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| 1 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 2 | Extensive neurite out-growth and active synapse formation on self-assembling peptide scaffolds 显示文摘 | Todd C H Sonsoles L Xing S | 2000 | PNAS2000，97，12： | 1 |
| 3 | Surveys of transmitted HIV drug resistance in 7 geographic regions in China, 2008-2009 显示文摘 | Liao L Xing H Dong Y Qin G Ma Y Lu H Chen L Zhang L Osborne C Seguy N Wei D Sun F Yang J Ru- an Y Shao Y | 2012 | Clin Infect Dis2012，54，4： | 1 |
| 4 | 2013, Antigenic and genetic characterization of a European avian-like H1N1 swine influenza virus from a boy in China in 2011显示文摘 | Qi x Cui L Jiao Y Pan Y Li X Zu R Huo X Wu B Tang F Song Y Zhou M Wang H Cardona C J Xing Z | 2013 | Archives of Virology2013，158，1： | 1 |
| 5 | Moisture absorption studies of sisal fibre reinforced polypropylene composites 显示文摘 | C P L Chow X S Xing R k Y Li | 2007 | Composites science and technology2007，67，： | 1 |
| 6 | Achieving higher resolution ISAR imaging with limited pulses via compressed sampling显示文摘 | Zhang L Xing M Qiu C | 2009 | IEEE Geoscience and Remote Sensing Letters2009，6，3： | 1 |
| 7 | Natural variation in GS5 plays an important role in regulating grain size and yield in rice显示文摘 | Li Y B Fan C C Xing Y Z Jiang Y H Luo L J Sun L Shao D Xu C J Li X H Xiao J H He Y Q Zhang Q F | 2011 | Nature genetics2011，2，43： | 1 |
| 8 | Therapeutic treatment plan optimization with probability density-based dose prescription 显示文摘 | Cotrutz C Xing L | 2003 | Med Phys2003，30，4： | 1 |
| 9 | Surface topography and character of gamma-aminopropyltriethoxysilane and dodecyltrimethoxysilane films adsorbed on the silicon dioxide substrate via vapour phase deposition显示文摘 | Cai C J Shen Z G Xing Y S Ma S L | 2006 | Journal of Physics D-AppliedPhysies2006，39，22： | 1 |
| 10 | Inducible co-stimulator (ICOS) is upregulated in experimental autoimmune uveoretinitis 显示文摘 | Xing L Yang P Wu C | 2006 | Graefe 's Arch Clin Exp Ophthalmol2006，244，： | 1 |
| 11 | 查看详情显示文摘 | Li H C Sheng L Xing D Y | | 0，，： | 1 |
| 12 | Detecting Bruises on ‘Golden Delicious’ Apples using Hyperspectral Imaging with Multiple Wavebands显示文摘 | Juan Xing Cédric Bravo Pál T. Jancsók Herman Ramon Josse De Baerdemaeker | 2004 | Biosystems Engineering2004，，1： | 1 |
| 13 | High Resolution Miniaturized Stepper Ultrasonic Motor Using Differential Composite Motion显示文摘 | Chu X C Xing Z P Li L T etal | 2004 | Ultrasonics2004，41，9： | 1 |
| 14 | Adaptation and mal-adaptation to ambient hypoxia; Andean, Ethiopian and Himalayan patterns显示文摘 | Xing G Quails C Huicho L | 2008 | PLoS One2008，3，6： | 1 |
| 15 | Genetic analysis for drought resistance of rice at reproductive stage in field with different types of soil 显示文摘 | Yue B Xiong L Z Xue W Y Xing Y Z Luo L J Xu C G | 2005 | Theoretical and Applied Genetics2005，111，6： | 1 |
| 16 | Vascular endothelial growth factor in human lung transplantation显示文摘 | Meyer K C Cardoni A L Xing Z | 2001 | Chest2001，119，1： | 1 |
| 17 | Natural variation in GS5 plays an important role in regulating grain size and yield in rice 显示文摘 | Li Y Fan C Xing Y Jiang Y Luo L Sun L Shao D Xu C Li X Xiao J He Y Zhang Q | 2011 | Nature Genetics2011，43，12： | 1 |
| 18 | Achieving higher resolution ISAR imaging with limited pulses via compressed sampling显示文摘 | Zhang L Xing M D Qiu C W | | 0，，03： | 1 |
| 19 | Porous Pd films as effective eth- anol oxidation electrocatalysts in alkaline medium显示文摘 | Xing X L Cherevko S Chung C H | 2011 | Mater Chem Phys2011，126，： | 1 |
| 20 | Plasma level of mitochondrial coupling factor 6 increases in patients with type 2 diabetes mellitus 显示文摘 | Li X L Xing Q C Gao Y Y | 2007 | Int J Cardiol2007，117，3： | 1 |
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