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| 1 | Excessive UBE3A dosage impairs retinoic acid signaling and synaptic plasticity in autism spectrum disorders显示文摘孤独性光谱混乱(ASD ) 是有异构的病原学的许多人的神经病学的混乱。E3 ubiquitin (Ub ) 的活动过度 ligase UBE3A,不完全地源自 15q11-q13 拷贝数字变化,为世界范围的 ASD 盒子的 1%-3% 的报道,而是内在的机制遗体描绘了。这里,我们报导 ALDH1A2 的功能, retinoic 酸(RA ) 的限制率的酶合成,被 UBE3A 否定地以一种 ubiquitylation 依赖的方式调整。过多的 UBE3A 剂量被发现损害调停 RA 的 neuronal homeostatic synaptic 粘性。象 ASD 一样症状被 overexpressing UBE3A 在前额的外皮或由一个 ALDH1A 对手的管理在老鼠概括,而 RA 补充显著地减轻了过多的 UBE3A 导致剂量的象 ASD 一样显型。由识别在 ASD 作为内在的机制发信号的减少的 RA,显型连接了到 UBE3A 活动过度,我们的调查结果介绍 ASD 病原学的新远景并且对这逐渐地流行的疾病便于治疗学的开发的一个模式。 | Xingxing Xu Chuanyin Li Xiaobo Gao Kun Xia Hui Guo Yali Li ZijianHao Lei Zhang Daming Gao Chenfan Xu Huatai Xu Zhi-Qi Xiong Zilong Qiu Ling Mei Xiaoduo Xie Kangcheng Ruan Ronggui Hu | 2018 | Cell Research2018，28，1： | 13 |
| 2 | Ubiquitylation of p62/sequestosome1 activates its autophagy receptor function and controls selective autophagy upon ubiquitin stress显示文摘在细胞的 ubiquitin (Ub ) 的改变动态平衡,作为 Ub 知道强调,展示并且影响处于多重条件的细胞的回答,然而,内在的机制不完全地被理解。这里,我们报导 autophagy 受体 p62/sequestosome-1 与结合酶, UBE2D2 和 UBE2D3 的 E2 Ub 交往。内长的 p62 在 Ub 动态平衡的 upregulation 期间经历 E2 依赖的 ubiquitylation,一个条件作为 Ub + 应力称为,那对由 bortezomib 的 Ub overexpression,热吃惊或延长 proteasomal 抑制内在,化学疗法的药。p62 的 Ubiquitylation 破坏 p62 的 UBA 领域的 dimerization,解放它的能力认出为选择 autophagy 的 polyubiquitylated 货物。我们进一步证明这机制可能为在 Ub + 压力条件之上的 autophagy 激活是批评的。机制的描述和在察觉到 Ub 应力并且控制选择 autophagy 的 p62 的规章的角色能帮助理解并且调制细胞的回答到许多内长、环境的挑战,潜在地对 autophagy 相关的病为治疗学的策略的发展打开一条新大街。 | Hong Peng Jiao Yang Guangyi Li Qing You Wen Han Tianrang Li Darning Gao Xiaoduo Xie Byung-Hoon Lee Juan Du Jian Hou Tao Zhang Hai Rao Ying Huang Qinrun Li Rong Zeng Lijian Hui Hongyan Wang Qin Xia Xuemin Zhang Yongning He Masaaki Komatsu Ivan Dikic Daniel Finley Ronggui Hu | 2017 | Cell Research2017，27，5： | 9 |
| 3 | Fibroblasts in an endocardial fibroelastosis disease model mainly originate from mesenchymal derivatives of epicardium显示文摘 | Hui Zhang Xiuzhen Huang Kuo Liu Juan Tang Lingjuan He Wenjuan pu Qiaozhen Liu Yan Li Xueying Tian Yue Wang Libo Zhang Ying Yu Hongyan Wang Ronggui Hu Fengchao Wang Ting Chen Qing-Dong Wang Zengyong Qiao Li Zhang Kathy O Lui Bin Zhou | 2017 | Cell Research2017，27，9： | 6 |
| 4 | Recent progress in ubiquitin and ubiquitin-like protein (Ubl) signaling显示文摘 | Ronggui Hu Mark Hochstrasser | 2016 | Cell Research2016，26，4： | 6 |
| 5 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 6 | Maternal exposure to triclosan constitutes a yet unrecognized risk factor for autism spectrum disorders显示文摘Dear Editor,Autism spectrum disorders(ASD)are complex neurodevelopmental disorders characteristic of core behavioral traits like restricted,repetitive behaviors and deficiency in social interactions.1 The prevalence of ASD has rapidly increased worldwide,rising from 1/149 in 2000,1/68 in 2012,and to?1/40 in 2016 of children at the age of 3-17 in the United States.2 ASD prevalence was found to be associated with socioeconomic status(SES)as overpresented in high-income households,3 and to be significantly enriched in certain regions,e.g.,reaching up to 4.88%in Florida.2 In the last decades,advances in genetic studies have led to unprecedented understanding of the genetic factors that were associated with<50%of human ASD. | Zijian Hao Qionghui Wu Zhengwei Li Yali Li Qiu Li Xi Lai Huan Liu Menghuan Zhang Ting Yang Jie Chen Yaping Tang Jingkun Miao Huatai Xu Tingyu Li Ronggui Hu | 2019 | Cell Research2019，29，10： | 5 |
| 7 | Spatial metabolomics for evaluating response to neoadjuvant therapy in non-small cell lung cancer patients显示文摘Background:The response to neoadjuvant chemotherapy(NAC)differs substantially among individual patients with non-small cell lung cancer(NSCLC).Major pathological response(MPR)is a histomorphological read-out used to assess treatment response and prognosis in patientsNSCLC afterNAC.Although spatial metabolomics is a promising tool for evaluating metabolic phenotypes,it has not yet been utilized to assess therapy responses in patients with NSCLC.We evaluated the potential application of spatial metabolomics in cancer tissues to assess the response to NAC,using a metabolic classifier that utilizes mass spectrometry imaging combined with machine learning.Methods:Resected NSCLC tissue specimens obtained after NAC(n=88)were subjected to high-resolution mass spectrometry,and these data were used to develop an approach for assessing the response to NAC in patients with NSCLC.The specificities of the generated tumor cell and stroma classifiers were validated by applying this approach to a cohort of biologically matched chemotherapy-naive patients with NSCLC(n=85).Results:The developed tumor cell metabolic classifier stratified patients into different prognostic groups with 81.6%accuracy,whereas the stroma metabolic classifier displayed 78.4%accuracy.By contrast,the accuracies of MPR and TNM staging for stratification were 62.5%and 54.1%,respectively.The combination of metabolic and MPR classifiers showed slightly lower accuracy than either individual metabolic classifier.In multivariate analysis,metabolic classifiers were the only independent prognostic factors identified(tumor:P=0.001,hazards ratio[HR]=3.823,95%confidence interval[CI]=1.716-8.514;stroma:P=0.049,HR=2.180,95%CI=1.004-4.737),whereasMPR(P=0.804;HR=0.913;95%CI=0.445-1.874)and TNM staging(P=0.078;HR=1.223;95%CI=0.977-1.550)were not independent prognostic factors.Using Kaplan-Meier survival analyses,both tumor and stroma metabolic classifiers were able to further stratify patients as NAC responders(P<0.001)and non-responders(P<0.001).Conclusions:Our findings indicate that the metabolic constitutions of both tumor cells and the stroma are valuable additions to the classical histomorphology-based assessment of tumor response. | Jian Shen Na Sun Philipp Zens Thomas Kunzke Achim Buck Verena M.Prade Jun Wang Qian Wang Ronggui Hu Annette Feuchtinger Sabina Berezowska Axel Walch | 2022 | Cancer Communications2022，42，6： | 3 |
| 8 | Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis显示文摘在蛋白质周转(蛋白质 degradome ) 的全球变化组成对内在或外来的刺激的细胞的回答的中央部分。然而,介绍蛋白质 degradome 仍然保持技术上挑战性。最近, proteasome 的抑制,例如由使用 bortezomib (BTZ ) ,为对待多重骨髓瘤和其它人恶意,但是药行动和肿瘤药抵抗还有待于被完成的为 BTZ 的机制的系统的理解作为主要化学疗法的策略出现了。这里,我们开发了并且适用 dual-fluorescence-based 蛋白质周转试金(ProTA ) 到份量上在导致 BTZ 的 proteasomal 抑制之上在人的蛋白质 degradome 介绍全球变化。ProTA 和随后的网络分析描出在 BTZ 化疗的 BTZ 行动和肿瘤药抵抗的潜在的分子的基础。最后,把 BTZ 的使用与指向识别 ProTA 的关键基因的药相结合或在 BTZ 行动的小径在多重骨髓瘤房间减少了 BTZ 抵抗。显著地, BTZ 稳定 proteasome 子单元 PSMC1 和 proteasome 集会因素 PSMD10,建议为调整 proteasome 动态平衡的以前下面欣赏的机制。因此, ProTA 是为介绍人的蛋白质 degradome 阐明的一个新奇工具药行动和抵抗的潜在的机制,它可能便于指向 proteostasis 对待人的混乱的治疗学的开发。 | Tao Yu Yonghui Tao Meiqiang Yang Peng Chen Xiaobo Gao Yanbo Zhang Tao Zhang Zi Chen Jian Hou Yan Zhang Kangcheng Ruan Hongyan Wang Ronggui Hu | 2014 | Cell Research2014，24，10： | 2 |
| 9 | MKRN3 regulates the epigenetic switch of mammalian puberty via ubiquitination of MBD3显示文摘Central precocious puberty(CPP)refers to a human syndrome of early puberty initiation with characteristic increase in hypothalamic production and release of gonadotropin-releasing hormone(GnRH).Previously,loss-of-function mutations in human MKRN3,encoding a putative E3 ubiquitin ligase,were found to contribute to about 30%of cases of familial CPP.MKRN3 was thereby suggested to serve as a‘brake’of mammalian puberty onset,but the underlying mechanisms remain as yet unknown.Here,we report that genetic ablation of Mkrn3 did accelerate mouse puberty onset with increased production of hypothalamic GnRH1.MKRN3 interacts with and ubiquitinates MBD3,which epigenetically silences GNRH1 through disrupting the MBD3 binding to the GNRH1 promoter and recruitment of DNA demethylase TET2.Our findings have thus delineated a molecular mechanism through which the MKRN3-MBD3 axis controls the epigenetic switch in the onset of mammalian puberty. | Chuanyin Li Wenli Lu Liguang Yang Zhengwei Li Xiaoyi Zhou Rong Guo Junqi Wang Zhebao Wu Zhiya Dong Guang Ning Yujiang Shi Yinmin Gu Peng Chen Zijian Hao Tianting Han Meiqiang Yang Wei Wang Xuehui Huang Yixue Li Shan Gao Ronggui Hu | 2020 | National Science Review2020，7，3： | 2 |
| 10 | A novel mutation in 5'-UTR of Makorin ring finger 3 gene associated with the familial precocious puberty显示文摘Central precocious puberty (CPP)is one of the most common and complex problems in clinical pediatric endocrinology practice. Currently,CPP is believed to result from complex interactions between genetic,endocrinal,nutritional,and environmental factors. Most CPP cases are commonly associated with an early activation of hypothalamic-pituitary-gonadal (HPG)axis followed by overproduction and release of GnRH from hypothalamus. | Wenli Lu Junqi Wang Chuanyin Li Manqing Sun Ronggui Hu Wei Wang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，12： | 1 |
| 11 | Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression显示文摘 | Zhengzhao Liu Peng Chen Hong Gao Yu Gu Jiao Yang Hong Peng Xingxing Xu Haifeng Wang Meiqiang Yang Xiaoying Liu Libin Fan Shiyao Chen Jian Zhou Yihong Sun Kangchen Ruan Shuqun Cheng Masaaki Komatsu Eileen White Lin Li Hongbin Ji Daniel Finley Ronggui Hu | 2014 | Cancer Cell2014，，： | 1 |
| 12 | Nitrous oxide emissions from rape field as affected by nitrogen fertilizer management: A case study in Central China显示文摘 | Shan Lin Javed Iqbal Ronggui Hu Jinshui Wu Jinsong Zhao Leilei Ruan Saadatullah Malghani | 2011 | Atmospheric Environment2011，，9： | 1 |
| 13 | CO 2 emission in a subtropical red paddy soil (Ultisol) as affected by straw and N-fertilizer applications: A case study in Southern China显示文摘 | Javed Iqbal Ronggui Hu Shan Lin Ryusuke Hatano Minglei Feng Lan Lu Bocar Ahamadou Lijun Du | 2009 | Agriculture, Ecosystems and Environment2009，，3： | 1 |
| 14 | The effect of dolomite amendment on soil organic carbon mineralization is determined by the dolomite size显示文摘Background:The size of lime material is vital for the efficiency of ameliorating soil acidity,thereby influencing soil biochemical processes.However,the effects of different sized lime material application on soil organic carbon(SOC)mineralization are yet to be elucidated.Therefore,a 35-day incubation experiment was conducted to determine the effects of three particle size fractions(0.5 to 0.25,0.25 to 0.15,and<0.15 mm)of dolomite on SOC mineralization of two acidic paddy soils.Results:CO_(2) emission was increased by 3–7%,11–21%,and 32–49%for coarse-,medium-,and fine-sized dolomite treatments,respectively,compared to the control in both soils.They also well conformed to a first-order model in all treatments,and the estimated decomposition rate constant was significantly higher in the fine-sized treatment than that of other treatments(P<0.05),indicating that SOC turnover rate was dependent on the dolomite size.The finer particle sizes were characterized with higher efficiencies of modifying soil pH,consequently resulting in higher dissolved organic carbon contents and microbial biomass carbon,eventually leading to higher CO_(2) emissions.Conclusions:The results demonstrate that the size of dolomite is a key factor in regulating SOC mineralization in acidic paddy soils when dolomite is applied to manipulate soil pH. | Hongtao Wu Jinli Hu Muhammad Shaaban Peng Xu Jinsong Zhao Ronggui Hu | 2021 | Ecological Processes2021，10，1： | 1 |
| 15 | Differences in nitrous oxide fluxes from red soil under different land uses in mid-subtropical China显示文摘 | Shan Lin Javed Iqbal Ronggui Hu Leilei Ruan Jinshui Wu Jinsong Zhao Pengju Wang | 2011 | Agriculture, Ecosystems and Environment2011，，1： | 1 |
| 16 | Structural studies of an eukaryotic cambialistic superoxide dismutase purified from the mature seeds of camphor tree显示文摘 | Chen Huaiyang Hu Ronggui Wang Baozhong | 2002 | Arch Biochem Biophys2002，404，2： | 1 |
| 17 | Impact of Long-Term Fertilization on the Composition of Denitrifier Communities Based on Nitrite Reductase Analyses in a Paddy Soil显示文摘 | Zhe Chen Xiqian Luo Ronggui Hu Minna Wu Jinshui Wu Wenxue Wei | 2010 | Microbial Ecology2010，，4： | 1 |
| 18 | Differences in soil CO 2 flux between different land use types in mid-subtropical China显示文摘 | Javed Iqbal Hu Ronggui Du Lijun Lu Lan Lin Shan Chen Tao Ruan Leilei | 2008 | Soil Biology and Biochemistry2008，，9： | 1 |
| 19 | Enterohemorrhagic E.coli effector NleL disrupts host NF-κB signaling by targeting multiple host proteins显示文摘Dear Editor,Enterohemorrhagic Escherichia coli(EHEC)0157:H7,a major diarrheagenic pathogen,can cause bloody diarrhea,hemorrhagic colitis,and>90%of hemolytic uremic syndrome in humans(Mead and Griffin,1998).Many previous studies have demonstrated that 0157:H7 could disrupt host ubiquitin(Ub)system by delivering virulence effectors into host cells with the type III secretion system(T3SS).NleL(also named EspX7)emerged as one of such effectors,whose E3-like activity was first identified in vitro in 2011(Lin et al.,2011). | Xiangpeng Sheng Qing You Hongnian Zhu Qingrun Li Hong Gao Haifeng Wang Chunping You Qing Meng Yingjie Nie Xiangyan Zhang Ronggui Hu | 2020 | Journal of Molecular Cell Biology2020，12，4： | 0 |
| 20 | A pseudovirus-based method to dynamically mimic SARS-CoV-2-associated cell-to-cell fusion and transmission显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),responsible for the COVID-19 pandemic,has caused tremendous global loss and continues to evolve to generate variants.Entry of SARS-CoV-2 into target host cells is primarily mediated by spike(S),which binds to the host receptor hACE2 and initiates virus-cell membrane fusion[1].Most COVID-19 patients show pneumocyte syncytia in the lungs[2]. | Xiangpeng Sheng Yi Yang Fang Zhu Fan Yang Honghua Wang Ronggui Hu | 2023 | Acta Biochimica et Biophysica Sinica2023，55，11： | 0 |
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