a candidate for a new nanocarrier for CLA with potential advantages over the current commercial formulation. | Haoyu Gong Sicong Geng Qi Zheng Puxiu Wang Lifeng Luo Xiuzhi Wang Yan Zhang Yu Zhang Haibing He Xing Tang | 2016 | Asian Journal of Pharmaceutical Sciences2016，11，5： | 1 |
| 10 | 'Lone Wolf' Terror and How to Prevent It显示文摘In comparison with organized terrorist attack, 'lone wolf' attack usually takes place more unexpectedly. Currently this kind of terror is regarded as the biggest threat to homeland security by many countries in Europe and North America. It is necessary for international community to take the 'lone wolf' terrorism seriously and to cope with the threat more effectively. | Yan Shuai Xing Haibing | 2014 | Contemporary International Relations2014，24，5： | 1 |
| 11 | Clarithromycin-loaded liposomes offering high drug loading and less irritation显示文摘 | Xiaona Liu Wei Sun Bo Zhang Bin Tian Xing Tang Na Qi Haibing He Huifang Li Xiangqun Jin | 2013 | International Journal of Pharmaceutics . 2013 (1-2)2013，，： | 1 |
| 12 | Chinese Academic Researches on Democratization of International Relations:Status and Problems显示文摘After the Cold War,hegemony and power politics remained the major obstacles in the process of establishing a fair,just,inclusive and orderly global political and economic order.Due to the complicated and volatile international political and economic situation,promoting democratization of international relations as well as establishing a fair | Xiao Wenchao Xing Haibing | 2014 | Contemporary International Relations2014，24，2： | 0 |
| 13 | An Analysis of the Rebalancing of China-U.S.Economic Relations显示文摘Sino-U.S. economic relations have been marked by mutual benefits and win-win results, but also great imbalances. The trend towards rebalancing has been evident in Sino-U.S. economic relations since the onset of the international financial crisis. The author tries to make an analysis of the rebalancing of Sino-U.S. economic relations from the perspectives of historical evolution and present development. | Zhang Jiye Xing Haibing | 2015 | Contemporary International Relations2015，25，1： | 0 |
| 14 | An Analysis of China's Power Status and International Standing显示文摘China's rise has attracted a lot of attention in the world. World situation and international security environment change has provided opportunity for China to have a new understanding of status and position. China needs to think more accurately and deeply about its own status for the sake of its foreign strategy and diplomatic work. | Wang Wenfeng Xing Haibing | 2014 | Contemporary International Relations2014，24，5： | 0 |
| 15 | Sino-U.S.Scientific/Technical Cooperation and China's Response显示文摘Sino-U.S.scientific/technical exchange and cooperation is one of the vital factors in bilateral relations.It is a reflection of win-win results.This area should be explored as a top priority in the construction of the new type big power relations between the two countries.But scientific/technical exchange and cooperation also faces many problems.For the healthy development of Sino-U.S.scientific/technical exchange and cooperation,great strategic importance should be attached to bilateral scientific/technical exchanges. | Wang Mingguo Xing Haibing | 2013 | Contemporary International Relations2013，23，5： | 0 |
| 16 | Why Is Shinzo Abe so Eager to Improve Relations with China?显示文摘Japanese Prime Minister Shinzo Abe has maintained a tough stance onChina since he took office.Not only has his administration antagonized China over sensitive issues such as territorial disputes but it has also launched a public opinion war,exaggerating the China threat to the international community.Abe’s government has also been trying to | Huang Dahui Xing Haibing | 2014 | Contemporary International Relations2014，24，6： | 0 |
| 17 | Thinking on the Theory of 'China's Century'显示文摘As China's economy and global influence increase,its international relations are quickly changing.As more credence is given to predictions of a'China Century'to follow the'American Century,'interest is also increasing in the adjustments China is making to its strategic diplomacy as it prepares to take the first chair from the United States.The conceptual innovation in China's diplomacy in 2014 is a significant harbinger in the eyes of many as to how this China Century will shape up.While China's new diplomacy is praised,opinion differs on its future intentions.After a series of proposals were put forward at summit meetings of CICA(Conference on Interaction and Confidence-Building Measures | He Lan Xing Haibing | 2015 | Contemporary International Relations2015，25，2： | 0 |
| 18 | Strategic Planning for Its Neighboring Diplomacy显示文摘Since security on the periphery is vital to a country’s overall security,China’s considerations of its peripheral areas have remained among the four pillars of its diplomacy,the others being big power,developing country,and multilateralism.With the establishment of the P.R.C.and the Cold War,past relations with neighboring countries were stormy,with policies toward some involving confrontation,even armed clashes.The Cold War’s end and China’s growing comprehensive power have affected security in peripheral areas and the power structure in neighboring countries,increasing the pressure for timely adjustment and reform of diplomatic strategy.Efforts were discernable during the CPC | Wu Zhicheng Xing Haibing | 2015 | Contemporary International Relations2015，25，2： | 0 |
| 19 | Russia-U.S. Rivalry in the Context of Power Imbalance显示文摘The proposals to 'restart' Russia-U.S. relations are bedeviled by bilateral conflicts over domestic politics, perceptions about political interference, and human rights. Any geopolitical contest in the post-Soviet region or the Middle East creates intense disagreement. Despite disparity in goals, Russia-U.S. relations will soon evolve to a state of 'Cold Peace' plus 'Cold Cooperation.' | Feng Yujun Xing Haibing | 2014 | Contemporary International Relations2014，24，3： | 0 |
| 20 | Go Ahead Steadily and Avoid Eagerness显示文摘If China's strategic planning is analyzed as a movement from goals to actions,it becomes possible to see whether short-term goals that lead to large results may not be best long-term.Strategic planning consists of three key factors,first to set up correct goals,second to evaluate the situation precisely,and third to act correctly.Evaluation,the second step,assesses advantages and disadvantages in the process toward strategic decision-making.The third step,creating the correct strategy,policies and guidelines,will mandate actions in accord with a well-organized format.To use short-hand,the three are:what we want to do,what we can do,and how we can do it.During the War of Resistance against Japanese Aggression。 | Lin Limin Xing Haibing | 2015 | Contemporary International Relations2015，25，2： | 0 |
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